AR105618A1 - Metilación del promotor del ligando al receptor de muerte programada (pd-l1) en cáncer - Google Patents

Metilación del promotor del ligando al receptor de muerte programada (pd-l1) en cáncer

Info

Publication number
AR105618A1
AR105618A1 ARP160101553A ARP160101553A AR105618A1 AR 105618 A1 AR105618 A1 AR 105618A1 AR P160101553 A ARP160101553 A AR P160101553A AR P160101553 A ARP160101553 A AR P160101553A AR 105618 A1 AR105618 A1 AR 105618A1
Authority
AR
Argentina
Prior art keywords
promoter
cancer
methylation
treatment
region
Prior art date
Application number
ARP160101553A
Other languages
English (en)
Spanish (es)
Inventor
Walter Kimberly
KOWANETZ Marcin
Kadel Edward
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR105618A1 publication Critical patent/AR105618A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ARP160101553A 2015-05-29 2016-05-27 Metilación del promotor del ligando al receptor de muerte programada (pd-l1) en cáncer AR105618A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562168668P 2015-05-29 2015-05-29

Publications (1)

Publication Number Publication Date
AR105618A1 true AR105618A1 (es) 2017-10-25

Family

ID=56118051

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160101553A AR105618A1 (es) 2015-05-29 2016-05-27 Metilación del promotor del ligando al receptor de muerte programada (pd-l1) en cáncer

Country Status (14)

Country Link
US (1) US11254987B2 (enExample)
EP (2) EP3303619B1 (enExample)
JP (2) JP6884111B2 (enExample)
KR (1) KR20180013881A (enExample)
CN (1) CN108064170B (enExample)
AR (1) AR105618A1 (enExample)
AU (1) AU2016271142A1 (enExample)
CA (1) CA2984638A1 (enExample)
ES (1) ES2810700T3 (enExample)
HK (1) HK1255200A1 (enExample)
IL (1) IL255375A0 (enExample)
MX (1) MX388405B (enExample)
PL (1) PL3303619T3 (enExample)
WO (1) WO2016196381A1 (enExample)

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CN108112254B (zh) 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
MX2018001507A (es) 2015-08-03 2018-09-18 Enb Therapeutics Llc Composiciones y metodos para tratar cánceres asociados con la activacion del etbr.
AR107303A1 (es) 2016-01-08 2018-04-18 Hoffmann La Roche Métodos de tratamiento de cánceres positivos para ace utilizando antagonistas de unión a eje pd-1 y anticuerpos biespecíficos anti-ace / anti-cd3, uso, composición, kit
DE102016005947B3 (de) * 2016-05-16 2017-06-08 Dimo Dietrich Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen
US11685955B2 (en) 2016-05-16 2023-06-27 Dimo Dietrich Method for predicting response of patients with malignant diseases to immunotherapy
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
BR112019025188A2 (pt) 2017-06-01 2020-06-23 Cytomx Therapeutics, Inc. Anticorpos anti-pdl1 ativáveis e métodos de uso dos mesmos
US11560431B2 (en) * 2017-06-25 2023-01-24 Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. Anti-PD-L1 antibodies and methods of making and using thereof
CN111886010A (zh) 2018-01-12 2020-11-03 Enb治疗公司 用于治疗与etbr激活相关的癌症的氘化化合物、组合物和方法
KR102708681B1 (ko) 2018-02-13 2024-09-26 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
UA126421C2 (uk) 2018-07-13 2022-09-28 Гіліад Сайєнсіз, Інк. Інгібітори pd-1/pd-l1
CN109355381A (zh) * 2018-09-14 2019-02-19 深圳市太空科技南方研究院 用于预测pd1/l1抑制剂疗效的生物标记物和方法
CN111035758A (zh) * 2018-10-11 2020-04-21 江苏康缘药业股份有限公司 药物组合物及其应用、无菌容器和试剂盒
EP3899019A4 (en) * 2018-12-21 2022-10-05 Agency for Science, Technology and Research METHOD OF PREDICTING THE BENEFITS OF IMMUNE CHECKPOINT INHIBITION THERAPY
WO2021035172A1 (en) * 2019-08-21 2021-02-25 H. Lee Moffitt Cancer Center And Research Institute, Inc. Diagnostics and methods for prognosing response to immunotherapy based on the methylation status of immune synapse gene signature
CN112735513B (zh) * 2021-01-04 2021-11-19 江苏先声医疗器械有限公司 基于dna甲基化谱的肿瘤免疫检查点抑制剂治疗有效性评估模型的构建方法
CN121532528A (zh) * 2023-06-30 2026-02-13 夸登特健康公司 用于癌症早期检测的方法

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AU2016271142A1 (en) 2017-11-23
IL255375A0 (en) 2017-12-31
US20180216196A1 (en) 2018-08-02
JP2018526323A (ja) 2018-09-13
EP3303619A1 (en) 2018-04-11
MX2017014735A (es) 2018-03-23
JP2021102621A (ja) 2021-07-15
CN108064170B (zh) 2022-07-15
ES2810700T3 (es) 2021-03-09
HK1255200A1 (zh) 2019-08-09
WO2016196381A1 (en) 2016-12-08
MX388405B (es) 2025-03-19
PL3303619T3 (pl) 2020-10-05
CN108064170A (zh) 2018-05-22
KR20180013881A (ko) 2018-02-07
US11254987B2 (en) 2022-02-22
JP6884111B2 (ja) 2021-06-09

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