DK136714B - Analogifremgangsmåde til fremstilling af substituerede piperidinderivater eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af substituerede piperidinderivater eller syreadditionssalte deraf.

Info

Publication number
DK136714B
DK136714B DK45173AA DK45173A DK136714B DK 136714 B DK136714 B DK 136714B DK 45173A A DK45173A A DK 45173AA DK 45173 A DK45173 A DK 45173A DK 136714 B DK136714 B DK 136714B
Authority
DK
Denmark
Prior art keywords
preparation
acid addition
addition salts
substituted piperidine
piperidine derivatives
Prior art date
Application number
DK45173AA
Other languages
English (en)
Other versions
DK136714C (da
Inventor
Albert Anthony Carr
Clyde Richard Kinsolving
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of DK136714B publication Critical patent/DK136714B/da
Application granted granted Critical
Publication of DK136714C publication Critical patent/DK136714C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
DK45173AA 1972-01-28 1973-01-26 Analogifremgangsmåde til fremstilling af substituerede piperidinderivater eller syreadditionssalte deraf. DK136714B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00221823A US3806526A (en) 1972-01-28 1972-01-28 1-aroylalkyl-4-diphenylmethyl piperidines

Publications (2)

Publication Number Publication Date
DK136714B true DK136714B (da) 1977-11-14
DK136714C DK136714C (da) 1978-04-24

Family

ID=22829547

Family Applications (1)

Application Number Title Priority Date Filing Date
DK45173AA DK136714B (da) 1972-01-28 1973-01-26 Analogifremgangsmåde til fremstilling af substituerede piperidinderivater eller syreadditionssalte deraf.

Country Status (27)

