AR092792A1 - Derivados de dihidrofurano-azetadina como agentes antiparasitarios - Google Patents

Derivados de dihidrofurano-azetadina como agentes antiparasitarios

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Publication number
AR092792A1
AR092792A1 ARP130100320A ARP130100320A AR092792A1 AR 092792 A1 AR092792 A1 AR 092792A1 AR P130100320 A ARP130100320 A AR P130100320A AR P130100320 A ARP130100320 A AR P130100320A AR 092792 A1 AR092792 A1 AR 092792A1
Authority
AR
Argentina
Prior art keywords
alkyl
cyano
haloalkyl
cycloalkyl
halo
Prior art date
Application number
ARP130100320A
Other languages
English (en)
Inventor
A L Chubb Nathan
Original Assignee
Zoetis Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47679106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR092792(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zoetis Llc filed Critical Zoetis Llc
Publication of AR092792A1 publication Critical patent/AR092792A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en la que A es fenilo, naftilo o heteroarilo, en el que dicho heteroarilo contiene de 1 a 4 heteroátomos cada uno seleccionado independientemente a partir de N, O y S; R¹ᵃ, R¹ᵇ y R¹ᶜ son cada uno independientemente hidrógeno, halo, hidroxilo, ciano, nitro, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, alquil C₀₋₃-cicloalquilo C₃₋₆, haloalcoxi C₁₋₆, -C(O)NH₂, -SF₅ o -S(O)ₚR; R² es halo, ciano, alquilo C₁₋₆, haloalquilo C₁₋₆, nitro, hidroxilo, -C(O)NRᵃRᵇ, alquenilo C₂₋₈, alquinilo C₂₋₆, -S(O)ₚR o -OR; R³ es hidrógeno, halo, hidroxilo, ciano, alquilo C₁₋₆, haloalquilo C₁₋₆, alquil C₀₋₃-cicloalquilo C₃₋₆, -C(O)NH₂, nitro, -SC(O)R, C(O)NRᵃRᵇ, alquil C₀₋₃-NRᵃR⁴, -NRᵃNRᵇR⁴, -NRᵃORᵇ, -ONRᵃRᵇ, N₃, -NHR⁴, -OR o -S(O)ₚR; R⁴ es hidrógeno, alquilo C₁₋₆, alquil C₀₋₆-cicloalquilo C₃₋₆, -C(O)R⁵, -C(S)R⁵, C(O)NRᵃR⁵, C(O)C(O)NRᵃR⁵, -S(O)ₚRᶜ, S(O)₂NRᵃR⁵, -C(NR⁷)R⁵, C(NR⁷)NRᵃR⁵, alquil C₀₋₆-fenilo, alquil C₀₋₆-heteroarilo o alquil C₀₋₆-heterociclo; R⁵ es hidrógeno, alquilo C₁₋₆, alquenilo C₂₋₆, alquil C₀₋₆-cicloalquilo C₃₋₆, alquil C₀₋₆-fenilo, alquil C₀₋₆-heteroarilo o alquil C₀₋₆-heterociclo; R⁶ es ciano, alquilo C₁₋₆, haloalquilo C₁₋₆, C₍O₎NRᵃRᵇ, alquenilo C₂₋₆, alquinilo C₂₋₆, haloalquenilo C₂₋₆ o haloalquinilo C₂₋₆; R⁷ es hidrógeno, alquilo C₁₋₆, hidroxilo, ciano, nitro, S(O)ₚRᶜ o alcoxi C₁₋₆; R es alquilo C₁₋₆ o cicloalquilo C₃₋₆, cada uno opcionalmente sustituido con al menos un halo; Rᵃ es hidrógeno, alquilo C₁₋₆ o alquil C₀₋₃-cicloalquilo C₃₋₆; en el que el alquilo y el alquilcicloalquilo están opcionalmente sustituidos con ciano o al menos un sustituyente halo; Rᵇ es hidrógeno, alquilo C₁₋₆, cicloalquilo C₃₋₆, alquil C₀₋₃-fenilo, alquil C₀₋₃-heteroarilo o alquil C₀₋₃-heterociclo, cada uno opcionalmente sustituido, cuando sea químicamente posible, con al menos un sustituyente seleccionado a partir de hidroxilo, ciano, halo o -S(O)ₚR; Rᶜ es alquilo C₁₋₆, haloalquilo C₁₋₆, haloalquil C₁₋₆-cicloalquilo C₃₋₆, alquil C₀₋₃-cicloalquilo C₃₋₆, alquil C₀₋₃-fenilo, alquil C₀₋₃-heteroarilo o alquil C₀₋₃-heterociclo, cada uno opcionalmente sustituido con al menos un sustituyente seleccionado a partir de ciano, halo, hidroxilo, oxo, alquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, haloalquilo C₁₋₆, -S(O)ₚR, -SH, -S(O)ₚNRᵃRᵇ, -NRᵃRᵇ, -NRᵃC(O)Rᵇ, -SC(O)Rᵇ, -SCN o -C(O)NRᵃRᵇ; cada uno de R⁴ y R⁵ alquilo C₁₋₆ o alquil C₀₋₆-cicloalquilo C₃₋₆ puede estar opcional e independientemente sustituido con al menos un sustituyente seleccionado a partir de alquilo C₁₋₆, ciano, halo, hidroxilo, hidroxialquilo C₁₋₆, oxo, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquilo C₁₋₆, haloalquilo C₁₋₆, -S(O)ₚRᶜ, -SH, -S(O)ₚNRᵃRᵇ, -NRᵃRᵇ, -NRᵃC(O)Rᵇ, -SC(O)Rᶜ, -SCN, o -C(O)NRᵃRᵇ; y en el que R⁴ y R⁵ alquil C₀₋₆-fenilo, alquil C₀₋₆-heteroarilo o resto alquil C₀₋₆-heterociclo puede estar, adicionalmente, opcionalmente sustituido con al menos un sustituyente seleccionado a partir de alquilo C₁₋₆, ciano, halo, oxo, =S, =NR⁷, hidroxilo, hidroxialquilo C₁₋₆, alcoxi C₁₋₆, alquilo C₁₋₆, haloalquilo C₁₋₆, -SH, -S(O)ₚR y haloalcoxi C₁₋₆; n es el número entero 0, 1 ó 2, y cuando n sea 2, cada uno de R² puede ser idéntico al otro o diferente al otro, y p es el número entero 0, 1 ó 2; estereoisómeros de los mismos y sales farmacéutica o veterinariamente aceptables del mismo.
ARP130100320A 2012-02-03 2013-02-01 Derivados de dihidrofurano-azetadina como agentes antiparasitarios AR092792A1 (es)

