AR115975A1 - Animales transgénicos y embriones transgénicos productores de una nucleasa de diseño mediante ingeniería - Google Patents
Animales transgénicos y embriones transgénicos productores de una nucleasa de diseño mediante ingenieríaInfo
- Publication number
- AR115975A1 AR115975A1 ARP190102344A ARP190102344A AR115975A1 AR 115975 A1 AR115975 A1 AR 115975A1 AR P190102344 A ARP190102344 A AR P190102344A AR P190102344 A ARP190102344 A AR P190102344A AR 115975 A1 AR115975 A1 AR 115975A1
- Authority
- AR
- Argentina
- Prior art keywords
- transgenic
- toolkit
- locus
- genome
- cell
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 6
- 241001465754 Metazoa Species 0.000 title abstract 4
- 101710163270 Nuclease Proteins 0.000 title abstract 3
- 210000002257 embryonic structure Anatomy 0.000 title 1
- 210000001161 mammalian embryo Anatomy 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000004533 Endonucleases Human genes 0.000 abstract 1
- 108010042407 Endonucleases Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente descripción se relaciona con un animal transgénico y un embrión transgénico que producen componentes de una nucleasa de diseño mediante ingeniería. De acuerdo con la divulgación de la presente descripción, el animal transgénico (o embrión) que produce los componentes de una nucleasa de diseño mediante ingeniería es un animal (o embrión) transgénico que incluye una primera célula que tiene un genoma que incluye una primera caja de herramientas; y una segunda célula que tiene un genoma que incluye una segunda caja de herramientas, en donde la primera caja de herramientas y la segunda caja de herramientas incluyen al menos uno de un polinucleótido que codifica una endonucleasa guiada por ARN y un polinucleótido que codifica un ácido nucleico guía que es capaz de unirse específicamente a un sitio diana, respectivamente, en donde la primera caja de herramientas está presente en un primer locus del genoma de la primera célula; la segunda caja de herramientas está presente en un segundo locus del genoma de la segunda célula; y el primer locus es diferente del segundo locus.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862764905P | 2018-08-16 | 2018-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115975A1 true AR115975A1 (es) | 2021-03-17 |
Family
ID=69637774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190102344A AR115975A1 (es) | 2018-08-16 | 2019-08-16 | Animales transgénicos y embriones transgénicos productores de una nucleasa de diseño mediante ingeniería |
Country Status (6)
Country | Link |
---|---|
US (1) | US12029204B2 (es) |
JP (4) | JP7060256B2 (es) |
KR (8) | KR102158428B1 (es) |
AR (1) | AR115975A1 (es) |
AU (3) | AU2019275586B2 (es) |
BR (1) | BR112020000388A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102158428B1 (ko) | 2018-08-16 | 2020-09-22 | (주)라트바이오 | 인위적 뉴클레아제를 생산하는 형질전환 배아 및 형질전환 동물의 제작 방법 |
JP2023176590A (ja) * | 2022-05-31 | 2023-12-13 | 株式会社ポル・メド・テック | 遺伝子導入ブタの製造方法、体細胞クローニング原料、遺伝子導入ブタ、樹立された体細胞、及び組織ないし臓器 |
WO2024020111A1 (en) * | 2022-07-20 | 2024-01-25 | Syntax Bio, Inc. | Systems for cell programming and methods thereof |
CN117737136A (zh) * | 2023-01-20 | 2024-03-22 | 中国科学院水生生物研究所 | 优化的雌鱼育性控制的方法及应用 |
CN117737122A (zh) * | 2023-01-20 | 2024-03-22 | 中国科学院水生生物研究所 | 雌鱼育性控制的方法及应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101552595B1 (ko) * | 2012-01-12 | 2015-09-14 | 서울대학교산학협력단 | 피기백 전위를 이용한 소 형질전환 배아의 제조방법 |
