AR095562A1 - Cristales de laquinimod sódico y proceso mejorado para su fabricación - Google Patents
Cristales de laquinimod sódico y proceso mejorado para su fabricaciónInfo
- Publication number
- AR095562A1 AR095562A1 ARP140101184A ARP140101184A AR095562A1 AR 095562 A1 AR095562 A1 AR 095562A1 AR P140101184 A ARP140101184 A AR P140101184A AR P140101184 A ARP140101184 A AR P140101184A AR 095562 A1 AR095562 A1 AR 095562A1
- Authority
- AR
- Argentina
- Prior art keywords
- laquinimod
- amount
- methyl
- chloro
- hydroxy
- Prior art date
Links
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 title abstract 17
- 229960004577 laquinimod Drugs 0.000 title abstract 17
- 238000000034 method Methods 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title abstract 3
- 229910052708 sodium Inorganic materials 0.000 title abstract 3
- 239000011734 sodium Substances 0.000 title abstract 3
- 239000013078 crystal Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 abstract 7
- OJGMBLNIHDZDGS-UHFFFAOYSA-N N-Ethylaniline Chemical compound CCNC1=CC=CC=C1 OJGMBLNIHDZDGS-UHFFFAOYSA-N 0.000 abstract 6
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 3
- 238000005259 measurement Methods 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- FTBWKSJUFWRKGL-UHFFFAOYSA-N 5-chloro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylic acid Chemical compound C1=CC(Cl)=C2C(O)=C(C(O)=O)C(=O)N(C)C2=C1 FTBWKSJUFWRKGL-UHFFFAOYSA-N 0.000 abstract 2
- ZFPGGAUWFSIDEL-UHFFFAOYSA-N 5-chloro-4-hydroxy-1-methylquinolin-2-one Chemical compound C1=CC(Cl)=C2C(O)=CC(=O)N(C)C2=C1 ZFPGGAUWFSIDEL-UHFFFAOYSA-N 0.000 abstract 2
- 229910001385 heavy metal Inorganic materials 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- PAIDZDPOJWEZLX-UHFFFAOYSA-N methyl 5-chloro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylate Chemical compound C1=CC=C2N(C)C(=O)C(C(=O)OC)=C(O)C2=C1Cl PAIDZDPOJWEZLX-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZIPTZCNNYJFVOF-UHFFFAOYSA-N 2-chloro-6-[[3-(n-ethylanilino)-2-hydroxy-3-oxopropanoyl]-methylamino]benzoic acid Chemical compound C=1C=CC=CC=1N(CC)C(=O)C(O)C(=O)N(C)C1=CC=CC(Cl)=C1C(O)=O ZIPTZCNNYJFVOF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- POQZLXDTXDVHMY-UHFFFAOYSA-N ethyl 5-chloro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylate Chemical compound C1=CC=C2N(C)C(=O)C(C(=O)OCC)=C(O)C2=C1Cl POQZLXDTXDVHMY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785575P | 2013-03-14 | 2013-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR095562A1 true AR095562A1 (es) | 2015-10-28 |
Family
ID=50631081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101184A AR095562A1 (es) | 2013-03-14 | 2014-03-17 | Cristales de laquinimod sódico y proceso mejorado para su fabricación |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9233927B2 (OSRAM) |
| EP (1) | EP2970129A2 (OSRAM) |
| JP (1) | JP2016514162A (OSRAM) |
| KR (1) | KR20150143499A (OSRAM) |
| CN (1) | CN105051013A (OSRAM) |
| AR (1) | AR095562A1 (OSRAM) |
| AU (1) | AU2014236232A1 (OSRAM) |
| BR (1) | BR112015021602A2 (OSRAM) |
| CA (1) | CA2901849A1 (OSRAM) |
| CL (1) | CL2015002712A1 (OSRAM) |
| EA (1) | EA201591699A1 (OSRAM) |
| HK (2) | HK1216311A1 (OSRAM) |
| IL (1) | IL240356A0 (OSRAM) |
| MX (1) | MX2015011627A (OSRAM) |
| NZ (1) | NZ630427A (OSRAM) |
| PE (1) | PE20151935A1 (OSRAM) |
| SG (1) | SG11201506409RA (OSRAM) |
| TW (1) | TW201519892A (OSRAM) |
| WO (1) | WO2014153145A2 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2542080B1 (en) * | 2010-03-03 | 2016-08-31 | Teva Pharmaceutical Industries Ltd. | Treatment of lupus arthritis using laquinimod |
| AR089862A1 (es) | 2012-02-03 | 2014-09-24 | Teva Pharma | USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| CA2901849A1 (en) * | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| SG11201608674UA (en) | 2014-04-29 | 2016-11-29 | Teva Pharma | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status |
| CN107966506B (zh) * | 2017-11-20 | 2019-09-13 | 福州大学 | 一种橡胶及橡胶制品中n-乙基苯胺含量的检测方法 |
| KR102069868B1 (ko) * | 2018-02-28 | 2020-01-23 | 고려대학교 산학협력단 | 합성가스 발효 균의 합성가스 발효 시의 대사체 분석을 위한 대사체 샘플링 및 분석 방법 |
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| CA2791709A1 (en) | 2010-03-03 | 2011-09-09 | Teva Pharmaceutical Industries Ltd. | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
