TW201321408A - 作為診斷標記之oxMIF - Google Patents

作為診斷標記之oxMIF Download PDF

Info

Publication number
TW201321408A
TW201321408A TW101137028A TW101137028A TW201321408A TW 201321408 A TW201321408 A TW 201321408A TW 101137028 A TW101137028 A TW 101137028A TW 101137028 A TW101137028 A TW 101137028A TW 201321408 A TW201321408 A TW 201321408A
Authority
TW
Taiwan
Prior art keywords
mif
oxmif
antibody
disease
antibodies
Prior art date
Application number
TW101137028A
Other languages
English (en)
Chinese (zh)
Inventor
Michael Thiele
Randolf J Kerschbaumer
Dirk Voelkel
Patrice Douillard
Friedrich Scheiflinger
Original Assignee
Baxter Healthcare Sa
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare Sa, Baxter Int filed Critical Baxter Healthcare Sa
Publication of TW201321408A publication Critical patent/TW201321408A/zh

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
TW101137028A 2011-10-07 2012-10-05 作為診斷標記之oxMIF TW201321408A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545042P 2011-10-07 2011-10-07
US201261624943P 2012-04-16 2012-04-16
US201261668841P 2012-07-06 2012-07-06

Publications (1)

Publication Number Publication Date
TW201321408A true TW201321408A (zh) 2013-06-01

Family

ID=46980957

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101137028A TW201321408A (zh) 2011-10-07 2012-10-05 作為診斷標記之oxMIF

Country Status (8)

Country Link
US (1) US9958456B2 (cg-RX-API-DMAC7.html)
EP (1) EP2748613B1 (cg-RX-API-DMAC7.html)
JP (1) JP2014530360A (cg-RX-API-DMAC7.html)
AR (1) AR088244A1 (cg-RX-API-DMAC7.html)
AU (1) AU2012320597C1 (cg-RX-API-DMAC7.html)
HK (1) HK1198591A1 (cg-RX-API-DMAC7.html)
TW (1) TW201321408A (cg-RX-API-DMAC7.html)
WO (1) WO2013050453A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106255884A (zh) * 2013-10-04 2016-12-21 赛尔爱迪尔私人有限公司 用于细胞治疗的生物标志物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2748613B1 (en) 2011-10-07 2021-05-05 Baxalta GmbH Oxmif as a diagnostic marker
AU2013202693B2 (en) * 2012-04-16 2015-01-22 Baxalta GmbH Combination Therapy of Anti-MIF Antibodies and Chemotherapeutics
CA2878494A1 (en) 2012-07-10 2014-01-16 Baxter Healthcare S.A. Anti-mif immunohistochemistry
US9536304B2 (en) * 2013-08-30 2017-01-03 Dairy Quality Inc. Determining pathogens based on an image of somatic cells in a fluid sample
WO2015106973A2 (en) * 2014-01-03 2015-07-23 Baxter Healthcare S.A. Anti-mif immunohistochemistry
US10626166B2 (en) 2014-08-22 2020-04-21 Baxalta Incorporated Detection of CHO-MIF contaminations
CA3098415A1 (en) * 2018-06-07 2019-12-12 Oncoone Research & Development Gmbh Anti-oxmif/anti-cd3 antibody for cancer treatment
KR20220110221A (ko) * 2019-12-06 2022-08-05 온코원 리서치 앤드 디벨롭먼트 게엠베하 항-oxMIF/항-CD3 이중특이적 항체 구축물
CA3210181A1 (en) * 2021-02-03 2022-08-11 Oncoone Research & Development Gmbh Anti-oxmif radioimmunoconjugate

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4299814A (en) 1979-05-25 1981-11-10 Monsanto Company Radioimmunoassay of MIF
JPH0672158B2 (ja) 1984-05-24 1994-09-14 チバ−ガイギ− アクチエンゲゼルシヤフト 精製されたヒトマクロファージ遊走阻止因子
US4946674A (en) 1984-10-05 1990-08-07 Bioferon Biochemische Substanzen Gmbh & Co. Process for treatment of rheumatic diseases
US4708937A (en) 1984-10-15 1987-11-24 Brigham & Women's Hospital Purified migration inhibitory factor also having colony stimulating factor activity
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
DE3789413T2 (de) 1986-10-03 1994-07-28 Ciba Geigy Ag Lymphokin-ähnliche Peptide.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2050332A1 (en) 1989-03-17 1990-09-18 Steven C. Clark Human macrophage migration inhibitory factor
US5785054A (en) 1989-06-06 1998-07-28 Kelly; Patrick D. Genital lubricant with zinc salt, labelled as anti-viral agent
GB8915414D0 (en) 1989-07-05 1989-08-23 Ciba Geigy Novel cytokines
EP0457875A4 (en) 1989-11-13 1993-03-03 Xoma Corporation Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen
US5227459A (en) 1990-05-18 1993-07-13 Yale University Synthetic melanin
US5786168A (en) 1990-06-04 1998-07-28 Kirin Beer Kabushiki Kaisha Method for recombinant production of antigen non-specific glycosylation inhibiting factor (GIF)
US5585479A (en) 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
US6774227B1 (en) 1993-05-17 2004-08-10 Cytokine Pharmasciences, Inc. Therapeutic uses of factors which inhibit or neutralize MIF activity
EP1741779A3 (en) 1993-05-17 2010-03-24 The Picower Institute For Medical Research Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine mediated toxicity
US6645493B1 (en) 1993-05-17 2003-11-11 The Picower Institute For Medical Research Composition containing anti-MIF antibody
US5559028A (en) 1993-05-19 1996-09-24 Antigen Express, Inc. Methods of enhancing or antigen presentation to T cells inhibiting
AU7394294A (en) 1994-05-16 1995-12-05 Human Genome Sciences, Inc. Macrophage migration inhibitory factor-3
US5747023A (en) 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
SI9400363A (en) 1994-09-19 1996-08-31 Mozetic Francky Bojana Human macrophage migration inhibitory factor of nonlymphoid origin, expression of mif in e. coli and purification of recombinant protein
AU4365796A (en) 1994-11-16 1996-06-06 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods for inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor
JPH0977799A (ja) 1995-09-13 1997-03-25 Sapporo Immuno Diagnostic Lab:Kk ヒト−マクロファージ遊走阻止因子(ヒト−mif)に対するモノクローナル抗体および該抗体を産生するハイブリドーマ
WO1997025344A1 (en) 1996-01-03 1997-07-17 The Australian National University Clip analogues and autoimmune disease
US6492428B1 (en) 2000-07-26 2002-12-10 The Picower Institute For Medical Research Compounds having MIF antagonist activity
US6420188B1 (en) 1996-02-16 2002-07-16 The Picower Institute For Medical Research Screening assay for the identification of inhibitors for macrophage migration inhibitory factor
US5726020A (en) 1996-06-11 1998-03-10 University Of Massachusetts Inhibition of II synthesis
US6297253B1 (en) 1996-10-15 2001-10-02 The Picower Institute For Medical Research Compounds and methods of use to treat infectious diseases
WO1998037178A1 (en) 1997-02-24 1998-08-27 The Johns Hopkins University Immunomodulatory polypeptides derived from the invariant chain of mhc class ii
JP3835827B2 (ja) 1997-05-02 2006-10-18 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ,アズ リプレゼンティッド バイ ザ セクレタリーオブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ 悪性細胞に対する、oncタンパク質を含む、免疫毒素
CA2205680A1 (en) 1997-05-16 1998-11-16 The University Of Western Ontario Clip immunomodulatory peptide
US6011005A (en) 1997-09-18 2000-01-04 The Picower Institute For Medical Research Prevention of pregnancy miscarriages
EP1028738B1 (en) 1997-11-05 2003-04-23 University Of Southern California Use of cytokines and mitogens to inhibit pathological immune responses
ES2313883T3 (es) 1999-02-12 2009-03-16 The Scripps Research Institute Procedimientos para el tratamiento de tumores y metastasis utilizando una combinacion de terapias antiangiogenicas e inmunoterapias.
CA2389229A1 (en) 1999-10-29 2001-05-10 The Picower Institute For Medical Research Compounds having mif antagonist activity
US6268151B1 (en) 2000-01-20 2001-07-31 Isis Pharmaceuticals, Inc. Antisense modulation of macrophage migration inhibitory factor expression
US20030235584A1 (en) 2000-02-28 2003-12-25 Kloetzer William S. Method for preparing anti-MIF antibodies
CA2455915C (en) 2001-03-29 2013-05-14 Cytokine Pharmasciences, Inc. Methods and compositions for using mhc class ii invariant chain polypeptide as a receptor for macrophage migration inhibitory factor
MY140679A (en) 2001-05-24 2010-01-15 Avanir Pharmaceuticals Inhibitors of macrohage migration inhibitory factor and methods for identifying the same
US7205107B2 (en) 2001-12-21 2007-04-17 Cytokine Pharmasciences, Inc. Macrophage migration inhibitory factor (MIF) promoter polymorphism in inflammatory disease
US20050202010A1 (en) 2003-08-29 2005-09-15 Giroir Brett P. Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor
US8883160B2 (en) 2004-02-13 2014-11-11 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) complexes for therapeutic and diagnostic use
JP5090366B2 (ja) 2005-12-16 2012-12-05 アイビーシー ファーマスーティカルズ,インク. 多価イムノグロブリン系生物活性アセンブリー
CN100457895C (zh) 2006-05-24 2009-02-04 中国科学院生物物理研究所 鼠抗人巨噬细胞迁移抑制因子单克隆抗体及其应用
SI2231707T1 (sl) * 2008-01-04 2015-04-30 Baxter International Inc. Anti-MIF protitelesa
EP2079202A1 (en) * 2008-01-08 2009-07-15 NEC Corporation Method for optimizing the triggering of the transmission of buffer status reporting (BSR) information
WO2011090492A1 (en) 2010-01-19 2011-07-28 Immunomedics, Inc. Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r)
WO2013050457A1 (en) 2011-10-07 2013-04-11 Baxter Healthcare S.A. Characterization of cho-mif gene and protein, and use thereof
EP2748613B1 (en) 2011-10-07 2021-05-05 Baxalta GmbH Oxmif as a diagnostic marker

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106255884A (zh) * 2013-10-04 2016-12-21 赛尔爱迪尔私人有限公司 用于细胞治疗的生物标志物
CN106255884B (zh) * 2013-10-04 2019-01-11 赛尔爱迪尔私人有限公司 用于细胞治疗的生物标志物

Also Published As

Publication number Publication date
EP2748613B1 (en) 2021-05-05
AU2012320597B2 (en) 2015-05-21
US9958456B2 (en) 2018-05-01
WO2013050453A4 (en) 2013-06-06
US20140248638A1 (en) 2014-09-04
EP2748613A1 (en) 2014-07-02
AU2012320597A1 (en) 2013-05-09
WO2013050453A1 (en) 2013-04-11
AU2012320597C1 (en) 2015-10-15
HK1198591A1 (en) 2015-04-30
JP2014530360A (ja) 2014-11-17
AR088244A1 (es) 2014-05-21

Similar Documents

Publication Publication Date Title
TW201321408A (zh) 作為診斷標記之oxMIF
RU2509777C2 (ru) Анти-mif антитела
TW201837056A (zh) B7-h3抗體、其抗原結合片段及其醫藥用途
WO2015115332A1 (ja) 抗トランスサイレチンヒト抗体
US20150355199A1 (en) Agents, kits and methods for complement factor h-related protein 1 detection
EP3090262B1 (en) Anti-mif immunohistochemistry
WO2021238854A1 (zh) 抗SARS-CoV-2刺突蛋白的单克隆抗体及其制备方法和用途
US11174310B2 (en) Disulfide-type HMGB1-specific antibody, method for measuring disulfide-type HMGB1 and kit for said measurement, and measurement method capable of quantitating all of HMGB1 molecules including reduced HMGB1, disulfide-type HMGB1 and thrombin-cleavable HMGB1 and kit for said measurement
KR20150029017A (ko) 항-mif 면역조직화학
TW201605886A (zh) 作爲治療標靶的mif
CN102639563A (zh) 2型糖尿病的标记蛋白
JP2016502669A (ja) 抗mif抗体細胞遊走アッセイ
HK1147762B (en) Anti mif antibodies
HK1181052A (en) Anti mif antibodies