Applications Claiming Priority (1)

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US201261594569P 2012-02-03 2012-02-03

Publications (1)

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AR092792A1 true AR092792A1 (es) 2015-05-06

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ID=47679106

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US (1) US9133172B2 (es)
EP (1) EP2814825B1 (es)
JP (1) JP5997779B2 (es)
CN (1) CN104169273B (es)
AR (1) AR092792A1 (es)
AU (1) AU2013215368A1 (es)
BR (1) BR112014018650A8 (es)
CA (1) CA2863625C (es)
CL (1) CL2014002033A1 (es)
ES (1) ES2571444T3 (es)
MX (1) MX336430B (es)
PL (1) PL2814825T3 (es)
RU (1) RU2014131951A (es)
WO (1) WO2013116230A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2872989A1 (en) * 2012-05-09 2013-11-14 Zoetis Llc Azetidine derivatives as antiparasitic agents
CA2881844A1 (en) * 2012-09-07 2014-03-13 Zoetis Llc Spirocyclic derivatives as antiparasitic agents
BR112017015137A2 (pt) * 2015-01-16 2018-01-30 Avista Pharma Solutions, Inc. compostos antiparasíticos

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
EP1654249A1 (en) * 2003-08-07 2006-05-10 Pharmacia & Upjohn Company LLC Anthelmintic and insecticide pyrimidine derivatives
GB0329314D0 (en) 2003-12-18 2004-01-21 Pfizer Ltd Substituted arylpyrazoles
TW200538433A (en) * 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
ZA200804080B (en) * 2005-12-16 2009-10-28 Du Pont 5-Aryl isoxazolines for controlling invertebrate pests
EP1997813B1 (en) 2006-03-10 2010-05-05 Nissan Chemical Industries, Ltd. Substituted isoxazoline compound and pest control agent
RU2009141185A (ru) * 2007-04-10 2011-05-20 Байер КропСайенс АГ (DE) Инсектицидные производные арилизоксазолина
CN101801940B (zh) 2007-09-10 2013-04-10 日产化学工业株式会社 取代异*唑啉化合物和有害生物防除剂
WO2010020522A1 (en) * 2008-08-22 2010-02-25 Syngenta Participations Ag Insecticidal compounds
MX2012009706A (es) * 2010-02-22 2012-09-12 Syngenta Participations Ag Derivados de dihidrofurano como compuestos insecticidas.
CN103270036B (zh) 2010-08-05 2015-11-25 佐蒂斯有限责任公司 作为抗寄生物剂的异噁唑啉衍生物

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EP2814825A1 (en) 2014-12-24
EP2814825B1 (en) 2016-03-23
BR112014018650A2 (es) 2017-06-20
CA2863625A1 (en) 2013-08-08
JP2015511233A (ja) 2015-04-16
MX2014009387A (es) 2014-08-27
CL2014002033A1 (es) 2014-10-03
RU2014131951A (ru) 2016-03-27
US9133172B2 (en) 2015-09-15
CN104169273A (zh) 2014-11-26
JP5997779B2 (ja) 2016-09-28
MX336430B (es) 2016-01-18
US20150038440A1 (en) 2015-02-05
WO2013116230A1 (en) 2013-08-08
PL2814825T3 (pl) 2016-08-31
AU2013215368A1 (en) 2014-08-21
CA2863625C (en) 2016-04-26
CN104169273B (zh) 2016-11-02
ES2571444T3 (es) 2016-05-25
BR112014018650A8 (pt) 2017-07-11

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