SG11201506409RA - Crystals of laquinimod sodium and improved process for the manufacture thereof - Google Patents
Crystals of laquinimod sodium and improved process for the manufacture thereofInfo
- Publication number
- SG11201506409RA SG11201506409RA SG11201506409RA SG11201506409RA SG11201506409RA SG 11201506409R A SG11201506409R A SG 11201506409RA SG 11201506409R A SG11201506409R A SG 11201506409RA SG 11201506409R A SG11201506409R A SG 11201506409RA SG 11201506409R A SG11201506409R A SG 11201506409RA
- Authority
- SG
- Singapore
- Prior art keywords
- crystals
- manufacture
- improved process
- laquinimod sodium
- laquinimod
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361785575P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/029292 WO2014153145A2 (en) | 2013-03-14 | 2014-03-14 | Crystals of laquinimod sodium and improved process for the manufacture thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201506409RA true SG11201506409RA (en) | 2015-09-29 |
Family
ID=50631081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201506409RA SG11201506409RA (en) | 2013-03-14 | 2014-03-14 | Crystals of laquinimod sodium and improved process for the manufacture thereof |
Country Status (19)
Country | Link |
---|---|
US (4) | US9233927B2 (en) |
EP (1) | EP2970129A2 (en) |
JP (1) | JP2016514162A (en) |
KR (1) | KR20150143499A (en) |
CN (1) | CN105051013A (en) |
AR (1) | AR095562A1 (en) |
AU (1) | AU2014236232A1 (en) |
BR (1) | BR112015021602A2 (en) |
CA (1) | CA2901849A1 (en) |
CL (1) | CL2015002712A1 (en) |
EA (1) | EA201591699A1 (en) |
HK (2) | HK1216311A1 (en) |
IL (1) | IL240356A0 (en) |
MX (1) | MX2015011627A (en) |
NZ (1) | NZ630427A (en) |
PE (1) | PE20151935A1 (en) |
SG (1) | SG11201506409RA (en) |
TW (1) | TW201519892A (en) |
WO (1) | WO2014153145A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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SG183515A1 (en) * | 2010-03-03 | 2012-10-30 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
EA201491460A1 (en) | 2012-02-03 | 2015-01-30 | Тева Фармасьютикал Индастриз Лтд. | APPLICATION OF LACHINIMODA IN THE TREATMENT OF PATIENTS WITH CRONE'S DISEASE, WHICH ARE NOT EFFECTIVE THERAPY OF THE FIRST LINE ANTI-TNFα |
TW201410244A (en) | 2012-08-13 | 2014-03-16 | Teva Pharma | Laquinimod for treatment of GABA mediated disorders |
US9233927B2 (en) * | 2013-03-14 | 2016-01-12 | Teva Pharmaceutical Industries, Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
WO2015168103A1 (en) | 2014-04-29 | 2015-11-05 | Teva Pharmaceutical Industries Ltd. | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status |
CN107966506B (en) * | 2017-11-20 | 2019-09-13 | 福州大学 | The detection method of N-ethylaniline content in a kind of Rubber & Rubber Products |
KR102069868B1 (en) * | 2018-02-28 | 2020-01-23 | 고려대학교 산학협력단 | Metabolome sampling and analytical method specific for metabolite analysis of synthetic gas fermenting microorganisms during synthesis gas fermentation |
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HUE029983T2 (en) | 2009-08-10 | 2017-04-28 | Teva Pharma | Treatment of bdnf-related disorders using laquinimod |
SG183515A1 (en) | 2010-03-03 | 2012-10-30 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
SG183512A1 (en) | 2010-03-03 | 2012-09-27 | Teva Pharma | Treatment of lupus nephritis using laquinimod |
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US20130259856A1 (en) | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
TW201804997A (en) | 2012-05-02 | 2018-02-16 | 以色列商泰瓦藥品工業有限公司 | Use of high dose LAQUINIMOD for treating multiple sclerosis |
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WO2014004733A1 (en) | 2012-06-26 | 2014-01-03 | The Regents Of The University Of California | Composition for lupus nephritis and methods of making and using the same |
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UY34896A (en) | 2012-07-12 | 2014-02-28 | Teva Pharma | TREATMENT OF MULTIPLE SCLEROSIS WITH A COMBINATION OF LAQUINIMOD AND FAMPRIDINE |
TW201410244A (en) | 2012-08-13 | 2014-03-16 | Teva Pharma | Laquinimod for treatment of GABA mediated disorders |
TW201410243A (en) | 2012-08-13 | 2014-03-16 | Teva Pharma | Laquinimod for treatment of cannabinoid receptor type 1 (CB1) mediated disorders |
US9233927B2 (en) * | 2013-03-14 | 2016-01-12 | Teva Pharmaceutical Industries, Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
-
2014
- 2014-03-14 US US14/214,191 patent/US9233927B2/en not_active Expired - Fee Related
- 2014-03-14 MX MX2015011627A patent/MX2015011627A/en unknown
- 2014-03-14 EP EP14721137.9A patent/EP2970129A2/en not_active Withdrawn
- 2014-03-14 JP JP2016503050A patent/JP2016514162A/en not_active Withdrawn
- 2014-03-14 AU AU2014236232A patent/AU2014236232A1/en not_active Abandoned
- 2014-03-14 BR BR112015021602A patent/BR112015021602A2/en not_active IP Right Cessation
- 2014-03-14 CN CN201480014512.1A patent/CN105051013A/en active Pending
- 2014-03-14 SG SG11201506409RA patent/SG11201506409RA/en unknown
- 2014-03-14 WO PCT/US2014/029292 patent/WO2014153145A2/en active Application Filing
- 2014-03-14 US US14/773,683 patent/US20160046582A1/en not_active Abandoned
- 2014-03-14 EA EA201591699A patent/EA201591699A1/en unknown
- 2014-03-14 KR KR1020157029570A patent/KR20150143499A/en not_active Application Discontinuation
- 2014-03-14 CA CA2901849A patent/CA2901849A1/en not_active Abandoned
- 2014-03-14 TW TW103109454A patent/TW201519892A/en unknown
- 2014-03-14 PE PE2015001974A patent/PE20151935A1/en not_active Application Discontinuation
- 2014-03-14 NZ NZ630427A patent/NZ630427A/en not_active IP Right Cessation
- 2014-03-17 AR ARP140101184A patent/AR095562A1/en unknown
-
2015
- 2015-08-04 IL IL240356A patent/IL240356A0/en unknown
- 2015-09-14 CL CL2015002712A patent/CL2015002712A1/en unknown
- 2015-12-03 US US14/958,396 patent/US20160158216A1/en not_active Abandoned
-
2016
- 2016-04-11 HK HK16104113.6A patent/HK1216311A1/en unknown
- 2016-06-22 HK HK16107245.0A patent/HK1220444A1/en unknown
-
2017
- 2017-08-01 US US15/666,259 patent/US20170327464A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2014236232A1 (en) | 2015-11-05 |
HK1216311A1 (en) | 2016-11-04 |
CN105051013A (en) | 2015-11-11 |
IL240356A0 (en) | 2015-09-24 |
HK1220444A1 (en) | 2017-05-05 |
PE20151935A1 (en) | 2016-01-15 |
JP2016514162A (en) | 2016-05-19 |
WO2014153145A3 (en) | 2015-04-23 |
AR095562A1 (en) | 2015-10-28 |
KR20150143499A (en) | 2015-12-23 |
TW201519892A (en) | 2015-06-01 |
EP2970129A2 (en) | 2016-01-20 |
US20170327464A1 (en) | 2017-11-16 |
CL2015002712A1 (en) | 2016-04-15 |
US20140271878A1 (en) | 2014-09-18 |
US20160158216A1 (en) | 2016-06-09 |
NZ630427A (en) | 2017-06-30 |
EA201591699A1 (en) | 2016-02-29 |
US20160046582A1 (en) | 2016-02-18 |
WO2014153145A2 (en) | 2014-09-25 |
MX2015011627A (en) | 2016-05-16 |
CA2901849A1 (en) | 2014-09-25 |
US9233927B2 (en) | 2016-01-12 |
BR112015021602A2 (en) | 2017-07-18 |
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