AT126318B - Process for the production of storable, stable toxin or serum preparations for the preparation of highly diluted solutions. - Google Patents
Process for the production of storable, stable toxin or serum preparations for the preparation of highly diluted solutions.Info
- Publication number
- AT126318B AT126318B AT126318DA AT126318B AT 126318 B AT126318 B AT 126318B AT 126318D A AT126318D A AT 126318DA AT 126318 B AT126318 B AT 126318B
- Authority
- AT
- Austria
- Prior art keywords
- storable
- container
- preparation
- production
- highly diluted
- Prior art date
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Herstellung lagerfähiger haltbarer Toxin- oder Serumpräparate zur
Bereitung hochverdünnter Lösungen.
Viele Toxine. wie Sera u. dgl. müssen vor ihrer Verwendung in der Praxis stark vprdiinnt werden. Da diese Präparate meistens nur in konzentriertem Zustand haltbar sind. hingegen in hochverdinntem Zustand verwendet werden, resultieren in der Regel grössere Flüssigkeitsmengen. die aber nur zum geringen Teil ihrer Bestimmung zugeführt werden können. Dadurch ist die Verwendung von Präparaten. die erst vor dem Gebrauch verdünnt werden sollen. vielfach für den praktischen Gehrauch ungeeignet.
Nun hat sich ergeben, dass die Präparate bei völliger Eintrocknung besonders haltbar sind. Diesem Umstande kann man im allgemeinen schwer Rechnung tragen, da diese Trocken-
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Lösungsvermögen fast unverändert vorhanden.
Sohin werden erfindungsgemäss lagerfähige Präparate, welche späterhin in hochverdiinnten Lösungen Verwendung finden, in der Weise hergestellt, dass geringe Mengen des wirksamen Stoffes in einen Behälter abgefüllt und in demselben nach unmittelbar anschliessender Einengung bis zur Trockene unter Vakuum eingeschmolzen werden. Dieser Behälter wird hierauf miL einem die abgemessene Verdünnungslösung in sterilem Zustande enthaltenden anderen Behälter luftdicht zu einer Doppelampulle verbunden. Die Lösung, welche hiebei in den ersten Behälter eingefüllt wird. ist zu ihrer leichteren Abmessung vorteilhaft unmittelbar vor der Abfüllung verdünnt worden, so dass ihre genaue Dosierung erleichtert ist.
Die Verbindung zwischen den beiden Behältern der Doppelampulle hingegen erfolgt in an und für sich bekannter Weise
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**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the production of storable, durable toxin or serum preparations for
Preparation of highly diluted solutions.
Lots of toxins. like Sera u. The like. Must be strongly vprdiinnt before their use in practice. Since these preparations can usually only be kept in a concentrated state. on the other hand, if they are used in a highly diluted state, larger amounts of liquid usually result. but only a small part of them can be used for their intended purpose. This makes the use of supplements. which should only be diluted before use. often unsuitable for practical ear smoke.
It has now been found that the preparations are particularly durable when they are completely dry. It is generally difficult to account for this fact, since these dry
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Solving power almost unchanged.
Thus, according to the invention, storable preparations which are later used in highly diluted solutions are produced in such a way that small amounts of the active substance are filled into a container and, after immediately subsequent concentration, are melted under vacuum to dryness. This container is then connected airtight to a double ampoule with another container containing the measured dilution solution in a sterile state. The solution that is poured into the first container. has been diluted immediately before filling to make it easier to measure, so that it is easier to dose it precisely.
The connection between the two containers of the double ampoule, however, takes place in a manner known per se
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** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT126318T | 1930-02-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AT126318B true AT126318B (en) | 1932-01-11 |
Family
ID=3634720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT126318D AT126318B (en) | 1930-02-12 | 1930-02-12 | Process for the production of storable, stable toxin or serum preparations for the preparation of highly diluted solutions. |
Country Status (1)
Country | Link |
---|---|
AT (1) | AT126318B (en) |
-
1930
- 1930-02-12 AT AT126318D patent/AT126318B/en active
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