AR088810A1 - Moduladores del receptor mas acoplado a la proteina g utiles en el tratamiento de trastornos cardiovasculares y composiciones farmaceuticas que los contienen - Google Patents

Moduladores del receptor mas acoplado a la proteina g utiles en el tratamiento de trastornos cardiovasculares y composiciones farmaceuticas que los contienen

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Publication number
AR088810A1
AR088810A1 ARP120104218A ARP120104218A AR088810A1 AR 088810 A1 AR088810 A1 AR 088810A1 AR P120104218 A ARP120104218 A AR P120104218A AR P120104218 A ARP120104218 A AR P120104218A AR 088810 A1 AR088810 A1 AR 088810A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
heterocyclyl
cycloalkyl
substituents
Prior art date
Application number
ARP120104218A
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English (en)
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of AR088810A1 publication Critical patent/AR088810A1/es

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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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Abstract

Que son útiles para tratar y aliviar enfermedades y trastornos del corazón, cerebro, riñón, sistema inmune y reproductivo que resultan de isquemia o reperfusión posterior a isquemia y cualquier complicación o complicaciones posteriores relacionadas con los mismos. Reivindicación 1: Un compuesto que se selecciona de compuestos de fórmula (1) y sales, solvatos e hidratos farmacéuticamente aceptables de los mismos, en donde: X es CH₂ o CH₂CH₂; o X está ausente; R⁴, R⁵, R⁶ y R⁷ se selecciona cada uno independientemente de: H y halógeno; y (A) R¹ se selecciona de: H, alquilo C₁₋₆, alquil C₁₋₆-O-alquilo C₁₋₆, cicloalquilo C₃₋₇, cicloalquil C₄₋₁₃alquilo, heteroarilo, heteroarilalquilo C₁₋₆, heterociclilo y heterociclil-alquilo C₁₋₆, cada uno opcionalmente sustituido por uno o más sustituyentes que se seleccionan de: alcoxi C₁₋₆carbonilamino, amino-alcoxi C₁₋₆, alcoxi C₁₋₆carbonilo, alquilo C₁₋₆, alquil C₁₋₆carboxamida, alquil C₁₋₆sulfinilo, amino, carboxamida, carboxilo, ciano, dialquil C₂₋₆amino, hidroxilo, hidroxi-alquilo C₁₋₆, imino, oxo, fenilo y fosfonooxi; R² se selecciona de: H y alquilo C₁₋₆, en donde dicho alquilo C₁₋₆ está opcionalmente sustituido por uno o más sustituyentes que se seleccionan de: hidroxilo y ciano; y R³ se selecciona de: H y halógeno; o (B) R¹ y R² junto con el átomo de nitrógeno al que ambos están unidos forman un grupo que se selecciona de: heteroarilo y heterociclilo, cada uno opcionalmente sustituido por uno o más sustituyentes que se seleccionan de: alcoxi C₁₋₆carbonilo, alcoxi C₁₋₆carbonilamino, alquilo C₁₋₆, alquil C₁₋₆carboxamida, alquil C₁₋₆sulfonilo, amino, cicloalquilo C₃₋₇, cicloalquil C₄₋₁₃alquilo, carboxamida, carboxilo, dialquil C₂₋₆amino, dialquil C₂₋₆carboxamida, heteroarilalquilo C₁₋₆, heterociclilo, heterociclil-alquilo C₁₋₆, hidroxilo, hidroxiheterociclilo y oxo, en donde dicho alquilo C₁₋₆ y alquil C₁₋₆carboxamida se sustituye cada uno opcionalmente por uno o más sustituyentes que se seleccionan de: carboxilo, hidroxilo y oxo; y R³ se selecciona de: H y halógeno; o (C) R¹ se selecciona de: H, alquilo C₁₋₆, alquil C₁₋₆-O-alquilo C₁₋₆, cicloalquilo C₃₋₇, cicloalquil C₄₋₁₃alquilo, heteroarilo, heteroarilalquilo C₁₋₆, heterociclilo y heterociclil-alquilo C₁₋₆, cada uno opcionalmente sustituido por uno o más sustituyentes que se seleccionan de: alcoxi C₁₋₆carbonilamino, amino-alcoxi C₁₋₆, alcoxi C₁₋₆carbonilo, alquilo C₁₋₆, alquil C₁₋₆carboxamida, alquil C₁₋₆sulfinilo, amino, carboxamida, carboxilo, ciano, dialquil C₂₋₆amino, hidroxilo, hidroxi-alquilo C₁₋₆, imino, oxo, fenilo y fosfonooxi; y R² y R³ juntos forman CH₂.
ARP120104218A 2011-11-08 2012-11-08 Moduladores del receptor mas acoplado a la proteina g utiles en el tratamiento de trastornos cardiovasculares y composiciones farmaceuticas que los contienen AR088810A1 (es)

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