AR244666A1 - Procedimiento para preparar compuestos piperidinilicos 1,4-disustituidos, utiles como analgesicos y relajantes musculares. - Google Patents
Procedimiento para preparar compuestos piperidinilicos 1,4-disustituidos, utiles como analgesicos y relajantes musculares.Info
- Publication number
- AR244666A1 AR244666A1 AR89313868A AR31386889A AR244666A1 AR 244666 A1 AR244666 A1 AR 244666A1 AR 89313868 A AR89313868 A AR 89313868A AR 31386889 A AR31386889 A AR 31386889A AR 244666 A1 AR244666 A1 AR 244666A1
- Authority
- AR
- Argentina
- Prior art keywords
- disubstituted
- piperidinyl compounds
- piperidinyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14664788A | 1988-01-21 | 1988-01-21 | |
| US07/279,900 US5064838A (en) | 1988-01-21 | 1988-12-07 | 1,4-disubstituted-piperidinyl compounds as pain relievers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR244666A1 true AR244666A1 (es) | 1993-11-30 |
Family
ID=48782796
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR89313027A AR247385A1 (es) | 1988-01-21 | 1989-01-19 | Procedimiento para preparar compuestos piperidinilicos 1,4-disustituidos, utiles como analgesicos y relajantes musculares. |
| AR89313868A AR244666A1 (es) | 1988-01-21 | 1989-05-09 | Procedimiento para preparar compuestos piperidinilicos 1,4-disustituidos, utiles como analgesicos y relajantes musculares. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR89313027A AR247385A1 (es) | 1988-01-21 | 1989-01-19 | Procedimiento para preparar compuestos piperidinilicos 1,4-disustituidos, utiles como analgesicos y relajantes musculares. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5064838A (es) |
| EP (1) | EP0325268B1 (es) |
| JP (1) | JP2967990B2 (es) |
| KR (1) | KR0131377B1 (es) |
| CN (1) | CN1035823A (es) |
| AR (2) | AR247385A1 (es) |
| AT (1) | ATE90077T1 (es) |
| AU (1) | AU615713B2 (es) |
| CA (1) | CA1330087C (es) |
| DE (1) | DE68906801T2 (es) |
| DK (1) | DK26389A (es) |
| ES (1) | ES2058346T3 (es) |
| FI (1) | FI90534C (es) |
| HU (2) | HU202494B (es) |
| NO (1) | NO174505B (es) |
| NZ (1) | NZ227643A (es) |
| PH (1) | PH27115A (es) |
| PT (1) | PT89497B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
| NZ236501A (en) * | 1989-12-21 | 1992-12-23 | Merrell Dow Pharma | Piperidine derivatives and antithrombotic compositions |
| US5292752A (en) * | 1989-12-21 | 1994-03-08 | Merrell Dow Pharmaceuticals Inc. | Antithrombotic compounds |
| WO1991018602A1 (en) * | 1990-06-01 | 1991-12-12 | Merrell Dow Pharmaceuticals Inc. | (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL |
| AU650031B2 (en) * | 1990-06-07 | 1994-06-09 | Aventisub Ii Inc. | 1-Piperidinyl alkanoylarylsulfonamide derivatives |
| FR2672286B1 (fr) * | 1991-01-31 | 1994-11-18 | Synthelabo | Derives de 1-(4-chlorophenyl)-2-[4-(phenylmethyl)piperidin-1-yl]ethanol, leur preparation et leur application en therapeutique. |
| US5292726A (en) * | 1991-05-22 | 1994-03-08 | Merck & Co., Inc. | N,N-diacylpiperazines |
| FR2678269B1 (fr) * | 1991-06-27 | 1995-01-13 | Synthelabo | Derives de 1-(4-chlorophenyl)-2-[4-(2-phenylethyl)piperidin-1-yl]ethanol, leur application et leur preparation en therapeutique. |
| US5637699A (en) * | 1992-06-29 | 1997-06-10 | Merck & Co., Inc. | Process for preparing morpholine tachykinin receptor antagonists |
| US6048859A (en) * | 1992-06-29 | 2000-04-11 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| US5719147A (en) * | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| US5387595A (en) * | 1992-08-26 | 1995-02-07 | Merck & Co., Inc. | Alicyclic compounds as tachykinin receptor antagonists |
| FR2696741B1 (fr) * | 1992-10-12 | 1994-11-25 | Synthelabo | Dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl]piperidin-1-yl] éthanol, leur préparation et leur application en thérapeutique. |
| US5344830A (en) * | 1992-12-10 | 1994-09-06 | Merck & Co., Inc. | N,N-diacylpiperazine tachykinin antagonists |
| US5348955A (en) * | 1993-06-22 | 1994-09-20 | Merck & Co., Inc. | N,N-diacylpiperazines |
| US5610165A (en) * | 1994-02-17 | 1997-03-11 | Merck & Co., Inc. | N-acylpiperidine tachykinin antagonists |
