MX343873B - Ensayo de diagnostico de anticuerpo. - Google Patents
Ensayo de diagnostico de anticuerpo.Info
- Publication number
- MX343873B MX343873B MX2013010571A MX2013010571A MX343873B MX 343873 B MX343873 B MX 343873B MX 2013010571 A MX2013010571 A MX 2013010571A MX 2013010571 A MX2013010571 A MX 2013010571A MX 343873 B MX343873 B MX 343873B
- Authority
- MX
- Mexico
- Prior art keywords
- antibody assay
- diagnostic antibody
- diagnostic
- amyloidosis
- diagnosis
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un anticuerpo monoclonal aislado que se enlaza a péptidos AßpGlu (11) o variantes de los mismos, en donde: dicho anticuerpo tiene un valor constante de disociación (KD) de 10-7M o menor; y la parte variable de la cadena ligera de dicho anticuerpo es codificada por una molécula de ácido nucleico que tiene la secuencia de nucleótidos de la SEQ ID NO: 51 o tiene la secuencia de aminoácidos de la SEQ ID NO: 52.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161453449P | 2011-03-16 | 2011-03-16 | |
PCT/EP2012/054629 WO2012123562A1 (en) | 2011-03-16 | 2012-03-16 | Diagnostic antibody assay |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013010571A MX2013010571A (es) | 2013-12-02 |
MX343873B true MX343873B (es) | 2016-11-25 |
Family
ID=45833428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013010571A MX343873B (es) | 2011-03-16 | 2012-03-16 | Ensayo de diagnostico de anticuerpo. |
Country Status (15)
Country | Link |
---|---|
US (2) | US8809508B2 (es) |
EP (1) | EP2686346B1 (es) |
JP (1) | JP6220675B2 (es) |
KR (1) | KR102020072B1 (es) |
CN (1) | CN103459421B (es) |
AU (1) | AU2012228236B2 (es) |
BR (1) | BR112013023211B1 (es) |
CA (1) | CA2828433C (es) |
DK (1) | DK2686346T3 (es) |
EA (1) | EA032054B1 (es) |
IL (1) | IL227847A0 (es) |
MX (1) | MX343873B (es) |
SG (1) | SG192805A1 (es) |
WO (1) | WO2012123562A1 (es) |
ZA (1) | ZA201305946B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2970235B1 (en) | 2013-03-15 | 2019-06-19 | Probiodrug AG | Novel inhibitors |
EP3234611A1 (en) | 2014-12-19 | 2017-10-25 | Probiodrug AG | Novel method for the detection of pglu-abeta peptides |
IL256579B2 (en) * | 2015-07-16 | 2023-03-01 | Probiodrug Ag | Human antibodies |
US20210096128A1 (en) * | 2019-10-01 | 2021-04-01 | Repligen Corporation | Determination of protein concentration in a fluid |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
CA2393763A1 (en) * | 1999-12-08 | 2001-06-14 | Mindset Biopharmaceuticals (Usa), Inc. | Chimeric peptides as immunogens, antibodies thereto, and methods for immunization using chimeric peptides or antibodies |
US7117096B2 (en) * | 2001-04-17 | 2006-10-03 | Abmaxis, Inc. | Structure-based selection and affinity maturation of antibody library |
EP1523499A2 (en) | 2002-07-24 | 2005-04-20 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
WO2004029629A1 (en) | 2002-09-27 | 2004-04-08 | Janssen Pharmaceutica N.V. | N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses |
CA2554809C (en) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
ES2259270B1 (es) | 2005-03-09 | 2007-11-01 | Consejo Superior De Investigaciones Cientificas | Metodo de diagnostico in vitro de la enfermedad de alzheimer mediante un anticuerpo monoclonal. |
WO2008002893A2 (en) | 2006-06-29 | 2008-01-03 | Centocor, Inc. | Anti-amyloid antibodies, compositions, methods and uses |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
DK2086960T3 (da) | 2006-11-09 | 2014-06-10 | Probiodrug Ag | Nye inhibitorer af glutaminylcyclase. |
EP2091945B1 (en) | 2006-11-09 | 2014-01-15 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
WO2008110523A1 (en) | 2007-03-09 | 2008-09-18 | Probiodrug Ag | Imidazo [1,5-a] pyridine derivatives as inhibitors of glutaminyl cyclase |
ES2474693T3 (es) | 2007-04-18 | 2014-07-09 | Probiodrug Ag | Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa |
WO2008128981A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors |
EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
US9034907B2 (en) | 2007-04-18 | 2015-05-19 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
WO2008128986A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Urea derivatives as glutaminyl cyclase inhibitors |
JP5676249B2 (ja) | 2007-04-20 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体 |
MX2010004179A (es) * | 2007-10-15 | 2010-08-04 | Janssen Pharmaceutica Nv | Anticuerpos anti-amiloide, composiciones, metodos y usos. |
AT506820B1 (de) * | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzine gegen alzheimer-krankheit |
EP3338796A1 (en) * | 2008-07-21 | 2018-06-27 | Probiodrug AG | Diagnostic antibody assay |
WO2010128139A1 (en) * | 2009-05-08 | 2010-11-11 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Biomarkers and methods for diagnosing alzheimer's disease and/ or mild cognitive impairment |
EP2448968B1 (en) * | 2009-06-29 | 2021-01-27 | BioArctic AB | ANTIBODIES SELECTIVE FOR N-TERMINALTRUNCATED AMYLOID-p PROTOFIBRILS/OLIGOMERS |
-
2012
- 2012-03-16 JP JP2013558453A patent/JP6220675B2/ja active Active
- 2012-03-16 EA EA201301029A patent/EA032054B1/ru not_active IP Right Cessation
- 2012-03-16 AU AU2012228236A patent/AU2012228236B2/en active Active
- 2012-03-16 KR KR1020137023118A patent/KR102020072B1/ko active IP Right Grant
- 2012-03-16 WO PCT/EP2012/054629 patent/WO2012123562A1/en active Application Filing
- 2012-03-16 SG SG2013062286A patent/SG192805A1/en unknown
- 2012-03-16 BR BR112013023211-0A patent/BR112013023211B1/pt active IP Right Grant
- 2012-03-16 MX MX2013010571A patent/MX343873B/es active IP Right Grant
- 2012-03-16 US US13/422,583 patent/US8809508B2/en active Active
- 2012-03-16 CN CN201280013607.2A patent/CN103459421B/zh active Active
- 2012-03-16 DK DK12708855.7T patent/DK2686346T3/en active
- 2012-03-16 CA CA2828433A patent/CA2828433C/en active Active
- 2012-03-16 EP EP12708855.7A patent/EP2686346B1/en active Active
-
2013
- 2013-08-07 IL IL227847A patent/IL227847A0/en active IP Right Grant
- 2013-08-07 ZA ZA2013/05946A patent/ZA201305946B/en unknown
-
2014
- 2014-05-19 US US14/280,919 patent/US9657089B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2828433A1 (en) | 2012-09-20 |
US8809508B2 (en) | 2014-08-19 |
EP2686346A1 (en) | 2014-01-22 |
EP2686346B1 (en) | 2016-12-14 |
CN103459421B (zh) | 2017-07-14 |
CA2828433C (en) | 2020-08-04 |
AU2012228236B2 (en) | 2016-10-27 |
SG192805A1 (en) | 2013-09-30 |
DK2686346T3 (en) | 2017-03-27 |
US20120237529A1 (en) | 2012-09-20 |
KR20140006019A (ko) | 2014-01-15 |
ZA201305946B (en) | 2014-10-29 |
EA201301029A1 (ru) | 2014-05-30 |
EA032054B1 (ru) | 2019-04-30 |
KR102020072B1 (ko) | 2019-11-04 |
AU2012228236A1 (en) | 2013-10-03 |
MX2013010571A (es) | 2013-12-02 |
JP2014509860A (ja) | 2014-04-24 |
JP6220675B2 (ja) | 2017-11-01 |
US9657089B2 (en) | 2017-05-23 |
CN103459421A (zh) | 2013-12-18 |
BR112013023211B1 (pt) | 2022-11-08 |
BR112013023211A2 (pt) | 2016-11-22 |
WO2012123562A1 (en) | 2012-09-20 |
IL227847A0 (en) | 2013-09-30 |
US20140255414A1 (en) | 2014-09-11 |
NZ614217A (en) | 2015-12-24 |
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