CO6970607A2 - Moduladores del receptor mas acoplado a la proteína g y el tratamiento de trastornos relacionados con el mismo - Google Patents

Moduladores del receptor mas acoplado a la proteína g y el tratamiento de trastornos relacionados con el mismo

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Publication number
CO6970607A2
CO6970607A2 CO14122871A CO14122871A CO6970607A2 CO 6970607 A2 CO6970607 A2 CO 6970607A2 CO 14122871 A CO14122871 A CO 14122871A CO 14122871 A CO14122871 A CO 14122871A CO 6970607 A2 CO6970607 A2 CO 6970607A2
Authority
CO
Colombia
Prior art keywords
complications
modulators
receptor
protein
coupled
Prior art date
Application number
CO14122871A
Other languages
English (en)
Inventor
Thuy-Anh Tran
Anthony C Blackburn
Bryan A Kramer
Maiko Nagura
Carleton R Sage
Young-Jun Shin
Ning Zou
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of CO6970607A2 publication Critical patent/CO6970607A2/es

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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

La presente invención se refiere a compuestos de Fórmula (I) y sales, solvatos e hidratos farmacéuticamente aceptables de los mismos: (I) que son útiles en métodos para tratar y aliviar enfermedades y trastornos del corazón, cerebro, riñón, sistema inmune y reproductivo que resultan de isquemia o reperfusión posterior a isquemia y cualquier complicación o complicaciones posteriores relacionadas con los mismos. La presente invención se refiere, además, a métodos para tratar y aliviar enfermedades y trastornos de la vasculatura que resultan de vasoconstricción o hipertensión y cualquier complicación o complicaciones posteriores que resultan de presión arterial elevada y/o perfusión tisular reducida.
CO14122871A 2011-11-08 2014-06-06 Moduladores del receptor mas acoplado a la proteína g y el tratamiento de trastornos relacionados con el mismo CO6970607A2 (es)

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WO2014182688A1 (en) * 2013-05-07 2014-11-13 Arena Pharmaceuticals, Inc. Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
WO2014182673A1 (en) * 2013-05-07 2014-11-13 Arena Pharmaceuticals, Inc. Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
WO2015097713A1 (en) 2013-11-14 2015-07-02 Cadila Healthcare Limited Novel heterocyclic compounds
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists
CN107709314A (zh) 2015-06-11 2018-02-16 巴斯利尔药物国际股份公司 外排泵抑制剂及其治疗性用途
WO2018026866A1 (en) * 2016-08-03 2018-02-08 Neuropore Therapies, Inc. Lipid-substituted amino 1,2-and 1,3-diol compounds as modulators of tlr2 dimerization
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WO2020061114A1 (en) * 2018-09-18 2020-03-26 Metacrine, Inc. Farnesoid x receptor agonists for the treatment of disease
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US20140309192A1 (en) 2014-10-16
AR088810A1 (es) 2014-07-10
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EA201490941A1 (ru) 2014-10-30
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