Country Link
US (1) US3806526A (da)
JP (1) JPS5115034B2 (da)
AR (1) AR195313A1 (da)
AT (2) AT321916B (da)
AU (1) AU464154B2 (da)
BE (1) BE794595A (da)
CA (2) CA994779A (da)
CH (1) CH584197A5 (da)
CS (1) CS177836B2 (da)
DD (1) DD104297A5 (da)
DE (1) DE2303305B2 (da)
DK (1) DK136714B (da)
ES (1) ES410730A1 (da)
FR (1) FR2181692B1 (da)
GB (1) GB1412605A (da)
HU (1) HU167948B (da)
IE (1) IE36984B1 (da)
IL (1) IL41058A (da)
LU (1) LU66915A1 (da)
NL (1) NL174348B (da)
NO (1) NO140059C (da)
PH (1) PH9202A (da)
PL (2) PL89087B1 (da)
SE (1) SE382059B (da)
SU (1) SU472502A3 (da)
YU (1) YU35581B (da)
ZA (1) ZA728542B (da)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3992546A (en) * 1973-10-18 1976-11-16 Ciba-Geigy Corporation 4-Piperidinobutyrophenones as neuroleptics
US4054570A (en) * 1973-10-18 1977-10-18 Ciba-Geigy Corporation 4-Piperidinobutyrophenones
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US4105849A (en) * 1974-09-30 1978-08-08 G. D. Searle & Co. [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines
US4032642A (en) * 1974-12-11 1977-06-28 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3984557A (en) * 1974-12-26 1976-10-05 A. H. Robins Company, Incorporated Antiarrhythmia compositions and methods
US4163790A (en) * 1977-05-11 1979-08-07 A. H. Robins Company, Inc. Method for increasing coronary blood flow in mammals
US4246268A (en) * 1979-02-09 1981-01-20 Richardson-Merrell Inc. Neuroleptic-4-(naphthylmethyl)piperidine derivatives
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
US4285958A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
IE49998B1 (en) * 1979-08-06 1986-01-22 Merrell Dow Pharma 4-(naphthalenyloxy)piperidine derivatives
NO157931C (no) * 1980-09-18 1988-06-15 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-(4-(difenylmethylen)-1-piperidinyl)-eddiksyrer samt deres amider og salter.
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0228893A3 (en) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
EP0298134B1 (en) * 1987-01-20 1992-11-11 Dainippon Pharmaceutical Co., Ltd. Aromatic heterocyclic carboxylic acid amide derivatives, process for their preparation, and pharmaceutical composition containing same
IT1205685B (it) * 1987-05-26 1989-03-31 Erregierre Spa Processo per la preparazione di alfa-(alchilfenil)-4-(idrossi difenilmetil)-1-piperidina butanolo
US5231105A (en) * 1987-06-02 1993-07-27 Ajinomoto Co., Inc. Ethylamine derivatives and antihypertensives containing the same
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
US5070087A (en) * 1989-05-08 1991-12-03 A. H. Robins Company, Incorporated Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5057524A (en) * 1990-02-08 1991-10-15 A. H. Robins Company Incorporated 4-[diaryl)hydroxymethyl]-1-piperidinealkylcarboxylic acids, salts and esters useful in the treatment of allergic disorders
EP0596120A4 (en) * 1991-08-09 1994-07-06 Yoshitomi Pharmaceutical Thiophene compound.
EP0626968B1 (en) * 1992-02-13 2001-09-26 Merrell Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
PT1026147E (pt) * 1993-06-24 2004-04-30 Albany Molecular Res Inc Compostos uteis como intermediarios na producao de derivados de piperidina
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
WO1995000480A1 (en) 1993-06-25 1995-01-05 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
EP0812195B1 (en) * 1995-02-28 2002-10-30 Aventis Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol compounds
CA2216877A1 (en) * 1995-05-08 1996-11-14 Hoechst Marion Roussel, Inc. Alpha-(substituted alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5795985A (en) * 1996-03-05 1998-08-18 Ciba Specialty Chemicals Corporation Phenyl alkyl ketone substituted by cyclic amine and a process for the preparation thereof
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
PT998272E (pt) * 1997-08-26 2003-09-30 Aventis Pharma Inc Composicao farmaceutica para combinacao do descongestionante piperidinoalcanol
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
CA2858520A1 (en) * 2006-05-18 2007-11-29 Pharmacyclics Inc. Intracellular kinase inhibitors
US7858666B2 (en) * 2007-06-08 2010-12-28 Mannkind Corporation IRE-1α inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3073835A (en) * 1961-07-13 1963-01-15 Searle & Co 1-acyl-alpha, alpha-diphenyl-4-piperidinemethanols
US3081303A (en) * 1961-10-13 1963-03-12 Searle & Co 1-aminoalkyl-alpha, alpha-diphenylpiperidine-methanols

Also Published As

Publication number Publication date
DE2303305A1 (de) 1973-08-02
PL92127B1 (da) 1977-03-31
US3806526A (en) 1974-04-23
DE2303305C3 (da) 1979-09-13
SU472502A3 (ru) 1975-05-30
HU167948B (da) 1976-01-28
AU464154B2 (en) 1975-08-14
IL41058A (en) 1976-08-31
NL174348B (nl) 1984-01-02
IE36984L (en) 1973-07-28
JPS5115034B2 (da) 1976-05-13
YU3273A (en) 1980-09-25
NL7300869A (da) 1973-07-31
BE794595A (fr) 1973-05-16
JPS4885576A (da) 1973-11-13
CA994784A (en) 1976-08-10
IE36984B1 (en) 1977-04-13
LU66915A1 (da) 1973-07-27
FR2181692A1 (da) 1973-12-07
NO140059C (no) 1979-07-04
DE2303305B2 (de) 1979-01-04
GB1412605A (en) 1975-11-05
PL89087B1 (da) 1976-10-30
CH584197A5 (da) 1977-01-31
AT321912B (de) 1975-04-25
ES410730A1 (es) 1976-04-16
SE382059B (sv) 1976-01-12
DK136714C (da) 1978-04-24
NO140059B (no) 1979-03-19
ZA728542B (en) 1973-08-29
CS177836B2 (da) 1977-08-31
DD104297A5 (da) 1974-03-05
PH9202A (en) 1975-07-03
CA994779A (en) 1976-08-10
AR195313A1 (es) 1973-09-28
AT321916B (de) 1975-04-25
AU4989472A (en) 1974-06-13
IL41058A0 (en) 1973-02-28
FR2181692B1 (da) 1975-10-10
YU35581B (en) 1981-04-30

