AR122325A2 - Antígeno ndv recombinante y usos del mismo - Google Patents

Antígeno ndv recombinante y usos del mismo

Info

Publication number
AR122325A2
AR122325A2 ARP200102888A ARP200102888A AR122325A2 AR 122325 A2 AR122325 A2 AR 122325A2 AR P200102888 A ARP200102888 A AR P200102888A AR P200102888 A ARP200102888 A AR P200102888A AR 122325 A2 AR122325 A2 AR 122325A2
Authority
AR
Argentina
Prior art keywords
ndv
polypeptide
vaccines
microalgae
plants
Prior art date
Application number
ARP200102888A
Other languages
English (en)
Inventor
Xuan Guo
Karolyn Troupe
Bradley Feilmeier
Joyce A Pritchard
Julio Cruz
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Publication of AR122325A2 publication Critical patent/AR122325A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/517—Plant cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Vacunas contra el NDV que comprenden vacunas de subunidades basadas en HN del NDV. El HN NDV se puede expresar en plantas o algas, inclusive microalgas. La invención también abarca vectores recombinantes que codifican y expresan antígenos, epitopes o inmunógenos del NDV que se pueden usar para proteger animales contra el NDV. También abarca un régimen de vacunación compatible con la estrategia DIVA, incluyendo un esquema desensibilización-refuerzo usando vacunas y vacunas de subunidades inactivadas o de vectores virales. Reivindicación 1: Una composición, caracterizada porque comprende un polipéptido o antígeno HN (hemaglutinina-neuraminidasa) del NDV (virus de la enfermedad de Newcastle) y un transportador, excipiente, vehículo o adyuvante farmacéuticamente aceptable o apto para uso veterinario. Reivindicación 16: Un polipéptido o antígeno del NDV sustancialmente purificado expresado en microalgas o plantas de lenteja de agua, caracterizado porque dicho polipéptido comprende una secuencia de aminoácidos que tiene al menos un 80% de identidad de secuencia con un polipéptido que tiene la secuencia que se muestra en la SEQ ID Nº 3, 5, 7, 9, 15, 17, 19 ó 20. Reivindicación 17: Un cultivo de microalgas o plantas de lenteja de agua, caracterizado porque fue transformado de manera estable con un gen que expresa un polipéptido HN NDV o un fragmento o una variante del mismo. Reivindicación 21: Un plásmido, caracterizado porque comprende un fragmento de ADN que codifica un péptido señal que tiene la secuencia que se muestra en la SEQ ID Nº 13 ó 21.
ARP200102888A 2009-12-28 2020-10-19 Antígeno ndv recombinante y usos del mismo AR122325A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29029709P 2009-12-28 2009-12-28

Publications (1)

Publication Number Publication Date
AR122325A2 true AR122325A2 (es) 2022-08-31

Family

ID=44189168

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP100104979A AR079767A1 (es) 2009-12-28 2010-12-28 Antigeno ndv (virus de la enfermedad de newcastle) recombinante y usos del mismo
ARP200102888A AR122325A2 (es) 2009-12-28 2020-10-19 Antígeno ndv recombinante y usos del mismo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP100104979A AR079767A1 (es) 2009-12-28 2010-12-28 Antigeno ndv (virus de la enfermedad de newcastle) recombinante y usos del mismo

Country Status (11)

