HUE060671T2 - Eljárás fibrotikus betegségek kezelésére - Google Patents

Eljárás fibrotikus betegségek kezelésére

Info

Publication number
HUE060671T2
HUE060671T2 HUE20194458A HUE20194458A HUE060671T2 HU E060671 T2 HUE060671 T2 HU E060671T2 HU E20194458 A HUE20194458 A HU E20194458A HU E20194458 A HUE20194458 A HU E20194458A HU E060671 T2 HUE060671 T2 HU E060671T2
Authority
HU
Hungary
Prior art keywords
treatment
methods
fibrotic diseases
fibrotic
diseases
Prior art date
Application number
HUE20194458A
Other languages
English (en)
Inventor
Raphaël Darteil
Robert Walczak
Carole Belanger
Emilie Negro
Pierre Daubersies
Philippe Delataille
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Publication of HUE060671T2 publication Critical patent/HUE060671T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
HUE20194458A 2016-04-11 2017-03-13 Eljárás fibrotikus betegségek kezelésére HUE060671T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16305425 2016-04-11

Publications (1)

Publication Number Publication Date
HUE060671T2 true HUE060671T2 (hu) 2023-04-28

Family

ID=55755536

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE17710285A HUE052886T2 (hu) 2016-04-11 2017-03-13 Módszerek kolesztázisos és fibrotikus betegségek kezelésére
HUE20194458A HUE060671T2 (hu) 2016-04-11 2017-03-13 Eljárás fibrotikus betegségek kezelésére

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE17710285A HUE052886T2 (hu) 2016-04-11 2017-03-13 Módszerek kolesztázisos és fibrotikus betegségek kezelésére

Country Status (24)

Country Link
US (7) US20170290812A1 (hu)
EP (3) EP3777854B1 (hu)
JP (1) JP6894923B2 (hu)
KR (1) KR102431257B1 (hu)
CN (1) CN109069648B (hu)
AU (1) AU2017249602B2 (hu)
CA (1) CA3019399A1 (hu)
DK (2) DK3442580T3 (hu)
EA (2) EA201892298A1 (hu)
ES (3) ES2928408T3 (hu)
HR (1) HRP20201954T1 (hu)
HU (2) HUE052886T2 (hu)
IL (1) IL262052B (hu)
LT (1) LT3442580T (hu)
MD (1) MD3442580T2 (hu)
MX (1) MX2018012287A (hu)
MY (1) MY195437A (hu)
PH (1) PH12018502142A1 (hu)
PL (1) PL3442580T3 (hu)
PT (2) PT3442580T (hu)
SG (2) SG10202004425XA (hu)
SI (1) SI3442580T1 (hu)
WO (1) WO2017178172A1 (hu)
ZA (1) ZA201807389B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2928408T3 (es) 2016-04-11 2022-11-17 Genfit Métodos para el tratamiento de enfermedades fibróticas
WO2017178174A1 (en) * 2016-04-11 2017-10-19 Genfit Methods of treatment of cholestasis and fibrosis
BR112019018162A2 (pt) 2017-03-13 2020-04-07 Genfit Composições farmacêuticas para terapia de combinação
WO2018173069A1 (en) * 2017-03-21 2018-09-27 Novalead Pharma Inc. Therapeutic agent for phosphodiesterase inhibition and its related disorders
CA3082859A1 (en) 2017-11-17 2019-05-23 Hubert Koster [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate for use in lymphangioleiomyomatosis and other diseases
EP3639822A1 (en) * 2018-10-15 2020-04-22 Universität Regensburg Compound for use in the treatment of a disease characterized by dysregulated mucus production and/or secretion
BR112021020496A2 (pt) 2019-04-12 2021-12-07 Genfit Nitazoxanida e tiazolidas para uso no tratamento de doenças associadas ao estresse oxidativo
CN110205302B (zh) * 2019-06-24 2021-03-23 扬州大学 一株分泌抗麦考酚酸单克隆抗体的细胞株、其单克隆抗体及其应用
CN110478357A (zh) * 2019-07-23 2019-11-22 哈尔滨医科大学 硝唑尼特及其体内代谢物在抗肥胖、降血脂、抗脂肪肝及抗动脉粥样硬化中的应用
CN110368498A (zh) * 2019-08-26 2019-10-25 瑞希(重庆)生物科技有限公司 一种促进伤口愈合的制剂及其制备方法
CN114630660A (zh) 2019-10-28 2022-06-14 基恩菲特公司 具有抗氧化特性的联合疗法
CN113398125B (zh) * 2020-03-16 2024-05-03 绍兴君科臻元医药科技有限公司 替唑尼特药物组合物及其医药用途
US20240000754A1 (en) * 2020-11-17 2024-01-04 Genfit Methods of treatment of liver failure
WO2022218239A1 (zh) * 2021-04-12 2022-10-20 杜心赟 新型噻唑类化合物及其制备方法和用途
CN116077502A (zh) * 2021-11-05 2023-05-09 广州市妇女儿童医疗中心 叶酸在预防、诊断和治疗遗传性、感染性或过敏性疾病中的应用
WO2024074515A1 (en) * 2022-10-04 2024-04-11 Genfit Nitazoxanide for the treatment of hepatic impairment
CN116911513B (zh) * 2023-02-07 2024-07-26 中国药科大学 硝唑尼特及其体内代谢物替唑尼特在制备抗心衰药物中的应用
CN117838690B (zh) * 2023-10-09 2024-09-13 中国药科大学 一种治疗以ampk激活为治疗靶点的疾病的复方药物及其应用

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437800A (en) 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
GB1440212A (en) 1973-08-29 1976-06-23 Phavic Sprl Derivatives of 2-phenoxyacetamido-5-nitrothiazoles
US5965590A (en) 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
MX9604483A (es) 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5968961A (en) 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US5935591A (en) 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
CA2436739A1 (en) 2000-12-26 2002-07-04 Takeda Chemical Industries, Ltd. Combination agent
MXPA06002567A (es) 2003-09-06 2006-09-04 Vertex Pharma Moduladores de transportadores con casete de union de atp.
UA90864C2 (en) 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
EP1971594A2 (en) 2005-11-21 2008-09-24 Biogen Idec MA Inc. Substituted pyrazalones
CA2636527C (en) * 2006-01-09 2016-05-17 Romark Laboratories, L.C. Viral hepatitis treatment
EP1983980A4 (en) 2006-01-25 2010-05-05 Synta Pharmaceuticals Corp THIAZOL AND THIADIAZOL COMPOUNDS FOR USES IN RELATION TO INFLAMMATION AND IMMUNITY
GB0619500D0 (en) 2006-10-03 2006-11-08 Univ Keele Treatment of fibrosis
BRPI0815057B8 (pt) 2007-08-03 2021-05-25 Romark Laboratories Lc composto, composição farmacêutica, e, uso de um composto
US20110177999A1 (en) * 2007-08-09 2011-07-21 Vertex Pharmaceuticals Incorporated Therapeutic Combinations Useful in Treating CFTR Related Diseases
KR101045572B1 (ko) 2007-08-14 2011-07-01 주식회사 엘지화학 Clostridium propionicum 유래의프로피오닐―CoA 트랜스퍼라아제 변이체 및 상기변이체를 이용한 락테이트 중합체 또는 락테이트공중합체의 제조방법
US9149463B2 (en) * 2007-09-18 2015-10-06 The Board Of Trustees Of The Leland Standford Junior University Methods and compositions of treating a Flaviviridae family viral infection
WO2009039248A2 (en) 2007-09-18 2009-03-26 Stanford University Methods of treating a flaviviridae family viral infection and compositions for treating a flaviviridae family viral infection
US20100016262A1 (en) 2007-10-18 2010-01-21 Yale University Compositions and methods for reducing hepatotoxicity associated with drug administration and treating non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and associated cirrhosis
JP2012520884A (ja) * 2009-03-18 2012-09-10 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー フラビウイルス科ウイルス感染症を治療する方法および組成物
PE20121118A1 (es) 2009-05-12 2012-09-05 Romark Lab Lc Compuestos de haloalquil heteroaril benzamida
EP2445349B1 (en) 2009-06-26 2022-02-09 Romark Laboratories, L.C. Compounds and methods for treating influenza
EA201270632A1 (ru) 2009-11-16 2013-01-30 Юниверсити Оф Джорджия Рисерч Фаундейшн, Инк. 2'-фтор-6'-метилен карбоциклические нуклеозиды и способы лечения вирусных инфекций
US8816074B2 (en) 2009-11-16 2014-08-26 University of Georgia Foundation, Inc. 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (en) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
US8697739B2 (en) 2010-07-29 2014-04-15 Novartis Ag Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
CN103180316A (zh) 2010-08-27 2013-06-26 钙医学公司 调节细胞内钙的化合物
AU2011323682B2 (en) 2010-11-01 2016-06-23 Romark Laboratories L.C. Alkylsulfinyl-substituted thiazolide compounds
US9370528B2 (en) 2011-03-02 2016-06-21 Volant Holdings Gmbh Compositions, methods of treatment and diagnostics for treatment of hepatic steatosis alone or in combination with a hepatitis C virus infection
WO2012158699A1 (en) 2011-05-16 2012-11-22 Romark Laboratories, L.C. Use of thiazolide compounds for the prevention and treatment of viral diseases, cancer and diseases caused by intracellular infections
WO2013059677A1 (en) 2011-10-19 2013-04-25 Calcimedica, Inc. Compounds that modulate intracellular calcium
AU2013202269A1 (en) * 2011-10-26 2013-05-16 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases
WO2013082469A2 (en) 2011-12-02 2013-06-06 University Of Vermont And State Agricultural College Methods and compositions for treating infections
US9750705B2 (en) 2012-08-31 2017-09-05 The Regents Of The University Of California Agents useful for treating obesity, diabetes and related disorders
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9974767B2 (en) 2014-07-14 2018-05-22 University Of Washington Statins in the treatment of muscular dystrophies and myopathies
AU2015346413B2 (en) 2014-11-11 2019-08-29 Romark Laboratories, L.C. Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof
WO2016210247A1 (en) 2015-06-24 2016-12-29 Duke University New methods of use for an anti-diarrhea agent
WO2017178174A1 (en) 2016-04-11 2017-10-19 Genfit Methods of treatment of cholestasis and fibrosis
WO2017178173A1 (en) 2016-04-11 2017-10-19 Genfit Methods of treatment for cholestatic and fibrotic diseases
ES2928408T3 (es) 2016-04-11 2022-11-17 Genfit Métodos para el tratamiento de enfermedades fibróticas