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| SG10201606204TA (en) | 2011-07-28 | 2016-09-29 | Teva Pharma | Treatment Of Multiple Sclerosis With Combination Of Laquinimod And Interferon-Beta |
| MX2014001050A (es) | 2011-07-28 | 2014-04-14 | Teva Pharma | Tratamiento de esclerosis multiple con combinacion de laquinimod y acetato de glatiramero. |
| HK1199820A1 (en) | 2011-10-12 | 2015-07-24 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| AR089862A1 (es) | 2012-02-03 | 2014-09-24 | Teva Pharma | USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA |
| EP2744498A4 (en) | 2012-02-16 | 2014-12-03 | Teva Pharma | N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-CHINOLINE CARBOXAMIDE AND THE PREPARATION AND USE THEREOF |
| US20130259856A1 (en) | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| TW201347762A (zh) | 2012-05-02 | 2013-12-01 | Teva Pharma | 高劑量拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）於治療多發性硬化症之用途 |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
| WO2014004733A1 (en) | 2012-06-26 | 2014-01-03 | The Regents Of The University Of California | Composition for lupus nephritis and methods of making and using the same |
| AR091706A1 (es) | 2012-07-11 | 2015-02-25 | Teva Pharma | Formulaciones de laquinimod sin agentes alcalinizantes |
| UY34896A (es) | 2012-07-12 | 2014-02-28 | Teva Pharma | Tratamiento de la esclerosis múltiple con una combinación de laquinimod y fampridina |
| TW201410243A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療大麻素受體型１（ｃｂ１）媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| CA2901849A1 (en) * | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
-
2014
- 2014-03-14 CA CA2901849A patent/CA2901849A1/en not_active Abandoned
- 2014-03-14 US US14/214,191 patent/US9233927B2/en not_active Expired - Fee Related
- 2014-03-14 AU AU2014236232A patent/AU2014236232A1/en not_active Abandoned
- 2014-03-14 PE PE2015001974A patent/PE20151935A1/es not_active Application Discontinuation
- 2014-03-14 NZ NZ630427A patent/NZ630427A/en not_active IP Right Cessation
- 2014-03-14 MX MX2015011627A patent/MX2015011627A/es unknown
- 2014-03-14 BR BR112015021602A patent/BR112015021602A2/pt not_active IP Right Cessation
- 2014-03-14 TW TW103109454A patent/TW201519892A/zh unknown
- 2014-03-14 US US14/773,683 patent/US20160046582A1/en not_active Abandoned
- 2014-03-14 WO PCT/US2014/029292 patent/WO2014153145A2/en not_active Ceased
- 2014-03-14 HK HK16104113.6A patent/HK1216311A1/zh unknown
- 2014-03-14 EP EP14721137.9A patent/EP2970129A2/en not_active Withdrawn
- 2014-03-14 HK HK16107245.0A patent/HK1220444A1/zh unknown
- 2014-03-14 KR KR1020157029570A patent/KR20150143499A/ko not_active Withdrawn
- 2014-03-14 SG SG11201506409RA patent/SG11201506409RA/en unknown
- 2014-03-14 CN CN201480014512.1A patent/CN105051013A/zh active Pending
- 2014-03-14 JP JP2016503050A patent/JP2016514162A/ja not_active Withdrawn
- 2014-03-14 EA EA201591699A patent/EA201591699A1/ru unknown
- 2014-03-17 AR ARP140101184A patent/AR095562A1/es unknown
-
2015
- 2015-08-04 IL IL240356A patent/IL240356A0/en unknown
- 2015-09-14 CL CL2015002712A patent/CL2015002712A1/es unknown
- 2015-12-03 US US14/958,396 patent/US20160158216A1/en not_active Abandoned
-
2017
- 2017-08-01 US US15/666,259 patent/US20170327464A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20160046582A1 (en) | 2016-02-18 |
| WO2014153145A2 (en) | 2014-09-25 |
| EA201591699A1 (ru) | 2016-02-29 |
| KR20150143499A (ko) | 2015-12-23 |
| NZ630427A (en) | 2017-06-30 |
| EP2970129A2 (en) | 2016-01-20 |
| CN105051013A (zh) | 2015-11-11 |
| TW201519892A (zh) | 2015-06-01 |
| US20140271878A1 (en) | 2014-09-18 |
| JP2016514162A (ja) | 2016-05-19 |
| CL2015002712A1 (es) | 2016-04-15 |
| CA2901849A1 (en) | 2014-09-25 |
| BR112015021602A2 (pt) | 2017-07-18 |
| MX2015011627A (es) | 2016-05-16 |
| HK1216311A1 (zh) | 2016-11-04 |
| WO2014153145A3 (en) | 2015-04-23 |
| HK1220444A1 (zh) | 2017-05-05 |
| US9233927B2 (en) | 2016-01-12 |
| AU2014236232A1 (en) | 2015-11-05 |
| PE20151935A1 (es) | 2016-01-15 |
| IL240356A0 (en) | 2015-09-24 |
| US20160158216A1 (en) | 2016-06-09 |
| SG11201506409RA (en) | 2015-09-29 |
| US20170327464A1 (en) | 2017-11-16 |
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