AR098508A1 - Soluciones para incrementar la estabilidad y la vida útil de un órgano, y solución de conservación de tejido - Google Patents
Soluciones para incrementar la estabilidad y la vida útil de un órgano, y solución de conservación de tejidoInfo
- Publication number
- AR098508A1 AR098508A1 ARP140104385A ARP140104385A AR098508A1 AR 098508 A1 AR098508 A1 AR 098508A1 AR P140104385 A ARP140104385 A AR P140104385A AR P140104385 A ARP140104385 A AR P140104385A AR 098508 A1 AR098508 A1 AR 098508A1
- Authority
- AR
- Argentina
- Prior art keywords
- solution
- preparation
- arginine
- tissue
- water
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
Reivindicación 1: Un equipo de conservación de órganos compuesto por una primera solución acuosa contenida en un primer recipiente, y una segunda solución contenida en un segundo recipiente, donde la primera solución acuosa está compuesta por una solución salina balanceada, y dicha primera solución tiene un pH de por lo menos 7,0; y donde la segunda solución está compuesta por agua, glutationa reducida, ácido ascórbico, un azúcar, L-Arginina, y dicha segunda solución tiene un pH de alrededor de 5,0 o inferior. Reivindicación 2: El equipo de la reivindicación 1, donde el primer y segundo recipientes son primera y segunda cámaras dentro de un solo recipiente, y la primera y segunda cámaras están divididas entre si por una división, donde, con la eliminación de la división, la primera solución se mezcla con la segunda solución para formar la solución de conservación de tejido y órganos completa. Reivindicación 6: Un método para la preparación de una solución de conservación de tejido u órganos, que comprende: la preparación de una primera solución que comprende la formación de una solución salina balanceada que tiene un pH de 7,6 a alrededor de 8,0; la preparación de una segunda solución compuesta por agua, D-Glucosa, L-Arginina; glutationa y ácido ascórbico, a un pH de alrededor de 3 - 5; y en el punto de uso, la mezcla de la primera solución junto con la segunda solución para formar una solución combinada que tiene un pH de 7,3 ± 0,4. Reivindicación 12: Un método para la preparación de una solución de conservación de tejido u órganos, que comprende: la preparación de una primera solución compuesta por una solución salina balanceada acuosa y un azúcar con un pH de alrededor de 7,6 a 8,0; la preparación de una segunda solución compuesta por agua, L-Arginina glutationa y ácido ascórbico a un pH de alrededor de 3 - 5; y la mezcla de la primera solución junto con la segunda solución. Reivindicación 17: Una solución que consiste en agua, L-Arginina, glutationa, un azúcar, un agente reductor y un agente regulador.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361963093P | 2013-11-22 | 2013-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR098508A1 true AR098508A1 (es) | 2016-06-01 |
Family
ID=52023642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140104385A AR098508A1 (es) | 2013-11-22 | 2014-11-21 | Soluciones para incrementar la estabilidad y la vida útil de un órgano, y solución de conservación de tejido |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US11291201B2 (es) |
| EP (1) | EP3027016B1 (es) |
| JP (1) | JP2016537333A (es) |
| KR (2) | KR102570322B1 (es) |
| CN (1) | CN105916374B (es) |
| AR (1) | AR098508A1 (es) |
| AU (1) | AU2014353199B2 (es) |
| BR (1) | BR112016006512B1 (es) |
| CA (1) | CA2923441C (es) |
| CL (1) | CL2016001003A1 (es) |
| CR (1) | CR20160188A (es) |
| DK (1) | DK3027016T3 (es) |
| EA (1) | EA201691066A1 (es) |
| ES (1) | ES2744637T3 (es) |
| HK (1) | HK1220081A1 (es) |
| IL (1) | IL244834B (es) |
| MX (1) | MX2016006651A (es) |
| MY (1) | MY181282A (es) |
| PE (1) | PE20160861A1 (es) |
| PH (1) | PH12016500909B1 (es) |
| SG (1) | SG10201709595WA (es) |
| TW (1) | TW201605342A (es) |
| WO (1) | WO2015077199A1 (es) |
