AT321912B - Verfahren zur herstellung von neuen substituierten piperidinderivaten und ihren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen substituierten piperidinderivaten und ihren saeureadditionssalzen

Info

Publication number
AT321912B
AT321912B AT306574*1A AT306574A AT321912B AT 321912 B AT321912 B AT 321912B AT 306574 A AT306574 A AT 306574A AT 321912 B AT321912 B AT 321912B
Authority
AT
Austria
Prior art keywords
production
acid addition
addition salts
substituted piperidine
piperidine derivatives
Prior art date
Application number
AT306574*1A
Other languages
English (en)
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Application granted granted Critical
Publication of AT321912B publication Critical patent/AT321912B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
AT306574*1A 1972-01-28 1972-12-29 Verfahren zur herstellung von neuen substituierten piperidinderivaten und ihren saeureadditionssalzen AT321912B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00221823A US3806526A (en) 1972-01-28 1972-01-28 1-aroylalkyl-4-diphenylmethyl piperidines

Publications (1)

Publication Number Publication Date
AT321912B true AT321912B (de) 1975-04-25

Family

ID=22829547

Family Applications (2)

Application Number Title Priority Date Filing Date
AT306574*1A AT321912B (de) 1972-01-28 1972-12-29 Verfahren zur herstellung von neuen substituierten piperidinderivaten und ihren saeureadditionssalzen
AT1115572A AT321916B (de) 1972-01-28 1972-12-29 Verfahren zur herstellung von neuen substituierten piperidinderivaten und ihren säureadditionssalzen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT1115572A AT321916B (de) 1972-01-28 1972-12-29 Verfahren zur herstellung von neuen substituierten piperidinderivaten und ihren säureadditionssalzen

Country Status (27)

Country Link
US (1) US3806526A (de)
JP (1) JPS5115034B2 (de)
AR (1) AR195313A1 (de)
AT (2) AT321912B (de)
AU (1) AU464154B2 (de)
BE (1) BE794595A (de)
CA (2) CA994784A (de)
CH (1) CH584197A5 (de)
CS (1) CS177836B2 (de)
DD (1) DD104297A5 (de)
DE (1) DE2303305B2 (de)
DK (1) DK136714B (de)
ES (1) ES410730A1 (de)
FR (1) FR2181692B1 (de)
GB (1) GB1412605A (de)
HU (1) HU167948B (de)
IE (1) IE36984B1 (de)
IL (1) IL41058A (de)
LU (1) LU66915A1 (de)
NL (1) NL174348B (de)
NO (1) NO140059C (de)
PH (1) PH9202A (de)
PL (2) PL92127B1 (de)
SE (1) SE382059B (de)
SU (1) SU472502A3 (de)
YU (1) YU35581B (de)
ZA (1) ZA728542B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3992546A (en) * 1973-10-18 1976-11-16 Ciba-Geigy Corporation 4-Piperidinobutyrophenones as neuroleptics
US4054570A (en) * 1973-10-18 1977-10-18 Ciba-Geigy Corporation 4-Piperidinobutyrophenones
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US4105849A (en) * 1974-09-30 1978-08-08 G. D. Searle & Co. [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US4032642A (en) * 1974-12-11 1977-06-28 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3984557A (en) * 1974-12-26 1976-10-05 A. H. Robins Company, Incorporated Antiarrhythmia compositions and methods
US4163790A (en) * 1977-05-11 1979-08-07 A. H. Robins Company, Inc. Method for increasing coronary blood flow in mammals
US4246268A (en) * 1979-02-09 1981-01-20 Richardson-Merrell Inc. Neuroleptic-4-(naphthylmethyl)piperidine derivatives
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285958A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
IE49998B1 (en) * 1979-08-06 1986-01-22 Merrell Dow Pharma 4-(naphthalenyloxy)piperidine derivatives
NO157931C (no) * 1980-09-18 1988-06-15 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-(4-(difenylmethylen)-1-piperidinyl)-eddiksyrer samt deres amider og salter.
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0235463A3 (de) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) N-substituierte Arylalkyl- und Arylalkylen-Piperidine und Anwendung als kardiovaskulär antihistaminische und antisekretorische Mittel
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
ATE82282T1 (de) * 1987-01-20 1992-11-15 Dainippon Pharmaceutical Co Aromatische heterozyklische karbonsaeureamidabkoemmlinge, verfahren zur herstellung und arzneimittel, die diese enthalten.
IT1205685B (it) * 1987-05-26 1989-03-31 Erregierre Spa Processo per la preparazione di alfa-(alchilfenil)-4-(idrossi difenilmetil)-1-piperidina butanolo
US5231105A (en) * 1987-06-02 1993-07-27 Ajinomoto Co., Inc. Ethylamine derivatives and antihypertensives containing the same
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
US5070087A (en) * 1989-05-08 1991-12-03 A. H. Robins Company, Incorporated Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5057524A (en) * 1990-02-08 1991-10-15 A. H. Robins Company Incorporated 4-[diaryl)hydroxymethyl]-1-piperidinealkylcarboxylic acids, salts and esters useful in the treatment of allergic disorders
EP0596120A4 (en) * 1991-08-09 1994-07-06 Yoshitomi Pharmaceutical Thiophene compound.
WO1993016081A1 (en) * 1992-02-13 1993-08-19 Merrell Dow Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
ATE322473T1 (de) * 1993-06-24 2006-04-15 Amr Technology Inc Verfahren zur herstellung von verbindungen geeignet als zwischenprodukte
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
HU226037B1 (en) 1993-06-25 2008-03-28 Aventis Inc Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates
DE69624559T2 (de) * 1995-02-28 2003-07-10 Aventis Pharma Inc Arzneizubereitungen für piperidinalkanolderivate
KR19990008406A (ko) * 1995-05-08 1999-01-25 스티븐엘.네스비트 알파-(치환된 알킬페닐)-4-(히드록시디페닐메틸)-1-피페리딘 부탄올 유도체들, 그들의 제조 방법 및 항히스타민제, 항알러지제및 기관지 확장제로서 그들의 용도
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5795985A (en) * 1996-03-05 1998-08-18 Ciba Specialty Chemicals Corporation Phenyl alkyl ketone substituted by cyclic amine and a process for the preparation thereof
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
HU224921B1 (hu) * 1997-08-26 2006-04-28 Aventis Pharma Inc Vérbõséget csökkentõ piperidinoszármazékot kombinációban tartalmazó gyógyszerkészítmény
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
CA2858520A1 (en) * 2006-05-18 2007-11-29 Pharmacyclics Inc. Intracellular kinase inhibitors
ES2601856T3 (es) 2007-06-08 2017-02-16 Mannkind Corporation Inhibidores de la IRE-1A

