AR094654A1 - Modulador del receptor de andrógeno y sus usos, método para tratamiento, composición farmacéutica - Google Patents

Modulador del receptor de andrógeno y sus usos, método para tratamiento, composición farmacéutica

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Publication number
AR094654A1
AR094654A1 ARP140100116A ARP140100116A AR094654A1 AR 094654 A1 AR094654 A1 AR 094654A1 AR P140100116 A ARP140100116 A AR P140100116A AR P140100116 A ARP140100116 A AR P140100116A AR 094654 A1 AR094654 A1 AR 094654A1
Authority
AR
Argentina
Prior art keywords
prostate cancer
per day
dose
castration
treatment
Prior art date
Application number
ARP140100116A
Other languages
English (en)
Original Assignee
Aragon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50029265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR094654(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aragon Pharmaceuticals Inc filed Critical Aragon Pharmaceuticals Inc
Publication of AR094654A1 publication Critical patent/AR094654A1/es

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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

En la presente descripción se describe un modulador de receptores de andrógeno en el tratamiento de cáncer de próstata en combinación con otras opciones terapéuticas y en el tratamiento de enfermedades o condiciones que son tratables con el tratamiento con el modulador de receptor de andrógeno, así como composiciones farmacéuticas y fármacos que incluyen este compuesto. Reivindicación 1: Un método para tratar un paciente humano masculino que padece cáncer de próstata avanzado sensible a la castración, cáncer de próstata resistente a la castración, o cáncer de próstata localizado de alto riesgo; el método comprende administrar el compuesto de la fórmula (1), o una sal farmacéuticamente aceptable de este, en una dosis en un intervalo de aproximadamente 30 mg por día a aproximadamente 480 mg por día a un paciente humano masculino que necesita el tratamiento. Reivindicación 3: Un método para tratar el cáncer de próstata resistente a la castración posterior al tratamiento con acetato de abiraterona, cáncer de próstata metastásico resistente a la castración, cáncer de próstata no metastásico resistente a la castración, cáncer de próstata metastásico sensible a la castración, cáncer de próstata no metastásico sensible a la castración o cáncer de próstata localizado de alto riesgo en un paciente humano masculino; el método comprende administrar por vía oral el compuesto de la fórmula (1), o una sal farmacéuticamente aceptable de este: en la forma de una capsula de gel blando a un paciente que necesita el tratamiento, en una dosis de aproximadamente 30 mg por día a aproximadamente 480 mg por día, preferentemente, en una dosis de aproximadamente 240 mg por día en combinación con: (a) un inhibidor de fosfoinositida 3-quinasa (Pl3K), inhibidor de TORC, o inhibidor doble de PI3K/TORC, preferentemente, everolimus, BEZ-235, BKM120, BGT226, BYL-719, GDC0068, GDC-0980, GDC0941, GDC0032, MK-2206, OSI-027, CC-223, AZD8055, SAR245408, SAR245409, PF04691502, WYE125132, GSK2126458, GSK-2636771, BAY806946, PF-05212384, SF1126, PX866, AMG319, ZSTK474, Cal101, PWT33597, LY-317615 (clorhidrato de enzastaurina), CU-906, o CUDC-907, y si el inhibidor de TORC es everolimus, se administra en una dosis de aproximadamente 5 mg por día a aproximadamente 20 mg por día; o (b) un inhibidor de quinasa, preferentemente, en donde el inhibidor de quinasa es: (i) un inhibidor de quinasa MET o VEGFR, con mayor preferencia, Cabozantinib (XL184), PF-2341066 (Crizotinib), ARQ-197 (Tivantinib), MK-2461, JNJ-38877605, MK-8033, INCB-28060, BMS-777607, AMG-208, LY-2801653, EMD-1214063, EMD-1204831, AMG-337, HMPL-504 (Volitinib), SAR-125844, LY2875358, ABR-215050 (Tasquinimod), CHIR-258 (Dovitinib), EXEL-7647, OSI-930, BIBF-1120, BAY-73-4506 (Regorafenib), BMS-582664 (Brivanib), JNJ-26483327, AZD-2171 (Cediranib), Sorafenib, Aflibercept, Enzastaurin, AG-013736 (Axitinib), OSl-632, o GSK-786034 (Pazopanib), y si es Cabozantinib, se administra por vía oral en una dosis de aproximadamente 40 mg por día a aproximadamente 100 mg por día; o (ii) un inhibidor de quinasa EGFR, MEK, o SRC, con mayor preferencia, Erlotinib, Cetuximab, Gefitinib, Canertinib, Panitumumab, Nimotuzumab, Lapatinib, Vandetanib, Afatinib, MP-412, AEE-788, Neratinib, XL-647, AC-480, Dacomitinib, AZD-8931, CUDC-101, AP-26113, CO-1686, Trametinib, Selumetinib, MEK-162, Refametinib, TAK-733, R0-5126766, Bl-847325, AZD6244, GSK1120212, PF-5208763 (Bosutinib), o AZD-0530 (Saracatinib), y si es Erlotinib, se administra por vía oral en una dosis en un intervalo de aproximadamente 100 mg a aproximadamente 150 mg; y si es Gefitinib, se administra por vía oral en una dosis de aproximadamente 250 mg; y si es Trametinib, se administra por vía oral en una dosis de aproximadamente 1 mg a aproximadamente 2 mg; o (iii) un inhibidor de quinasa AKT, RAF, FGFR, o CDK4/6, con mayor preferencia, GDC0068, MK-2206, AT7867, GSK2110183, GSK2141795, GSK690693, Vemurafenib (PLX4032/RG7204), GSK2118436, Dabrafenib (GSK208436), LGX818, RAF265, LY2780301, Dovitinib (TKl258), BGJ398, AZD4547, PD-0332991 o LEE011.
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