| ZA (1) | ZA202210899B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016537333A (ja) * | 2013-11-22 | 2016-12-01 | ソマールション・エルエルシー | 臓器組織保存溶液の安定性及び保存可能期間を増加させる溶液 |
| WO2018081213A1 (en) * | 2016-10-25 | 2018-05-03 | Marquette University | Storage media and powder formulations for avulsed teeth and explanted tissues comprising fibroblasts |
| US11980700B2 (en) | 2017-03-08 | 2024-05-14 | Alafair Biosciences, Inc. | Hydrogel medium for the storage and preservation of tissue |
| WO2023201038A1 (en) | 2022-04-15 | 2023-10-19 | Marizyme, Inc. | Powder formulations and use thereof in medical and/or surgical procedures |
| WO2023224887A1 (en) * | 2022-05-16 | 2023-11-23 | Marizyme, Inc. | Use of cytoprotectant formulations in cell or tissue transport and/or storage |
| WO2024076634A1 (en) * | 2022-10-04 | 2024-04-11 | Marizyme, Inc. | Kits and use thereof in surgical procedures for endoscopic harvesting of vessels |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4550022A (en) | 1981-10-05 | 1985-10-29 | Alcon Laboratories, Inc. | Tissue irrigating solution |
| US4443432A (en) | 1981-10-05 | 1984-04-17 | Alcon Laboratories, Inc. | Ophthmalic irrigating solution |
| US5409904A (en) | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
| US4879283A (en) | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US4837021A (en) | 1986-12-31 | 1989-06-06 | Laboratoires P.O.S. | Two part tissue irrigating solution |
| US5304724A (en) | 1988-09-09 | 1994-04-19 | Entravision, Inc. | Tissue irrigating solution |
| US4938961A (en) | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
| US5257985A (en) | 1989-12-04 | 1993-11-02 | Richard Puhl | Multi-chamber intravenous bag apparatus |
| US5066578A (en) * | 1989-12-21 | 1991-11-19 | The Regents Of The University Of California | Long-term preservation of organs for transplantation |
| WO1992008349A1 (en) | 1990-11-07 | 1992-05-29 | Baxter International Inc. | Blood platelet storage medium |
| DE69126861T2 (de) * | 1990-11-07 | 1998-02-26 | Baxter Int | Lösung zur aufbewahrung roter blutzellen |
| US5498427A (en) | 1990-11-20 | 1996-03-12 | Pasteur Merieux Serums Et Vaccines | Solutions for the perfusion, preservation and reperfusion of organs |
| EP0647398B1 (en) * | 1992-06-26 | 1997-09-17 | Torii Pharmaceutical Co., Ltd. | Organ preserving fluid |
| BE1007500A3 (fr) | 1992-09-18 | 1995-07-18 | Pasteur Merieux Serums Vacc | Solution de perfusion, de conservation et de reperfusion d'organes. |
| ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
| JP3623294B2 (ja) | 1995-11-28 | 2005-02-23 | 株式会社新素材総合研究所 | 電解質液が収容された医療用容器及びその製造方法 |
| US8409846B2 (en) * | 1997-09-23 | 2013-04-02 | The United States Of America As Represented By The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
| US6153582A (en) | 1998-11-05 | 2000-11-28 | Bausch & Lomb Surgical, Inc. | Defined serumfree medical solution for ophthalmology |
| US7611830B2 (en) | 2000-04-10 | 2009-11-03 | The United States Of America As Represented By The Department Of Veteran's Affairs | Device to lavage a blood vessel |
| US6569615B1 (en) | 2000-04-10 | 2003-05-27 | The United States Of America As Represented By The Department Of Veteran's Affairs | Composition and methods for tissue preservation |
| SI21704A (en) | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
| US20060093765A1 (en) | 2004-10-29 | 2006-05-04 | Sealed Air Corporation (Us) | Multi-compartment pouch having a frangible seal |
| US20060160062A1 (en) | 2005-01-14 | 2006-07-20 | Young Lindon H | Perfusion and/or preservation solution for organs |
| US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US7575856B2 (en) | 2005-10-28 | 2009-08-18 | The United States Of America As Represented By The Department Of Veterans Affairs | Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant |
| EP1942726B1 (en) * | 2006-04-19 | 2017-01-04 | Transmedics, Inc. | Methods for ex vivo organ care |
| WO2008100636A2 (en) | 2007-02-17 | 2008-08-21 | President And Fellows Of Harvard College | Compositions and method for tissue preservation |
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| JP5406049B2 (ja) * | 2008-02-05 | 2014-02-05 | 協和発酵バイオ株式会社 | グルタチオンの保存安定性向上方法 |
| JP2011512351A (ja) * | 2008-02-15 | 2011-04-21 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 心臓手術のための心停止液 |
| US8608922B2 (en) | 2008-11-07 | 2013-12-17 | The University Of Connecticut | Biosensor for continuous monitoring of metabolites and proteins and methods of manufacture thereof |
| WO2010054495A2 (en) | 2008-11-14 | 2010-05-20 | Profimed S.R.O. | Non-aqueous colloidal formulation |
| US8288084B2 (en) | 2009-07-12 | 2012-10-16 | Revive Organtech, Inc. | Composition and method for flushing and cold/cryo preserving organs, tissues, and cells |
| JP5752123B2 (ja) * | 2009-09-01 | 2015-07-22 | メドヴェント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | キトサン組織被覆材 |
| FR2963965B1 (fr) | 2010-08-20 | 2013-02-15 | Vallourec Mannesmann Oil & Gas | Procede et dispositif de controle d'un filetage de joint tubulaire utilise dans l'industrie du petrole |
| BR112015015092A2 (pt) * | 2012-12-31 | 2017-07-11 | Somahlution Llc | processos para preservar a função de tecido ou órgão e para preparar formulação para preservar a mesma e kit respectivo |
| CN104919066A (zh) * | 2013-01-09 | 2015-09-16 | 三菱综合材料株式会社 | 电子电气设备用铜合金、电子电气设备用铜合金薄板、电子电气设备用铜合金的制造方法、电子电气设备用导电元件及端子 |
| WO2014176224A1 (en) | 2013-04-24 | 2014-10-30 | Somahlution, Llc | Organ and tissue preservation solutions having increased oxygen-content, stability and shelf life |
| WO2014179113A1 (en) * | 2013-04-29 | 2014-11-06 | Somahlution, Llc | Formulations containing poly (0-2-hydroxyethyl) starch for increasing the oxygen-content, stability and shelf life of an organ and tissue preservation solution |
| JP2016537333A (ja) * | 2013-11-22 | 2016-12-01 | ソマールション・エルエルシー | 臓器組織保存溶液の安定性及び保存可能期間を増加させる溶液 |
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2014
- 2014-11-18 JP JP2016525916A patent/JP2016537333A/ja active Pending
- 2014-11-18 BR BR112016006512-3A patent/BR112016006512B1/pt active IP Right Grant
- 2014-11-18 EP EP14812052.0A patent/EP3027016B1/en active Active
- 2014-11-18 MX MX2016006651A patent/MX2016006651A/es unknown
- 2014-11-18 US US14/906,582 patent/US11291201B2/en active Active
- 2014-11-18 EA EA201691066A patent/EA201691066A1/ru unknown
- 2014-11-18 PE PE2016000488A patent/PE20160861A1/es not_active Application Discontinuation
- 2014-11-18 DK DK14812052.0T patent/DK3027016T3/da active
- 2014-11-18 KR KR1020227026130A patent/KR102570322B1/ko active IP Right Grant
- 2014-11-18 KR KR1020167015581A patent/KR102428676B1/ko active IP Right Grant
- 2014-11-18 ES ES14812052T patent/ES2744637T3/es active Active
- 2014-11-18 CA CA2923441A patent/CA2923441C/en active Active
- 2014-11-18 SG SG10201709595WA patent/SG10201709595WA/en unknown
- 2014-11-18 CN CN201480061943.3A patent/CN105916374B/zh active Active
- 2014-11-18 AU AU2014353199A patent/AU2014353199B2/en active Active
- 2014-11-18 MY MYPI2016701801A patent/MY181282A/en unknown
- 2014-11-18 WO PCT/US2014/066054 patent/WO2015077199A1/en active Application Filing
- 2014-11-21 TW TW103140510A patent/TW201605342A/zh unknown
- 2014-11-21 AR ARP140104385A patent/AR098508A1/es active IP Right Grant
-
2016
- 2016-03-30 IL IL244834A patent/IL244834B/en active IP Right Grant
- 2016-04-22 CR CR20160188A patent/CR20160188A/es unknown
- 2016-04-27 CL CL2016001003A patent/CL2016001003A1/es unknown
- 2016-05-17 PH PH12016500909A patent/PH12016500909B1/en unknown
- 2016-07-13 HK HK16108205.6A patent/HK1220081A1/zh unknown
-
2022
- 2022-03-02 US US17/684,495 patent/US20220232822A1/en active Pending
- 2022-10-04 ZA ZA2022/10899A patent/ZA202210899B/en unknown
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |