DOP2014000096A - Moduladores del receptor mas acoplado a la proteína g y el tratamiento de trastornos relacionados con el mismo - Google Patents

Moduladores del receptor mas acoplado a la proteína g y el tratamiento de trastornos relacionados con el mismo

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Publication number
DOP2014000096A
DOP2014000096A DO2014000096A DO2014000096A DOP2014000096A DO P2014000096 A DOP2014000096 A DO P2014000096A DO 2014000096 A DO2014000096 A DO 2014000096A DO 2014000096 A DO2014000096 A DO 2014000096A DO P2014000096 A DOP2014000096 A DO P2014000096A
Authority
DO
Dominican Republic
Prior art keywords
complications
modulators
protein
receiver
coupled
Prior art date
Application number
DO2014000096A
Other languages
English (en)
Inventor
Thuy-Anh Tran
Anthony C Blackburn
Bryan A Kramer
Maiko Nagura
Carleton R Sage
Young-Jun Shin
Ning Zou
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of DOP2014000096A publication Critical patent/DOP2014000096A/es

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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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Abstract

La presente invención se refiere a compuestos de Fórmula (I) y sales, solvatos e hidratos farmacéuticamente aceptables de los mismos: que son útiles en métodos para tratar y aliviar enfermedades y trastornos del corazón, cerebro, riñón, sistema inmune y reproductivo que resultan de isquemia o reperfusión posterior a isquemia y cualquier complicación o complicaciones posteriores relacionadas con los mismos. La presente invención se refiere, además, a métodos para tratar y aliviar enfermedades y trastornos de la vasculatura que resultan de vasoconstricción o hipertensión y cualquier complicación o complicaciones posteriores que resultan de presión arterial elevada y/o perfusión tisular reducida.
DO2014000096A 2011-11-08 2014-05-07 Moduladores del receptor mas acoplado a la proteína g y el tratamiento de trastornos relacionados con el mismo DOP2014000096A (es)

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WO2014182688A1 (en) * 2013-05-07 2014-11-13 Arena Pharmaceuticals, Inc. Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
KR20160077213A (ko) 2013-11-14 2016-07-01 카딜라 핼쓰캐어 리미티드 새로운 헤테로시클릭 화합물
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists
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