AR086586A1 - Forma cristalina de ciclosporina a, metodos de preparacion y metodos para utilizar la misma - Google Patents
Forma cristalina de ciclosporina a, metodos de preparacion y metodos para utilizar la mismaInfo
- Publication number
- AR086586A1 AR086586A1 ARP120101878A ARP120101878A AR086586A1 AR 086586 A1 AR086586 A1 AR 086586A1 AR P120101878 A ARP120101878 A AR P120101878A AR P120101878 A ARP120101878 A AR P120101878A AR 086586 A1 AR086586 A1 AR 086586A1
- Authority
- AR
- Argentina
- Prior art keywords
- methods
- cyclosporin
- crystalline form
- same
- preparation
- Prior art date
Links
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 4
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
- 108010036949 Cyclosporine Proteins 0.000 title abstract 4
- 229960001265 ciclosporin Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 208000022873 Ocular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490887P | 2011-05-27 | 2011-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086586A1 true AR086586A1 (es) | 2014-01-08 |
Family
ID=46178866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101878A AR086586A1 (es) | 2011-05-27 | 2012-05-28 | Forma cristalina de ciclosporina a, metodos de preparacion y metodos para utilizar la misma |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US8772245B2 (https=) |
| EP (2) | EP3521302A1 (https=) |
| JP (1) | JP6163482B2 (https=) |
| KR (1) | KR102079402B1 (https=) |
| CN (1) | CN103649108B (https=) |
| AR (1) | AR086586A1 (https=) |
| AU (4) | AU2012262513B2 (https=) |
| BR (1) | BR112013030554B1 (https=) |
| CA (1) | CA2836946C (https=) |
| CL (1) | CL2013003400A1 (https=) |
| IL (2) | IL229475A0 (https=) |
| MX (1) | MX362271B (https=) |
| MY (1) | MY180581A (https=) |
| RU (1) | RU2602062C2 (https=) |
| SG (1) | SG10201607344UA (https=) |
| TW (1) | TWI554522B (https=) |
| UA (1) | UA113627C2 (https=) |
| WO (1) | WO2012166610A1 (https=) |
| ZA (1) | ZA201308665B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6363506B2 (ja) * | 2011-11-15 | 2018-07-25 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | シクロスポリンａ２型の懸濁剤 |
| ES2666191T3 (es) * | 2011-11-15 | 2018-05-03 | Allergan, Inc. | Un proceso para la cristalización de la forma 2 de la ciclosporina A |
| RU2630970C2 (ru) * | 2011-11-15 | 2017-09-15 | Аллерган, Инк. | Автоклавируемые взвеси циклоспорина а формы 2 |
| RU2639393C2 (ru) * | 2011-11-15 | 2017-12-21 | Аллерган, Инк. | Состав пролонгированного действия циклоспорина формы 2 |
| JP2015519368A (ja) | 2012-06-01 | 2015-07-09 | アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | シクロスポリンａ類似体 |
| GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
| US10524661B2 (en) * | 2013-06-12 | 2020-01-07 | Proactive Live, Inc. | Sleep monitoring and stimulation |
| MY196111A (en) | 2014-07-18 | 2023-03-15 | Allergan Inc | Suspension Compositions of Cyclosporin a for Subconjunctival and Periocular Injection |
| US9914755B2 (en) | 2015-01-08 | 2018-03-13 | Allergan, Inc. | Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized |
| US10443292B2 (en) * | 2016-04-25 | 2019-10-15 | Magna Closures, Inc. | Non-contact obstacle detection system for motor vehicles |
| KR102287226B1 (ko) | 2017-05-17 | 2021-08-11 | 주식회사 유유제약 | 신규한 펩타이드 및 이를 유효성분으로 포함하는 안구질환 치료용 약학 조성물 |
| US11613558B2 (en) | 2018-11-14 | 2023-03-28 | Yuyu Pharma, Inc. | Peptides and pharmaceutical compositions for treating eye diseases |
| WO2021224901A2 (en) * | 2021-08-20 | 2021-11-11 | Sun Pharmaceutical Industries Limited | Stable cyclosporine ophthalmic formulation and manufacturing process thereof |
| EP4585605A1 (en) * | 2022-10-20 | 2025-07-16 | Chugai Seiyaku Kabushiki Kaisha | Method for producing cyclic peptide crystals |
| KR20250160895A (ko) | 2023-03-20 | 2025-11-14 | 추가이 세이야쿠 가부시키가이샤 | 고리형 펩타이드의 공결정을 제조하는 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU203564B (en) * | 1987-12-21 | 1991-08-28 | Sandoz Ag | Process for producing new orthorombos cyclosporin without solvatation |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| US6656504B1 (en) * | 1999-09-09 | 2003-12-02 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
| CA2686234A1 (en) * | 2007-05-04 | 2008-11-13 | Allergan, Inc. | Use of cyclosporines in the treatment of patients with intraocular lenses |
| JP2011508776A (ja) * | 2008-01-04 | 2011-03-17 | アルコン ファーマシューティカルズ リミテッド | 安定な水性シクロスポリン組成物 |
-
2012
- 2012-05-25 CA CA2836946A patent/CA2836946C/en active Active
- 2012-05-25 RU RU2013155033/04A patent/RU2602062C2/ru active
- 2012-05-25 BR BR112013030554-1A patent/BR112013030554B1/pt not_active IP Right Cessation
- 2012-05-25 KR KR1020137034444A patent/KR102079402B1/ko not_active Expired - Fee Related
- 2012-05-25 US US13/480,710 patent/US8772245B2/en active Active
- 2012-05-25 MY MYPI2013004226A patent/MY180581A/en unknown
- 2012-05-25 JP JP2014512145A patent/JP6163482B2/ja not_active Expired - Fee Related
- 2012-05-25 CN CN201280033382.7A patent/CN103649108B/zh active Active
- 2012-05-25 EP EP18211911.5A patent/EP3521302A1/en not_active Withdrawn
- 2012-05-25 WO PCT/US2012/039611 patent/WO2012166610A1/en not_active Ceased
- 2012-05-25 UA UAA201314231A patent/UA113627C2/uk unknown
- 2012-05-25 EP EP12724525.6A patent/EP2714720B1/en not_active Not-in-force
- 2012-05-25 MX MX2013013855A patent/MX362271B/es active IP Right Grant
- 2012-05-25 AU AU2012262513A patent/AU2012262513B2/en not_active Ceased
- 2012-05-25 SG SG10201607344UA patent/SG10201607344UA/en unknown
- 2012-05-28 TW TW101119051A patent/TWI554522B/zh not_active IP Right Cessation
- 2012-05-28 AR ARP120101878A patent/AR086586A1/es not_active Application Discontinuation
-
2013
- 2013-11-17 IL IL229475A patent/IL229475A0/en unknown
- 2013-11-19 ZA ZA2013/08665A patent/ZA201308665B/en unknown
- 2013-11-26 CL CL2013003400A patent/CL2013003400A1/es unknown
-
2014
- 2014-07-02 US US14/322,475 patent/US9206228B2/en active Active
-
2015
- 2015-12-07 US US14/961,132 patent/US20160083432A1/en not_active Abandoned
-
2016
- 2016-06-15 AU AU2016203990A patent/AU2016203990A1/en not_active Abandoned
-
2017
- 2017-11-21 AU AU2017265008A patent/AU2017265008A1/en not_active Abandoned
-
2019
- 2019-06-14 AU AU2019204192A patent/AU2019204192B2/en not_active Ceased
-
2021
- 2021-01-13 US US17/148,315 patent/US20210269484A1/en not_active Abandoned
-
2022
- 2022-01-27 IL IL290158A patent/IL290158A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |