AR123154A1 - Derivados heterocíclicos sustituidos de pirazolo[1,5-a]pirimidina farmacológicamente activos - Google Patents
Derivados heterocíclicos sustituidos de pirazolo[1,5-a]pirimidina farmacológicamente activosInfo
- Publication number
- AR123154A1 AR123154A1 ARP210102183A ARP210102183A AR123154A1 AR 123154 A1 AR123154 A1 AR 123154A1 AR P210102183 A ARP210102183 A AR P210102183A AR P210102183 A ARP210102183 A AR P210102183A AR 123154 A1 AR123154 A1 AR 123154A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- pyrazolo
- pyrimidine
- relates
- pharmacologically active
- Prior art date
Links
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000003281 allosteric effect Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a nuevos derivados de pirazolo[1,5-a]pirimidina de fórmula (1) o sales farmacéuticamente aceptables, metabolitos biológicamente activos, profármacos, racematos, enantiómeros, diastereómeros, solvatos e hidratos de estos que sirven como moduladores alostéricos positivos del receptor GABAB. La invención también se refiere al proceso para producir dichos compuestos y los intermedios clave utilizados en el proceso. La invención se refiere además a las composiciones farmacéuticas que comprenden dichos compuestos opcionalmente en combinación con dos o más agentes terapéuticos diferentes y al uso de dichos compuestos en métodos para tratar enfermedades y afecciones mediadas y moduladas por el mecanismo alostérico positivo del receptor GABAB. La invención también proporciona un método para la fabricación de medicamentos útiles en el tratamiento de dichos trastornos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP2000254 | 2020-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR123154A1 true AR123154A1 (es) | 2022-11-02 |
Family
ID=89662993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210102183A AR123154A1 (es) | 2020-08-05 | 2021-08-05 | Derivados heterocíclicos sustituidos de pirazolo[1,5-a]pirimidina farmacológicamente activos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230286988A1 (es) |
| EP (1) | EP4192833A1 (es) |
| JP (1) | JP2023536197A (es) |
| KR (1) | KR20230049677A (es) |
| CN (1) | CN116075514A (es) |
| AR (1) | AR123154A1 (es) |
| AU (1) | AU2021319420A1 (es) |
| BR (1) | BR112023001060A2 (es) |
| CA (1) | CA3185566A1 (es) |
| CL (1) | CL2023000352A1 (es) |
| CO (1) | CO2023001367A2 (es) |
| IL (1) | IL300208A (es) |
| MX (1) | MX2023001444A (es) |
| PE (1) | PE20240107A1 (es) |
| TW (1) | TW202220992A (es) |
| WO (1) | WO2022029666A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116077459B (zh) * | 2023-04-10 | 2023-07-07 | 上海赛默罗生物科技有限公司 | α5-GABAA受体调节剂的胶囊剂及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20011900A3 (cs) | 1998-12-18 | 2002-02-13 | Schering Corporation | Látka, způsob léčby a farmaceutický přípravek tuto látku obsahující a jeho pouľití k inhibici farnesyl protein transferázy |
| WO2005094828A1 (en) | 2004-03-02 | 2005-10-13 | F. Hoffmann-La Roche Ag | 4- (sulfanyl-pyrimidin-4-ylmethyl) -morpholine derivatives and related compounds as gaba receptor ligands for the treatment of anxiety, depression and epilepsy |
| GB0512844D0 (en) | 2005-06-23 | 2005-08-03 | Novartis Ag | Organic compounds |
| CN101573334A (zh) | 2006-08-21 | 2009-11-04 | 普雷萨药品公司 | 用于治疗中枢神经系统障碍的多介质转运体抑制剂 |
| US20120157433A1 (en) | 2009-09-04 | 2012-06-21 | Pfister Keith B | Heteroaryl Compounds as Kinase Inhibitors |
| TWI648281B (zh) | 2013-10-17 | 2019-01-21 | 日商安斯泰來製藥股份有限公司 | 含硫二環式化合物 |
| NZ725161A (en) | 2014-04-23 | 2017-10-27 | Dart Neuroscience (Cayman) Ltd | Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as pde2 inhibitors |
| TWI709561B (zh) * | 2014-05-28 | 2020-11-11 | 瑞士商諾華公司 | 新穎吡唑并嘧啶衍生物 |
| EP3286192A1 (en) | 2015-04-20 | 2018-02-28 | AbbVie Deutschland GmbH & Co KG | Substituted pyrazolopyrimidines and method of use |
| JP2018199623A (ja) * | 2015-10-22 | 2018-12-20 | 大正製薬株式会社 | 含窒素縮合複素環化合物 |
| HU231058B1 (hu) * | 2017-03-13 | 2020-04-28 | Richter Gedeon Nyrt. | Gyógyászatilag hatékony aliciklusos-szubsztituált pirazolo[1,5-a]pirimidin származékok |
| HU231057B1 (hu) * | 2017-03-13 | 2020-04-28 | Richter Gedeon Nyrt | Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok |
| HU231150B1 (hu) | 2017-03-13 | 2021-03-29 | Richter Gedeon Nyrt | Eljárás racém 3-alkilpiperidin-3-karbonsav-etil-észterek optikai izomerjeinek elválasztására |
-
2021
- 2021-08-02 TW TW110128314A patent/TW202220992A/zh unknown
- 2021-08-05 MX MX2023001444A patent/MX2023001444A/es unknown
- 2021-08-05 WO PCT/IB2021/057180 patent/WO2022029666A1/en active Application Filing
- 2021-08-05 US US18/040,456 patent/US20230286988A1/en active Pending
- 2021-08-05 IL IL300208A patent/IL300208A/en unknown
- 2021-08-05 AR ARP210102183A patent/AR123154A1/es unknown
- 2021-08-05 BR BR112023001060A patent/BR112023001060A2/pt unknown
- 2021-08-05 KR KR1020237007966A patent/KR20230049677A/ko unknown
- 2021-08-05 PE PE2023000205A patent/PE20240107A1/es unknown
- 2021-08-05 CA CA3185566A patent/CA3185566A1/en active Pending
- 2021-08-05 EP EP21755582.0A patent/EP4192833A1/en active Pending
- 2021-08-05 JP JP2023507435A patent/JP2023536197A/ja active Pending
- 2021-08-05 AU AU2021319420A patent/AU2021319420A1/en active Pending
- 2021-08-05 CN CN202180058179.4A patent/CN116075514A/zh active Pending
-
2023
- 2023-02-03 CL CL2023000352A patent/CL2023000352A1/es unknown
- 2023-02-08 CO CONC2023/0001367A patent/CO2023001367A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL300208A (en) | 2023-03-01 |
| CN116075514A (zh) | 2023-05-05 |
| AU2021319420A1 (en) | 2023-03-16 |
| JP2023536197A (ja) | 2023-08-23 |
| TW202220992A (zh) | 2022-06-01 |
| PE20240107A1 (es) | 2024-01-22 |
| WO2022029666A1 (en) | 2022-02-10 |
| EP4192833A1 (en) | 2023-06-14 |
| AU2021319420A8 (en) | 2023-03-30 |
| BR112023001060A2 (pt) | 2023-03-07 |
| MX2023001444A (es) | 2023-03-08 |
| CA3185566A1 (en) | 2022-02-10 |
| CO2023001367A2 (es) | 2023-02-16 |
| KR20230049677A (ko) | 2023-04-13 |
| CL2023000352A1 (es) | 2023-09-01 |
| US20230286988A1 (en) | 2023-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP19072975A (es) | Derivados pirazol[1,5-a]pirimidina sustituidos con alicíclicos farmacológicamente activos | |
| PA8587101A1 (es) | Nuevos derivados de dihidropirimido [4,5-d] pirimidinona sustituida por amiino, fabricacion y uso de los mismos como agentes farmaceuticos | |
| PA8580301A1 (es) | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos | |
| UY28135A1 (es) | Derivados de pirimidina para el tratamiento de crecimiento celular anormal | |
| ATE440834T1 (de) | Substituierte arylaminderivate und verwendungsverfahren | |
| EA200500018A1 (ru) | Бензконденсированные гетероариламидные производные тиенопиридинов, применяемые в качестве терапевтических агентов, фармацевтические композиции, включающие их, и способы их применения | |
| EA202091450A1 (ru) | Производные 2h-индазола в качестве ингибиторов cdk4 и cdk6 и их терапевтические применения | |
| BRPI0614168A2 (pt) | Composto ou um sal, hidrato, solvato, isoforma, tautômero, isômero óptico farmaceuticamente aceitável ou uma combinação dos mesmos, composição farmacêutica, método para o tratamento ou prevenção de distúrbios neurológicos e psquiátricos, uso de um composto, e, processo para a preparação de um composto | |
| PA8550101A1 (es) | Derivados de benzamida tiazol y composiciones farmacéuticas para inhibir la proliferación de células, y métodos para su utilización | |
| CO2023001367A2 (es) | Derivados de pirazolo[1,5-a]pirimidina sustituidos con heterocíclicos farmacológicamente activos | |
| ECSP055958A (es) | 4-aminopirimidina-5-ona | |
| CY1124346T1 (el) | ΠΑΡΑΓΩΓΑ ΧΡΩΜΑΝΙΟΥ, ΙΣΟΧΡΩΜΑΝΙΟΥ ΚΑΙ ΔΙΥΔΡΟΪΣΟΒΕΝΖΟΦΟΥΡΑΝΙΟΥ ΩΣ mGluR2-APNHTIKOI ΑΛΛΟΣΤΕΡΙΚΟΙ ΔΙΑΜΟΡΦΩΤΕΣ, ΣΥΝΘΕΣΕΙΣ, ΚΑΙ ΧΡΗΣΗ ΑΥΤΩΝ | |
| AR121296A1 (es) | Moduladores de monoacilglicerol lipasa | |
| AR127470A1 (es) | Inhibidores de lrrk2 | |
| CL2022002386A1 (es) | Compuestos de amino pirimidina fusionados | |
| CO2024003953A2 (es) | Derivados de benzodiazepina como moduladores alostéricos positivos del receptor de gaba a gamma1 | |
| EA202190857A1 (ru) | Бициклические производные как модуляторы 5 рецепторов gabaa | |
| MX2023009285A (es) | Compuestos novedosos. | |
| ES2052019T3 (es) | Espiro-isoquinolein-pirrolidin tetronas y analogos de las mismas, utiles como inhibidores de la aldosa-reductasa. | |
| UY28440A1 (es) | "n-(3-(3-sustituidas.pirazolo (1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y métodos relacionados" | |
| AR005472A1 (es) | Inhibidores de la formacion cd23 humana soluble, un procedimiento para su preparacion, el uso de los mismos para la manufactura de un medicamento,composicion farmaceutica y compuestos intermediarios | |
| ECSP23073082A (es) | Nuevos moduladores alostéricos negativos ciclopenta[c]pirrol de NR2B | |
| CO2024005424A2 (es) | Derivados de amina bicíclicos como moduladores de receptor gabaa α5 | |
| UY26785A1 (es) | Derivados bicíclicos sustituidos para el tratamiento del crecimiento celular anormal |