AR113827A1 - Composiciones farmacéuticas y métodos para tratar enfermedades cardiovasculares - Google Patents

Composiciones farmacéuticas y métodos para tratar enfermedades cardiovasculares

Info

Publication number
AR113827A1
AR113827A1 ARP180103206A ARP180103206A AR113827A1 AR 113827 A1 AR113827 A1 AR 113827A1 AR P180103206 A ARP180103206 A AR P180103206A AR P180103206 A ARP180103206 A AR P180103206A AR 113827 A1 AR113827 A1 AR 113827A1
Authority
AR
Argentina
Prior art keywords
histamine
receptor agonist
methods
pharmaceutical compositions
cardiovascular diseases
Prior art date
Application number
ARP180103206A
Other languages
English (en)
Inventor
Jin Jean Wang
Jing H Gao
Ting N Lin
Gerald J Yakatan
Original Assignee
Cardix Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardix Therapeutics LLC filed Critical Cardix Therapeutics LLC
Publication of AR113827A1 publication Critical patent/AR113827A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

En la presente descripción se proporciona una composición farmacéutica que comprende dos, tres o cuatro compuestos, en donde cada compuesto es independientemente un inhibidor de fosfodiesterasa, un antagonista del receptor de adenosina, un bloqueador de canales de calcio, un agonista del receptor de histamina H₁, un agonista del receptor de histamina H₂, un antagonista del receptor de histamina H₃, o un agonista del receptor adrenérgico b₂. En la presente se proporciona, además, la composición farmacéutica usada para tratar o mejorar una enfermedad cardiovascular en un sujeto, que comprende administrar al sujeto en necesidad de estos dos, tres o cuatro compuestos, en donde cada compuesto es independientemente un inhibidor de fosfodiesterasa, un antagonista del receptor de adenosina, un bloqueador de canales de calcio, un agonista del receptor de histamina H₁, un agonista del receptor de histamina H₂, un antagonista del receptor de histamina H₃, o un agonista del receptor adrenérgico b₂.
ARP180103206A 2017-05-09 2018-11-05 Composiciones farmacéuticas y métodos para tratar enfermedades cardiovasculares AR113827A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762503902P 2017-05-09 2017-05-09
US201862652812P 2018-04-04 2018-04-04
US15/973,132 US11266651B2 (en) 2017-05-09 2018-05-07 Pharmaceutical compositions and methods of treating cardiovascular diseases

Publications (1)

Publication Number Publication Date
AR113827A1 true AR113827A1 (es) 2020-06-17

Family

ID=64096944

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180103206A AR113827A1 (es) 2017-05-09 2018-11-05 Composiciones farmacéuticas y métodos para tratar enfermedades cardiovasculares

Country Status (19)

Country Link
US (6) US11266651B2 (es)
EP (1) EP3621593A4 (es)
JP (1) JP6714796B2 (es)
KR (1) KR102197429B1 (es)
CN (1) CN109890366B (es)
AR (1) AR113827A1 (es)
AU (1) AU2018266106B2 (es)
BR (1) BR112019023101B1 (es)
CA (1) CA3038153C (es)
CL (1) CL2019003216A1 (es)
CO (1) CO2019010510A2 (es)
IL (1) IL269901B (es)
JO (1) JOP20190219A1 (es)
MX (1) MX2019006233A (es)
PE (1) PE20200741A1 (es)
PH (1) PH12019502330A1 (es)
RU (1) RU2715419C1 (es)
SG (1) SG11201902949PA (es)
WO (1) WO2018208723A1 (es)

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JOP20190219A1 (ar) * 2017-05-09 2019-09-22 Cardix Therapeutics LLC تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية
US11510924B2 (en) 2017-05-09 2022-11-29 CARDIX Therapeutics, LLC Deuterated pharmaceutical compositions and methods of treating cardiovascular diseases
US10582716B1 (en) * 2019-06-14 2020-03-10 Lennham Pharmaceuticals, Inc. Deuterated caffeine and uses thereof
EP4281065A1 (en) * 2021-01-20 2023-11-29 Alto Neuroscience, Inc. Enhancement of camp signaling as a combination drug strategy for the treatment of depression and related conditions
CN112717092A (zh) * 2021-01-22 2021-04-30 行艳丽 一种预防心脑血管疾病的中药及制备方法
US11452690B1 (en) 2021-01-27 2022-09-27 ECI Pharmaceuticals, LLC Oral liquid compositions comprising amlodipine besylate and methods of using the same
WO2023076547A1 (en) * 2021-10-29 2023-05-04 Sensorium Therapeutics, Inc. Deuterated forms of alkaloid compounds and therapeutic uses thereof
TW202325275A (zh) 2021-10-29 2023-07-01 美商感覺中樞治療公司 治療性生物鹼化合物之遞送

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Publication number Publication date
EP3621593A4 (en) 2021-04-07
AU2018266106B2 (en) 2021-02-25
US11266651B2 (en) 2022-03-08
CN109890366A (zh) 2019-06-14
PH12019502330A1 (en) 2020-09-28
JOP20190219A1 (ar) 2019-09-22
AU2018266106A1 (en) 2019-04-11
US20200397793A1 (en) 2020-12-24
EP3621593A1 (en) 2020-03-18
WO2018208723A1 (en) 2018-11-15
JP2019534250A (ja) 2019-11-28
KR102197429B1 (ko) 2020-12-31
US11491159B2 (en) 2022-11-08
IL269901B (en) 2021-03-25
CO2019010510A2 (es) 2020-01-17
US20190231786A1 (en) 2019-08-01
US20220184089A1 (en) 2022-06-16
MX2019006233A (es) 2019-08-01
BR112019023101A2 (pt) 2020-08-04
CN109890366B (zh) 2020-12-25
PE20200741A1 (es) 2020-07-24
US20240207279A1 (en) 2024-06-27
US10758544B2 (en) 2020-09-01
SG11201902949PA (en) 2019-05-30
CL2019003216A1 (es) 2020-05-29
CA3038153A1 (en) 2018-11-15
JP6714796B2 (ja) 2020-07-01
US11878017B2 (en) 2024-01-23
US11911389B2 (en) 2024-02-27
RU2715419C1 (ru) 2020-02-28
CA3038153C (en) 2022-03-29
US20230071157A1 (en) 2023-03-09
BR112019023101B1 (pt) 2021-11-16
US20180325907A1 (en) 2018-11-15
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