AR246271A1 - Un procedimiento para la preparacion de derivados de las cefalosporinas. - Google Patents

Un procedimiento para la preparacion de derivados de las cefalosporinas.

Info

Publication number
AR246271A1
AR246271A1 AR88312142A AR31214288A AR246271A1 AR 246271 A1 AR246271 A1 AR 246271A1 AR 88312142 A AR88312142 A AR 88312142A AR 31214288 A AR31214288 A AR 31214288A AR 246271 A1 AR246271 A1 AR 246271A1
Authority
AR
Argentina
Prior art keywords
group
groups
alk
salt
hydrogen
Prior art date
Application number
AR88312142A
Other languages
English (en)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of AR246271A1 publication Critical patent/AR246271A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE LAS CEFALOSPORINAS, QUE RESPONDEN A LA FORMULA (I), DONDE: R1, R2 Y R3 SON HIDROGENO, O SINO R1 Y R2 SON HIDROGENO O UN GRUPO METILO Y R3 ES CARBONILO, O TAMBIEN R1 Y R2 TOMADOS EN CONJUNTO CON EL ATOMO DE CARBONO AL CUAL ESTAN ENLAZADOS, FORMAN UN NUCLEO CICLOBUTILO Y R3 INDICA UN GRUPO CARBOXILO; LOS 2 GRUPOS A SON DIFERENTES: UNO ES HIDROXILO Y EL OTRO ES -NH-SO2-ALK-NH2 EN EL CUAL ALK ES ALQUILENO INFERIOR; ASI COMO SUS SALES-COMPRENDIDAS LAS SALES INTERNAS- Y DE SUS ESTERES FARMACEUTICAMENTE ACEPTABLES, CONSISTE EN: HACER REACCIONAR EN SOLUCION EN UN SOLVENTE APROTICO POLAR SOBRE UN COMPUESTO DE FORMULA (II), DONDE R'3 ES HIDROGENO, O UN GRUPO ESTER FACILMENTE LABIL Y TR ES PROTECTOR DE LA FUNCION AMINA, UN ACIDO DE FORMULA (III),(O UNO DE SUS DERIVADOS REACTIVOS) EN LA CUAL LOS DOS GRUPOS A' SON DIFERENTES Y SON HIDROXILO, CORRESPONDIENDO EL OTRO GRUPO AL GRUPO -NH-SO2-ALK-NH2 EN DONDE ALK TIENE EL SIGNIFICADO DADO PRECEDE NTEMENTE Y CUYO GRUPO AMINADO HA SIDO PROTEGIDO POR UN GRUPO LABIL; ELIMINAR LOS GRUPOS PROTECTORES PRESENTES SOBRE LAS FUNCIONES AMINAS Y CARBOXILICA(S) POR HIDROLISIS EN MEDIO ACIDO FUERTE; ASILAR EL COMPUESTO (I) ASI OBTENIDO BAJO LA FORMA DE UNA SAL DE GRUPOS AMINADOS; TRANSFORMAR LA SAL EN UNA SAL INTERNA O EN OTRA DE GRUPOS AMINADOS; AISLAR, A PARTIR DE UNA SALDE AMINA EL COMPUESTO (I) CORRESPONDIENTE BAJO LA FORMA DE BASE Y EN TRANSFORMAR ESTA EN UNA SAL O UN ESTER DERIVADO DE UNO O DE LOS DOS GRUPOS CARBOXILICOS PRESENTES EN LA MOLECULA.
AR88312142A 1987-10-08 1988-10-07 Un procedimiento para la preparacion de derivados de las cefalosporinas. AR246271A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8713925A FR2621589B1 (fr) 1987-10-08 1987-10-08 Derives des cephalosporines a pharmacocinetique amelioree, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
AR246271A1 true AR246271A1 (es) 1994-07-29

Family

ID=9355637

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88312142A AR246271A1 (es) 1987-10-08 1988-10-07 Un procedimiento para la preparacion de derivados de las cefalosporinas.

Country Status (19)

Country Link
US (1) US5079241A (es)
EP (1) EP0311521B1 (es)
JP (1) JPH0637502B2 (es)
KR (1) KR970004044B1 (es)
AR (1) AR246271A1 (es)
AT (1) ATE74607T1 (es)
AU (2) AU612414B2 (es)
DE (1) DE3869895D1 (es)
DK (1) DK555288A (es)
ES (1) ES2036702T3 (es)
FI (1) FI89715C (es)
FR (1) FR2621589B1 (es)
GR (1) GR3005122T3 (es)
IE (1) IE61508B1 (es)
IL (2) IL103721A (es)
NO (1) NO171275C (es)
NZ (1) NZ226487A (es)
PT (1) PT88694B (es)
ZA (1) ZA887546B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4282699B2 (ja) 2006-09-01 2009-06-24 株式会社東芝 半導体装置
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024133A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
US4033950A (en) * 1971-05-14 1977-07-05 Glaxo Laboratories Limited 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US4138555A (en) * 1971-05-14 1979-02-06 Glaxo Laboratories, Limited (6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4203899A (en) * 1974-12-19 1980-05-20 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
JPS5760345B2 (es) * 1974-12-19 1982-12-18 Takeda Chemical Industries Ltd
US4668783A (en) * 1974-12-19 1987-05-26 Takeda Chemical Industries, Ltd. Thiazolylacetamido cephalosporin compounds
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
US4871860A (en) * 1976-04-12 1989-10-03 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-caroxylic acid compounds and processes for the preparation thereof
US4493833A (en) * 1976-04-12 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds
US4304770A (en) * 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US4331664A (en) * 1976-04-12 1982-05-25 Fujisawa Pharmaceutical Co., Ltd. Syn isomer of 7-[2-cyclo(lower) alkoxyimino-2-(2-amino-or substituted aminothiazol-4-yl)acetamido]-3-lower alkanoyloxymethyl or heterocyclicthiomethyl-3-cephem-4-carboxylic acid compounds
US4804752A (en) * 1976-04-12 1989-02-14 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US4364943A (en) * 1976-04-12 1982-12-21 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 7-[2-alkoxyimino-2-(2-amino-alkanoylamino-or haloalkanoylamino-thiazol-4-yl) acetamids]-3-[hexanoyl-, or phenylalkanoyl-oxymethyl or benzothiazolylthiomethyl]-3-cephem-4-carboxylic acid
DE2760484C2 (es) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4655166A (en) * 1979-12-26 1987-04-07 Hitachi, Ltd. Apparatus for preventing oscillation of running strip
FR2546520B1 (fr) * 1983-05-27 1985-08-30 Sanofi Sa Nouveaux composes antibiotiques derives des cephalosporines
FR2570702B1 (fr) * 1984-09-27 1987-01-09 Sanofi Sa Derives des cephalosporines, procedes d'obtention et leur application a titre d'antibiotiques
ZA877987B (en) * 1986-11-12 1988-08-31 Ici Pharma Antibiotic compounds
FR2607135B1 (fr) * 1986-11-20 1989-04-28 Sanofi Sa Nouveaux derives des cephalosporines a pharmacocinetique amelioree, procede pour leur preparation et compositions pharmaceutiques les contenant
ZA884093B (en) * 1987-06-16 1989-04-26 Hoffmann La Roche Acyl derivatives

Also Published As

Publication number Publication date
PT88694A (pt) 1988-11-01
AU2349588A (en) 1989-04-13
KR970004044B1 (ko) 1997-03-24
JPH0637502B2 (ja) 1994-05-18
AU637915B2 (en) 1993-06-10
IL87975A0 (en) 1989-03-31
GR3005122T3 (es) 1993-05-24
ZA887546B (en) 1989-06-28
DK555288A (da) 1989-04-09
IL103721A (en) 1994-06-24
NO171275B (no) 1992-11-09
FI884614A0 (fi) 1988-10-07
DE3869895D1 (de) 1992-05-14
FI89715B (fi) 1993-07-30
NO884486L (no) 1989-04-10
NZ226487A (en) 1990-08-28
IL87975A (en) 1993-04-04
AU612414B2 (en) 1991-07-11
FR2621589A1 (fr) 1989-04-14
AU7945191A (en) 1991-09-12
PT88694B (pt) 1992-12-31
FR2621589B1 (fr) 1990-03-02
IE61508B1 (en) 1994-11-02
ES2036702T3 (es) 1993-06-01
IE883046L (en) 1989-04-08
KR890006656A (ko) 1989-06-15
US5079241A (en) 1992-01-07
NO884486D0 (no) 1988-10-07
DK555288D0 (da) 1988-10-04
FI884614A (fi) 1989-04-09
EP0311521B1 (fr) 1992-04-08
JPH01128985A (ja) 1989-05-22
FI89715C (fi) 1993-11-10
EP0311521A1 (fr) 1989-04-12
ATE74607T1 (de) 1992-04-15
NO171275C (no) 1993-02-17

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