AT375326B - Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin) - Google Patents

Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin)

Info

Publication number
AT375326B
AT375326B AT0374981A AT374981A AT375326B AT 375326 B AT375326 B AT 375326B AT 0374981 A AT0374981 A AT 0374981A AT 374981 A AT374981 A AT 374981A AT 375326 B AT375326 B AT 375326B
Authority
AT
Austria
Prior art keywords
platin
cisplatin
diamine dichloride
producing microcrystalline
microcrystalline cis
Prior art date
Application number
AT0374981A
Other languages
English (en)
Other versions
ATA374981A (de
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ATA374981A publication Critical patent/ATA374981A/de
Application granted granted Critical
Publication of AT375326B publication Critical patent/AT375326B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G55/00—Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
    • C01G55/002—Compounds containing, besides ruthenium, rhodium, palladium, osmium, iridium, or platinum, two or more other elements, with the exception of oxygen or hydrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
    • C01P2002/72—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by d-values or two theta-values, e.g. as X-ray diagram
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
    • C01P2002/74—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by peak-intensities or a ratio thereof only
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/51—Particles with a specific particle size distribution
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/80—Compositional purity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
AT0374981A 1979-10-02 1981-08-28 Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin) AT375326B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/081,301 US4302446A (en) 1979-10-02 1979-10-02 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
ATA374981A ATA374981A (de) 1983-12-15
AT375326B true AT375326B (de) 1984-07-25

Family

ID=22163311

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0374981A AT375326B (de) 1979-10-02 1981-08-28 Verfahren zur herstellung von mikrokristallinem cis-platin(ii)-diamindichlorid (cisplatin)

Country Status (12)

Country Link
US (2) US4302446A (de)
JP (1) JPS5832029A (de)
AT (1) AT375326B (de)
AU (1) AU551710B2 (de)
BE (1) BE890192A (de)
CA (1) CA1152289A (de)
CH (1) CH647216A5 (de)
DE (1) DE3133443A1 (de)
FR (1) FR2511357B1 (de)
GB (1) GB2103591B (de)
NL (1) NL8103784A (de)
SE (2) SE450830B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275559A1 (de) * 1986-12-29 1988-07-27 LACHEMA, n.p. Platin enthaltender cytostatischer Wirkstoff

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3305248A1 (de) * 1983-02-16 1984-08-16 Degussa Ag, 6000 Frankfurt Verfahren zur herstellung von reinem cis-platin-(ii)-diammin-dichlorid
NL8303657A (nl) * 1983-10-24 1985-05-17 Pharmachemie Bv Voor injectie geschikte, stabiele, waterige, zoutzuur bevattende oplossing van cisplatine, alsmede werkwijze ter bereiding daarvan.
US4699978A (en) * 1985-01-18 1987-10-13 The Trustees Of Columbia University In The City Of New York Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US4686104A (en) * 1985-04-30 1987-08-11 Sloan-Kettering Institute For Cancer Research Methods of treating bone disorders
JPS61293655A (ja) * 1985-05-31 1986-12-24 Trinity Ind Corp 砂型鋳造品の砂落し装置
JP2657393B2 (ja) * 1988-05-18 1997-09-24 日本化薬株式会社 化学塞栓療法剤
FI895340A0 (fi) * 1988-11-14 1989-11-09 Bristol Myers Squibb Co Hypertonisk cisplatin-loesning.
US4946689A (en) * 1988-11-23 1990-08-07 Bristol-Myers Company Concentrated, stabilized cis-diamminedinitratoplatinum solutions for conversion to cisplatin
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
CN1104378C (zh) 1996-12-25 2003-04-02 日本化药株式会社 顺铂细粉及其制备方法
US6074626A (en) * 1998-03-20 2000-06-13 Molecular Radiation Management, Inc. Radioactive cisplatin in the treatment of cancer
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
AUPQ641100A0 (en) * 2000-03-23 2000-04-15 Australia Nuclear Science & Technology Organisation Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents
AU5721301A (en) * 2000-04-24 2001-11-07 Teva Pharma Zolpidem hemitartrate
EP1475093B1 (de) 2000-04-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Mikronisierter zolpidem Hemitartrat
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
JP2005510471A (ja) * 2001-09-24 2005-04-21 トスク インコーポレーティッド 減少した毒性のシスプラチン製剤及びそれを使用する方法
DE602004028585D1 (de) * 2003-03-15 2010-09-23 Brin Tech Internat Ltd Verpackung für Arzneimittel
RS20050714A (sr) * 2003-03-31 2008-04-04 Pliva-Lachema A.S., Farmaceutski preparati koji kao aktivnu suptancu sadrže kompleks platine i postupci za njihovo dobijanje
ES2284068T3 (es) * 2003-10-16 2007-11-01 Teva Pharmaceutical Industries Limited Preparacion de candesartan cilexetilo.
ES2300979T3 (es) * 2004-01-05 2008-06-16 Teva Pharmaceutical Industries Ltd. Procedimiento para la produccion de sildenafilo base y de su sal citrato.
US7692023B2 (en) * 2004-02-11 2010-04-06 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
US20080085882A1 (en) * 2006-08-18 2008-04-10 University Of North Texas Health Science Center At Fort Worth Compositions and Methods for Potentiation of Cancer Agents
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) * 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
CA2677639A1 (en) * 2007-02-09 2008-08-14 Poniard Pharmaceuticals, Inc. Encapsulated picoplatin
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
CN101809024A (zh) * 2007-07-16 2010-08-18 铂雅制药公司 吡铂的口服制剂
AU2009210656A1 (en) * 2008-02-08 2009-08-13 Poniard Pharmaceuticals, Inc. Use of picoplatin and cetuximab to treat colorectal cancer
JP5667886B2 (ja) 2008-03-14 2015-02-12 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド 癌患者の生存時間を増大させるための組成物及び化合物の使用方法
JP5694782B2 (ja) 2008-03-14 2015-04-01 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド 肺癌、腺癌及び他の病状のための治療方法及び組成物
US20100035853A1 (en) * 2008-08-07 2010-02-11 Hyogo College Of Medicine Method for preventing or treating cisplatin-induced nephrotoxicity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4079121A (en) * 1974-12-13 1978-03-14 Mobil Oil Corporation Complexes of beta platinum chloride and ammonia
CA1119954A (en) * 1978-05-30 1982-03-16 Edmund S. Granatek Aqueous solution of cisplatin
US4273755A (en) * 1979-08-16 1981-06-16 Mpd Technology Corporation Preparation of platinum complexes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275559A1 (de) * 1986-12-29 1988-07-27 LACHEMA, n.p. Platin enthaltender cytostatischer Wirkstoff

Also Published As

Publication number Publication date
JPS5832029A (ja) 1983-02-24
NL8103784A (nl) 1983-03-01
SE455469B (sv) 1988-07-18
CA1152289A (en) 1983-08-23
SE8300623D0 (sv) 1983-02-07
AU551710B2 (en) 1986-05-08
FR2511357A1 (fr) 1983-02-18
GB2103591B (en) 1985-03-06
ATA374981A (de) 1983-12-15
SE450830B (sv) 1987-08-03
FR2511357B1 (fr) 1986-09-05
SE8104661L (sv) 1983-02-04
AU7390681A (en) 1983-02-10
GB2103591A (en) 1983-02-23
DE3133443A1 (de) 1983-03-10
BE890192A (fr) 1982-03-02
JPH0313174B2 (de) 1991-02-21
US4322391A (en) 1982-03-30
US4302446A (en) 1981-11-24
SE8300623L (sv) 1983-02-07
CH647216A5 (de) 1985-01-15

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Legal Events

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ELJ Ceased due to non-payment of the annual fee
ELJ Ceased due to non-payment of the annual fee