Country Link
US (1) US10633667B2 (es)
EP (2) EP2519258B1 (es)
JP (1) JP5933451B2 (es)
KR (1) KR20120101572A (es)
CN (1) CN103260643A (es)
AR (2) AR079767A1 (es)
CA (1) CA2785653C (es)
DO (1) DOP2012000187A (es)
MX (1) MX351643B (es)
PE (1) PE20121685A1 (es)
WO (1) WO2011090708A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012197B2 (en) * 2009-12-28 2015-04-21 Merial, Inc. Production of hemagglutinin-neuraminidase protein in microalgae
CA3153553A1 (en) * 2009-12-28 2011-07-28 Sanofi Vaccine Technologies, S.A.S. Methods of producing heterologous proteins comprising membrane domains in microalgal extracellular bodies
MX351695B (es) * 2011-05-07 2017-10-24 Laboratorio Avi Mex S A De C V Vacuna recombinante contra el síndrome reproductivo y respiratorio porcino en vector viral.
WO2013063388A1 (en) * 2011-10-28 2013-05-02 The Regents Of The University Of California Diatom-based vaccines
EP2660324A1 (en) * 2012-05-02 2013-11-06 Algenics Production of secreted therapeutic antibodies in microalgae
EP2660323A1 (en) * 2012-05-02 2013-11-06 Algenics Production of secreted therapeutic antibodies in phaeodactylum tricornutum microalgae
US20150112045A1 (en) * 2012-05-02 2015-04-23 Algenics Production of secreted therapeutic antibodies in microalgae
EP2671950A1 (de) * 2012-06-06 2013-12-11 Philipps-Universität Marburg Expression und Sekretion von rekombinanten, vollständig assemblierten Proteinkomplexen durch Mikroalgen
CN104059927B (zh) * 2014-05-09 2018-01-09 中国农业科学院生物技术研究所 鸡新城疫糖蛋白病毒抗原的制备方法及其产品
CN105567715B (zh) * 2014-10-17 2021-06-29 丰益(上海)生物技术研发中心有限公司 裂殖壶菌α-微管蛋白相关序列及其应用
WO2016073739A1 (en) * 2014-11-05 2016-05-12 Research Institute At Nationwide Children's Hospital Methods and materials for producing recombinant viruses in eukaryotic microalgae
US10196616B2 (en) * 2017-02-15 2019-02-05 The United States Of America, As Represented By The Secretary Of Agriculture Altered avian virus for in-ovo inoculation and methods of use thereof
CN107099513B (zh) * 2017-06-22 2020-07-14 北京邦卓生物科技有限公司 一种共表达ndv hn和ibdv vp2基因的hvt的构建及其应用
CN113652406B (zh) * 2021-09-01 2023-05-02 青岛易邦生物工程有限公司 一种鸡传染性喉气管炎重组病毒株及其应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
CA1247080A (en) 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US5380831A (en) 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
US4761373A (en) 1984-03-06 1988-08-02 Molecular Genetics, Inc. Herbicide resistance in plants
EP0173552B1 (en) 1984-08-24 1991-10-09 The Upjohn Company Recombinant dna compounds and the expression of polypeptides such as tpa
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
KR950008571B1 (ko) 1986-01-08 1995-08-03 롱쁠랑 아그로시미 할로아릴니트릴 분해 유전자, 그의 용도 및 이를 함유한 세포
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5990387A (en) 1988-06-10 1999-11-23 Pioneer Hi-Bred International, Inc. Stable transformation of plant cells
NZ230375A (en) 1988-09-09 1991-07-26 Lubrizol Genetics Inc Synthetic gene encoding b. thuringiensis insecticidal protein
DE69033816T2 (de) 1989-02-24 2002-08-08 Monsanto Technology Llc Synthetische pflanzengene und verfahren zu ihrer herstellung
US5879918A (en) 1989-05-12 1999-03-09 Pioneer Hi-Bred International, Inc. Pretreatment of microprojectiles prior to using in a particle gun
US5202422A (en) 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
EP0528819A1 (en) 1990-04-18 1993-03-03 Plant Genetic Systems, N.V. Modified bacillus thuringiensis insecticidal-crystal protein genes and their expression in plant cells
US5932782A (en) 1990-11-14 1999-08-03 Pioneer Hi-Bred International, Inc. Plant transformation method using agrobacterium species adhered to microprojectiles
US6309647B1 (en) 1999-07-15 2001-10-30 Aventis Pasteur Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants
DE69233158T2 (de) 1991-03-07 2004-05-13 Connaught Technology Corp., Greenville Gentechnologisch hergestellter stamm für impfstoffe
US5863542A (en) 1991-03-07 1999-01-26 Virogenetics Corporation Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts
TW261517B (es) 1991-11-29 1995-11-01 Mitsubishi Shozi Kk
EP0652965A1 (en) 1992-07-27 1995-05-17 Pioneer Hi-Bred International, Inc. An improved method of agrobacterium-mediated transformation of cultured soybean cells
JP3347736B2 (ja) 1993-11-19 2002-11-20 バイオテクノロジー・リサーチ・アンド・デイベロツプメント・コーポレイシヨン 植物中で遺伝子を発現させるためのキメラ調節領域及び遺伝子カセット
EP0826063A1 (en) 1995-04-25 1998-03-04 Vical Incorporated Single-vial formulations of dna/lipid complexes
US6020169A (en) 1995-07-20 2000-02-01 Washington State University Research Foundation Production of secreted foreign polypeptides in plant cell culture
US5846946A (en) 1996-06-14 1998-12-08 Pasteur Merieux Serums Et Vaccins Compositions and methods for administering Borrelia DNA
FR2750866B1 (fr) 1996-06-27 1998-11-27 Rhone Merieux Vaccin vivant recombinant aviaire, utilisant comme vecteur le virus de la laryngotracheite infectieuse aviaire
FR2751229B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins
FR2751224B1 (fr) 1996-07-19 1998-11-20 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies respiratoires et de reproduction des porcs
FR2751228B1 (fr) 1996-07-19 1998-11-20 Rhone Merieux Vaccin polynucleotidique bovin pour voie intradermique
FR2751226B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies du cheval
FR2751227B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies canines, notamment les pathologies respiratoires et digestives
FR2751225B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique aviaire
ES2241042T3 (es) 1996-10-11 2005-10-16 The Regents Of The University Of California Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora.
US5981840A (en) 1997-01-24 1999-11-09 Pioneer Hi-Bred International, Inc. Methods for agrobacterium-mediated transformation
FR2758986B1 (fr) 1997-01-31 1999-04-30 Rhone Merieux Vaccin vivant recombinant aviaire, utilisant comme vecteur le virus de la laryngotracheite infectieuse aviaire
WO1999001158A1 (fr) 1997-06-30 1999-01-14 Rhone-Poulenc Rorer S.A. Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US7161064B2 (en) * 1997-08-12 2007-01-09 North Carolina State University Method for producing stably transformed duckweed using microprojectile bombardment
FR2778858B1 (fr) 1998-05-20 2000-06-16 Oreal Emulsion e/h/e stable et son utilisation comme composition cosmetique et/ou dermatologique
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
FR2801607B1 (fr) 1999-11-26 2001-12-28 Merial Sas Pneumovirus du canard et vaccins correspondants
US6852705B2 (en) 2000-01-21 2005-02-08 Merial DNA vaccines for farm animals, in particular bovines and porcines
PT1305437E (pt) 2000-07-31 2010-11-12 Biolex Therapeutics Inc Expressão de polipéptidos biologicamente activos na lentilha de água
ES2278810T3 (es) 2000-11-02 2007-08-16 Intervet International Bv Nucleoproteina recombinante mutante del virus de la enfermedad de newcastle (ndv) como marcador de vacuna.
TWI350854B (en) * 2001-04-16 2011-10-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
US7709699B2 (en) 2001-05-30 2010-05-04 Biolex Therapeutics, Inc. Use of duckweed in high throughput screening
ES2320119T3 (es) * 2002-08-27 2009-05-19 Dow Agrosciences Llc Uso de toxina remolabil de escherichia coli como adyvante en aves de corral.
NZ542933A (en) * 2003-05-05 2009-08-28 Dow Agrosciences Llc Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production
US7132291B2 (en) 2003-05-05 2006-11-07 Dow Agro Sciences Llc Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
RU2354399C2 (ru) 2003-07-24 2009-05-10 Мериал Лимитед Вакцинная композиция и способ индуцирования иммунологического ответа у животного
EP1789530B1 (en) * 2004-08-05 2015-10-07 Ben Gurion University of the Negev Research and Development Autority Red microalgae expressing exogenous polypeptides and methods of generating and utilizing same
JP4796786B2 (ja) * 2005-04-28 2011-10-19 富士フイルム株式会社 ラビリンチュラ類を形質転換可能なベクター
JP4796787B2 (ja) 2005-04-28 2011-10-19 富士フイルム株式会社 ラビリンチュラ類への遺伝子導入法
US7951384B2 (en) * 2005-08-05 2011-05-31 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
US9216212B2 (en) * 2005-08-05 2015-12-22 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
WO2009076778A1 (en) 2007-11-27 2009-06-25 Medicago Inc. Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
CA2615372A1 (en) * 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
EP2090648A1 (en) * 2008-02-12 2009-08-19 Institut Francais de Recherche pour l'Exploitation de la Mere(Ifremer) Production of glycosylated polypeptides in microalgae
US7794714B2 (en) * 2008-03-14 2010-09-14 The United States Of America As Represented By The Secretary Of Agriculture Newcastle disease virus monoclonal antibodies
US8394384B2 (en) 2008-11-28 2013-03-12 Merial Limited Recombinant avian influenza vaccine and uses thereof
CA3153553A1 (en) * 2009-12-28 2011-07-28 Sanofi Vaccine Technologies, S.A.S. Methods of producing heterologous proteins comprising membrane domains in microalgal extracellular bodies
US9012197B2 (en) * 2009-12-28 2015-04-21 Merial, Inc. Production of hemagglutinin-neuraminidase protein in microalgae