| TW385308B (en) * | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
| EP0796619A1 (en) | 1996-03-21 | 1997-09-24 | Merrell Pharmaceuticals Inc. | Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders |
| US6028083A (en) * | 1997-07-25 | 2000-02-22 | Hoechst Marion Roussel, Inc. | Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
| DK0958280T3 (da) | 1997-10-31 | 2005-08-29 | Daiichi Suntory Pharma Co Ltd | Arylpiperidinopropanol- og arylpiperazinopropanolderivater og farmaceutiske midler der indeholder disse |
| US6713627B2 (en) | 1998-03-13 | 2004-03-30 | Aventis Pharmaceuticals Inc. | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| US20050261341A1 (en) * | 1998-03-13 | 2005-11-24 | Aventis Pharmaceuticals Inc. | Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| US6939879B2 (en) * | 1998-08-28 | 2005-09-06 | Aventis Pharmaceuticals Inc. | Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia |
| US6277864B1 (en) | 1998-08-28 | 2001-08-21 | Aventis Pharmaceuticals Inc. | Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
| GB1402889A (en) * | 1973-02-03 | 1975-08-13 | Ciba Geigy Ag | Piperidine derivatives |
| FR2581993B1 (fr) * | 1985-05-14 | 1988-03-18 | Synthelabo | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
| KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
-
1988
- 1988-12-07 US US07/279,900 patent/US5064838A/en not_active Expired - Fee Related
-
1989
- 1989-01-16 CA CA000588352A patent/CA1330087C/en not_active Expired - Fee Related
- 1989-01-17 NZ NZ227643A patent/NZ227643A/xx unknown
- 1989-01-17 FI FI890245A patent/FI90534C/fi not_active IP Right Cessation
- 1989-01-18 HU HU89189A patent/HU202494B/hu not_active IP Right Cessation
- 1989-01-18 HU HU90238A patent/HU205073B/hu not_active IP Right Cessation
- 1989-01-19 AR AR89313027A patent/AR247385A1/es active
- 1989-01-20 PH PH38074A patent/PH27115A/en unknown
- 1989-01-20 NO NO890269A patent/NO174505B/no unknown
- 1989-01-20 PT PT89497A patent/PT89497B/pt not_active IP Right Cessation
- 1989-01-20 DE DE8989100955T patent/DE68906801T2/de not_active Expired - Fee Related
- 1989-01-20 AU AU28687/89A patent/AU615713B2/en not_active Ceased
- 1989-01-20 KR KR1019890000597A patent/KR0131377B1/ko not_active IP Right Cessation
- 1989-01-20 AT AT89100955T patent/ATE90077T1/de not_active IP Right Cessation
- 1989-01-20 DK DK026389A patent/DK26389A/da not_active Application Discontinuation
- 1989-01-20 ES ES89100955T patent/ES2058346T3/es not_active Expired - Lifetime
- 1989-01-20 EP EP89100955A patent/EP0325268B1/en not_active Expired - Lifetime
- 1989-01-20 JP JP1013022A patent/JP2967990B2/ja not_active Expired - Fee Related
- 1989-01-21 CN CN89100339A patent/CN1035823A/zh active Pending
- 1989-05-09 AR AR89313868A patent/AR244666A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| HU205073B (en) | 1992-03-30 |
| HU202494B (en) | 1991-03-28 |
| FI890245A (fi) | 1989-07-22 |
| PT89497B (pt) | 1994-03-31 |
| DK26389A (da) | 1989-07-22 |
| NO174505B (no) | 1994-02-07 |
| EP0325268A1 (en) | 1989-07-26 |
| CA1330087C (en) | 1994-06-07 |
| HUT53871A (en) | 1990-12-28 |
| JPH01224360A (ja) | 1989-09-07 |
| AR247385A1 (es) | 1994-12-29 |
| ES2058346T3 (es) | 1994-11-01 |
| AU615713B2 (en) | 1991-10-10 |
| PT89497A (pt) | 1989-10-04 |
| NZ227643A (en) | 1991-01-29 |
| DE68906801T2 (de) | 1993-09-23 |
| DE68906801D1 (de) | 1993-07-08 |
| DK26389D0 (da) | 1989-01-20 |
| FI890245A0 (fi) | 1989-01-17 |
| FI90534B (fi) | 1993-11-15 |
| FI90534C (fi) | 1994-02-25 |
| NO890269L (no) | 1989-07-24 |
| KR890011840A (ko) | 1989-08-22 |
| HU900238D0 (en) | 1990-03-28 |
| US5064838A (en) | 1991-11-12 |
| NO890269D0 (no) | 1989-01-20 |
| NO174505C (es) | 1994-05-18 |
| ATE90077T1 (de) | 1993-06-15 |
| AU2868789A (en) | 1989-07-27 |
| PH27115A (en) | 1993-03-16 |
| EP0325268B1 (en) | 1993-06-02 |
| JP2967990B2 (ja) | 1999-10-25 |
| KR0131377B1 (ko) | 1998-04-17 |
| CN1035823A (zh) | 1989-09-27 |
| HUT52050A (en) | 1990-06-28 |
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