CL2019003216A1 - Composiciones farmacéuticas y métodos para tratar enfermedades cardiovasculares. - Google Patents
Composiciones farmacéuticas y métodos para tratar enfermedades cardiovasculares.Info
- Publication number
- CL2019003216A1 CL2019003216A1 CL2019003216A CL2019003216A CL2019003216A1 CL 2019003216 A1 CL2019003216 A1 CL 2019003216A1 CL 2019003216 A CL2019003216 A CL 2019003216A CL 2019003216 A CL2019003216 A CL 2019003216A CL 2019003216 A1 CL2019003216 A1 CL 2019003216A1
- Authority
- CL
- Chile
- Prior art keywords
- histamine
- individual
- receptor
- agonist
- receptor antagonist
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
EN LA PRESENTE SOLICITUD SE PROVEE UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE DOS O MÁS COMPUESTOS, EN LA CUAL CADA COMPUESTO ES DE MANERA INDEPENDIENTE UN INHIBIDOR DE FOSFODIESTERASA, UN ANTAGONISTA DEL RECEPTOR DE ADENOSINA, UN BLOQUEADOR DEL CANAL DE CALCIO, UN AGONISTA DEL RECEPTOR H1 DE HISTAMINA, UN AGONISTA DEL RECEPTOR H2 DE HISTAMINA, UN ANTAGONISTA DEL RECEPTOR H3 DE HISTAMINA, O UN AGONISTA DEL RECEPTOR ADRENÉRGICO Β2. EN LA PRESENTE SOLICITUD TAMBIÉN SE PROVEE UN MÉTODO PARA TRATAR O MEJORAR UNA ENFERMEDAD CARDIOVASCULAR EN UN INDIVIDUO, QUE COMPRENDE ADMINISTRAR AL INDIVIDUO QUE LO NECESITE DOS O MÁS COMPUESTOS, EN EL CUAL CADA COMPUESTO ES DE MANERA INDEPENDIENTE UN INHIBIDOR DE FOSFODIESTERASA (TEOFILINA), UN ANTAGONISTA DEL RECEPTOR DE ADENOSINA (AMINOFILINA), UN BLOQUEADOR DEL CANAL DE CALCIO (NIFEDIPINA), UN AGONISTA DEL RECEPTOR H1 DE HISTAMINA, UN AGONISTA DEL RECEPTOR H2 DE HISTAMINA, UN ANTAGONISTA DEL RECEPTOR H3 DE HISTAMINA (BETAHISTINA O UN METABOLITO DE LA MISMA), O UN AGONISTA DEL RECEPTOR ADRENÉRGICO Β2 (LEVALBUTEROL O ALBUTEROL), EN EL CUAL LA COMPOSICIÓN FARMACÉUTICA ESTÁ FORMULADA EN UNA FORMA DE DOSIFICACIÓN PARA ADMINISTRACIÓN INYECTABLE U ORAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762503902P | 2017-05-09 | 2017-05-09 | |
US201862652812P | 2018-04-04 | 2018-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019003216A1 true CL2019003216A1 (es) | 2020-05-29 |
Family
ID=64096944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019003216A CL2019003216A1 (es) | 2017-05-09 | 2019-11-08 | Composiciones farmacéuticas y métodos para tratar enfermedades cardiovasculares. |
Country Status (19)
Country | Link |
---|---|
US (6) | US11266651B2 (es) |
EP (1) | EP3621593A4 (es) |
JP (1) | JP6714796B2 (es) |
KR (1) | KR102197429B1 (es) |
CN (1) | CN109890366B (es) |
AR (1) | AR113827A1 (es) |
AU (1) | AU2018266106B2 (es) |
BR (1) | BR112019023101B1 (es) |
CA (1) | CA3038153C (es) |
CL (1) | CL2019003216A1 (es) |
CO (1) | CO2019010510A2 (es) |
IL (1) | IL269901B (es) |
JO (1) | JOP20190219A1 (es) |
MX (1) | MX2019006233A (es) |
PE (1) | PE20200741A1 (es) |
PH (1) | PH12019502330A1 (es) |
RU (1) | RU2715419C1 (es) |
SG (1) | SG11201902949PA (es) |
WO (1) | WO2018208723A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20190219A1 (ar) * | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية |
US11510924B2 (en) | 2017-05-09 | 2022-11-29 | CARDIX Therapeutics, LLC | Deuterated pharmaceutical compositions and methods of treating cardiovascular diseases |
US10582716B1 (en) | 2019-06-14 | 2020-03-10 | Lennham Pharmaceuticals, Inc. | Deuterated caffeine and uses thereof |
WO2022159632A1 (en) * | 2021-01-20 | 2022-07-28 | Alto Neuroscience, Inc. | Enhancement of camp signaling as a combination drug strategy for the treatment of depression and related conditions |
CN112717092A (zh) * | 2021-01-22 | 2021-04-30 | 行艳丽 | 一种预防心脑血管疾病的中药及制备方法 |
US11452690B1 (en) | 2021-01-27 | 2022-09-27 | ECI Pharmaceuticals, LLC | Oral liquid compositions comprising amlodipine besylate and methods of using the same |
WO2023076586A1 (en) | 2021-10-29 | 2023-05-04 | Sensorium Therapeutics, Inc. | Delivery of therapeutic alkaloid compounds |
WO2023076547A1 (en) * | 2021-10-29 | 2023-05-04 | Sensorium Therapeutics, Inc. | Deuterated forms of alkaloid compounds and therapeutic uses thereof |
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JOP20190219A1 (ar) * | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية |
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2017
- 2017-06-16 JO JOP/2019/0219A patent/JOP20190219A1/ar unknown
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2018
- 2018-05-07 US US15/973,132 patent/US11266651B2/en active Active
- 2018-05-08 WO PCT/US2018/031505 patent/WO2018208723A1/en unknown
- 2018-05-08 BR BR112019023101-3A patent/BR112019023101B1/pt not_active IP Right Cessation
- 2018-05-08 SG SG11201902949PA patent/SG11201902949PA/en unknown
- 2018-05-08 AU AU2018266106A patent/AU2018266106B2/en active Active
- 2018-05-08 JP JP2019515882A patent/JP6714796B2/ja active Active
- 2018-05-08 RU RU2019110247A patent/RU2715419C1/ru active
- 2018-05-08 CA CA3038153A patent/CA3038153C/en active Active
- 2018-05-08 EP EP18798353.1A patent/EP3621593A4/en active Pending
- 2018-05-08 CN CN201880003608.6A patent/CN109890366B/zh active Active
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- 2018-05-08 KR KR1020197014692A patent/KR102197429B1/ko active IP Right Grant
- 2018-11-05 AR ARP180103206A patent/AR113827A1/es not_active Application Discontinuation
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2019
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2020
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2022
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