AR099473A1 - Macrociclos de imidazopiridina como inhibidores de la replicación del virus de la inmunodeficiencia humana - Google Patents

Macrociclos de imidazopiridina como inhibidores de la replicación del virus de la inmunodeficiencia humana

Info

Publication number
AR099473A1
AR099473A1 ARP150100454A ARP150100454A AR099473A1 AR 099473 A1 AR099473 A1 AR 099473A1 AR P150100454 A ARP150100454 A AR P150100454A AR P150100454 A ARP150100454 A AR P150100454A AR 099473 A1 AR099473 A1 AR 099473A1
Authority
AR
Argentina
Prior art keywords
alkyl
halo
hydrogen
substituents selected
immunodeficiency virus
Prior art date
Application number
ARP150100454A
Other languages
English (en)
Inventor
Narasimhulu Naidu B
Sivaprakasam Prasanna
F Kadow John
Wang Zhongyu
Peese Kevin
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR099473A1 publication Critical patent/AR099473A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos macrocíclicos y su uso para tratar la infección por el virus de inmunodeficiencia humana (VIH). Inhibidores del VIH, composiciones farmacéuticas que contienen tales compuestos y métodos para usar estos compuestos en el tratamiento de una infección por VIH. Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en donde: R¹ es hidrógeno, alquilo o cicloalquilo; R² es hidrógeno o alquilo; R³ es hidrógeno, halo, alquilo o (alquil)SO₂NH-; R⁴ es hidrógeno o alquilo; R⁵ es azetidìnilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo, homopiperidinilo, homopiperazinilo u homomorfolinilo sustituido con 0 - 3 sustituyentes seleccionados de halo, alquilo, haloalquilo, hidroxi, alcoxi y haloalcoxi; Ar¹ es fenilo sustituido con 0 - 3 sustituyentes seleccionados de ciano, halo, alquilo, haloalquilo, alcoxi y haloalcoxi; Ar² es imidazolilo u oxadiazolilo y se sustituye con 0 - 3 sustituyentes seleccionados de halo y alquilo; X¹ es CONHCH₂-, Ar¹ o (Ar²)CH₂-; X² es fenilo sustituido con 0 - 3 sustituyentes seleccionados de ciano, halo, alquilo, haloalquilo, alcoxi y haloalcoxi; X³ es -CH-, -CH₂- o -O-; X⁴ es alquileno o alquenileno; y X⁵ es -CH-, -CH₂- o -O-; o una sal de aquel aceptable desde el punto de vista farmacéutico.
ARP150100454A 2014-02-18 2015-02-13 Macrociclos de imidazopiridina como inhibidores de la replicación del virus de la inmunodeficiencia humana AR099473A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461941004P 2014-02-18 2014-02-18

Publications (1)

Publication Number Publication Date
AR099473A1 true AR099473A1 (es) 2016-07-27

Family

ID=53797504

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100454A AR099473A1 (es) 2014-02-18 2015-02-13 Macrociclos de imidazopiridina como inhibidores de la replicación del virus de la inmunodeficiencia humana

Country Status (5)

Country Link
US (1) US9409922B2 (es)
EP (1) EP3114129A1 (es)
AR (1) AR099473A1 (es)
TW (1) TW201613939A (es)
WO (1) WO2015126751A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015126758A1 (en) * 2014-02-18 2015-08-27 Bristol-Myers Squibb Company Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
JP2018522924A (ja) * 2015-08-10 2018-08-16 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤としてのイミダゾピリジン大環状化合物
CN108358797A (zh) * 2018-04-20 2018-08-03 南京农业大学 一种烷基甘氨酸的合成方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
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JP2005504808A (ja) 2001-09-26 2005-02-17 バイエル・フアーマシユーチカルズ・コーポレーシヨン 抗糖尿病薬としての１，６−ナフチリジン誘導体
WO2006088246A1 (ja) * 2005-02-18 2006-08-24 Takeda Pharmaceutical Company Limited Ｇｐｒ３４受容体機能調節剤
US7939545B2 (en) 2006-05-16 2011-05-10 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
CA2705318C (en) 2007-11-15 2013-12-31 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
KR20100108337A (ko) 2007-11-15 2010-10-06 베링거 인겔하임 인터내셔날 게엠베하 사람 면역결핍 바이러스 복제의 억제제
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CA2705338A1 (en) 2007-11-16 2009-05-22 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
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SG10201408512RA (en) 2009-12-23 2015-02-27 Univ Leuven Kath Novel antiviral compounds
ES2634490T3 (es) 2010-07-02 2017-09-28 Gilead Sciences, Inc. Derivados de ácido napht-2-ylacetico para tratar el sida
PE20130525A1 (es) 2010-07-02 2013-05-05 Gilead Sciences Inc Derivados de acido 2 quinolinil acetico como compuestos antivirales frente a vih
US8633200B2 (en) 2010-09-08 2014-01-21 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
BR112013011991A2 (pt) 2010-11-15 2016-08-30 Viiv Healthcare Uk Ltd composto, composição farmacêutica, uso de um composto, método de tratamento, produto, e kit.
RU2013121785A (ru) 2010-11-15 2014-12-27 Католике Универзитайт Лойфен Новые противовирусные соединения
WO2013012649A1 (en) 2011-07-15 2013-01-24 Glaxosmithkline Llc Azaindole compounds and methods for treating hiv
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US9034882B2 (en) 2012-03-05 2015-05-19 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US8906929B2 (en) 2012-08-16 2014-12-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
EP2970301B1 (en) 2013-03-13 2017-01-11 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
CN105008358B (zh) 2013-03-13 2017-12-29 百时美施贵宝公司 人免疫缺陷病毒复制的抑制剂
CN105008369B (zh) 2013-03-14 2017-07-11 百时美施贵宝公司 人类免疫缺陷病毒复制抑制剂
WO2015123182A1 (en) 2014-02-12 2015-08-20 Bristol-Myers Squibb Company Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
US9944656B2 (en) 2014-02-12 2018-04-17 VIIV Healthcare UK (No.5) Limited Benzothiazole macrocycles as inhibitors of human immunodeficiency virus replication
WO2015126758A1 (en) 2014-02-18 2015-08-27 Bristol-Myers Squibb Company Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
WO2015126743A1 (en) 2014-02-18 2015-08-27 Bristol-Myers Squibb Company Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
US9273067B2 (en) 2014-02-19 2016-03-01 Bristol-Myers Squibb Company Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
EP3107913B1 (en) 2014-02-19 2018-07-04 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
WO2015127003A1 (en) 2014-02-20 2015-08-27 Bristol-Myers Squibb Company Pyridin-3-yl acetic acid macrocycles as inhibitors of human immunodeficiency virus replication

Also Published As

Publication number Publication date
WO2015126751A1 (en) 2015-08-27
US9409922B2 (en) 2016-08-09
EP3114129A1 (en) 2017-01-11
US20150232480A1 (en) 2015-08-20
TW201613939A (en) 2016-04-16

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