AR103156A1 - Ácidos piridil-cicloalquil-carboxílicos sustituidos, composiciones que los contienen y usos de los mismos - Google Patents
Ácidos piridil-cicloalquil-carboxílicos sustituidos, composiciones que los contienen y usos de los mismosInfo
- Publication number
- AR103156A1 AR103156A1 ARP150104175A ARP150104175A AR103156A1 AR 103156 A1 AR103156 A1 AR 103156A1 AR P150104175 A ARP150104175 A AR P150104175A AR P150104175 A ARP150104175 A AR P150104175A AR 103156 A1 AR103156 A1 AR 103156A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- same
- different
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se relaciona con ácidos piridil-cicloalquil-carboxílicos sustituidos de fórmula general (1) como se describe y define en la presente, con métodos para preparar dichos compuestos, con composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y con el uso de dichos compuestos para fabricar una composición farmacéutica para el tratamiento o profilaxis de una enfermedad, en particular en mamíferos, tal como a titulo enunciativo no taxativo enfermedades asociadas con dolores, o para el tratamiento o profilaxis de síndromes de dolor (agudo y crónico), dolor inducido por inflamación, dolor pélvico, dolor asociado con cáncer, dolor asociado con endometriosis así como también. endometriosis; y adenomiosis como tales, cáncer como tal, y enfermedades proliferativas como endometriosis. Reivindicación 1: Un compuesto de fórmula general (1), en donde: R¹ representa halógeno, C₁₋₄-alquilo ó O-(C₁₋₄-alquilo), donde C₁₋₄-alquilo y O-(C₁₋₄-alquilo) están opcionalmente sustituidos con 1 - 5 átomos de halógeno que son iguales o diferentes; R² representa hidrógeno, halógeno, C₁₋₄-alquilo ó O-(C₁₋₄-alquilo), donde C₁₋₄-alquilo y O-(C₁₋₄-alquilo) están opcionalmente sustituidos con 1 - 5 átomos de halógeno que son iguales o diferentes; X es -C₂H₄, -CH₂-Y-, -CH₂-CR⁶R⁷-, -CR⁶R⁷-CH₂- o 1,2-ciclopropilideno; R³ es C₃₋₆-cicloalquilo, que está opcionalmente sustituido con uno o más sustituyentes que son iguales o diferentes y se seleccionan entre halógeno o C₁₋₄-alquilo; R⁴ᵃ y R⁴ᵇ representan hidrógeno, halógeno, C₁₋₄-alquilo, -O-(C₁₋₄-alquilo), (CH₂)ₙ-OH, donde C₁₋₄-alquilo está opcionalmente sustituido con uno o más sustituyentes que son iguales o diferentes y se seleccionan entre halógeno, o C₁₋₄-alquilo; R⁵ es piridina, que está sustituida con uno o dos sustituyentes que son iguales o diferentes y se seleccionan entre el grupo que consiste en halógeno, C₁₋₄-alquilo, -O-(C₁₋₄-alquilo), OH, CN, -CH₂-OH, -CH₂-O-(C₁₋₄-alquilo), C₃₋₆-cicloalquilo, -O-(C₃₋₆-cicloalquilo), heterocicloalquilo de 3 a 7 miembros, y -O-(heterocicloalquilo de 3 a 7 miembros), y donde dichos C₁₋₄-alquilo y -O-(C₁₋₄-alquilo) están opcionalmente sustituidos con 1 - 5 átomos de halógeno que son iguales o diferentes; R⁶ y R⁷ son diferentes y se seleccionan entre el grupo que consiste en hidrógeno, halógeno, C₁₋₄-alquilo y C₃₋₆-cicloalquilo; R⁸ representa hidrógeno o C₁₋₄-alquilo; Y representa O ó NR⁸; n es 0, 1 ó 2; o un tautómero, un isómero, enantiómero, diasterómero, racemato, un N-óxido, un hidrato, un solvato, o una sal del mismo, o una mezcla de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14199006 | 2014-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR103156A1 true AR103156A1 (es) | 2017-04-19 |
Family
ID=52133974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150104175A AR103156A1 (es) | 2014-12-18 | 2015-12-18 | Ácidos piridil-cicloalquil-carboxílicos sustituidos, composiciones que los contienen y usos de los mismos |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US10172814B2 (es) |
| EP (1) | EP3233802A1 (es) |
| JP (1) | JP2017537957A (es) |
| KR (1) | KR20170098869A (es) |
| CN (1) | CN107257790A (es) |
| AR (1) | AR103156A1 (es) |
| AU (1) | AU2015367540B2 (es) |
| BR (1) | BR112017012844A2 (es) |
| CA (1) | CA2970987A1 (es) |
| CL (1) | CL2017001588A1 (es) |
| CO (1) | CO2017005983A2 (es) |
| CR (1) | CR20170258A (es) |
| CU (1) | CU24413B1 (es) |
| DO (1) | DOP2017000142A (es) |
| EA (1) | EA035788B1 (es) |
| EC (1) | ECSP17038136A (es) |
| GT (1) | GT201700126A (es) |
| IL (1) | IL252683B (es) |
| MA (1) | MA41171A (es) |
| MX (1) | MX2017008091A (es) |
| MY (1) | MY182134A (es) |
| NI (1) | NI201700077A (es) |
| PE (1) | PE20171247A1 (es) |
| PH (1) | PH12017501122A1 (es) |
| SG (1) | SG11201704971UA (es) |
| SV (1) | SV2017005465A (es) |
| TN (1) | TN2017000256A1 (es) |
| TW (1) | TWI694986B (es) |
| UY (1) | UY36461A (es) |
| WO (1) | WO2016097013A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| CA3039188A1 (en) * | 2016-10-05 | 2018-04-12 | The Global Alliance For Tb Drug Development, Inc. | Heteroaryltrifluoroborate compounds for the treatment of mycobacterial infections |
| CN110590548B (zh) * | 2019-09-06 | 2020-09-08 | 中国药科大学 | Akr1c3抑制剂或其可药用的盐、其制备方法及用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20013834A3 (cs) | 1999-04-28 | 2002-04-17 | Aventis Pharma Deutschland Gmbh | Deriváty kyselin se třemi arylovými zbytky jako ligandy receptorů PPAR a farmaceutické prostředky, které je obsahují |
| US7244861B2 (en) | 2001-03-30 | 2007-07-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
| CN1812978A (zh) | 2003-04-30 | 2006-08-02 | 药物研发有限责任公司 | 作为蛋白酪氨酸磷酸酶－1b抑制剂的苯基取代羧酸 |
| CN1875002B (zh) | 2003-11-05 | 2011-08-03 | 霍夫曼-拉罗奇有限公司 | 作为ppar激动剂的苯基衍生物 |
| BRPI0508098A (pt) | 2004-02-27 | 2007-07-17 | Amgen Inc | compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos |
| DE102008018675A1 (de) * | 2008-04-14 | 2009-10-15 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Carbonsäure-Derivate und ihre Verwendung |
| DE102009046115A1 (de) * | 2009-10-28 | 2011-09-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 3-Phenylpropansäuren und ihre Verwendung |
| BR112013013663A2 (pt) | 2010-12-07 | 2016-09-06 | Bayer Ip Gmbh | ácidos 1-benzilcicloalquilcarboxílicos substituídos e sua utilização |
| DE102011007272A1 (de) | 2011-04-13 | 2012-10-18 | Bayer Pharma Aktiengesellschaft | Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung |
-
2015
- 2015-12-16 CN CN201580076218.8A patent/CN107257790A/zh active Pending
- 2015-12-16 EP EP15810650.0A patent/EP3233802A1/en not_active Withdrawn
- 2015-12-16 MX MX2017008091A patent/MX2017008091A/es unknown
- 2015-12-16 KR KR1020177019444A patent/KR20170098869A/ko unknown
- 2015-12-16 MA MA041171A patent/MA41171A/fr unknown
- 2015-12-16 WO PCT/EP2015/080041 patent/WO2016097013A1/en active Application Filing
- 2015-12-16 BR BR112017012844A patent/BR112017012844A2/pt not_active Application Discontinuation
- 2015-12-16 PE PE2017001094A patent/PE20171247A1/es unknown
- 2015-12-16 CR CR20170258A patent/CR20170258A/es unknown
- 2015-12-16 MY MYPI2017702201A patent/MY182134A/en unknown
- 2015-12-16 CA CA2970987A patent/CA2970987A1/en not_active Abandoned
- 2015-12-16 US US15/537,280 patent/US10172814B2/en not_active Expired - Fee Related
- 2015-12-16 AU AU2015367540A patent/AU2015367540B2/en not_active Ceased
- 2015-12-16 SG SG11201704971UA patent/SG11201704971UA/en unknown
- 2015-12-16 TN TN2017000256A patent/TN2017000256A1/en unknown
- 2015-12-16 CU CU2017000083A patent/CU24413B1/es unknown
- 2015-12-16 EA EA201791365A patent/EA035788B1/ru not_active IP Right Cessation
- 2015-12-16 JP JP2017532082A patent/JP2017537957A/ja not_active Ceased
- 2015-12-18 AR ARP150104175A patent/AR103156A1/es unknown
- 2015-12-18 TW TW104142848A patent/TWI694986B/zh not_active IP Right Cessation
- 2015-12-18 UY UY0001036461A patent/UY36461A/es not_active Application Discontinuation
-
2017
- 2017-06-05 IL IL252683A patent/IL252683B/en not_active IP Right Cessation
- 2017-06-15 PH PH12017501122A patent/PH12017501122A1/en unknown
- 2017-06-16 DO DO2017000142A patent/DOP2017000142A/es unknown
- 2017-06-16 SV SV2017005465A patent/SV2017005465A/es unknown
- 2017-06-16 CO CONC2017/0005983A patent/CO2017005983A2/es unknown
- 2017-06-16 GT GT201700126A patent/GT201700126A/es unknown
- 2017-06-16 NI NI201700077A patent/NI201700077A/es unknown
- 2017-06-16 CL CL2017001588A patent/CL2017001588A1/es unknown
- 2017-06-19 EC ECIEPI201738136A patent/ECSP17038136A/es unknown
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