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US3073835A (en) * 1961-07-13 1963-01-15 Searle & Co 1-acyl-alpha, alpha-diphenyl-4-piperidinemethanols
US3081303A (en) * 1961-10-13 1963-03-12 Searle & Co 1-aminoalkyl-alpha, alpha-diphenylpiperidine-methanols

Also Published As

Publication number Publication date
AT321916B (de) 1975-04-25
SU472502A3 (ru) 1975-05-30
IE36984B1 (en) 1977-04-13
NL174348B (nl) 1984-01-02
SE382059B (sv) 1976-01-12
PL92127B1 (de) 1977-03-31
US3806526A (en) 1974-04-23
DK136714B (da) 1977-11-14
JPS5115034B2 (de) 1976-05-13
PH9202A (en) 1975-07-03
PL89087B1 (de) 1976-10-30
AR195313A1 (es) 1973-09-28
CS177836B2 (de) 1977-08-31
ES410730A1 (es) 1976-04-16
HU167948B (de) 1976-01-28
IE36984L (en) 1973-07-28
FR2181692B1 (de) 1975-10-10
IL41058A0 (en) 1973-02-28
DK136714C (de) 1978-04-24
DE2303305B2 (de) 1979-01-04
LU66915A1 (de) 1973-07-27
GB1412605A (en) 1975-11-05
DD104297A5 (de) 1974-03-05
IL41058A (en) 1976-08-31
YU3273A (en) 1980-09-25
CH584197A5 (de) 1977-01-31
CA994779A (en) 1976-08-10
AU464154B2 (en) 1975-08-14
NL7300869A (de) 1973-07-31
AU4989472A (en) 1974-06-13
NO140059B (no) 1979-03-19
YU35581B (en) 1981-04-30
DE2303305C3 (de) 1979-09-13
BE794595A (fr) 1973-05-16
JPS4885576A (de) 1973-11-13
DE2303305A1 (de) 1973-08-02
CA994784A (en) 1976-08-10
NO140059C (no) 1979-07-04
ZA728542B (en) 1973-08-29
FR2181692A1 (de) 1973-12-07

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ELA Expired due to lapse of time