Also Published As

Publication number Publication date
PL3442580T3 (pl) 2021-04-06
US10130613B2 (en) 2018-11-20
HUE052886T2 (hu) 2021-05-28
EP3777855A1 (en) 2021-02-17
DK3777855T3 (da) 2023-01-09
AU2017249602A1 (en) 2018-10-18
EA202191466A1 (ru) 2021-12-31
EP3442580A1 (en) 2019-02-20
IL262052B (en) 2021-12-01
CA3019399A1 (en) 2017-10-19
ES2928408T3 (es) 2022-11-17
HRP20201954T1 (hr) 2021-02-05
US20180092886A1 (en) 2018-04-05
US20170290812A1 (en) 2017-10-12
EP3777855B1 (en) 2022-10-19
US10130612B2 (en) 2018-11-20
SG11201808402RA (en) 2018-10-30
US10117856B2 (en) 2018-11-06
US20180092884A1 (en) 2018-04-05
WO2017178172A1 (en) 2017-10-19
US20200316031A1 (en) 2020-10-08
PT3777855T (pt) 2023-01-10
ES2839453T3 (es) 2021-07-05
CN109069648B (zh) 2022-01-14
US20190000813A1 (en) 2019-01-03
JP6894923B2 (ja) 2021-06-30
SI3442580T1 (sl) 2021-01-29
PT3442580T (pt) 2020-12-23
CN109069648A (zh) 2018-12-21
MD3442580T2 (ro) 2021-04-30
KR20180129934A (ko) 2018-12-05
US20180085354A1 (en) 2018-03-29
LT3442580T (lt) 2020-12-28
ZA201807389B (en) 2020-01-29
KR102431257B1 (ko) 2022-08-10
JP2019513761A (ja) 2019-05-30
BR112018069684A2 (pt) 2019-01-29
DK3442580T3 (da) 2020-12-21
US10117855B2 (en) 2018-11-06
US20180092885A1 (en) 2018-04-05
SG10202004425XA (en) 2020-06-29
MY195437A (en) 2023-01-20
EP3777854B1 (en) 2022-07-20
AU2017249602B2 (en) 2022-06-16
EP3442580B1 (en) 2020-09-23
EP3777854A1 (en) 2021-02-17
EA201892298A1 (ru) 2019-04-30
ES2935185T3 (es) 2023-03-02
PH12018502142A1 (en) 2019-07-29
US11103484B2 (en) 2021-08-31
IL262052A (en) 2018-11-29
MX2018012287A (es) 2019-02-07

Similar Documents

Publication Publication Date Title
HUE060671T2 (hu) Eljárás fibrotikus betegségek kezelésére
ZA202006746B (en) Methods of treatment
HK1246179A1 (zh) 治療視網膜疾病的方法
GB201701673D0 (en) Methods of well treatment
ZA201807084B (en) Methods of treatment of cholestatic diseases
EP3630101A4 (en) DISEASE TREATMENT METHODS
IL274541A (en) A method for treating diseases of the digestive tract using Tradifitant
HK1258994A1 (zh) 用於疾病治療的方法
HK1247818A1 (zh) 治療疾病的方法
PT3192524T (pt) Preparação de hgf adequada para tratamento de distúrbios neurológicos
ZA201807390B (en) Methods of treatment for cholestatic and fibrotic diseases
GB201416832D0 (en) Methods of treatment
GB201412578D0 (en) Treatment of neurological diseases
GB201602802D0 (en) Method of treatment
SG11202005850VA (en) Methods of treatment of hypertrigl yceridemia
HK1243937A1 (zh) 治療疾病的方法
HK1246679A1 (zh) 絲蟲病的治療
EP3193935A4 (en) Treatment of fibrotic diseases
GB201512139D0 (en) Methods of treatment
GB201801249D0 (en) Methods of treatment
GB201621398D0 (en) Treatment of emt-associated disease
GB201602640D0 (en) Treatment of fibrotic disorders
GB201602641D0 (en) Treatment of fibrotic disorders
GB201504413D0 (en) Treatment of disease
GB201414023D0 (en) Treatment of autoimmune diseases