ZA728542B - Substituted piperidine derivatives - Google Patents

Substituted piperidine derivatives

Info

Publication number
ZA728542B
ZA728542B ZA728542A ZA728542A ZA728542B ZA 728542 B ZA728542 B ZA 728542B ZA 728542 A ZA728542 A ZA 728542A ZA 728542 A ZA728542 A ZA 728542A ZA 728542 B ZA728542 B ZA 728542B
Authority
ZA
South Africa
Prior art keywords
substituted piperidine
piperidine derivatives
derivatives
substituted
piperidine
Prior art date
Application number
ZA728542A
Other languages
English (en)
Inventor
A Carr
C Kinsolving
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ZA728542B publication Critical patent/ZA728542B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
ZA728542A 1972-01-28 1972-12-04 Substituted piperidine derivatives ZA728542B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00221823A US3806526A (en) 1972-01-28 1972-01-28 1-aroylalkyl-4-diphenylmethyl piperidines

Publications (1)

Publication Number Publication Date
ZA728542B true ZA728542B (en) 1973-08-29

Family

ID=22829547

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA728542A ZA728542B (en) 1972-01-28 1972-12-04 Substituted piperidine derivatives

Country Status (27)

Country Link
US (1) US3806526A (da)
JP (1) JPS5115034B2 (da)
AR (1) AR195313A1 (da)
AT (2) AT321912B (da)
AU (1) AU464154B2 (da)
BE (1) BE794595A (da)
CA (2) CA994779A (da)
CH (1) CH584197A5 (da)
CS (1) CS177836B2 (da)
DD (1) DD104297A5 (da)
DE (1) DE2303305B2 (da)
DK (1) DK136714B (da)
ES (1) ES410730A1 (da)
FR (1) FR2181692B1 (da)
GB (1) GB1412605A (da)
HU (1) HU167948B (da)
IE (1) IE36984B1 (da)
IL (1) IL41058A (da)
LU (1) LU66915A1 (da)
NL (1) NL174348B (da)
NO (1) NO140059C (da)
PH (1) PH9202A (da)
PL (2) PL89087B1 (da)
SE (1) SE382059B (da)
SU (1) SU472502A3 (da)
YU (1) YU35581B (da)
ZA (1) ZA728542B (da)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3992546A (en) * 1973-10-18 1976-11-16 Ciba-Geigy Corporation 4-Piperidinobutyrophenones as neuroleptics
US4054570A (en) * 1973-10-18 1977-10-18 Ciba-Geigy Corporation 4-Piperidinobutyrophenones
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US4105849A (en) * 1974-09-30 1978-08-08 G. D. Searle & Co. [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US4032642A (en) * 1974-12-11 1977-06-28 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3984557A (en) * 1974-12-26 1976-10-05 A. H. Robins Company, Incorporated Antiarrhythmia compositions and methods
US4163790A (en) * 1977-05-11 1979-08-07 A. H. Robins Company, Inc. Method for increasing coronary blood flow in mammals
US4246268A (en) * 1979-02-09 1981-01-20 Richardson-Merrell Inc. Neuroleptic-4-(naphthylmethyl)piperidine derivatives
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285958A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
IE49998B1 (en) * 1979-08-06 1986-01-22 Merrell Dow Pharma 4-(naphthalenyloxy)piperidine derivatives
FI74950C (fi) * 1980-09-18 1988-04-11 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiva 2-/4-(difenylmetylen)-1-piperidinyl-aettiksyror.
EP0228893A3 (en) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
ATE82282T1 (de) * 1987-01-20 1992-11-15 Dainippon Pharmaceutical Co Aromatische heterozyklische karbonsaeureamidabkoemmlinge, verfahren zur herstellung und arzneimittel, die diese enthalten.
IT1205685B (it) * 1987-05-26 1989-03-31 Erregierre Spa Processo per la preparazione di alfa-(alchilfenil)-4-(idrossi difenilmetil)-1-piperidina butanolo
US5231105A (en) * 1987-06-02 1993-07-27 Ajinomoto Co., Inc. Ethylamine derivatives and antihypertensives containing the same
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
US5070087A (en) * 1989-05-08 1991-12-03 A. H. Robins Company, Incorporated Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5057524A (en) * 1990-02-08 1991-10-15 A. H. Robins Company Incorporated 4-[diaryl)hydroxymethyl]-1-piperidinealkylcarboxylic acids, salts and esters useful in the treatment of allergic disorders
EP0596120A4 (en) * 1991-08-09 1994-07-06 Yoshitomi Pharmaceutical Thiophene compound.
PT626968E (pt) * 1992-02-13 2002-03-28 Merrell Pharma Inc Derivados de piperidinilo tiaciclicos
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
DE69433346T2 (de) * 1993-06-24 2004-09-09 Albany Molecular Research, Inc. Herstellung von Verbindungen, die in der Produktion von Piperidin-Derivaten nützlich sind
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
AU699559B2 (en) 1993-06-25 1998-12-10 Aventisub Ii Inc. Novel intermediates for the preparation of antihistaminic piperidine derivatives
EP0812195B1 (en) * 1995-02-28 2002-10-30 Aventis Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol compounds
NZ306319A (en) * 1995-05-08 1999-08-30 Hoechst Marion Roussel Inc 1-alkylphenyl substituted 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butanol derivatives and medicaments
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5795985A (en) * 1996-03-05 1998-08-18 Ciba Specialty Chemicals Corporation Phenyl alkyl ketone substituted by cyclic amine and a process for the preparation thereof
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
KR100514264B1 (ko) * 1997-08-26 2005-09-15 아벤티스 파마슈티칼스 인크. 피페리디노알칸올-충혈완화제 조합용 제약 조성물
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
MX2008014450A (es) * 2006-05-18 2009-03-09 Mannkind Corp Inhibidores de cinasa intracelular.
US7858666B2 (en) 2007-06-08 2010-12-28 Mannkind Corporation IRE-1α inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3073835A (en) * 1961-07-13 1963-01-15 Searle & Co 1-acyl-alpha, alpha-diphenyl-4-piperidinemethanols
US3081303A (en) * 1961-10-13 1963-03-12 Searle & Co 1-aminoalkyl-alpha, alpha-diphenylpiperidine-methanols