Also Published As

Publication number Publication date
JP2013515747A (ja) 2013-05-09
CA2785653C (en) 2018-05-01
US10633667B2 (en) 2020-04-28
EP2519258B1 (en) 2017-07-26
PE20121685A1 (es) 2012-12-28
US20110162115A1 (en) 2011-06-30
WO2011090708A3 (en) 2011-12-15
EP3213766A1 (en) 2017-09-06
JP5933451B2 (ja) 2016-06-08
DOP2012000187A (es) 2012-12-15
CN103260643A (zh) 2013-08-21
WO2011090708A2 (en) 2011-07-28
MX351643B (es) 2017-10-23
KR20120101572A (ko) 2012-09-13
MX2012007545A (es) 2012-11-12
EP2519258A2 (en) 2012-11-07
AR079767A1 (es) 2012-02-15
CA2785653A1 (en) 2011-07-28

Similar Documents

Publication Publication Date Title
AR122325A2 (es) Antígeno ndv recombinante y usos del mismo
JP2020039347A (ja) 新規多価ナノ粒子に基づくワクチン
ES2612741T3 (es) Proteínas de fusión proteína n de un virus de la familia paramyxoviridae-proteína de interés
ES2330309T3 (es) Adnc infeccioso de una cepa de vacuna aprobada de virus del sarampion. uso para composiciones inmunogenicas.
RU2012143624A (ru) Рекомбинантные вакцины против вируса " синего языка ", их применение
AR089039A1 (es) Vectores recombinantes de hvt que expresan antigenos de patogenos de aves y sus usos
JP2013515747A5 (es)
AR061484A1 (es) Secuencias de adn vectores proteinas y usos de hemaglutinina de gripe aviar
MX347997B (es) Vacunas aviares vectorizadas con el virus de la enfermedad de newcastle.
SI2445928T1 (en) HYPER PARTICULARS, SIMILAR VIRUSES OF GRIPE, WHICH HAVE EXPOSED HEMAGLUTININE
MX2021015465A (es) Vacuna para fiebre porcina africana.
RU2015135890A (ru) Композиция вакцины
RU2011126359A (ru) Рекомбинантная вакцина от птичьего гриппа и ее применение
EP2571990A4 (en) UNIVERSAL DENGUE VIRUS SEQUENCES AND METHOD FOR THEIR USE
RU2018122755A (ru) Слитые белки fmdv-e2 и их применение
Xu et al. Immunogenicity of T7 bacteriophage nanoparticles displaying GH loop of foot-and-mouth disease virus (FMDV)
JP7472019B2 (ja) 狂犬病ウイルスワクチン
WO2014205579A4 (en) Modified matrix proteins of vesicular stomatitis virus
JP2023159327A (ja) ネコ白血病ウイルスワクチン
NZ598605A (en) Vaccine against african horse sickness virus
JP2023024998A5 (es)
RU2012149036A (ru) Векторы парапоксвируса, содержащие антиген вируса бешенства
RU2013102413A (ru) Парапоксвирусные векторы
CN104119442A (zh) 牛a型口蹄疫多表位疫苗及其制备方法和应用
AR122379A1 (es) Composiciones inmunogénicas y vacunas de covid-19 vectorizadas con sarampión