AR088244A1 - oxMIF COMO MARCADOR DE DIAGNOSTICO - Google Patents
oxMIF COMO MARCADOR DE DIAGNOSTICOInfo
- Publication number
- AR088244A1 AR088244A1 ARP120103713A ARP120103713A AR088244A1 AR 088244 A1 AR088244 A1 AR 088244A1 AR P120103713 A ARP120103713 A AR P120103713A AR P120103713 A ARP120103713 A AR P120103713A AR 088244 A1 AR088244 A1 AR 088244A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxmif
- mif
- refers
- diagnostic
- diagnostic marker
- Prior art date
Links
- 239000003550 marker Substances 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 206010061818 Disease progression Diseases 0.000 abstract 1
- 102000028589 Rab4 Human genes 0.000 abstract 1
- 102000028677 Rab9 Human genes 0.000 abstract 1
- 108050007276 Rab9 Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000005750 disease progression Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 108010044923 rab4 GTP-Binding Proteins Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545042P | 2011-10-07 | 2011-10-07 | |
| US201261624943P | 2012-04-16 | 2012-04-16 | |
| US201261668841P | 2012-07-06 | 2012-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088244A1 true AR088244A1 (es) | 2014-05-21 |
Family
ID=46980957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120103713A AR088244A1 (es) | 2011-10-07 | 2012-10-05 | oxMIF COMO MARCADOR DE DIAGNOSTICO |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9958456B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2748613B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2014530360A (cg-RX-API-DMAC7.html) |
| AR (1) | AR088244A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012320597C1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1198591A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW201321408A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013050453A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2748613B1 (en) | 2011-10-07 | 2021-05-05 | Baxalta GmbH | Oxmif as a diagnostic marker |
| AU2013202693B2 (en) * | 2012-04-16 | 2015-01-22 | Baxalta GmbH | Combination Therapy of Anti-MIF Antibodies and Chemotherapeutics |
| CA2878494A1 (en) | 2012-07-10 | 2014-01-16 | Baxter Healthcare S.A. | Anti-mif immunohistochemistry |
| US9536304B2 (en) * | 2013-08-30 | 2017-01-03 | Dairy Quality Inc. | Determining pathogens based on an image of somatic cells in a fluid sample |
| CN106255884B (zh) * | 2013-10-04 | 2019-01-11 | 赛尔爱迪尔私人有限公司 | 用于细胞治疗的生物标志物 |
| WO2015106973A2 (en) * | 2014-01-03 | 2015-07-23 | Baxter Healthcare S.A. | Anti-mif immunohistochemistry |
| US10626166B2 (en) | 2014-08-22 | 2020-04-21 | Baxalta Incorporated | Detection of CHO-MIF contaminations |
| CA3098415A1 (en) * | 2018-06-07 | 2019-12-12 | Oncoone Research & Development Gmbh | Anti-oxmif/anti-cd3 antibody for cancer treatment |
| KR20220110221A (ko) * | 2019-12-06 | 2022-08-05 | 온코원 리서치 앤드 디벨롭먼트 게엠베하 | 항-oxMIF/항-CD3 이중특이적 항체 구축물 |
| CA3210181A1 (en) * | 2021-02-03 | 2022-08-11 | Oncoone Research & Development Gmbh | Anti-oxmif radioimmunoconjugate |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299814A (en) | 1979-05-25 | 1981-11-10 | Monsanto Company | Radioimmunoassay of MIF |
| JPH0672158B2 (ja) | 1984-05-24 | 1994-09-14 | チバ−ガイギ− アクチエンゲゼルシヤフト | 精製されたヒトマクロファージ遊走阻止因子 |
| US4946674A (en) | 1984-10-05 | 1990-08-07 | Bioferon Biochemische Substanzen Gmbh & Co. | Process for treatment of rheumatic diseases |
| US4708937A (en) | 1984-10-15 | 1987-11-24 | Brigham & Women's Hospital | Purified migration inhibitory factor also having colony stimulating factor activity |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3789413T2 (de) | 1986-10-03 | 1994-07-28 | Ciba Geigy Ag | Lymphokin-ähnliche Peptide. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2050332A1 (en) | 1989-03-17 | 1990-09-18 | Steven C. Clark | Human macrophage migration inhibitory factor |
| US5785054A (en) | 1989-06-06 | 1998-07-28 | Kelly; Patrick D. | Genital lubricant with zinc salt, labelled as anti-viral agent |
| GB8915414D0 (en) | 1989-07-05 | 1989-08-23 | Ciba Geigy | Novel cytokines |
| EP0457875A4 (en) | 1989-11-13 | 1993-03-03 | Xoma Corporation | Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen |
| US5227459A (en) | 1990-05-18 | 1993-07-13 | Yale University | Synthetic melanin |
| US5786168A (en) | 1990-06-04 | 1998-07-28 | Kirin Beer Kabushiki Kaisha | Method for recombinant production of antigen non-specific glycosylation inhibiting factor (GIF) |
| US5585479A (en) | 1992-07-24 | 1996-12-17 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ELAM-I RNA |
| US6774227B1 (en) | 1993-05-17 | 2004-08-10 | Cytokine Pharmasciences, Inc. | Therapeutic uses of factors which inhibit or neutralize MIF activity |
| EP1741779A3 (en) | 1993-05-17 | 2010-03-24 | The Picower Institute For Medical Research | Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine mediated toxicity |
| US6645493B1 (en) | 1993-05-17 | 2003-11-11 | The Picower Institute For Medical Research | Composition containing anti-MIF antibody |
| US5559028A (en) | 1993-05-19 | 1996-09-24 | Antigen Express, Inc. | Methods of enhancing or antigen presentation to T cells inhibiting |
| AU7394294A (en) | 1994-05-16 | 1995-12-05 | Human Genome Sciences, Inc. | Macrophage migration inhibitory factor-3 |
| US5747023A (en) | 1994-07-01 | 1998-05-05 | Genentech, Inc. | Cancer therapy using lymphotoxin |
| SI9400363A (en) | 1994-09-19 | 1996-08-31 | Mozetic Francky Bojana | Human macrophage migration inhibitory factor of nonlymphoid origin, expression of mif in e. coli and purification of recombinant protein |
| AU4365796A (en) | 1994-11-16 | 1996-06-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methods for inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor |
| JPH0977799A (ja) | 1995-09-13 | 1997-03-25 | Sapporo Immuno Diagnostic Lab:Kk | ヒト−マクロファージ遊走阻止因子（ヒト−ｍｉｆ）に対するモノクローナル抗体および該抗体を産生するハイブリドーマ |
| WO1997025344A1 (en) | 1996-01-03 | 1997-07-17 | The Australian National University | Clip analogues and autoimmune disease |
| US6492428B1 (en) | 2000-07-26 | 2002-12-10 | The Picower Institute For Medical Research | Compounds having MIF antagonist activity |
| US6420188B1 (en) | 1996-02-16 | 2002-07-16 | The Picower Institute For Medical Research | Screening assay for the identification of inhibitors for macrophage migration inhibitory factor |
| US5726020A (en) | 1996-06-11 | 1998-03-10 | University Of Massachusetts | Inhibition of II synthesis |
| US6297253B1 (en) | 1996-10-15 | 2001-10-02 | The Picower Institute For Medical Research | Compounds and methods of use to treat infectious diseases |
| WO1998037178A1 (en) | 1997-02-24 | 1998-08-27 | The Johns Hopkins University | Immunomodulatory polypeptides derived from the invariant chain of mhc class ii |
| JP3835827B2 (ja) | 1997-05-02 | 2006-10-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ，アズ リプレゼンティッド バイ ザ セクレタリーオブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 悪性細胞に対する、ｏｎｃタンパク質を含む、免疫毒素 |
| CA2205680A1 (en) | 1997-05-16 | 1998-11-16 | The University Of Western Ontario | Clip immunomodulatory peptide |
