AR085990A1 - Derivados de 1-oxido de 3-hidroxiisotiazol utiles en el tratamiento de la diabetes y composiciones farmaceuticas que los contienen - Google Patents
Derivados de 1-oxido de 3-hidroxiisotiazol utiles en el tratamiento de la diabetes y composiciones farmaceuticas que los contienenInfo
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- AR085990A1 AR085990A1 ARP120101245A ARP120101245A AR085990A1 AR 085990 A1 AR085990 A1 AR 085990A1 AR P120101245 A ARP120101245 A AR P120101245A AR P120101245 A ARP120101245 A AR P120101245A AR 085990 A1 AR085990 A1 AR 085990A1
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- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/425—Thiazoles
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- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/47—Quinolines; Isoquinolines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
Reivindicación 1: Un compuesto de la fórmula (1) (caracterizado porque p es un entero de 0 hasta 4; j es un entero de 0 hasta 2; k es 0 ó 1; un anillo A es un grupo arilo C6-14 que está opcionalmente sustituido con 1 hasta 5 sustituyentes L, un grupo heterocíclico de 3 hasta 14 miembros que está opcionalmente sustituido con 1 hasta 5 sustituyentes L, un grupo cicloalquilo C5-7 que está opcionalmente sustituido con 1 hasta 5 sustituyentes L, un grupo cicloalquenilo C5-7 que está opcionalmente sustituido con 1 hasta 5 sustituyentes L, un grupo espirocíclico de 6 hasta 14 miembros que está opcionalmente sustituido con 1 hasta 5 sustituyentes L, o un grupo 2-fenilamino-2-oxoacetilo que está opcionalmente sustituido con 1 hasta 5 sustituyentes L; un anillo B es grupo arilo C6-14 o grupo heteroarilo de 5 hasta 14 miembros; X es un átomo de oxígeno o -NR7-; R1s son independientemente un grupo seleccionado arbitrariamente de un átomo de halógeno, un grupo alquilo C1-6 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo alquenilo C2-6 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo alquinilo C2-6 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo alcoxi C1-6 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI y un grupo ciano; R2 es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C1-6, un grupo alquenilo C2-6, un grupo alquinilo C2-6, un grupo alcoxi C1-6 o un grupo ciano; R3, R4, R5, R6, y R7 son independientemente un átomo de hidrógeno o un grupo alquilo C1-6; los sustituyentes L son independientemente un grupo seleccionados arbitrariamente de un átomo de halógeno, -OH, un grupo oxo, un grupo ciano, un grupo alquilo C1-10 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo alquenilo C2-10 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo alquinilo C2-10 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo alcoxi C1-10 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo alqueniloxi C2-10 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo alquiniloxi C2-10 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI, un grupo arilo que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo heterocíclico que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo aralquilo que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo heteroarilalquilo que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo alquilo heterocíclico no aromático que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo ariloxi que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo heteroariloxi que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo oxi heterocíclico no aromático que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo aralquiloxi que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, un grupo heteroarilalquiloxi que está opcionalmente sustituido con 1 hasta 5 sustituyentes RII, -SH, -SF5, un grupo: -S(O)iRa (i es un entero de 0 hasta 2), un grupo: -NRbRc y un grupo espiropiperidinilmetilo sustituido; Ra es un grupo seleccionados arbitrariamente de un grupo alquilo C1-6 y un grupo alquilo C1-6 halogenado; Rb y Rc son independientemente un grupo seleccionados arbitrariamente de un átomo de hidrógeno, un grupo alquilo C1-6, un grupo alquilo C1-6 halogenado, un grupo alquenilo C2-6, un grupo alquinilo C2-6, un grupo alcanoilo C2-7 (el grupo alcanoilo está opcionalmente sustituido con -OH o un grupo alcoxi C1-6), un grupo alquilsulfonilo C1-6, un grupo arilcarbonilo y un grupo carbonilo heterocíclico, o Rb y Rc forman opcionalmente en conjunto con un átomo de nitrógeno al cual Rb y Rc se unen, un grupo cíclico de 3 hasta 8 miembros, donde en el grupo cíclico, uno o dos átomos de carbono están opcionalmente sustituidos con un átomo seleccionados arbitrariamente de un átomo de oxígeno, un átomo de azufre, y un átomo de nitrógeno (el átomo de nitrógeno está opcionalmente sustituido con un grupo alquilo C1-6 que está opcionalmente sustituido con 1 hasta 5 sustituyentes RI) o con un grupo carbonilo, y el grupo cíclico está opcionalmente sustituido además con 1 hasta 5 sustituyentes RII; los sustituyentes RI antes mencionado son el mismo como o diferente uno del otro y son cada uno un grupo seleccionado arbitrariamente de un átomo de halógeno, -OH, un grupo ciano, un grupo alcoxi C1-6 (el grupo alcoxi C1-6 está opcionalmente sustituido con 1 hasta 5 átomos de halógeno, 1 hasta 5 -OH, 1 hasta 5 grupos alcoxi C1-6, 1 hasta 5 grupos arilo (el grupo arilo opcionalmente está arbitrariamente sustituido con 1 hasta 3 átomos de halógeno), 1 hasta 5 grupos heterocíclico (el grupo heterocíclico opcionalmente está arbitrariamente sustituido con 1 hasta 3 grupos alquilo C1-6 o 1 hasta 3 grupos oxo), 1 hasta 5 grupos: -S(O)iRa (i es un entero de 0 hasta 2), 1 hasta 5 grupos: -SO2NRdRe, 1 hasta 5 grupos: -CONRdRe o 1 hasta 5 grupos: -NRb1Rc1), un grupo: -NRb1Rc1 y un grupo oxi heterocíclico (el grupo oxi heterocíclico opcionalmente está arbitrariamente sustituido con 1 hasta 3 grupos alquilo C1-6 o 1 hasta 3 grupos oxo); los sustituyentes RII antes mencionado son el mismo como o diferente uno del otro y son cada uno un grupo seleccionado arbitrariamente del sustituyente RI antes mencionado, un grupo alquilo C1-6 (el grupo alquilo C1-6 opcionalmente está arbitrariamente sustituido con 1 hasta 5 átomos de halógeno, 1 hasta 5 -OH, 1 hasta 5 grupos alcoxi C1-6, 1 hasta 5 grupos: -S(O)iRa (i es un entero de 0 hasta 2), 1 hasta 5 grupos: -SO2NRdRe, 1 hasta 5 grupos: -CONRdRe o 1 hasta 5 grupos: -NRb1Rc1), un grupo alquenilo C2-6, un grupo alcanoilo C2-7, un grupo aralquiloxi, un grupo heterocíclico (el grupo heterocíclico opcionalmente está arbitrariamente sustituido con 1 hasta 3 grupos alquilo C1-6 o 1 hasta 3 grupos oxo), un grupo carbonilo heterocíclico (el grupo carbonilo heterocíclico opcionalmente está arbitrariamente sustituido con 1 hasta 3 grupos alquilo C1-6 o 1 hasta 3 grupos oxo), un grupo: -S(O)iRa (i es un entero de 0 hasta 2), un grupo: -CONRdRe1, y un grupo: -CONRdRe1; Rd y Re son independientemente un átomo de hidrógeno o un grupo alquilo C1-6 (el grupo alquilo C1-6 está opcionalmente sustituido con 1 hasta 5 átomos de halógeno, 1 hasta 5 -OH o 1 hasta 5 grupos alcoxilo C1-6); Re1 es un grupo alquilo C1-6 (el grupo alquilo C1-6 está opcionalmente sustituido con 1 hasta 5 -OH, 1 hasta 5 grupos alcoxilo C1-6, 1 hasta 5 grupos arilo (el grupo arilo está opcionalmente sustituido con 1 hasta 3 átomos de halógeno), 1 hasta 5 grupos heterocíclico (el grupo heterocíclico está opcionalmente sustituido con 1 hasta 3 grupo alquilo C1-6 o 1 hasta 3 grupos oxo), 1 hasta 5 grupos -S(O)iRa (i es un entero de 0 hasta 2), 1 hasta 5 grupos -SO2NRdRe, 1 hasta 5 grupos -CONRdRe o 1 hasta 5 grupos -NRb1Rc1; Rb1 y Rc1 son independientemente un grupo seleccionados arbitrariamente de un átomo de hidrógeno, un grupo alquilo C1-6, un grupo alcanoilo C2-7 y un grupo alquilsulfonilo C1-6, o Rb1 y Rc1 forman opcionalmente en conjunto con un átomo de nitrógeno al cual Rb1 y Rc1 se unen, un grupo cíclico de 3 hasta 8 miembros, donde en el grupo cíclico, uno o dos átomos de carbono están opcionalmente sustituidos con un átomo seleccionado arbitrariamente de un átomo de oxígeno, un átomo de azufre, y un átomo de nitrógeno (el átomo de nitrógeno está opcionalmente sustituido con un grupo alquilo C1-6) o con un grupo carbonilo; en un grupo isotiazolilo, en un caso donde el anillo B se une en la posición 5, R2 se une en la posición 4, y en un caso donde el anillo B se une en la posición 4, R2 se une en la posición 5), o una sal farmacéuticamente aceptable del compuesto, o un solvato farmacéuticamente aceptable de la sal o un solvato farmacéuticamente aceptable del compuesto.
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Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012046869A1 (ja) | 2010-10-08 | 2012-04-12 | 持田製薬株式会社 | 環状アミド誘導体 |
MX2013012520A (es) * | 2011-04-27 | 2014-02-03 | Mochida Pharm Co Ltd | Derivado novedoso de 1-oxido de 3-hidroxi isotiazol. |
JPWO2012147516A1 (ja) * | 2011-04-28 | 2014-07-28 | 持田製薬株式会社 | 環状アミド誘導体 |
AU2013290100A1 (en) | 2012-07-11 | 2015-01-29 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
US20160200734A1 (en) * | 2013-08-23 | 2016-07-14 | Xinshan Kang | Carboxylic acid compounds in treatment of diabetes mellitus |
CA2995325A1 (en) * | 2015-08-12 | 2017-02-16 | Mochida Pharmaceutical Co., Ltd. | Isothiazole derivative |
CN106124550A (zh) * | 2016-05-16 | 2016-11-16 | 山东省分析测试中心 | 一种基于氢核磁共振快速测定维格列汀纯度的方法 |
PL3752501T3 (pl) | 2018-02-13 | 2023-08-21 | Gilead Sciences, Inc. | Inhibitory pd-1/pd-l1 |
JP7242702B2 (ja) | 2018-04-19 | 2023-03-20 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ,インク. | Gpr119アゴニスト |
UY39222A (es) | 2020-05-19 | 2021-11-30 | Kallyope Inc | Activadores de la ampk |
