AR098283A1 - Polinucleótido donante universal para reconocimiento de genes - Google Patents
Polinucleótido donante universal para reconocimiento de genesInfo
- Publication number
- AR098283A1 AR098283A1 ARP140104120A ARP140104120A AR098283A1 AR 098283 A1 AR098283 A1 AR 098283A1 AR P140104120 A ARP140104120 A AR P140104120A AR P140104120 A ARP140104120 A AR P140104120A AR 098283 A1 AR098283 A1 AR 098283A1
- Authority
- AR
- Argentina
- Prior art keywords
- domain
- plant cell
- site
- genome
- nuclease
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 abstract 5
- 102000040430 polynucleotide Human genes 0.000 abstract 5
- 239000002157 polynucleotide Substances 0.000 abstract 5
- 101710163270 Nuclease Proteins 0.000 abstract 4
- 230000004568 DNA-binding Effects 0.000 abstract 3
- 230000010354 integration Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000004570 RNA-binding Effects 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8209—Selection, visualisation of transformants, reporter constructs, e.g. antibiotic resistance markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8209—Selection, visualisation of transformants, reporter constructs, e.g. antibiotic resistance markers
- C12N15/821—Non-antibiotic resistance markers, e.g. morphogenetic, metabolic markers
- C12N15/8212—Colour markers, e.g. beta-glucoronidase [GUS], green fluorescent protein [GFP], carotenoid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
- C12N15/8275—Glyphosate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361899543P | 2013-11-04 | 2013-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR098283A1 true AR098283A1 (es) | 2016-05-26 |
Family
ID=53005271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140104120A AR098283A1 (es) | 2013-11-04 | 2014-11-03 | Polinucleótido donante universal para reconocimiento de genes |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10077449B2 (https=) |
| EP (1) | EP3066192B1 (https=) |
| JP (1) | JP6560203B2 (https=) |
| KR (1) | KR102248730B1 (https=) |
| CN (1) | CN105683357B (https=) |
| AR (1) | AR098283A1 (https=) |
| AU (1) | AU2014341928B2 (https=) |
| BR (1) | BR102014027448A8 (https=) |
| CA (1) | CA2926534A1 (https=) |
| IL (1) | IL245313B (https=) |
| RU (1) | RU2687369C2 (https=) |
| TW (1) | TWI669395B (https=) |
| WO (1) | WO2015066637A1 (https=) |
| ZA (1) | ZA201601929B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2831144A1 (en) | 2011-03-23 | 2012-09-27 | Pioneer Hi-Bred International, Inc. | Methods for producing a complex transgenic trait locus |
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| MX2017002930A (es) | 2014-09-12 | 2017-06-06 | Du Pont | Generacion de sitios de integracion especifica de sitio para loci de rasgos complejos en maiz y soja, y metodos de uso. |
| CA2969619A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| JP2018503392A (ja) | 2015-01-27 | 2018-02-08 | 中国科学院遺▲伝▼与▲発▼育生物学研究所Ｉｎｓｔｉｔｕｔｅ ｏｆ Ｇｅｎｅｔｉｃｓ ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔａｌ Ｂｉｏｌｏｇｙ， Ｃｈｉｎｅｓｅ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ | 遺伝子一過性発現により完全な植物において部位特異的改変を行うための方法 |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| EP3095870A1 (en) | 2015-05-19 | 2016-11-23 | Kws Saat Se | Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom |
| AU2016309392A1 (en) * | 2015-08-14 | 2018-02-22 | Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences | Method for obtaining glyphosate-resistant rice by site-directed nucleotide substitution |
| WO2017040967A1 (en) * | 2015-09-04 | 2017-03-09 | Octavo Systems Llc | Improved system using system in package components |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| WO2017083766A1 (en) * | 2015-11-13 | 2017-05-18 | Massachusetts Institute Of Technology | High-throughput crispr-based library screening |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| CN106591293A (zh) * | 2016-12-28 | 2017-04-26 | 贵州省草业研究所 | 基于酶切连接从未知基因组中分离已知序列侧翼序列的方法 |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| CN107545153B (zh) * | 2017-10-25 | 2021-06-11 | 桂林电子科技大学 | 一种基于卷积神经网络的核小体分类预测方法 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| SG11202103917VA (en) | 2018-10-16 | 2021-05-28 | Blueallele Llc | Methods for targeted insertion of dna in genes |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CN114317588B (zh) * | 2020-09-29 | 2023-06-27 | 中国农业科学院生物技术研究所 | 一种作物高温响应型基因组精准甲基化调控回路 |
