AR087725A1 - Compuestos de tiazolida sustituidos con alquilsulfinilo - Google Patents
Compuestos de tiazolida sustituidos con alquilsulfiniloInfo
- Publication number
- AR087725A1 AR087725A1 ARP110104017A ARP110104017A AR087725A1 AR 087725 A1 AR087725 A1 AR 087725A1 AR P110104017 A ARP110104017 A AR P110104017A AR P110104017 A ARP110104017 A AR P110104017A AR 087725 A1 AR087725 A1 AR 087725A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- 6sulfinyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado porque es de fórmula estructural (1), y sales farmacéuticamente aceptables del mismo, donde R¹ se selecciona entre el grupo que consiste en hidrógeno y Q-C(=O)-, cualquiera de los cuales puede estar opcionalmente sustituido; R² a R⁵ se seleccionan en forma independiente entre el grupo que consiste en hidrógeno, D, hidroxi, F, Cl, Br, CN, NO₂, alquilo C₁₋₆, cicloalquilo C₃₋₈, alcoxi C₁₋₆, carboxi, alcoxi C₁₋₆carbonilo, amino, acil C₁₋₆amino, amido, alquil C₁₋₆amido, dialquil C₁₋₆amido, alquil C₁₋₆sulfonilamino, haloalquilo C₁₋₆, perhaloalquilo C₁₋₆, perhaloalcoxi C₁₋₆, alquiltio C₁₋₆, alquiltioalquilo C₁₋₆, alquil C₁₋₆sulfonilo, cicloalquil C₃₋₈sulfonilo, arilsulfonilo, arilalquilsulfonilo, heteroarilsulfonilo, heteroarilalquilsulfonilo, alquil C₁₋₆sulfonamido, N,N-dialquil C₁₋₆sulfonamido, arilo, ariloxi, ariltio, arilalquiltio, heteroarilo, heteroariloxi, heteroarilalcoxi, heteroariltio, heteroarilalquiltio, heterocicloalquilo, heterocicloalcoxi, y Q-C(=O)-, cualquiera de los cuales puede estar opcionalmente sustituido; o dos porciones R¹, R² ó R³ contiguas cualesquiera pueden combinarse junto con los átomos a los cuales están unidos y unirse para formar un anillo heterocicloalquilo de entre 5 y 8 miembros opcionalmente sustituido; cuando uno de R⁶ ó R⁷ es hidrógeno, el otro se selecciona en forma independiente entre el grupo que consiste en alquil C₁₋₆sulfinilo, alquil C₁₋₆sulfinilalquilo, alquenil C₂₋₆sulfinilo, alquinil C₂₋₆sulfinilo, cicloalquil C₃₋₈sulfinilo, cicloalquenil C₅₋₈sulfinilo, arilsulfinilo, arilalquilsulfinilo, arilalquenilsulfinilo, heteroarilsulfinilo, heteroarilalquilsulfinilo, heteroarilalquenilsulfinilo, y heterocicloalquilsulfinilo, cualquiera de los cuales puede estar opcionalmente sustituido; o las porciones R⁶ y R⁷ pueden combinarse junto con los átomos a los cuales están unidas y unirse para formar un anillo de entre 5 y 8 miembros opcionalmente sustituido que incorpora una porción sulfinilo (-S[O]-); y donde Q es R⁸, OR⁸, NHR⁸, o NR⁸R⁹; R⁸ y R⁹ se seleccionan en forma independiente entre el grupo que consiste en hidrógeno, alquilo C₁₋₁₂, alquenilo C₂₋₁₂, alquinilo C₂₋₁₂, cicloalquilo C₃₋₈, arilo, arilalquilo, arilalquenilo, heterocicloalquilo, heteroarilo, heteroarilalquilo y heteroarilalquenilo, cualquiera de los cuales puede estar opcionalmente sustituido; o R⁸ y R⁹, junto con los átomos a los cuales están unidos, pueden unirse para formar un anillo heterocicloalquilo de entre 5 y 8 miembros opcionalmente sustituido; cualquiera de los cuales puede estar opcionalmente sustituido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40893810P | 2010-11-01 | 2010-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR087725A1 true AR087725A1 (es) | 2014-04-16 |
Family
ID=45997374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104017A AR087725A1 (es) | 2010-11-01 | 2011-10-28 | Compuestos de tiazolida sustituidos con alquilsulfinilo |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8772502B2 (es) |
| EP (1) | EP2635124A4 (es) |
| JP (1) | JP5837936B2 (es) |
| CN (1) | CN103269593A (es) |
| AR (1) | AR087725A1 (es) |
| AU (1) | AU2011323682B2 (es) |
| BR (1) | BR112013010738B1 (es) |
| MX (1) | MX2013004724A (es) |
| NZ (1) | NZ611410A (es) |
| RU (1) | RU2605745C2 (es) |
| WO (1) | WO2012061190A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103159697A (zh) * | 2013-04-10 | 2013-06-19 | 安徽中升药业有限公司 | 硝唑尼特的制备方法 |
| WO2015000431A1 (zh) * | 2013-07-04 | 2015-01-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 替唑尼特氨基甲酸酯及其在药学中的应用 |
