ES2109988T3 - Derivados cefalosporinicos. - Google Patents

Derivados cefalosporinicos.

Info

Publication number
ES2109988T3
ES2109988T3 ES92402278T ES92402278T ES2109988T3 ES 2109988 T3 ES2109988 T3 ES 2109988T3 ES 92402278 T ES92402278 T ES 92402278T ES 92402278 T ES92402278 T ES 92402278T ES 2109988 T3 ES2109988 T3 ES 2109988T3
Authority
ES
Spain
Prior art keywords
atom
derivatives
group
derivative
presented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92402278T
Other languages
English (en)
Inventor
Masaki Tsushima
Katsuyoshi Iwamatsu
Atsushi Tamura
Seiji Shibahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of ES2109988T3 publication Critical patent/ES2109988T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTAN NUEVOS AGENTES ANTIBACTERIANOS QUE COMPRENDEN DERIVADOS DE LA CEFALOSPORINA QUE TIENEN LA FORMULA GENERAL (I): EN LA QUE R1 ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL INFERIOR O UN GRUPO ALQUIL INFERIOR SUBSTITUIDO, R2 ES UN ATOMO DE HIDROGENO O UN GRUPO FORMADOR DE UN ESTER FACILMENTE SEPARABLE POR UNA ESTERASA PRESENTE EN EL TRACTO DIGESTIVO, R3 Y R4 PUEDEN SER IGUALES Y CADA UNA REPRESENTA INDEPENDIENTEMENTE UN ATOMO DE HALOGENO, UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL INFERIOR, UN GRUPO ALQUENIL INFERIOR, UN GRUPO HIDROXIL, UN GRUPO AMINO O UN GRUPO ALCOXIDO INFERIOR, TAMBIEN SE PRESENTAN LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS DERIVADOS. EL DERIVADO DE LA CEFALOSPORINA DE LA FORMULA (I) ES UTIL COMO DERIVADO DE ADMINISTRACION ORAL O INYECTABLE DE LA CEFALOSPORINA Y EXHIBE UNA ALTA ACTIVIDAD ANTIBACTERIANA Y CARACTERISTICAS FAVORABLES CAPACES DE FORMAR ALTAS CONCENTRACIONES DE ESTE COMPUESTO EN LA SANGRE UNA VEZ ADMINISTRADO.
ES92402278T 1991-08-13 1992-08-12 Derivados cefalosporinicos. Expired - Lifetime ES2109988T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3226401A JPH05132488A (ja) 1991-08-13 1991-08-13 新規セフアロスポリン誘導体

Publications (1)

Publication Number Publication Date
ES2109988T3 true ES2109988T3 (es) 1998-02-01

Family

ID=16844548

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92402278T Expired - Lifetime ES2109988T3 (es) 1991-08-13 1992-08-12 Derivados cefalosporinicos.

Country Status (5)

Country Link
US (1) US5461044A (es)
EP (1) EP0527686B1 (es)
JP (1) JPH05132488A (es)
DE (1) DE69222599T2 (es)
ES (1) ES2109988T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100576A (en) * 1991-01-18 1995-11-27 Eli Lilley And Company Cephalosporin antibiotics
US5247073A (en) * 1991-01-18 1993-09-21 Eli Lilly And Company 7-(Amino or protected amino)-3-thioheterobicyclic cephalosporins
JP2857532B2 (ja) * 1992-03-12 1999-02-17 明治製菓株式会社 新規セファロスポリン誘導体
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
US5698547A (en) * 1994-04-01 1997-12-16 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US5607926A (en) * 1994-04-01 1997-03-04 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US5498777A (en) * 1994-07-20 1996-03-12 Merck & Co., Inc. 3-thioheteroaryl cephalosporin compounds, compositions and methods of use
MY127641A (en) * 1995-10-12 2006-12-29 Essential Therapeutics Inc Cephalosporin antibiotics
US6025352A (en) * 1997-09-29 2000-02-15 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US6030965A (en) * 1997-09-30 2000-02-29 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
CN104447798A (zh) * 2014-12-09 2015-03-25 苏州中联化学制药有限公司 一种合成盐酸头孢甲肟的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009008A3 (de) * 1978-09-08 1980-05-14 Ciba-Geigy Ag Cephalosporinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4812562A (en) * 1985-07-25 1989-03-14 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4921953A (en) * 1988-02-18 1990-05-01 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
EP0432042B1 (en) * 1989-12-07 1996-08-28 Meiji Seika Kaisha Ltd. Cephalosporin derivatives and their production and uses
IL100576A (en) * 1991-01-18 1995-11-27 Eli Lilley And Company Cephalosporin antibiotics
US5247073A (en) * 1991-01-18 1993-09-21 Eli Lilly And Company 7-(Amino or protected amino)-3-thioheterobicyclic cephalosporins

Also Published As

Publication number Publication date
DE69222599T2 (de) 1998-02-05
DE69222599D1 (de) 1997-11-13
JPH05132488A (ja) 1993-05-28
EP0527686A1 (en) 1993-02-17
EP0527686B1 (en) 1997-10-08
US5461044A (en) 1995-10-24

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