Similar Documents

Publication Publication Date Title
DK136714B (da) Analogifremgangsmåde til fremstilling af substituerede piperidinderivater eller syreadditionssalte deraf.
DK138076B (da) Analogifremgangsmåde til fremstilling af indolderivater eller syreadditionssalte deraf.
DK124547B (da) Analogifremgangsmåde til fremstilling af (3-amino-2-hydroxy-propyloxy)-thiochromanderivater eller syreadditionssalte deraf.
DK120996B (da) Analogifremgangsmåde til fremstilling af piperidinderivater eller syreadditionssalte deraf.
DK135278B (da) Analogifremgangsmåde til fremstilling af fenoksyisopropanolaminderivater eller syreadditionssalte deraf.
DK136713B (da) Analogifremgangsmåde til fremstilling af alfa-aryl-4-substituerede piperidinoalkanolderivater eller deres syreadditionssalte.
DK139575B (da) Analogifremgangsmåde til fremstilling af 2-aminomethylen-1-indanon-forbindelser eller syreadditionssalte deraf.
DK145574C (da) Analogifremgangsmaade til fremstilling af substituerede cyclopropylalkylaminer eller syreadditionssalte deraf
DK140833B (da) Analogifremgangsmåde til fremstilling af phenylethylaminderivater eller syreadditionssalte deraf.
DK141875C (da) Analogifremgangsmaade til fremstilling af normorphinonderivater eller syreadditionssalte deraf
DK131778B (da) Fremgangsmåde til fremstilling af substituerede 3-hydroksymetylisokinolinderivater eller syreadditionssalte heraf.
DK138491B (da) Analogifremgangsmåde til fremstilling af N-(1-cyclohexyl-3-pyrrolidinyl)-benzamider eller syreadditionssalte deraf.
DK125245B (da) Fremgangsmåde til fremstilling af γpiperidinobutyrophenonderivater eller syreadditionssalte deraf.
DK138117B (da) Analogifremgangsmåde til fremstilling af isoindolinderivater eller syreadditionssalte deraf.
DK138943B (da) Analogifremgangsmåde til fremstilling af substituerede dibenzocyclohepten-carboxamider eller syreadditionssalte deraf.
DK136722B (da) Analogifremgangsmåde til fremstilling af oxazolidinon-(2)-derivater eller syreadditionssalte heraf.
DK131857B (da) Analogifremgangsmåde til fremstilling af 4-hydroxymethyl-1-phthalazonderivater eller syreadditionssalte deraf.
DK126327B (da) Analogifremgangsmåde til fremstilling af derivater af p-aminoalkylbenzensulfonamid eller syreadditionssalte deraf.
DK125472B (da) Analogifremgangsmåde til fremstilling af pyrimidopyridazinderivater eller syreadditionssalte deraf.
DK134014B (da) Analogifremgangsmåde til fremstilling af cycloalkyllactamimider eller syreadditionssalte deraf.
DK140431B (da) Analogifremgangsmåde til fremstilling af et N2-dansyl-L-arginin-derivat eller syreadditionssalte deraf.
DK137044B (da) Analogifremgangsmåde til fremstilling af 4,4-diphenylhexahydroazepinderivater eller syreadditionssalte deraf.
DK133677B (da) Analogifremgangsmåde til fremstilling af 2-alkyl-4-(1-alkyl-4-piperidyliden)-benzocycloheptathiophenderivater eller syreadditionssalte deraf.
DK127431B (da) Analogifremgangsmåde til fremstilling af thiepinderivater eller syreadditionssalte deraf.
DK144159C (da) Analogifremgangsmaade til fremstilling af 3-(trifluormethylphenyl)-2-aminopropanderivater eller syreadditionssalte heraf

Legal Events

Date Code Title Description
PUP Patent expired