AR246952A1 - Procedimiento para preparar beta-fluormetilen-5-hidroxitriptofano y sus derivados, utiles como inhibidores de la monoamino oxidasa y en el tratamiento de la depresion. - Google Patents
Procedimiento para preparar beta-fluormetilen-5-hidroxitriptofano y sus derivados, utiles como inhibidores de la monoamino oxidasa y en el tratamiento de la depresion.Info
- Publication number
- AR246952A1 AR246952A1 AR88310862A AR31086288A AR246952A1 AR 246952 A1 AR246952 A1 AR 246952A1 AR 88310862 A AR88310862 A AR 88310862A AR 31086288 A AR31086288 A AR 31086288A AR 246952 A1 AR246952 A1 AR 246952A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- metoximetio
- formula
- treatment
- substituted
- Prior art date
Links
- IWARRHXTRWGFED-NSHDSACASA-N (2s)-2-amino-4-fluoro-3-(5-hydroxy-1h-indol-3-yl)but-3-enoic acid Chemical compound C1=C(O)C=C2C(C(=CF)[C@@H](C(O)=O)N)=CNC2=C1 IWARRHXTRWGFED-NSHDSACASA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- -1 p-toluenesulfonyl Chemical group 0.000 abstract 4
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical compound CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- 125000005076 adamantyloxycarbonyl group Chemical group C12(CC3CC(CC(C1)C3)C2)OC(=O)* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 abstract 1
- 150000002917 oxazolidines Chemical class 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Chemical group O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 238000006894 reductive elimination reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/053,212 US4822812A (en) | 1987-05-21 | 1987-05-21 | β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR246952A1 true AR246952A1 (es) | 1994-10-31 |
Family
ID=21982670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR88310862A AR246952A1 (es) | 1987-05-21 | 1988-05-16 | Procedimiento para preparar beta-fluormetilen-5-hidroxitriptofano y sus derivados, utiles como inhibidores de la monoamino oxidasa y en el tratamiento de la depresion. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4822812A (OSRAM) |
| EP (1) | EP0291998A3 (OSRAM) |
| JP (1) | JP2520285B2 (OSRAM) |
| KR (1) | KR960016521B1 (OSRAM) |
| CN (1) | CN1031222A (OSRAM) |
| AR (1) | AR246952A1 (OSRAM) |
| AU (1) | AU605865B2 (OSRAM) |
| CA (1) | CA1310973C (OSRAM) |
| DK (1) | DK169330B1 (OSRAM) |
| FI (1) | FI90531C (OSRAM) |
| HU (2) | HU199790B (OSRAM) |
| IL (1) | IL86387A0 (OSRAM) |
| NO (1) | NO172576C (OSRAM) |
| NZ (1) | NZ224661A (OSRAM) |
| PH (1) | PH25384A (OSRAM) |
| PT (1) | PT87538B (OSRAM) |
| ZA (1) | ZA883442B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5488188A (en) * | 1994-09-29 | 1996-01-30 | Merrell Dow Pharmaceuticals Inc. | Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof |
| ITRM20020255A1 (it) * | 2002-05-09 | 2003-11-10 | Polifarma Spa | Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici. |
| US6972014B2 (en) * | 2003-01-04 | 2005-12-06 | Endocare, Inc. | Open system heat exchange catheters and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2513597B2 (de) * | 1975-03-27 | 1977-06-02 | L-5-hydroxytryptophan-l-glutamatmonohydrat, verfahren zu seiner herstellung und arzneimittel | |
| US4183858A (en) * | 1977-07-01 | 1980-01-15 | Merrell Toraude Et Compagnie | α-Vinyl tryptophanes |
| FR2499076A1 (fr) * | 1981-02-02 | 1982-08-06 | Panmedica Laboratoires | Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant |
| US4454158A (en) * | 1981-06-01 | 1984-06-12 | Merrell Toraude Et Compagnie | Allyl amine MAO inhibitors |
| US4421767A (en) * | 1981-06-01 | 1983-12-20 | Merrell Toraude Et Compagnie | Compounds and methods for treating depression |
| ZA855101B (en) * | 1984-07-13 | 1986-05-28 | Merrell Dow Pharma | Fluoroallylaine derivatives |
-
1987
- 1987-05-21 US US07/053,212 patent/US4822812A/en not_active Expired - Lifetime
-
1988
- 1988-05-15 IL IL86387A patent/IL86387A0/xx not_active IP Right Cessation
- 1988-05-16 CA CA000566913A patent/CA1310973C/en not_active Expired - Lifetime
- 1988-05-16 AR AR88310862A patent/AR246952A1/es active
- 1988-05-16 ZA ZA883442A patent/ZA883442B/xx unknown
- 1988-05-17 AU AU16347/88A patent/AU605865B2/en not_active Ceased
- 1988-05-17 NZ NZ224661A patent/NZ224661A/xx unknown
- 1988-05-18 PH PH36944A patent/PH25384A/en unknown
- 1988-05-19 PT PT87538A patent/PT87538B/pt not_active IP Right Cessation
- 1988-05-19 FI FI882360A patent/FI90531C/fi not_active IP Right Cessation
- 1988-05-19 KR KR1019880005872A patent/KR960016521B1/ko not_active Expired - Fee Related
- 1988-05-20 EP EP88108125A patent/EP0291998A3/en not_active Withdrawn
- 1988-05-20 DK DK278388A patent/DK169330B1/da not_active IP Right Cessation
- 1988-05-20 JP JP63122187A patent/JP2520285B2/ja not_active Expired - Lifetime
- 1988-05-20 HU HU882617A patent/HU199790B/hu not_active IP Right Cessation
- 1988-05-20 HU HU89172A patent/HUT50117A/hu unknown
- 1988-05-20 NO NO882240A patent/NO172576C/no not_active IP Right Cessation
- 1988-05-20 CN CN88103199A patent/CN1031222A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK278388A (da) | 1988-11-22 |
| CN1031222A (zh) | 1989-02-22 |
| IL86387A0 (en) | 1988-11-15 |
| FI90531C (fi) | 1994-02-25 |
| KR880013891A (ko) | 1988-12-22 |
| FI882360L (fi) | 1988-11-22 |
| IL86387A (OSRAM) | 1992-12-01 |
| HUT50117A (en) | 1989-12-28 |
| ZA883442B (en) | 1988-11-16 |
| AU605865B2 (en) | 1991-01-24 |
| NO882240L (no) | 1988-11-22 |
| KR960016521B1 (ko) | 1996-12-14 |
| NO882240D0 (no) | 1988-05-20 |
| DK169330B1 (da) | 1994-10-10 |
| EP0291998A2 (en) | 1988-11-23 |
| EP0291998A3 (en) | 1989-01-25 |
| FI882360A0 (fi) | 1988-05-19 |
| NO172576C (no) | 1993-08-11 |
| NO172576B (no) | 1993-05-03 |
| PT87538B (pt) | 1992-09-30 |
| JPS63303965A (ja) | 1988-12-12 |
| FI90531B (fi) | 1993-11-15 |
| US4822812A (en) | 1989-04-18 |
| NZ224661A (en) | 1990-08-28 |
| PT87538A (pt) | 1989-05-31 |
| CA1310973C (en) | 1992-12-01 |
| HU199790B (en) | 1990-03-28 |
| JP2520285B2 (ja) | 1996-07-31 |
| AU1634788A (en) | 1988-11-24 |
| DK278388D0 (da) | 1988-05-20 |
| HUT47905A (en) | 1989-04-28 |
| PH25384A (en) | 1991-06-03 |
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