| US6011005A (en) | 1997-09-18 | 2000-01-04 | The Picower Institute For Medical Research | Prevention of pregnancy miscarriages |
| EP1028738B1 (en) | 1997-11-05 | 2003-04-23 | University Of Southern California | Use of cytokines and mitogens to inhibit pathological immune responses |
| ES2313883T3 (es) | 1999-02-12 | 2009-03-16 | The Scripps Research Institute | Procedimientos para el tratamiento de tumores y metastasis utilizando una combinacion de terapias antiangiogenicas e inmunoterapias. |
| CA2389229A1 (en) | 1999-10-29 | 2001-05-10 | The Picower Institute For Medical Research | Compounds having mif antagonist activity |
| US6268151B1 (en) | 2000-01-20 | 2001-07-31 | Isis Pharmaceuticals, Inc. | Antisense modulation of macrophage migration inhibitory factor expression |
| US20030235584A1 (en) | 2000-02-28 | 2003-12-25 | Kloetzer William S. | Method for preparing anti-MIF antibodies |
| CA2455915C (en) | 2001-03-29 | 2013-05-14 | Cytokine Pharmasciences, Inc. | Methods and compositions for using mhc class ii invariant chain polypeptide as a receptor for macrophage migration inhibitory factor |
| MY140679A (en) | 2001-05-24 | 2010-01-15 | Avanir Pharmaceuticals | Inhibitors of macrohage migration inhibitory factor and methods for identifying the same |
| US7205107B2 (en) | 2001-12-21 | 2007-04-17 | Cytokine Pharmasciences, Inc. | Macrophage migration inhibitory factor (MIF) promoter polymorphism in inflammatory disease |
| US20050202010A1 (en) | 2003-08-29 | 2005-09-15 | Giroir Brett P. | Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor |
| US8883160B2 (en) | 2004-02-13 | 2014-11-11 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) complexes for therapeutic and diagnostic use |
| JP5090366B2 (ja) | 2005-12-16 | 2012-12-05 | アイビーシー ファーマスーティカルズ，インク． | 多価イムノグロブリン系生物活性アセンブリー |
| CN100457895C (zh) | 2006-05-24 | 2009-02-04 | 中国科学院生物物理研究所 | 鼠抗人巨噬细胞迁移抑制因子单克隆抗体及其应用 |
| SI2231707T1 (sl) * | 2008-01-04 | 2015-04-30 | Baxter International Inc. | Anti-MIF protitelesa |
| EP2079202A1 (en) * | 2008-01-08 | 2009-07-15 | NEC Corporation | Method for optimizing the triggering of the transmission of buffer status reporting (BSR) information |
| WO2011090492A1 (en) | 2010-01-19 | 2011-07-28 | Immunomedics, Inc. | Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r) |
| WO2013050457A1 (en) | 2011-10-07 | 2013-04-11 | Baxter Healthcare S.A. | Characterization of cho-mif gene and protein, and use thereof |
| EP2748613B1 (en) | 2011-10-07 | 2021-05-05 | Baxalta GmbH | Oxmif as a diagnostic marker |
-
2012
- 2012-10-04 EP EP12769097.2A patent/EP2748613B1/en active Active
- 2012-10-04 JP JP2014533883A patent/JP2014530360A/ja active Pending
- 2012-10-04 AU AU2012320597A patent/AU2012320597C1/en active Active
- 2012-10-04 US US14/350,186 patent/US9958456B2/en active Active
- 2012-10-04 WO PCT/EP2012/069598 patent/WO2013050453A1/en not_active Ceased
- 2012-10-04 HK HK14112074.8A patent/HK1198591A1/xx unknown
- 2012-10-05 TW TW101137028A patent/TW201321408A/zh unknown
- 2012-10-05 AR ARP120103713A patent/AR088244A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2748613B1 (en) | 2021-05-05 |
| AU2012320597B2 (en) | 2015-05-21 |
| US9958456B2 (en) | 2018-05-01 |
| WO2013050453A4 (en) | 2013-06-06 |
| US20140248638A1 (en) | 2014-09-04 |
| EP2748613A1 (en) | 2014-07-02 |
| AU2012320597A1 (en) | 2013-05-09 |
| WO2013050453A1 (en) | 2013-04-11 |
| AU2012320597C1 (en) | 2015-10-15 |
| HK1198591A1 (en) | 2015-04-30 |
| JP2014530360A (ja) | 2014-11-17 |
| TW201321408A (zh) | 2013-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |