AR086259A1 - Procesos para la preparacion de inhibidores del virus de la hepatitis c - Google Patents
Procesos para la preparacion de inhibidores del virus de la hepatitis cInfo
- Publication number
- AR086259A1 AR086259A1 ARP120101561A ARP120101561A AR086259A1 AR 086259 A1 AR086259 A1 AR 086259A1 AR P120101561 A ARP120101561 A AR P120101561A AR P120101561 A ARP120101561 A AR P120101561A AR 086259 A1 AR086259 A1 AR 086259A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- formula
- compound
- hepatitis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procesos sintéticos útiles en la preparación de compuestos de fórmula (1) que son útiles como inhibidores de la proteasa NS3 del virus de la hepatitis C (VHC) y tienen aplicación en el tratamiento de afecciones causadas por el VHC.Reivindicación 1: Un proceso para preparar un compuesto de fórmula (1), en la que: A y E son independientemente un enlace directo; R1 es -NH(alquilo C1-8); R2 es alquilo C1-8; R3 se selecciona independientemente entre el grupo que consiste en alquilo C1-8, alquil C1-8(cicloalquilo C3-8) y alquil C1-8(cicloalquilo C3-8) sustituido; o cada uno de R4 y R5 se selecciona independientemente entre el grupo que consiste en H, alquilo C1-8, cicloalquilo C3-8, alquil C1-8(cicloalquilo C3-8) y alquil C1-8(cicloalquilo C3-8) sustituido, o R4 y R5 pueden tomarse juntos para formar un cicloalquilo C3-8; R6 y R7 son independientemente metilo; comprendiendo el proceso: hacer reaccionar un compuesto de fórmula (2), en la que A, E, R1, R2, R3, R4, R5, R6 y R7 son como se han definido anteriormente, con un agente de oxidación seleccionado entre el grupo que consiste en KMnO4, NaMnO4, K2FeO4, V2O5, RuO2, NaNO2, CrO3, K2CrO4, K2Cr2O7, H5PV2Mo10O4, peróxidos y PhI(OAc)2, en presencia de al menos un catalizador para producir un compuesto de fórmula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161482592P | 2011-05-04 | 2011-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086259A1 true AR086259A1 (es) | 2013-12-04 |
Family
ID=47108028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101561A AR086259A1 (es) | 2011-05-04 | 2012-05-03 | Procesos para la preparacion de inhibidores del virus de la hepatitis c |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20140044759A1 (es) |
| EP (2) | EP2704576A4 (es) |
| JP (2) | JP2014515764A (es) |
| KR (2) | KR20140030169A (es) |
| CN (2) | CN103476260A (es) |
| AR (1) | AR086259A1 (es) |
| AU (2) | AU2012250811A1 (es) |
| BR (2) | BR112013027652A2 (es) |
| CA (2) | CA2833887A1 (es) |
| CO (1) | CO6801768A2 (es) |
| IL (1) | IL228601A0 (es) |
| MX (2) | MX2013012771A (es) |
| RU (2) | RU2013153588A (es) |
| SG (1) | SG194711A1 (es) |
| TW (1) | TW201247668A (es) |
| WO (2) | WO2012151283A1 (es) |
| ZA (1) | ZA201308011B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011014487A1 (en) | 2009-07-30 | 2011-02-03 | Merck Sharp & Dohme Corp. | Hepatitis c virus ns3 protease inhibitors |
| DK3010891T3 (da) * | 2013-06-19 | 2019-06-24 | Aicuris Anti Infective Cures Gmbh | Amorf letermovir og faste farmaceutiske formuleringer deraf til oral indgivelse |
| MX2019010452A (es) * | 2017-03-07 | 2019-10-15 | Orion Corp | Fabricacion de un producto farmaceutico cristalino. |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR044694A1 (es) * | 2003-06-17 | 2005-09-21 | Schering Corp | Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo |
| AR056805A1 (es) * | 2005-11-14 | 2007-10-24 | Schering Corp | Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados |
| US8420122B2 (en) * | 2006-04-28 | 2013-04-16 | Merck Sharp & Dohme Corp. | Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same |
| CN101495095B (zh) * | 2006-04-28 | 2013-05-29 | 默沙东公司 | 通过受控的沉淀来沉淀和分离6,6-二甲基-3-氮杂-双环[3.1.0]己烷-酰胺化合物的方法和含有其的药学制剂 |
| JP4955779B2 (ja) * | 2006-12-20 | 2012-06-20 | シェーリング コーポレイション | （１ｒ，２ｓ，５ｓ）−ｎ−［（１ｓ）−３−アミノ−１−（シクロブチルメチル）−２，３−ジオキソプロピル］−３−［（２ｓ）−２−［［［（１，１−ジメチルエチル）アミノ］カルボニル］−アミノ］−３，３−ジメチル−１−オキソブチル］−６，６−ジメチル−３−アザビシクロ［３．１．０］ヘキサン−２−カルボキサミドを調製するための方法 |
| BRPI0806945A2 (pt) * | 2007-02-01 | 2014-05-06 | Tibotec Pharm Ltd | Formas polimórficas de um inibidor macrocíclico de hcv |
| JP4803074B2 (ja) * | 2007-03-06 | 2011-10-26 | 日産化学工業株式会社 | アルコール酸化触媒およびその合成方法 |
| CA2699280A1 (en) * | 2007-09-14 | 2009-03-26 | Schering Corporation | Method of treating hepatitis c patients |
| DE102009000662A1 (de) * | 2009-02-06 | 2010-08-12 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Aldehyden und Ketonen aus primären und sekundären Alkoholen |
-
2012
- 2012-05-02 MX MX2013012771A patent/MX2013012771A/es unknown
- 2012-05-02 RU RU2013153588/15A patent/RU2013153588A/ru unknown
- 2012-05-02 RU RU2013153533/04A patent/RU2013153533A/ru not_active Application Discontinuation
- 2012-05-02 CA CA2833887A patent/CA2833887A1/en not_active Abandoned
- 2012-05-02 CN CN2012800200308A patent/CN103476260A/zh active Pending
- 2012-05-02 AU AU2012250811A patent/AU2012250811A1/en not_active Abandoned
- 2012-05-02 WO PCT/US2012/036131 patent/WO2012151283A1/en active Application Filing
- 2012-05-02 BR BR112013027652A patent/BR112013027652A2/pt not_active IP Right Cessation
- 2012-05-02 JP JP2014509384A patent/JP2014515764A/ja active Pending
- 2012-05-02 EP EP12779558.1A patent/EP2704576A4/en not_active Withdrawn
- 2012-05-02 WO PCT/US2012/036112 patent/WO2012151271A1/en active Application Filing
- 2012-05-02 JP JP2014509388A patent/JP2014513127A/ja active Pending
- 2012-05-02 CN CN201280020032.7A patent/CN103501608A/zh active Pending
- 2012-05-02 US US14/114,357 patent/US20140044759A1/en not_active Abandoned
- 2012-05-02 CA CA2832869A patent/CA2832869A1/en not_active Abandoned
- 2012-05-02 KR KR1020137028709A patent/KR20140030169A/ko not_active Application Discontinuation
- 2012-05-02 MX MX2013012773A patent/MX2013012773A/es unknown
- 2012-05-02 AU AU2012250799A patent/AU2012250799A1/en not_active Abandoned
- 2012-05-02 BR BR112013027642A patent/BR112013027642A2/pt not_active IP Right Cessation
- 2012-05-02 KR KR1020137028743A patent/KR20140022855A/ko not_active Application Discontinuation
- 2012-05-02 SG SG2013080643A patent/SG194711A1/en unknown
- 2012-05-02 EP EP12779536.7A patent/EP2704570A4/en not_active Withdrawn
- 2012-05-02 US US14/114,251 patent/US20140058116A1/en not_active Abandoned
- 2012-05-03 AR ARP120101561A patent/AR086259A1/es not_active Application Discontinuation
- 2012-05-04 TW TW101116053A patent/TW201247668A/zh unknown
-
2013
- 2013-09-29 IL IL228601A patent/IL228601A0/en unknown
- 2013-10-29 ZA ZA2013/08011A patent/ZA201308011B/en unknown
- 2013-11-01 CO CO13259875A patent/CO6801768A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2704576A4 (en) | 2014-12-10 |
| NZ617300A (en) | 2015-06-26 |
| US20140044759A1 (en) | 2014-02-13 |
| CA2833887A1 (en) | 2012-11-08 |
| ZA201308011B (en) | 2015-05-27 |
| SG194711A1 (en) | 2013-12-30 |
| EP2704570A1 (en) | 2014-03-12 |
| JP2014513127A (ja) | 2014-05-29 |
| MX2013012771A (es) | 2013-11-21 |
| AU2012250811A1 (en) | 2013-12-19 |
| CO6801768A2 (es) | 2013-11-29 |
| CN103476260A (zh) | 2013-12-25 |
| WO2012151283A1 (en) | 2012-11-08 |
| TW201247668A (en) | 2012-12-01 |
| BR112013027652A2 (pt) | 2016-07-26 |
| CN103501608A (zh) | 2014-01-08 |
| RU2013153533A (ru) | 2015-06-10 |
| EP2704570A4 (en) | 2015-02-18 |
| AU2012250799A1 (en) | 2013-10-10 |
| IL228601A0 (en) | 2013-12-31 |
| CA2832869A1 (en) | 2012-11-08 |
| KR20140022855A (ko) | 2014-02-25 |
| KR20140030169A (ko) | 2014-03-11 |
| EP2704576A1 (en) | 2014-03-12 |
| BR112013027642A2 (pt) | 2016-07-26 |
| JP2014515764A (ja) | 2014-07-03 |
| RU2013153588A (ru) | 2015-06-10 |
| MX2013012773A (es) | 2013-11-21 |
| US20140058116A1 (en) | 2014-02-27 |
| WO2012151271A1 (en) | 2012-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |