CR20160188A - Soluciones para incrementar la estabilidad y la vida útil de un órgano y solución de conservación de tejido - Google Patents

Soluciones para incrementar la estabilidad y la vida útil de un órgano y solución de conservación de tejido

Info

Publication number
CR20160188A
CR20160188A CR20160188A CR20160188A CR20160188A CR 20160188 A CR20160188 A CR 20160188A CR 20160188 A CR20160188 A CR 20160188A CR 20160188 A CR20160188 A CR 20160188A CR 20160188 A CR20160188 A CR 20160188A
Authority
CR
Costa Rica
Prior art keywords
solution
solutions
organ
stability
increase
Prior art date
Application number
CR20160188A
Other languages
English (en)
Inventor
Mahendra Suryan
Original Assignee
Somahlution Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somahlution Llc filed Critical Somahlution Llc
Publication of CR20160188A publication Critical patent/CR20160188A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Se divulgan soluciones de conservación de tejido y órganos que tienen mejorada establidad. Las soluciones están compuestas por dos soluciones separadas. La primera solución, Solución A, está compuesta por una solución salina balanceada que es estable en solución a un pH de 7,0 o superior. Una segunda solución, solución B, está compuesta por una solución acuosa que contiene L-glutationa y/o cisteinilglicina, un azúcar tal como D-Glucosa, L-Arginina, un agente reductor tal como ácido ascórbico y agua, a un pH inferior a 7,0, preferentemente, de alrededor de 3,0 a 5,0.
CR20160188A 2013-11-22 2016-04-22 Soluciones para incrementar la estabilidad y la vida útil de un órgano y solución de conservación de tejido CR20160188A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361963093P 2013-11-22 2013-11-22
PCT/US2014/066054 WO2015077199A1 (en) 2013-11-22 2014-11-18 Solutons for increasing the stability and shelf life of an organ tissue preservation solution

Publications (1)

Publication Number Publication Date
CR20160188A true CR20160188A (es) 2016-07-04

Family

ID=52023642

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160188A CR20160188A (es) 2013-11-22 2016-04-22 Soluciones para incrementar la estabilidad y la vida útil de un órgano y solución de conservación de tejido

Country Status (24)

Country Link
US (2) US11291201B2 (es)
EP (1) EP3027016B1 (es)
JP (1) JP2016537333A (es)
KR (2) KR102428676B1 (es)
CN (1) CN105916374B (es)
AR (1) AR098508A1 (es)
AU (1) AU2014353199B2 (es)
BR (1) BR112016006512B1 (es)
CA (1) CA2923441C (es)
CL (1) CL2016001003A1 (es)
CR (1) CR20160188A (es)
DK (1) DK3027016T3 (es)
EA (1) EA201691066A1 (es)
ES (1) ES2744637T3 (es)
HK (1) HK1220081A1 (es)
IL (1) IL244834B (es)
MX (1) MX2016006651A (es)
MY (1) MY181282A (es)
PE (1) PE20160861A1 (es)
PH (1) PH12016500909B1 (es)
SG (1) SG10201709595WA (es)
TW (1) TW201605342A (es)
WO (1) WO2015077199A1 (es)
ZA (1) ZA202210899B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201691066A1 (ru) * 2013-11-22 2016-09-30 СОМАЛЮШН, ЭлЭлСи Растворы для повышения стабильности и срок годности раствора для консервирования органов и тканей
EP3531832A4 (en) 2016-10-25 2020-08-05 Marquette University STORAGE MEDIUM AND POWDER FORMULATIONS FOR AVULSATED TEETH AND EXPLANATED TISSUE WITH FIBROBLASTS
US11980700B2 (en) 2017-03-08 2024-05-14 Alafair Biosciences, Inc. Hydrogel medium for the storage and preservation of tissue
WO2023201038A1 (en) 2022-04-15 2023-10-19 Marizyme, Inc. Powder formulations and use thereof in medical and/or surgical procedures
WO2023224887A1 (en) * 2022-05-16 2023-11-23 Marizyme, Inc. Use of cytoprotectant formulations in cell or tissue transport and/or storage
WO2024076634A1 (en) * 2022-10-04 2024-04-11 Marizyme, Inc. Kits and use thereof in surgical procedures for endoscopic harvesting of vessels

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550022A (en) 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
US4443432A (en) 1981-10-05 1984-04-17 Alcon Laboratories, Inc. Ophthmalic irrigating solution
US5409904A (en) 1984-11-13 1995-04-25 Alcon Laboratories, Inc. Hyaluronic acid compositions and methods
US4798824A (en) 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US4879283A (en) 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4837021A (en) 1986-12-31 1989-06-06 Laboratoires P.O.S. Two part tissue irrigating solution
US5304724A (en) 1988-09-09 1994-04-19 Entravision, Inc. Tissue irrigating solution
US4938961A (en) 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia
US5257985A (en) 1989-12-04 1993-11-02 Richard Puhl Multi-chamber intravenous bag apparatus
US5066578A (en) * 1989-12-21 1991-11-19 The Regents Of The University Of California Long-term preservation of organs for transplantation
WO1992008349A1 (en) 1990-11-07 1992-05-29 Baxter International Inc. Blood platelet storage medium
CA2071833C (en) * 1990-11-07 1998-11-03 Jean-Marc Payrat Red blood cell storage solution
US5498427A (en) 1990-11-20 1996-03-12 Pasteur Merieux Serums Et Vaccines Solutions for the perfusion, preservation and reperfusion of organs
EP0647398B1 (en) * 1992-06-26 1997-09-17 Torii Pharmaceutical Co., Ltd. Organ preserving fluid
FR2695827B1 (fr) 1992-09-18 1995-07-28 Pasteur Merieux Serums Vacc Solution de perfusion, de conservation et de reperfusion d'organes.
ITPD940054A1 (it) 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
JP3623294B2 (ja) 1995-11-28 2005-02-23 株式会社新素材総合研究所 電解質液が収容された医療用容器及びその製造方法
US8409846B2 (en) * 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6153582A (en) 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
US6569615B1 (en) 2000-04-10 2003-05-27 The United States Of America As Represented By The Department Of Veteran's Affairs Composition and methods for tissue preservation
US7611830B2 (en) 2000-04-10 2009-11-03 The United States Of America As Represented By The Department Of Veteran's Affairs Device to lavage a blood vessel
SI21704A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
US20060093765A1 (en) 2004-10-29 2006-05-04 Sealed Air Corporation (Us) Multi-compartment pouch having a frangible seal
US20060160062A1 (en) 2005-01-14 2006-07-20 Young Lindon H Perfusion and/or preservation solution for organs
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US7575856B2 (en) * 2005-10-28 2009-08-18 The United States Of America As Represented By The Department Of Veterans Affairs Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant
DK3178319T3 (da) * 2006-04-19 2020-02-03 Transmedics Inc Systemer til ex vivo-organpleje
CN101790306A (zh) 2007-02-17 2010-07-28 哈佛学院董事会 用于进行组织保存的组合物以及方法
US20090035240A1 (en) * 2007-07-31 2009-02-05 Maes Daniel H Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent
JP5406049B2 (ja) * 2008-02-05 2014-02-05 協和発酵バイオ株式会社 グルタチオンの保存安定性向上方法
AU2009215884A1 (en) * 2008-02-15 2009-08-27 President And Fellows Of Harvard College Cardioplegia solution for cardiac surgery
US8608922B2 (en) 2008-11-07 2013-12-17 The University Of Connecticut Biosensor for continuous monitoring of metabolites and proteins and methods of manufacture thereof
WO2010054495A2 (en) 2008-11-14 2010-05-20 Profimed S.R.O. Non-aqueous colloidal formulation
US8288084B2 (en) 2009-07-12 2012-10-16 Revive Organtech, Inc. Composition and method for flushing and cold/cryo preserving organs, tissues, and cells
US10207022B2 (en) * 2009-09-01 2019-02-19 Medoderm Gmbh Chitosan tissue dressing
FR2963965B1 (fr) 2010-08-20 2013-02-15 Vallourec Mannesmann Oil & Gas Procede et dispositif de controle d'un filetage de joint tubulaire utilise dans l'industrie du petrole
ES2724238T3 (es) * 2012-12-31 2019-09-09 Somahlution Llc Formulaciones para la preservación de órganos y tejidos con mayor estabilidad y vida útil
EP2944703A1 (en) * 2013-01-09 2015-11-18 Mitsubishi Materials Corporation Copper alloy for electronic or electrical device, copper alloy thin sheet for electronic or electrical device, process for manufacturing copper alloy for electronic or electrical device, conductive component for electronic or electrical device, and terminal
JP2016516830A (ja) 2013-04-24 2016-06-09 ソマールション・エルエルシー 酸素含有量が増加され、安定性が向上され、貯蔵寿命が長くなった臓器及び組織の保存溶液
CN105407716A (zh) * 2013-04-29 2016-03-16 索玛解有限公司 用于增加器官和组织保存溶液的氧含量、稳定性和保存期的含聚(o-2-羟乙基)淀粉的制剂
EA201691066A1 (ru) * 2013-11-22 2016-09-30 СОМАЛЮШН, ЭлЭлСи Растворы для повышения стабильности и срок годности раствора для консервирования органов и тканей

Also Published As

Publication number Publication date
ZA202210899B (en) 2024-02-28
JP2016537333A (ja) 2016-12-01
CN105916374A (zh) 2016-08-31
CL2016001003A1 (es) 2016-12-02
MX2016006651A (es) 2016-09-06
AU2014353199B2 (en) 2018-07-19
BR112016006512A2 (pt) 2017-08-01
EP3027016A1 (en) 2016-06-08
PE20160861A1 (es) 2016-09-03
CN105916374B (zh) 2021-11-05
IL244834B (en) 2021-06-30
ES2744637T3 (es) 2020-02-25
PH12016500909A1 (en) 2016-06-20
MY181282A (en) 2020-12-21
US11291201B2 (en) 2022-04-05
IL244834A0 (en) 2016-05-31
WO2015077199A1 (en) 2015-05-28
HK1220081A1 (zh) 2017-04-28
US20160249603A1 (en) 2016-09-01
BR112016006512B1 (pt) 2021-11-23
DK3027016T3 (da) 2019-09-16
KR102428676B1 (ko) 2022-08-03
SG10201709595WA (en) 2017-12-28
EP3027016B1 (en) 2019-06-12
AU2014353199A1 (en) 2016-04-14
US20220232822A1 (en) 2022-07-28
CA2923441C (en) 2023-03-28
AR098508A1 (es) 2016-06-01
KR20160093636A (ko) 2016-08-08
PH12016500909B1 (en) 2016-06-20
TW201605342A (zh) 2016-02-16
KR20220111736A (ko) 2022-08-09
KR102570322B1 (ko) 2023-08-23
CA2923441A1 (en) 2015-05-28
EA201691066A1 (ru) 2016-09-30

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