MX388405B - Un anticuerpo anti-pd-l1 para usarse en el tratamiento de cáncer en sujetos que tienen nivel medio o bajo de metilación en la región promotora pd-l1. - Google Patents
Un anticuerpo anti-pd-l1 para usarse en el tratamiento de cáncer en sujetos que tienen nivel medio o bajo de metilación en la región promotora pd-l1.Info
- Publication number
- MX388405B MX388405B MX2017014735A MX2017014735A MX388405B MX 388405 B MX388405 B MX 388405B MX 2017014735 A MX2017014735 A MX 2017014735A MX 2017014735 A MX2017014735 A MX 2017014735A MX 388405 B MX388405 B MX 388405B
- Authority
- MX
- Mexico
- Prior art keywords
- subjects
- cancer
- treatment
- medium
- promoter region
- Prior art date
Links
- 108700039691 Genetic Promoter Regions Proteins 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000011987 methylation Effects 0.000 title abstract 2
- 238000007069 methylation reaction Methods 0.000 title abstract 2
- 102000008096 B7-H1 Antigen Human genes 0.000 title 1
- 108010074708 B7-H1 Antigen Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562168668P | 2015-05-29 | 2015-05-29 | |
| PCT/US2016/034856 WO2016196381A1 (en) | 2015-05-29 | 2016-05-27 | Pd-l1 promoter methylation in cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017014735A MX2017014735A (es) | 2018-03-23 |
| MX388405B true MX388405B (es) | 2025-03-19 |
Family
ID=56118051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017014735A MX388405B (es) | 2015-05-29 | 2016-05-27 | Un anticuerpo anti-pd-l1 para usarse en el tratamiento de cáncer en sujetos que tienen nivel medio o bajo de metilación en la región promotora pd-l1. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11254987B2 (enExample) |
| EP (2) | EP3303619B1 (enExample) |
| JP (2) | JP6884111B2 (enExample) |
| KR (1) | KR20180013881A (enExample) |
| CN (1) | CN108064170B (enExample) |
| AR (1) | AR105618A1 (enExample) |
| AU (1) | AU2016271142A1 (enExample) |
| CA (1) | CA2984638A1 (enExample) |
| ES (1) | ES2810700T3 (enExample) |
| HK (1) | HK1255200A1 (enExample) |
| IL (1) | IL255375A0 (enExample) |
| MX (1) | MX388405B (enExample) |
| PL (1) | PL3303619T3 (enExample) |
| WO (1) | WO2016196381A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| CA2994544C (en) | 2015-08-03 | 2021-03-30 | Enb Therapeutics, Llc | Compositions and methods for treating cancers associated with etbr activation |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| US11685955B2 (en) | 2016-05-16 | 2023-06-27 | Dimo Dietrich | Method for predicting response of patients with malignant diseases to immunotherapy |
| DE102016005947B3 (de) * | 2016-05-16 | 2017-06-08 | Dimo Dietrich | Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| EP3630838A1 (en) | 2017-06-01 | 2020-04-08 | CytomX Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
| EP3645738A4 (en) * | 2017-06-25 | 2021-08-18 | Systimmune, Inc. | ANTI-PD-L1 ANTIBODIES AND METHODS FOR PREPARATION AND USE |
| US10435434B2 (en) | 2018-01-12 | 2019-10-08 | Enb Therapeutics, Inc. | Deuterated compounds, compositions, and methods for treating cancers associated with ETBR activation |
| JP7062792B2 (ja) | 2018-02-13 | 2022-05-06 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
| CN118221646A (zh) | 2018-07-13 | 2024-06-21 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| CN109355381A (zh) * | 2018-09-14 | 2019-02-19 | 深圳市太空科技南方研究院 | 用于预测pd1/l1抑制剂疗效的生物标记物和方法 |
| CN111035758A (zh) * | 2018-10-11 | 2020-04-21 | 江苏康缘药业股份有限公司 | 药物组合物及其应用、无菌容器和试剂盒 |
| SG11202106708VA (en) * | 2018-12-21 | 2021-07-29 | Agency Science Tech & Res | Method of predicting for benefit from immune checkpoint inhibition therapy |
| WO2021035172A1 (en) * | 2019-08-21 | 2021-02-25 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Diagnostics and methods for prognosing response to immunotherapy based on the methylation status of immune synapse gene signature |
| CN112735513B (zh) * | 2021-01-04 | 2021-11-19 | 江苏先声医疗器械有限公司 | 基于dna甲基化谱的肿瘤免疫检查点抑制剂治疗有效性评估模型的构建方法 |
| WO2025007038A1 (en) * | 2023-06-30 | 2025-01-02 | Guardant Health, Inc. | Methods for early detection of cancer |
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-
2016
- 2016-05-27 EP EP16728525.3A patent/EP3303619B1/en active Active
- 2016-05-27 HK HK18114323.9A patent/HK1255200A1/zh unknown
- 2016-05-27 CN CN201680030947.4A patent/CN108064170B/zh active Active
- 2016-05-27 EP EP20170755.1A patent/EP3763827A1/en not_active Withdrawn
- 2016-05-27 KR KR1020177032871A patent/KR20180013881A/ko not_active Withdrawn
- 2016-05-27 JP JP2017561962A patent/JP6884111B2/ja active Active
- 2016-05-27 CA CA2984638A patent/CA2984638A1/en not_active Abandoned
- 2016-05-27 ES ES16728525T patent/ES2810700T3/es active Active
- 2016-05-27 AR ARP160101553A patent/AR105618A1/es not_active Application Discontinuation
- 2016-05-27 MX MX2017014735A patent/MX388405B/es unknown
- 2016-05-27 PL PL16728525T patent/PL3303619T3/pl unknown
- 2016-05-27 WO PCT/US2016/034856 patent/WO2016196381A1/en not_active Ceased
- 2016-05-27 AU AU2016271142A patent/AU2016271142A1/en not_active Abandoned
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2017
- 2017-11-01 IL IL255375A patent/IL255375A0/en unknown
- 2017-11-22 US US15/821,407 patent/US11254987B2/en active Active
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2021
- 2021-03-08 JP JP2021036418A patent/JP2021102621A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3763827A1 (en) | 2021-01-13 |
| MX2017014735A (es) | 2018-03-23 |
| US11254987B2 (en) | 2022-02-22 |
| IL255375A0 (en) | 2017-12-31 |
| KR20180013881A (ko) | 2018-02-07 |
| CN108064170A (zh) | 2018-05-22 |
| AR105618A1 (es) | 2017-10-25 |
| PL3303619T3 (pl) | 2020-10-05 |
| CA2984638A1 (en) | 2016-12-08 |
| JP6884111B2 (ja) | 2021-06-09 |
| ES2810700T3 (es) | 2021-03-09 |
| AU2016271142A1 (en) | 2017-11-23 |
| WO2016196381A1 (en) | 2016-12-08 |
| EP3303619A1 (en) | 2018-04-11 |
| JP2021102621A (ja) | 2021-07-15 |
| JP2018526323A (ja) | 2018-09-13 |
| US20180216196A1 (en) | 2018-08-02 |
| CN108064170B (zh) | 2022-07-15 |
| EP3303619B1 (en) | 2020-06-10 |
| HK1255200A1 (zh) | 2019-08-09 |
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