AU2013204327B2 (en) * | 2012-04-20 | 2016-09-01 | Aviagen | Cell transfection method |
EP3141604A1 (en) | 2012-12-06 | 2017-03-15 | Sigma-Aldrich Co. LLC | Crispr-based genome modification and regulation |
SG10201912328UA (en) * | 2012-12-12 | 2020-02-27 | Broad Inst Inc | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications |
KR101573793B1 (ko) | 2013-10-16 | 2015-12-03 | 전남대학교 산학협력단 | 넉-인 형질전환 동물, 그의 선별 방법 및 키트 |
MX2016012492A (es) | 2014-03-26 | 2017-06-26 | Univ Maryland | Edicion de genoma dirigida en cigotos de animales grandes domesticos. |
BR112016024945A2 (pt) | 2014-04-28 | 2017-10-24 | Recombinetics Inc | edição de gene multiplex em suínos |
BR112017024514A2 (pt) * | 2015-05-16 | 2018-07-24 | Genzyme Corporation | edição genética de mutações intrônicas profundas |
US20180249688A1 (en) | 2015-09-09 | 2018-09-06 | Revivicor, Inc | Multi-Transgenic Pig for Xenotransplantation |
JP7059468B2 (ja) * | 2015-10-08 | 2022-04-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 多重ゲノム編集 |
US11882815B2 (en) * | 2016-06-15 | 2024-01-30 | University Of Massachusetts | Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells |
KR102515727B1 (ko) | 2017-01-11 | 2023-03-30 | 주식회사 툴젠 | 중첩된 가이드핵산을 이용한 표적 핵산에 특정 핵산 서열을 삽입하기 위한 조성물 및 방법 |
WO2018132936A1 (en) | 2017-01-17 | 2018-07-26 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Genetical alternation and disease modelling using cre-dependent cas9 expressing mammals |
KR20190065615A (ko) | 2017-12-04 | 2019-06-12 | 주식회사 신라엔텍 | 미세기포장치를 활용한 하폐수의 잉여슬러지 및 탈수반류수중의 슬러지 자동농축 시스템 및 그 장치 |
KR102158428B1 (ko) | 2018-08-16 | 2020-09-22 | (주)라트바이오 | 인위적 뉴클레아제를 생산하는 형질전환 배아 및 형질전환 동물의 제작 방법 |
-
2019
- 2019-06-03 KR KR1020190065615A patent/KR102158428B1/ko active IP Right Grant
- 2019-06-03 KR KR1020190065613A patent/KR102103103B1/ko active IP Right Grant
- 2019-06-03 KR KR1020190065614A patent/KR102103104B1/ko active IP Right Grant
- 2019-08-14 JP JP2019562368A patent/JP7060256B2/ja active Active
- 2019-08-14 BR BR112020000388-3A patent/BR112020000388A2/pt unknown
- 2019-08-14 US US16/626,227 patent/US12029204B2/en active Active
- 2019-08-14 AU AU2019275586A patent/AU2019275586B2/en active Active
- 2019-08-16 AR ARP190102344A patent/AR115975A1/es unknown
-
2020
- 2020-04-14 KR KR1020200045471A patent/KR102197707B1/ko active IP Right Grant
- 2020-04-14 KR KR1020200045470A patent/KR102197703B1/ko active IP Right Grant
- 2020-12-24 KR KR1020200183963A patent/KR102471750B1/ko active IP Right Grant
- 2020-12-24 KR KR1020200183964A patent/KR102471751B1/ko active IP Right Grant
-
2021
- 2021-09-17 AU AU2021232802A patent/AU2021232802A1/en active Pending
- 2021-09-17 AU AU2021232801A patent/AU2021232801B2/en active Active
-
2022
- 2022-04-07 JP JP2022063839A patent/JP7430414B2/ja active Active
- 2022-04-07 JP JP2022063838A patent/JP7430413B2/ja active Active
- 2022-11-23 KR KR1020220158481A patent/KR102608838B1/ko active IP Right Grant
-
2024
- 2024-01-24 JP JP2024008570A patent/JP2024045299A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210337776A1 (en) | 2021-11-04 |
KR20210004925A (ko) | 2021-01-13 |
KR102103104B1 (ko) | 2020-04-22 |
JP2020534789A (ja) | 2020-12-03 |
KR20200045452A (ko) | 2020-05-04 |
KR102158428B1 (ko) | 2020-09-22 |
JP7060256B2 (ja) | 2022-04-26 |
KR102471750B1 (ko) | 2022-11-28 |
AU2019275586B2 (en) | 2021-06-17 |
KR102197703B1 (ko) | 2020-12-31 |
KR20200020580A (ko) | 2020-02-26 |
KR20200045453A (ko) | 2020-05-04 |
