AR099487A1 - Macrociclos de pirazolopirimidina como inhibidores de la replicación del virus de la inmunodeficiencia humana - Google Patents

Macrociclos de pirazolopirimidina como inhibidores de la replicación del virus de la inmunodeficiencia humana

Info

Publication number
AR099487A1
AR099487A1 ARP150100473A ARP150100473A AR099487A1 AR 099487 A1 AR099487 A1 AR 099487A1 AR P150100473 A ARP150100473 A AR P150100473A AR P150100473 A ARP150100473 A AR P150100473A AR 099487 A1 AR099487 A1 AR 099487A1
Authority
AR
Argentina
Prior art keywords
alkyl
halo
haloalkyl
substituted
hydrogen
Prior art date
Application number
ARP150100473A
Other languages
English (en)
Inventor
Gonzalez-Bobes Francisco
Chen Ke
D Eastgate Martin
Zheng Bin
F Kadow John
Barbara Zheng Zhizhen
Patel Manoj
E Sorenson Margaret
A Walker Michael
Narasimhulu Naidu B
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR099487A1 publication Critical patent/AR099487A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1) en donde: R¹ es alquilo o haloalquilo; R² es hidrógeno o alquilo; R³ es hidrógeno, halo o alquilo; R⁴ es hidrógeno, alquilo o cicloalquilo; R⁵ es hidrógeno, alquilo o (Ar⁴)alquilo; Ar¹ es fenilo o naftilo y se sustituye con 0 - 3 sustituyentes seleccionados de ciano, halo, alquilo, haloalquilo, alcoxi y haloalcoxi; Ar² es pirrolilo, pirazolilo o triazolilo sustituido con 0 - 2 sustituyentes de alquilo; Ar³ es fenilo sustituido con 0 - 3 sustituyentes seleccionados de ciano, halo, alquilo, haloalquilo, alcoxi y haloalcoxi; Ar⁴ es fenilo sustituido con 0 - 3 sustituyentes seleccionados de ciano, halo, alquilo, haloalquilo, alcoxi y haloalcoxi; X¹ es alquileno, alquenileno, -CH₂O-, -CH₂OCH₂-, -CH₂N(R⁴)CH₂- o -CH₂CON(R⁴)-; X² es -O-, -Ar¹-, -Ar²-, -CON(R⁵)-, -(Ar³)CH-, -((benciIoxi)CH₂)CH-, -O(Ar³)CH-, -CH₂CON(R⁵)- o -N(R⁵)COCON(R⁵)-; X³ está ausente o es -O-, alquiloxi, cicloalquiloxi, cicloalquilo, Ar³, (Ar³)O- o ((Ar³)alquil)O-; X⁴ es alquileno, alquenileno, alquilenoxi o alquenilenoxi; X⁵ está ausente o es -O-; y X⁶ es azetidinilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo, homopiperidinilo, homopiperazinilo u homomorfolinilo, y se sustituye con 0 - 3 sustituyentes de halo o alquilo; o una sal de aquel aceptable desde el punto de vista farmacéutico.
ARP150100473A 2014-02-19 2015-02-18 Macrociclos de pirazolopirimidina como inhibidores de la replicación del virus de la inmunodeficiencia humana AR099487A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461941931P 2014-02-19 2014-02-19

Publications (1)

Publication Number Publication Date
AR099487A1 true AR099487A1 (es) 2016-07-27

Family

ID=53797505

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100473A AR099487A1 (es) 2014-02-19 2015-02-18 Macrociclos de pirazolopirimidina como inhibidores de la replicación del virus de la inmunodeficiencia humana

Country Status (5)

Country Link
US (1) US9273067B2 (es)
EP (1) EP3107918A1 (es)
AR (1) AR099487A1 (es)
TW (1) TW201615644A (es)
WO (1) WO2015126737A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9932353B2 (en) * 2014-02-18 2018-04-03 Viiv Healthcare Uk (No. 5) Limited Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
US9409922B2 (en) 2014-02-18 2016-08-09 Bristol-Myers Squibb Company Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication
CA3124783A1 (en) * 2018-12-27 2020-07-02 Taisho Pharmaceutical Co., Ltd. Pyrazolo[1,5-a]pyrimidine macrocyclic compound
CN113773335A (zh) * 2019-06-21 2021-12-10 成都海博为药业有限公司 一种作为蛋白质激酶抑制剂的化合物及其制备方法和用途
KR20220122637A (ko) 2019-11-28 2022-09-02 바이엘 악티엔게젤샤프트 면역 활성화를 위한 dgk알파 억제제로서의 치환된 아미노퀴놀론

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CN1980912A (zh) * 2004-07-01 2007-06-13 第一制药株式会社 吡唑衍生物
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EP2054416B8 (en) 2006-08-04 2014-07-16 Merz Pharma GmbH & Co. KGaA Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine
US20080287479A1 (en) * 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase
WO2009062288A1 (en) 2007-11-15 2009-05-22 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
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WO2009062308A1 (en) 2007-11-16 2009-05-22 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
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JP2013515692A (ja) 2009-12-23 2013-05-09 カトリック・ユニベルシティト・ルーヴァン 新規抗ウイルス化合物
KR20130135826A (ko) 2010-07-02 2013-12-11 길리애드 사이언시즈, 인코포레이티드 Ａｉｄｓ를 치료하기 위한 나프트-2-일아세트산 유도체
CN103209963A (zh) 2010-07-02 2013-07-17 吉里德科学公司 作为hiv抗病毒化合物的2-喹啉基-乙酸衍生物
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WO2013062028A1 (ja) 2011-10-25 2013-05-02 塩野義製薬株式会社 Ｈｉｖ複製阻害剤
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US9034882B2 (en) 2012-03-05 2015-05-19 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US8906929B2 (en) 2012-08-16 2014-12-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9663536B2 (en) 2013-03-13 2017-05-30 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
EP2970297A1 (en) 2013-03-14 2016-01-20 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication

Also Published As

Publication number Publication date
US20150232481A1 (en) 2015-08-20
TW201615644A (zh) 2016-05-01
EP3107918A1 (en) 2016-12-28
WO2015126737A1 (en) 2015-08-27
US9273067B2 (en) 2016-03-01

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