Also Published As

Publication number Publication date
DD104297A5 (da) 1974-03-05
CA994779A (en) 1976-08-10
IE36984L (en) 1973-07-28
PH9202A (en) 1975-07-03
NO140059B (no) 1979-03-19
FR2181692A1 (da) 1973-12-07
JPS5115034B2 (da) 1976-05-13
SE382059B (sv) 1976-01-12
YU35581B (en) 1981-04-30
BE794595A (fr) 1973-05-16
AU4989472A (en) 1974-06-13
CA994784A (en) 1976-08-10
ES410730A1 (es) 1976-04-16
HU167948B (da) 1976-01-28
IE36984B1 (en) 1977-04-13
AU464154B2 (en) 1975-08-14
DE2303305C3 (da) 1979-09-13
CS177836B2 (da) 1977-08-31
AT321912B (de) 1975-04-25
IL41058A (en) 1976-08-31
NL7300869A (da) 1973-07-31
DK136714C (da) 1978-04-24
GB1412605A (en) 1975-11-05
NO140059C (no) 1979-07-04
AR195313A1 (es) 1973-09-28
LU66915A1 (da) 1973-07-27
AT321916B (de) 1975-04-25
SU472502A3 (ru) 1975-05-30
DE2303305B2 (de) 1979-01-04
DK136714B (da) 1977-11-14
IL41058A0 (en) 1973-02-28
FR2181692B1 (da) 1975-10-10
PL89087B1 (da) 1976-10-30
NL174348B (nl) 1984-01-02
CH584197A5 (da) 1977-01-31
DE2303305A1 (de) 1973-08-02
YU3273A (en) 1980-09-25
PL92127B1 (da) 1977-03-31
US3806526A (en) 1974-04-23
JPS4885576A (da) 1973-11-13

Similar Documents

Publication Publication Date Title
ZA728542B (en) Substituted piperidine derivatives
MY7800026A (en) New piperidine derivatives
IL43795A (en) 3-aminoalkylamino-1-phenoxy-2-propanol derivatives
ZA728544B (en) Alpha-aryl-4-substituted piperidinoalkanol derivatives
MY7900114A (en) Benzocycloheptathiophene derivatives
GB1402219A (en) Berbine derivatives
ZA728917B (en) Oxaziniondole-and thiaziniondole derivatives
IL42943A (en) 16-methyl-prednisolone derivatives
IL43280A0 (en) Amidinourea derivatives
PH10465A (en) Debenzazecine derivatives
ZA731557B (en) Diphenylalkyllactamimide derivatives
GB1405227A (en) Pheynlthioethyl-imidazole derivatives
ZA732129B (en) New phenylformamidine derivatives
ZA728875B (en) Pyrano-and thiopyranoindole derivatives
ZA734945B (en) New beta-aminoketone derivatives
PH10653A (en) Indolylimidoylquinoline derivatives
HK380A (en) Benzoisoindoline derivatives
AU5423773A (en) Alpha-pyrone derivatives
PH10601A (en) Diaza-oxa-bicyclodecane derivatives
AU5872373A (en) Isoxolidine derivatives
AU5916873A (en) Cyclohexanepentol derivative
GB1402890A (en) Piperidine derivatives
HK63177A (en) New piperidine derivatives
IL41850A0 (en) Substituted benzhydryl lactamimide derivatives
GB1404382A (en) Homopyrimidazole derivatives