KR20200021042A (ko) | 2020-02-27 |
KR102103103B1 (ko) | 2020-04-21 |
BR112020000388A2 (pt) | 2021-03-09 |
JP2022095839A (ja) | 2022-06-28 |
JP2022095840A (ja) | 2022-06-28 |
AU2021232801B2 (en) | 2024-05-02 |
JP2024045299A (ja) | 2024-04-02 |
JP7430413B2 (ja) | 2024-02-13 |
KR102608838B1 (ko) | 2023-12-01 |
KR102471751B1 (ko) | 2022-11-28 |
AU2021232802A1 (en) | 2021-10-14 |
KR20210003070A (ko) | 2021-01-11 |
AU2021232801A1 (en) | 2021-10-14 |
JP7430414B2 (ja) | 2024-02-13 |
KR20220163905A (ko) | 2022-12-12 |
US12029204B2 (en) | 2024-07-09 |
KR102197707B1 (ko) | 2020-12-31 |
KR20200020579A (ko) | 2020-02-26 |
AU2019275586A1 (en) | 2020-03-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR115975A1 (es) | Animales transgénicos y embriones transgénicos productores de una nucleasa de diseño mediante ingeniería | |
AR100216A1 (es) | Edición de genes multiplexados | |
CY1121738T1 (el) | Μεθοδοι και συνθεσεις για στοχευμενη γενετικη τροποποιηση χρησιμοποιωντας συζευγμενα rna-οδηγους | |
AR113154A1 (es) | Polinucleótidos, composiciones y métodos para edición del genoma | |
CL2018003074A1 (es) | Métodos mejorados para la modificación de ácidos nucleicos diana | |
CL2023000238A1 (es) | Generación de plantas haploides | |
BR112018002558A2 (pt) | método para produção de um animal compreendendo uma modificação genética na linhagem germinativa | |
CR20190260A (es) | Edición génica e inducción de haploides simultáneas | |
MX2017007907A (es) | Composiciones y métodos para la edición genética eficaz en e. coli usando sistemas de ácido desoxirribonucleico (arn) guía/endonucleasa de sistema asociado a repeticiones palindrómicas cortas agrupadas regularmente espaciadas (cas) en combinación con moldes de modificación de polinucleótido circular. | |
CO7151523A2 (es) | Método y composiciones para la modificación de adn objetivo dirigida por arn y para la modulación de la transcripción dirigida por arn | |
GB2544001A (en) | Methods for increasing Cas9-mediated engineering efficiency | |
BR112019004629A2 (pt) | variantes de endonuclease de homing pd-1, composições e métodos de uso | |
BR112017000621A2 (pt) | método para melhorar um traço agronômico de uma planta, método para melhorar a produtividade de grãos ou a eficiência de uso de nitrogênio de uma planta de milho ou de cultura, método para editar, substituir ou eliminar uma sequência reguladora, método para inserir um promotor ou elemento do promotor no genoma de uma célula vegetal e método para fornecer um perfil de expressão adicional para um polinucleotídeo endógeno de uma célula vegetal | |
AR098299A1 (es) | Locus óptimos del maíz | |
CO2017006967A2 (es) | Compuestos de azolina sustituidos con un sistema de anillos condensado | |
BR112018011242A2 (pt) | métodos para modificação genética de plantas | |
AR103927A1 (es) | Método para mejorar la habilidad de resistir a adn de virus que infectan plantas | |
WO2016073990A3 (en) | Methods for improving crispr/cas-mediated genome-editing | |
BR112017012837A2 (pt) | sistemas de modificação de genoma fúngico e métodos de uso | |
PH12015501797A1 (en) | Hornless livestock | |
CL2017001665A1 (es) | Inductor haploide | |
AR091482A1 (es) | Celulas modificadas geneticamente y metodos par su obtencion | |
MX2021007400A (es) | Expansion de repeticiones mediada por nucleasas. | |
AR109700A1 (es) | Optimización dirigida de genomas en plantas | |
PH12020551663A1 (en) | Genetic loci associated with increased fertility in maize |