| JP2024534945A (ja) | 2021-09-10 | 2024-09-26 | アジレント・テクノロジーズ・インク | 化学修飾を有するプライム編集のためのガイドｒｎａ |
| WO2023049728A1 (en) * | 2021-09-21 | 2023-03-30 | Pairwise Plants Services, Inc. | Color-based and/or visual methods for identifying the presence of a transgene and compositions and constructs relating to the same |
| CN114369677A (zh) * | 2022-01-04 | 2022-04-19 | 江汉大学 | 一种检测小麦转基因成分和转基因品系的引物组合、试剂盒、检测方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1354035B1 (en) * | 2001-01-26 | 2016-08-24 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for producing efficient silencing construct using recombinational cloning |
| WO2003080809A2 (en) | 2002-03-21 | 2003-10-02 | Sangamo Biosciences, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| BRPI0716427A2 (pt) * | 2006-08-11 | 2014-03-11 | Dow Agrosciences Llc | Recombinação homóloga mediada por nuclease de apêndice de zinco |
| BRPI0812233B1 (pt) | 2007-06-05 | 2022-10-04 | Bayer Cropscience Ag | Processos para troca de uma sequência de dna-alvo no genoma de uma célula de planta ou planta por uma sequência de dna de interesse, e vetor de dna |
| AU2009267007B2 (en) * | 2008-07-01 | 2016-02-25 | Monsanto Technology, Llc | Recombinant DNA constructs and methods for modulating expression of a target gene |
| CN102333868B (zh) | 2008-12-17 | 2015-01-07 | 陶氏益农公司 | 靶向整合入Zp15 基因座 |
| WO2010106163A1 (en) * | 2009-03-20 | 2010-09-23 | Basf Plant Science Company Gmbh | Nematode-resistant transgenic plants |
| PT2525650T (pt) * | 2010-01-22 | 2017-06-27 | Dow Agrosciences Llc | Zonas de entrada geneticamente manipuladas para o direcionamento de genes em plantas |
| PH12012501467B1 (en) | 2010-01-22 | 2018-07-04 | Corteva Agriscience Llc | Excision of transgenes in genetically modified organisms |
| US9593317B2 (en) | 2010-06-09 | 2017-03-14 | Bayer Cropscience Nv | Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering |
| EP2729567B1 (en) * | 2011-07-08 | 2016-10-05 | Cellectis | Method for increasing the efficiency of double-strand break-induced mutagenssis |
| US9765404B2 (en) * | 2013-09-04 | 2017-09-19 | Dow Agrosciences Llc | Rapid assay for identifying transformants having targeted donor insertion |
-
2014
- 2014-11-03 JP JP2016526812A patent/JP6560203B2/ja not_active Expired - Fee Related
- 2014-11-03 RU RU2016122038A patent/RU2687369C2/ru active
- 2014-11-03 EP EP14858498.0A patent/EP3066192B1/en not_active Not-in-force
- 2014-11-03 CA CA2926534A patent/CA2926534A1/en not_active Abandoned
- 2014-11-03 KR KR1020167014602A patent/KR102248730B1/ko not_active Expired - Fee Related
- 2014-11-03 US US14/531,710 patent/US10077449B2/en not_active Expired - Fee Related
- 2014-11-03 TW TW103138081A patent/TWI669395B/zh not_active IP Right Cessation
- 2014-11-03 AU AU2014341928A patent/AU2014341928B2/en not_active Ceased
- 2014-11-03 CN CN201480060417.5A patent/CN105683357B/zh not_active Expired - Fee Related
- 2014-11-03 AR ARP140104120A patent/AR098283A1/es unknown
- 2014-11-03 WO PCT/US2014/063732 patent/WO2015066637A1/en not_active Ceased
- 2014-11-03 BR BR102014027448A patent/BR102014027448A8/pt not_active Application Discontinuation
-
2016
- 2016-03-18 ZA ZA2016/01929A patent/ZA201601929B/en unknown
- 2016-04-25 IL IL245313A patent/IL245313B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN105683357A (zh) | 2016-06-15 |
| KR102248730B1 (ko) | 2021-05-07 |
| AU2014341928B2 (en) | 2017-11-30 |
| TWI669395B (zh) | 2019-08-21 |
| EP3066192A4 (en) | 2017-07-19 |
| JP2016534727A (ja) | 2016-11-10 |
| CA2926534A1 (en) | 2015-05-07 |
| BR102014027448A8 (pt) | 2021-08-24 |
| WO2015066637A1 (en) | 2015-05-07 |
| IL245313B (en) | 2019-05-30 |
| CN105683357B (zh) | 2020-10-30 |
| ZA201601929B (en) | 2019-06-26 |
| IL245313A0 (en) | 2016-06-30 |
| JP6560203B2 (ja) | 2019-08-14 |
| KR20160079090A (ko) | 2016-07-05 |
| US10077449B2 (en) | 2018-09-18 |
| TW201522630A (zh) | 2015-06-16 |
| BR102014027448A2 (pt) | 2015-09-15 |
| RU2016122038A (ru) | 2017-12-11 |
| EP3066192A1 (en) | 2016-09-14 |
| RU2016122038A3 (https=) | 2018-06-21 |
| RU2687369C2 (ru) | 2019-05-13 |
| EP3066192B1 (en) | 2019-05-01 |
| AU2014341928A1 (en) | 2016-04-07 |
| US20150143588A1 (en) | 2015-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |