AT375326B - Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin) - Google Patents

Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin)

Info

Publication number
AT375326B
AT375326B AT0374981A AT374981A AT375326B AT 375326 B AT375326 B AT 375326B AT 0374981 A AT0374981 A AT 0374981A AT 374981 A AT374981 A AT 374981A AT 375326 B AT375326 B AT 375326B
Authority
AT
Austria
Prior art keywords
platin
cisplatin
diamine dichloride
producing microcrystalline
microcrystalline cis
Prior art date
Application number
AT0374981A
Other languages
English (en)
Other versions
ATA374981A (de
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ATA374981A publication Critical patent/ATA374981A/de
Application granted granted Critical
Publication of AT375326B publication Critical patent/AT375326B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G55/00—Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
    • C01G55/002—Compounds containing ruthenium, rhodium, palladium, osmium, iridium or platinum, with or without oxygen or hydrogen, and containing two or more other elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
    • C01P2002/72—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by d-values or two theta-values, e.g. as X-ray diagram
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
    • C01P2002/74—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by peak-intensities or a ratio thereof only
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/51—Particles with a specific particle size distribution
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/80—Compositional purity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
AT0374981A 1979-10-02 1981-08-28 Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin) AT375326B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/081,301 US4302446A (en) 1979-10-02 1979-10-02 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
ATA374981A ATA374981A (de) 1983-12-15
AT375326B true AT375326B (de) 1984-07-25

Family

ID=22163311

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0374981A AT375326B (de) 1979-10-02 1981-08-28 Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin)

Country Status (12)

Country Link
US (2) US4302446A (de)
JP (1) JPS5832029A (de)
AT (1) AT375326B (de)
AU (1) AU551710B2 (de)
BE (1) BE890192A (de)
CA (1) CA1152289A (de)
CH (1) CH647216A5 (de)
DE (1) DE3133443A1 (de)
FR (1) FR2511357B1 (de)
GB (1) GB2103591B (de)
NL (1) NL8103784A (de)
SE (2) SE450830B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275559A1 (de) * 1986-12-29 1988-07-27 LACHEMA, n.p. Platin enthaltender cytostatischer Wirkstoff

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3305248C2 (de) * 1983-02-16 1987-04-09 Degussa Ag, 6000 Frankfurt Verfahren zur Reinigung von cis-Platin-(II)-diammin-dichlorid
NL8303657A (nl) * 1983-10-24 1985-05-17 Pharmachemie Bv Voor injectie geschikte, stabiele, waterige, zoutzuur bevattende oplossing van cisplatine, alsmede werkwijze ter bereiding daarvan.
US4699978A (en) * 1985-01-18 1987-10-13 The Trustees Of Columbia University In The City Of New York Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US4686104A (en) * 1985-04-30 1987-08-11 Sloan-Kettering Institute For Cancer Research Methods of treating bone disorders
JPS61293655A (ja) * 1985-05-31 1986-12-24 Trinity Ind Corp 砂型鋳造品の砂落し装置
JP2657393B2 (ja) * 1988-05-18 1997-09-24 日本化薬株式会社 化学塞栓療法剤
FI895340A7 (fi) * 1988-11-14 1990-05-15 Bristol Myers Squibb Co Hypertoninen cisplatin-liuos
US4946689A (en) * 1988-11-23 1990-08-07 Bristol-Myers Company Concentrated, stabilized cis-diamminedinitratoplatinum solutions for conversion to cisplatin
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
CN1104378C (zh) * 1996-12-25 2003-04-02 日本化药株式会社 顺铂细粉及其制备方法
US6074626A (en) * 1998-03-20 2000-06-13 Molecular Radiation Management, Inc. Radioactive cisplatin in the treatment of cancer
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
RU2186068C2 (ru) * 1999-12-02 2002-07-27 Институт химии и химической технологии СО РАН Способ очистки цис-дихлороамминизопропиламинплатины (ii)
AUPQ641100A0 (en) * 2000-03-23 2000-04-15 Australia Nuclear Science & Technology Organisation Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents
EP1475093B1 (de) 2000-04-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Mikronisierter zolpidem Hemitartrat
IL152411A0 (en) * 2000-04-24 2003-05-29 Teva Pharma Zolpidem hemitartrate
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
CN101062053A (zh) * 2001-09-24 2007-10-31 托斯克公司 减低毒性的顺铂制剂及其使用方法
WO2004082557A2 (en) * 2003-03-15 2004-09-30 Brin Tech International Limited Package for and formulation of medicaments
JP2006521300A (ja) * 2003-03-31 2006-09-21 プリヴァ−ラケマ，エー．エス． 活性物質として白金錯体を含有する医薬組成物およびその製造方法
ES2284068T3 (es) * 2003-10-16 2007-11-01 Teva Pharmaceutical Industries Limited Preparacion de candesartan cilexetilo.
CA2552003A1 (en) * 2004-01-05 2005-07-28 Teva Pharmaceutical Industries Ltd. Methods for the production of sildenafil base and citrate salt
CA2555294A1 (en) * 2004-02-11 2005-08-25 Marina Yu Etinger Candesartan cilexetil polymorphs
RU2292210C1 (ru) * 2005-05-03 2007-01-27 Институт химии и химической технологии СО РАН (ИХХТ СО РАН) Способ получения стерилизованной микрокристаллической цис-дихлородиамминплатины (ii)
US20080085882A1 (en) * 2006-08-18 2008-04-10 University Of North Texas Health Science Center At Fort Worth Compositions and Methods for Potentiation of Cancer Agents
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) * 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
WO2008097658A1 (en) * 2007-02-09 2008-08-14 Poniard Pharmaceuticals, Inc. Encapsulated picoplatin
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200920347A (en) * 2007-07-16 2009-05-16 Poniard Pharmaceuticals Inc Oral formulations for picoplatin
AU2009210654A1 (en) * 2008-02-08 2009-08-13 Poniard Pharmaceuticals, Inc. Use of picoplatin and bevacizumab to treat colorectal cancer
WO2009113989A1 (en) 2008-03-14 2009-09-17 Bionumerik Pharmaceuticals, Inc. Compositions and methods of use of compounds to increase cancer patient survival time
DK2249825T3 (en) 2008-03-14 2016-01-11 Bionumerik Pharmaceuticals Inc Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions
US20100035853A1 (en) * 2008-08-07 2010-02-11 Hyogo College Of Medicine Method for preventing or treating cisplatin-induced nephrotoxicity
RU2421231C1 (ru) * 2010-03-15 2011-06-20 Учреждение Российской академии наук Институт химии и химической технологии Сибирского отделения РАН (ИХХТ СО РАН) Способ получения стерилизованной микрокристаллической соли цис-дихлороамминэтиламинплатины (ii)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4079121A (en) * 1974-12-13 1978-03-14 Mobil Oil Corporation Complexes of beta platinum chloride and ammonia
CA1119954A (en) * 1978-05-30 1982-03-16 Edmund S. Granatek Aqueous solution of cisplatin
US4273755A (en) * 1979-08-16 1981-06-16 Mpd Technology Corporation Preparation of platinum complexes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275559A1 (de) * 1986-12-29 1988-07-27 LACHEMA, n.p. Platin enthaltender cytostatischer Wirkstoff