| BR112017009651A2 (pt) | 2014-11-11 | 2017-12-19 | Romark Laboratories Lc | composto, composição farmacêutica, e, método para tratamento de uma infecção por protozoário intracelular, uma infecção viral ou um câncer. |
| EP3677282A1 (en) | 2016-03-31 | 2020-07-08 | Romark Laboratories, L.C. | Thiazolide compounds for treating viral infections |
| AU2017245679B2 (en) * | 2016-04-06 | 2021-07-01 | Innovative Molecules Gmbh | Aminothiazole derivatives useful as antiviral agents |
| HUE060671T2 (hu) | 2016-04-11 | 2023-04-28 | Genfit | Eljárás fibrotikus betegségek kezelésére |
| US11173149B2 (en) | 2017-04-18 | 2021-11-16 | Romark Laboratories L.C. | Inhibition of protein disulfide-isomerase A3 |
| CN107556201B (zh) * | 2017-09-08 | 2020-10-27 | 山西智创药研科技有限公司 | 一种制备间氨基苯酚的工艺方法 |
| CN107522595A (zh) * | 2017-09-08 | 2017-12-29 | 山西新元太新材料科技发展有限公司 | 一种制备间苯二酚的工艺方法 |
| HUE061307T2 (hu) * | 2017-10-05 | 2023-06-28 | Innovative Molecules Gmbh | Szubsztituált tiazolok enantiomerei mint vírusellenes vegyületek |
| CN112480104B (zh) * | 2019-09-11 | 2024-06-18 | 绍兴君科臻元医药科技有限公司 | 硝唑尼特衍生物及其医药用途 |
| FR3110164A1 (fr) * | 2020-05-15 | 2021-11-19 | Phv Pharma | Procédé de préparation du nitazoxanide et de ses dérivés et utilisation pour la prévention ou le traitement d’états pathologiques dus à l’infection par des virus du type coronavirus, et plus particulièrement du type SARS-CoV-2 |
| JP2023537237A (ja) | 2020-07-20 | 2023-08-31 | ロマーク ラボラトリーズ，リミティド カンパニー | チゾキサニドおよび２－ヒドロキシ－ｎ－（５－クロロ－１，３－チアゾル－２－イル）ベンズアミド（ｒｍ－４８４８）とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびｎ－メチルピペラジンの結晶塩 |
| CN116367892A (zh) | 2020-08-24 | 2023-06-30 | 罗马克实验室有限公司 | 噻唑化物抗冠状病毒的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169846A (en) | 1989-10-12 | 1992-12-08 | Crooks Michael J | Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators |
| US5578621A (en) | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
| US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| DE10129714A1 (de) * | 2001-06-22 | 2003-01-02 | Bayer Ag | Topische Anwendung von Thiazolylamiden |
| SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| WO2008123469A1 (ja) * | 2007-03-30 | 2008-10-16 | Japan Tobacco Inc. | ６員環アミド化合物およびその用途 |
| BRPI0815057B8 (pt) * | 2007-08-03 | 2021-05-25 | Romark Laboratories Lc | composto, composição farmacêutica, e, uso de um composto |
| BRPI1014322A2 (pt) * | 2009-06-26 | 2015-08-25 | Romark Lab Lc | Método para tratar infecção, e para interromper ou evitar a produção de partículas virais infecciosas, combinação, e, composição farmacêutica. |
-
2011
- 2011-10-27 EP EP11838562.4A patent/EP2635124A4/en not_active Withdrawn
- 2011-10-27 WO PCT/US2011/058009 patent/WO2012061190A1/en active Application Filing
- 2011-10-27 MX MX2013004724A patent/MX2013004724A/es active IP Right Grant
- 2011-10-27 JP JP2013536808A patent/JP5837936B2/ja not_active Expired - Fee Related
- 2011-10-27 CN CN2011800626842A patent/CN103269593A/zh active Pending
- 2011-10-27 NZ NZ611410A patent/NZ611410A/en not_active IP Right Cessation
- 2011-10-27 RU RU2013123401/04A patent/RU2605745C2/ru active
- 2011-10-27 AU AU2011323682A patent/AU2011323682B2/en not_active Ceased
- 2011-10-27 BR BR112013010738-3A patent/BR112013010738B1/pt not_active IP Right Cessation
- 2011-10-28 AR ARP110104017A patent/AR087725A1/es unknown
- 2011-10-28 US US13/284,242 patent/US8772502B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013010738B1 (pt) | 2020-03-17 |
| EP2635124A1 (en) | 2013-09-11 |
| US20120108591A1 (en) | 2012-05-03 |
| NZ611410A (en) | 2016-02-26 |
| AU2011323682A1 (en) | 2013-06-20 |
| RU2605745C2 (ru) | 2016-12-27 |
| EP2635124A4 (en) | 2014-04-16 |
| MX2013004724A (es) | 2013-08-29 |
| JP5837936B2 (ja) | 2015-12-24 |
| AU2011323682B2 (en) | 2016-06-23 |
| JP2013544806A (ja) | 2013-12-19 |
| WO2012061190A1 (en) | 2012-05-10 |
| US8772502B2 (en) | 2014-07-08 |
| CN103269593A (zh) | 2013-08-28 |
| BR112013010738A2 (pt) | 2016-07-12 |
| RU2013123401A (ru) | 2014-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |