AR248142A1 - Procedimiento para preparar esteres de 5-dihidropiridina del acido ciclopropilenofosfonico, sus sales y solvatos. - Google Patents
Procedimiento para preparar esteres de 5-dihidropiridina del acido ciclopropilenofosfonico, sus sales y solvatos.Info
- Publication number
- AR248142A1 AR248142A1 AR87306539A AR30653987A AR248142A1 AR 248142 A1 AR248142 A1 AR 248142A1 AR 87306539 A AR87306539 A AR 87306539A AR 30653987 A AR30653987 A AR 30653987A AR 248142 A1 AR248142 A1 AR 248142A1
- Authority
- AR
- Argentina
- Prior art keywords
- phosphonic acid
- formula
- dihydropyridine
- halogen
- hydrogen
- Prior art date
Links
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- -1 IMINO Chemical group 0.000 abstract 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 2
- 101000740162 Homo sapiens Sodium- and chloride-dependent transporter XTRP3 Chemical group 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 102100037189 Sodium- and chloride-dependent transporter XTRP3 Human genes 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PREPARACION DE 5-DIHIDROPIRIDINA ESTER DEL ACIDO CICLOPROPILENO FOSFONICO DE FORMULA (I) DONDE R1, R2, R3, R4, R5 Y R6 IGUALES O DIFERENTES SON HIDROGENO O ALQUILO; X1 ES HIDROGENO, HALOGENO O NITRO; X2 ES HIDROGENO, HALOGENO O -OCHF2; Y ES -ANAR1AR2, DONDE A ES ALQUILENO AR1 Y AR2 SON FENILO SUSTITUIDO O NO POR HALOGENO Y M ES 0, 1, 2, 3 O 4 O ES UN GRUPO (II) Y LAS SALES FARMACEUTICAMENTE ACEPTABLES, SOLVATOS Y SALES DE LOS MISMOS, QUE COMPRENDE: (I) HACER REACCIONAR COMPUESTOS DE FORMULA (III) DONDE X ES OXO O IMINO Y X3 ES HIDROXILO O AMINO Y (Z)2 ES OXO O DOS GRUPOS MORFOLINO; II) HACER REACCIONAR LOS COMPUESTOS PREFORMADOS (IV) CON III) UN COMPUESTO CROTONICO DE FORMULA (V) RESPECTIVAMENTE CON COMPUESTOS DE ACIDO FOSFONICO DE FORMULA (VI).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61011255A JPH0655751B2 (ja) | 1986-01-22 | 1986-01-22 | ジヒドロピリジンホスホン酸環状エステル |
| JP1275586 | 1986-01-23 | ||
| US06/851,158 US4885284A (en) | 1986-01-22 | 1986-04-14 | Dihydropyridine-5-phosphonic acid cyclic propylene ester |
| JP28015986 | 1986-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR248142A1 true AR248142A1 (es) | 1995-06-30 |
Family
ID=27455571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR87306539A AR248142A1 (es) | 1986-01-22 | 1987-01-21 | Procedimiento para preparar esteres de 5-dihidropiridina del acido ciclopropilenofosfonico, sus sales y solvatos. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0230944B1 (es) |
| CN (1) | CN1016063B (es) |
| AR (1) | AR248142A1 (es) |
| BG (1) | BG60236B2 (es) |
| DE (1) | DE3761662D1 (es) |
| DK (1) | DK168821B1 (es) |
| FI (1) | FI85491C (es) |
| GR (2) | GR3000478T3 (es) |
| HU (1) | HU196605B (es) |
| IL (1) | IL81315A (es) |
| WO (1) | WO1987004439A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2528706B2 (ja) * | 1988-05-30 | 1996-08-28 | ゼリア新薬工業株式会社 | ジヒドロピリジン化合物の製剤組成物 |
| JP2850376B2 (ja) * | 1988-08-02 | 1999-01-27 | 日産化学工業株式会社 | 抗癌剤薬効増強剤 |
| ATE128623T1 (de) * | 1988-08-02 | 1995-10-15 | Nissan Chemical Ind Ltd | Mittel zur verbesserung von arzneimitteleffekten für antitumormittel. |
| KR100457273B1 (ko) * | 1996-03-18 | 2005-04-08 | 닛산 가가쿠 고교 가부시키 가이샤 | 에포니디핀염산염제제의제조방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59161392A (ja) | 1983-03-04 | 1984-09-12 | Nippon Shinyaku Co Ltd | ジヒドロピリジン誘導体及びその製法 |
| EP0141222B1 (en) | 1983-09-26 | 1989-04-12 | Nissan Chemical Industries Ltd. | Dihydropyridine-5-phosphonic acid cyclic ester |
| EP0141221A1 (en) | 1983-09-26 | 1985-05-15 | Nissan Chemical Industries Ltd. | 1,4-Dihydropyridine-5-phosphonic acid ester |
| JPS6069089A (ja) | 1983-09-26 | 1985-04-19 | Nissan Chem Ind Ltd | ジヒドロピリジン−５−ホスホネ−ト誘導体およびその製造法 |
| JPS60248693A (ja) | 1984-04-19 | 1985-12-09 | Nippon Shinyaku Co Ltd | ピリジン誘導体及び製法 |
-
1987
- 1987-01-14 CN CN87100286.8A patent/CN1016063B/zh not_active Expired
- 1987-01-19 EP EP87100602A patent/EP0230944B1/en not_active Expired
- 1987-01-19 DE DE8787100602T patent/DE3761662D1/de not_active Expired - Lifetime
- 1987-01-20 WO PCT/JP1987/000032 patent/WO1987004439A1/en active IP Right Grant
- 1987-01-20 IL IL81315A patent/IL81315A/xx not_active IP Right Cessation
- 1987-01-20 HU HU87768A patent/HU196605B/hu not_active IP Right Cessation
- 1987-01-21 AR AR87306539A patent/AR248142A1/es active
- 1987-08-03 BG BG80825A patent/BG60236B2/xx unknown
- 1987-08-12 FI FI873503A patent/FI85491C/fi not_active IP Right Cessation
- 1987-08-17 DK DK428087A patent/DK168821B1/da not_active IP Right Cessation
-
1990
- 1990-05-07 GR GR90400281T patent/GR3000478T3/el unknown
- 1990-10-31 GR GR89300192T patent/GR890300192T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI873503A (fi) | 1987-08-12 |
| HUT44570A (en) | 1988-03-28 |
| DE3761662D1 (de) | 1990-03-15 |
| FI85491B (fi) | 1992-01-15 |
| BG60236B1 (bg) | 1994-01-24 |
| AU6763587A (en) | 1987-07-23 |
| FI873503A0 (fi) | 1987-08-12 |
| HU196605B (en) | 1988-12-28 |
| IL81315A0 (en) | 1987-08-31 |
| BG60236B2 (en) | 1994-01-24 |
| EP0230944A1 (en) | 1987-08-05 |
| DK428087D0 (da) | 1987-08-17 |
| DK428087A (da) | 1987-08-17 |
| CN1016063B (zh) | 1992-04-01 |
| AU589485B2 (en) | 1989-10-12 |
| GR3000478T3 (en) | 1991-06-28 |
| WO1987004439A1 (en) | 1987-07-30 |
| EP0230944B1 (en) | 1990-02-07 |
| DK168821B1 (da) | 1994-06-20 |
| CN87100286A (zh) | 1988-01-13 |
| GR890300192T1 (en) | 1990-10-31 |
| IL81315A (en) | 1991-11-21 |
| FI85491C (fi) | 1992-04-27 |
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