Also Published As

Publication number Publication date
FR2511357A1 (fr) 1983-02-18
US4302446A (en) 1981-11-24
SE8300623D0 (sv) 1983-02-07
FR2511357B1 (fr) 1986-09-05
JPS5832029A (ja) 1983-02-24
US4322391A (en) 1982-03-30
SE450830B (sv) 1987-08-03
GB2103591A (en) 1983-02-23
AU551710B2 (en) 1986-05-08
SE8300623L (sv) 1983-02-07
CA1152289A (en) 1983-08-23
BE890192A (fr) 1982-03-02
JPH0313174B2 (de) 1991-02-21
CH647216A5 (de) 1985-01-15
DE3133443A1 (de) 1983-03-10
NL8103784A (nl) 1983-03-01
ATA374981A (de) 1983-12-15
AU7390681A (en) 1983-02-10
GB2103591B (en) 1985-03-06
SE8104661L (sv) 1983-02-04
SE455469B (sv) 1988-07-18

Similar Documents

Publication Publication Date Title
ATA374981A (de) Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin)
AT373146B (de) Verfahren zur herstellung von tabletten
DD130037A5 (de) Verfahren zur herstellung von aminoalkylheterocyclen
AT348544B (de) Verfahren zur herstellung von n-phosphono- methylglycin
DD133563A5 (de) Verfahren zur herstellung von trisubstituierten 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepinen
DD131751A5 (de) Verfahren zur herstellung von phosphonigen saeuren
ATA373083A (de) Verfahren zur herstellung von neuen platin-(ii) -diaminkomplexen
AT349446B (de) Verfahren zur herstellung von neuen polycyclo- aliphatischen diaminen
ATE5874T1 (de) Verfahren zur herstellung von platinkomplexen.
AT371802B (de) Verfahren zur herstellung von n,n,n',n'-tetraacetyl[thylendiamin
DD131470A5 (de) Verfahren zur herstellung von 2-oxy-5-isopropyliden-7-hydroxy-9-substituierten-2,6-methano-3,4,5,6-tetrahydro-2h-1-benzoxocinen
AT370996B (de) Verfahren zur herstellung einer stabilen loesung von cis-platin-(ii)-diamindichlorid
DD129212A5 (de) Verfahren zur herstellung von polyaminen
AT343624B (de) Verfahren zur herstellung von neuen n-alkyl -2,4-dinitro-6- trifluormethyldiphenylaminen
AT355592B (de) Verfahren zur herstellung von aluminiumaethyl- phosphit
AT364345B (de) Verfahren zur herstellung von n-aethylaethylendiamin
DD130248A5 (de) Verfahren zur herstellung von thiophosphorsaeure-0,0-dialkylesterchlorid
DD129445A6 (de) Verfahren zur herstellung von 1-sulfonyl-5(6)-subst.-benzimidazolen
AT368144B (de) Verfahren zur herstellung von chlor-amino-striazinen
AT358010B (de) Verfahren zur herstellung von 2(n-(2-hydroxy- aethyl)-n-niederalkylaminomethyl)-benzhydrolen
AT358055B (de) Verfahren zur herstellung von 2-chlor-4,6-bis- -alkylamino-s-triazinen
AT353759B (de) Verfahren zur herstellung von 1,2-dichloraethan
AT375653B (de) Verfahren zur herstellung von 2-oxodihydrobenzo(d)(1,3)-oxazinen
AT373872B (de) Verfahren zur herstellung von 2,2-dialkyl-4-methyl-5,5-dialkyl-3-formyl-3-pyr olinen
DD129211A5 (de) Verfahren zur herstellung von polyaminen

Legal Events

Date Code Title Description
EIH Change in the person of patent owner
ELJ Ceased due to non-payment of the annual fee
ELJ Ceased due to non-payment of the annual fee