CU20190080A7 - Derivados de isoindolina útiles para tratar la esteatohepatitis no alcohólica y otras enfermedades de curación disfuncional del tejido y fibrosis - Google Patents

Derivados de isoindolina útiles para tratar la esteatohepatitis no alcohólica y otras enfermedades de curación disfuncional del tejido y fibrosis

Info

Publication number
CU20190080A7
CU20190080A7 CU2019000080A CU20190080A CU20190080A7 CU 20190080 A7 CU20190080 A7 CU 20190080A7 CU 2019000080 A CU2019000080 A CU 2019000080A CU 20190080 A CU20190080 A CU 20190080A CU 20190080 A7 CU20190080 A7 CU 20190080A7
Authority
CU
Cuba
Prior art keywords
fibrosis
tissue
alcoholic steatohepatitis
derivatives useful
isoindoline derivatives
Prior art date
Application number
CU2019000080A
Other languages
English (en)
Inventor
Samuel David Brown
Original Assignee
Seal Rock Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seal Rock Therapeutics Inc filed Critical Seal Rock Therapeutics Inc
Publication of CU20190080A7 publication Critical patent/CU20190080A7/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

<p>En el presente documento se describen derivados de isoindolina de la estructura de fórmula I,</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>que incluyen sales, solvatos, metabolitos, profármacos farmacéuticamente aceptables de los mismos para tratar la esteatohepatitis no alcohólica y otras enfermedades de curación disfuncional del tejido y fibrosis y métodos para preparar tales compuestos, composiciones farmacéuticas que comprenden tales compuestos.</p>
CU2019000080A 2017-04-05 2018-04-04 Derivados de isoindolina útiles para tratar la esteatohepatitis no alcohólica y otras enfermedades de curación disfuncional del tejido y fibrosis CU20190080A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762482085P 2017-04-05 2017-04-05
PCT/US2018/026134 WO2018187506A1 (en) 2017-04-05 2018-04-04 Ask1 inhibitor compounds and uses thereof

Publications (1)

Publication Number Publication Date
CU20190080A7 true CU20190080A7 (es) 2020-10-20

Family

ID=63712299

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2019000080A CU20190080A7 (es) 2017-04-05 2018-04-04 Derivados de isoindolina útiles para tratar la esteatohepatitis no alcohólica y otras enfermedades de curación disfuncional del tejido y fibrosis

Country Status (28)

Country Link
US (2) US20210087167A1 (es)
EP (1) EP3606519B1 (es)
JP (1) JP7196093B2 (es)
KR (1) KR102665145B1 (es)
CN (1) CN110730661B (es)
AR (1) AR111407A1 (es)
AU (1) AU2018250217B2 (es)
BR (1) BR112019021021A2 (es)
CA (1) CA3059107A1 (es)
CL (1) CL2019002810A1 (es)
CO (1) CO2019011708A2 (es)
CR (1) CR20190503A (es)
CU (1) CU20190080A7 (es)
DO (1) DOP2019000255A (es)
EA (1) EA201992299A1 (es)
EC (1) ECSP19078393A (es)
IL (1) IL269711B (es)
JO (1) JOP20190221A1 (es)
MA (1) MA49047A (es)
MX (1) MX2019012013A (es)
NI (1) NI201900102A (es)
NZ (1) NZ758345A (es)
PE (1) PE20200009A1 (es)
PH (1) PH12019502288A1 (es)
RU (1) RU2019134679A (es)
SG (1) SG11201909155VA (es)
TW (1) TWI779022B (es)
WO (1) WO2018187506A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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EP3572401B1 (en) * 2017-01-22 2021-09-29 Fujian Cosunter Pharmaceutical Co., Ltd. Ask1 inhibitor and preparation method and use thereof
WO2018209354A1 (en) 2017-05-12 2018-11-15 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN111801314B (zh) 2018-01-02 2023-10-31 西尔洛克治疗公司 Ask1抑制剂化合物及其用途
CN110407806B (zh) * 2018-04-28 2021-08-17 深圳微芯生物科技股份有限公司 甲酰胺类化合物、其制备方法及其应用
AU2019262016A1 (en) 2018-05-02 2020-11-19 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020006429A1 (en) * 2018-06-28 2020-01-02 Hepatikos Therapeutics, Llc Ask1 isoindolin-1-one inhibitors and methods of use thereof
WO2020041417A1 (en) 2018-08-22 2020-02-27 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11345699B2 (en) 2018-11-19 2022-05-31 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020198214A1 (en) * 2019-03-25 2020-10-01 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN112409332B (zh) * 2019-08-23 2023-12-08 广东东阳光药业股份有限公司 三氮唑衍生物及其在药物中的应用
JP2023514019A (ja) 2019-12-27 2023-04-05 ルピン・リミテッド 置換三環式化合物
WO2021220185A1 (en) 2020-05-01 2021-11-04 Pfizer Inc. Azalactam compounds as hpk1 inhibitors
WO2021224818A1 (en) * 2020-05-08 2021-11-11 Pfizer Inc. Isoindolone compounds as hpk1 inhibitors
WO2024020458A1 (en) * 2022-07-20 2024-01-25 Seal Rock Therapeutics, Inc. Method of treating organ diseases or disorders with ask1 inhibitors

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Also Published As

Publication number Publication date
ECSP19078393A (es) 2019-12-27
AU2018250217B2 (en) 2022-05-19
WO2018187506A1 (en) 2018-10-11
PH12019502288A1 (en) 2020-07-13
TWI779022B (zh) 2022-10-01
CR20190503A (es) 2020-02-28
CA3059107A1 (en) 2018-10-11
IL269711A (en) 2019-11-28
US10150755B2 (en) 2018-12-11
US20210087167A1 (en) 2021-03-25
JP2020515589A (ja) 2020-05-28
AR111407A1 (es) 2019-07-10
AU2018250217A1 (en) 2019-11-07
PE20200009A1 (es) 2020-01-06
EP3606519B1 (en) 2024-06-05
MA49047A (fr) 2020-02-12
NI201900102A (es) 2020-05-15
MX2019012013A (es) 2019-12-18
BR112019021021A2 (pt) 2020-05-05
NZ758345A (en) 2022-02-25
JP7196093B2 (ja) 2022-12-26
KR20190141166A (ko) 2019-12-23
EP3606519A1 (en) 2020-02-12
RU2019134679A (ru) 2021-05-05
IL269711B (en) 2021-12-01
US20180291002A1 (en) 2018-10-11
KR102665145B1 (ko) 2024-05-09
JOP20190221A1 (ar) 2019-09-23
CL2019002810A1 (es) 2020-03-27
EP3606519A4 (en) 2020-12-02
CO2019011708A2 (es) 2020-01-17
TW201838983A (zh) 2018-11-01
CN110730661B (zh) 2023-06-13
EA201992299A1 (ru) 2020-03-26
SG11201909155VA (en) 2019-10-30
CN110730661A (zh) 2020-01-24
DOP2019000255A (es) 2019-12-15

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