EP4172162A4 (en) | 2020-06-26 | 2024-08-07 | Kallyope Inc | AMPK ACTIVATORS |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3562283A (en) | 1968-07-01 | 1971-02-09 | Rohm & Haas | 1-oxo and 1,1-dioxo-3-isothiazolones |
US3801575A (en) | 1972-01-24 | 1974-04-02 | Rohm & Haas | 3-hydroxyisothiazoles |
AU711927B2 (en) | 1996-02-27 | 1999-10-21 | Sankyo Company Limited | Isoxazole derivatives |
JP2000204077A (ja) | 1999-01-13 | 2000-07-25 | Warner Lambert Co | ジアリ―ルアミン |
US6545030B1 (en) | 1999-01-13 | 2003-04-08 | Warner-Lambert Company | 1-heterocycle substituted diarylamines |
WO2002088989A1 (en) | 2001-04-30 | 2002-11-07 | Goraya Tanvir Y | Adaptive dynamic personal modeling system and method |
AU2003263814A1 (en) | 2002-07-26 | 2004-02-16 | Bayer Pharmaceuticals Corporation | Indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives and their use as antidiabetics |
WO2004022551A1 (ja) | 2002-09-06 | 2004-03-18 | Takeda Pharmaceutical Company Limited | フランまたはチオフェン誘導体およびその医薬用途 |
WO2004041266A1 (ja) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | 受容体機能調節剤 |
JP4594611B2 (ja) * | 2002-11-08 | 2010-12-08 | 武田薬品工業株式会社 | 受容体機能調節剤 |
WO2004069798A1 (ja) | 2003-02-10 | 2004-08-19 | Banyu Pharmaceutical Co.,Ltd. | ピペリジン誘導体を有効成分とするメラニン凝集ホルモン受容体拮抗剤 |
US7820837B2 (en) | 2003-05-30 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Condensed ring compound |
WO2005035551A2 (en) | 2003-10-08 | 2005-04-21 | Incyte Corporation | Inhibitors of proteins that bind phosphorylated molecules |
WO2005051890A1 (en) | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
RU2006126978A (ru) | 2003-12-25 | 2008-01-27 | Такеда Фармасьютикал Компани Лимитед (Jp) | Производные 3-(4-бензилоксифенил)пропановой кислоты |
EP1737809B1 (en) | 2004-02-27 | 2013-09-18 | Amgen, Inc | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
US20060173183A1 (en) | 2004-12-31 | 2006-08-03 | Alantos Pharmaceuticals, Inc., | Multicyclic bis-amide MMP inhibitors |
AU2006291234A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
TW200815377A (en) | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
PT2248812E (pt) | 2006-06-27 | 2014-03-12 | Takeda Pharmaceutical | Compostos cíclicos fundidos como moduladores do receptor gpr40 |
AU2007293028B2 (en) | 2006-09-07 | 2012-05-31 | Amgen Inc. | Heterocyclic GPR40 modulators |
WO2008033931A1 (en) | 2006-09-13 | 2008-03-20 | The Institutes For Pharmaceutical Discovery, Llc | Para-xylylene carboxylic acids and isothiazolones useful as protein tyrosine phosphatases (ptps) in particular ptp-ib |
CA2668713C (en) | 2006-12-01 | 2015-09-08 | Banyu Pharmaceutical Co., Ltd. | Novel phenyl-isoxazol-3-ol derivative |
JP2010524932A (ja) | 2007-04-16 | 2010-07-22 | アムジエン・インコーポレーテツド | 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸gpr40調節物質 |
JP5427784B2 (ja) | 2007-09-21 | 2014-02-26 | サノフイ | (カルボキシルアルキレン−フェニル)−フェニル−オキサルアミド、その製造方法、及び薬剤としてのその使用 |
BRPI0818253A2 (pt) | 2007-10-10 | 2015-04-07 | Amgen Inc | Moduladores de gpr40 bifenil substituídos |
JP2011016722A (ja) | 2007-10-23 | 2011-01-27 | Astellas Pharma Inc | チアゾリジンジオン化合物 |
TW200932219A (en) | 2007-10-24 | 2009-08-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
CL2008003153A1 (es) | 2007-10-26 | 2009-07-24 | Japan Tobacco Inc | Compuestos espiro condensados, agonistas de gpr40: composicion farmaceutica que comprende a uno de los compuestos; y el uso de los compuestos en la preparacion de medicamentos para el tratamiento de la diabetes, hiperglicemia, alteracion de tolerancia a la glucosa en ayuna, entre otras. |
AU2009220163B2 (en) | 2008-03-06 | 2011-10-06 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
EP2264017A4 (en) * | 2008-04-04 | 2011-07-27 | Takeda Pharmaceutical | Heterocyclic derivative and its use |
JPWO2009147990A1 (ja) | 2008-06-02 | 2011-10-27 | Msd株式会社 | 新規イソオキサゾール誘導体 |
KR20110027657A (ko) | 2008-06-25 | 2011-03-16 | 다이이찌 산쿄 가부시키가이샤 | 카르복실산 화합물 |
WO2010040077A1 (en) | 2008-10-03 | 2010-04-08 | Osmetech Technology Inc. | Cyp2c9*8 alleles correlate with decreased warfarin metabolism and increased warfarin sensitivity |
CA2739888C (en) | 2008-10-15 | 2013-11-19 | Amgen Inc. | Spirocyclic gpr40 modulators |
JP2012515781A (ja) | 2009-01-23 | 2012-07-12 | シェーリング コーポレイション | 架橋および縮合複素環式抗糖尿病化合物 |
EP2393810A1 (en) | 2009-02-05 | 2011-12-14 | Schering Corporation | Phthalazine-containing antidiabetic compounds |
CN102421739A (zh) | 2009-04-22 | 2012-04-18 | 安斯泰来制药株式会社 | 羧酸化合物 |
JP2012136438A (ja) | 2009-04-22 | 2012-07-19 | Astellas Pharma Inc | テトラゾール化合物 |
EP2440541A1 (en) | 2009-06-09 | 2012-04-18 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
WO2011037771A1 (en) | 2009-09-23 | 2011-03-31 | Merck Sharp & Dohme Corp. | Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism |
AR078522A1 (es) | 2009-10-15 | 2011-11-16 | Lilly Co Eli | Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis |
EP2495238A4 (en) | 2009-10-30 | 2013-04-24 | Mochida Pharm Co Ltd | NEW 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE |
BR112012012644A2 (pt) | 2009-11-25 | 2016-07-12 | Mitsubishi Electric Corp | controlador de freio |
AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
MX2012007474A (es) * | 2009-12-25 | 2012-08-01 | Mochida Pharm Co Ltd | Derivados de 3-hidroxi-5-arilisotiazol novedosos. |
CN101781268B (zh) | 2010-02-25 | 2012-05-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 异噻唑酮取代的苯二羧酸衍生物及其用于制备β-分泌酶抑制剂的用途 |
WO2012046869A1 (ja) * | 2010-10-08 | 2012-04-12 | 持田製薬株式会社 | 環状アミド誘導体 |
MX2013012520A (es) * | 2011-04-27 | 2014-02-03 | Mochida Pharm Co Ltd | Derivado novedoso de 1-oxido de 3-hidroxi isotiazol. |
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MX2013012520A (es) | 2014-02-03 |
EP2703394A1 (en) | 2014-03-05 |
NZ617409A (en) | 2015-08-28 |
JP5420796B2 (ja) | 2014-02-19 |
CA2834417A1 (en) | 2012-11-01 |
JP5905437B2 (ja) | 2016-04-20 |
WO2012147518A1 (ja) | 2012-11-01 |
IL229064A0 (en) | 2013-12-31 |
AU2012248629A1 (en) | 2013-11-28 |
US20120277150A1 (en) | 2012-11-01 |
US8557766B2 (en) | 2013-10-15 |
BR112013027883A2 (pt) | 2017-08-08 |
US20130217690A1 (en) | 2013-08-22 |
RU2013152631A (ru) | 2015-06-10 |
KR20140021624A (ko) | 2014-02-20 |
EP2703394A4 (en) | 2014-11-05 |
US8765752B2 (en) | 2014-07-01 |
JP2014122211A (ja) | 2014-07-03 |
TW201247636A (en) | 2012-12-01 |
US8629102B2 (en) | 2014-01-14 |
CN105153146A (zh) | 2015-12-16 |
US20130210721A1 (en) | 2013-08-15 |
CN103517898A (zh) | 2014-01-15 |
CN103517898B (zh) | 2015-09-30 |
JPWO2012147518A1 (ja) | 2014-07-28 |
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