TWI554522B - 新穎環孢靈ａ晶形、其製備方法及其使用方法 - Google Patents

新穎環孢靈ａ晶形、其製備方法及其使用方法 Download PDF

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Publication number
TWI554522B
TWI554522B TW101119051A TW101119051A TWI554522B TW I554522 B TWI554522 B TW I554522B TW 101119051 A TW101119051 A TW 101119051A TW 101119051 A TW101119051 A TW 101119051A TW I554522 B TWI554522 B TW I554522B
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TW
Taiwan
Prior art keywords
eye
crystal form
cyclosporin
csa
crystal
Prior art date
Application number
TW101119051A
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English (en)
Chinese (zh)
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TW201311730A (zh
Inventor
奇歐瑪斯 卡拉米
理查Ｓ 葛拉漢
安奴拉達Ｖ 高爾
史考特Ｗ 史密斯
吳凱
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歐樂根公司
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46178866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI554522(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 歐樂根公司 filed Critical 歐樂根公司
Publication of TW201311730A publication Critical patent/TW201311730A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
TW101119051A 2011-05-27 2012-05-28 新穎環孢靈ａ晶形、其製備方法及其使用方法 TWI554522B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161490887P 2011-05-27 2011-05-27

Publications (2)

Publication Number Publication Date
TW201311730A TW201311730A (zh) 2013-03-16
TWI554522B true TWI554522B (zh) 2016-10-21

Family

ID=46178866

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101119051A TWI554522B (zh) 2011-05-27 2012-05-28 新穎環孢靈ａ晶形、其製備方法及其使用方法

Country Status (19)

Country Link
US (4) US8772245B2 (https=)
EP (2) EP2714720B1 (https=)
JP (1) JP6163482B2 (https=)
KR (1) KR102079402B1 (https=)
CN (1) CN103649108B (https=)
AR (1) AR086586A1 (https=)
AU (4) AU2012262513B2 (https=)
BR (1) BR112013030554B1 (https=)
CA (1) CA2836946C (https=)
CL (1) CL2013003400A1 (https=)
IL (2) IL229475A0 (https=)
MX (1) MX362271B (https=)
MY (1) MY180581A (https=)
RU (1) RU2602062C2 (https=)
SG (1) SG10201607344UA (https=)
TW (1) TWI554522B (https=)
UA (1) UA113627C2 (https=)
WO (1) WO2012166610A1 (https=)
ZA (1) ZA201308665B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3701939A1 (en) * 2011-11-15 2020-09-02 Allergan, Inc. Suspensions of cyclosporin a form 2
WO2013074610A1 (en) 2011-11-15 2013-05-23 Allergan, Inc. Sustained action formulation of cyclosporin form 2
BR112014011768A2 (pt) * 2011-11-15 2017-05-09 Allergan Inc forma 2 de ciclosporina a e método de produção da mesma
US20130123194A1 (en) * 2011-11-15 2013-05-16 Allergan, Inc. Autoclavable suspensions of cyclosporin a form 2
JP2015519368A (ja) 2012-06-01 2015-07-09 アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ類似体
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
US10524661B2 (en) * 2013-06-12 2020-01-07 Proactive Live, Inc. Sleep monitoring and stimulation
RU2713953C2 (ru) 2014-07-18 2020-02-11 Аллерган, Инк. Суспензионные составы циклоспорина а для субконъюнктивального и периокулярного введения
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
US10443292B2 (en) * 2016-04-25 2019-10-15 Magna Closures, Inc. Non-contact obstacle detection system for motor vehicles
RU2766160C2 (ru) 2017-05-17 2022-02-08 Юю Фарма, Инк. Новый пептид и фармацевтический состав для лечения глазного заболевания, содержащий пептид в качестве активного фармацевтического ингредиента
US11613558B2 (en) 2018-11-14 2023-03-28 Yuyu Pharma, Inc. Peptides and pharmaceutical compositions for treating eye diseases
MX2024002234A (es) * 2021-08-20 2024-04-17 Sun Pharmaceutical Ind Ltd Formulación oftalmológica de ciclosporina estable y proceso de fabricación de esta.
TW202430537A (zh) 2022-10-20 2024-08-01 日商中外製藥股份有限公司 環狀胜肽的結晶的製造方法
WO2024195801A1 (ja) 2023-03-20 2024-09-26 中外製薬株式会社 環状ペプチドの共結晶の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
RU2009144186A (ru) 2007-05-04 2011-06-10 Аллерган, Инк. (Us) Применение циклоспоринов при лечении пациентов с интраокулярными линзами
US20090286718A1 (en) * 2008-01-04 2009-11-19 Sirion Therapeutics, Inc. Stable Aqueous Cyclosporin Compositions

Also Published As

Publication number Publication date
KR20140047054A (ko) 2014-04-21
US9206228B2 (en) 2015-12-08
AU2012262513B2 (en) 2016-03-17
US20210269484A1 (en) 2021-09-02
UA113627C2 (xx) 2017-02-27
US20160083432A1 (en) 2016-03-24
WO2012166610A1 (en) 2012-12-06
EP3521302A1 (en) 2019-08-07
SG10201607344UA (en) 2016-10-28
CA2836946A1 (en) 2012-12-06
CL2013003400A1 (es) 2014-08-18
CN103649108A (zh) 2014-03-19
JP2014515372A (ja) 2014-06-30
EP2714720A1 (en) 2014-04-09
RU2602062C2 (ru) 2016-11-10
TW201311730A (zh) 2013-03-16
AU2016203990A1 (en) 2016-06-30
BR112013030554B1 (pt) 2020-12-15
AU2012262513A1 (en) 2013-12-12
AU2019204192B2 (en) 2021-02-04
MY180581A (en) 2020-12-02
MX362271B (es) 2019-01-10
MX2013013855A (es) 2014-02-17
BR112013030554A2 (pt) 2016-09-06
ZA201308665B (en) 2014-07-30
JP6163482B2 (ja) 2017-07-12
KR102079402B1 (ko) 2020-02-19
NZ719272A (en) 2017-10-27
CA2836946C (en) 2017-08-01
AR086586A1 (es) 2014-01-08
US20130023482A1 (en) 2013-01-24
EP2714720B1 (en) 2018-12-26
IL229475A0 (en) 2014-01-30
US20140315827A1 (en) 2014-10-23
RU2013155033A (ru) 2015-07-20
IL290158A (en) 2022-03-01
US8772245B2 (en) 2014-07-08
AU2017265008A1 (en) 2017-12-07
AU2019204192A1 (en) 2019-07-04
NZ618213A (en) 2016-05-27
CN103649108B (zh) 2017-03-29

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