AR085507A1 - Animales modificados geneticamente y metodos para su obtencion - Google Patents
Animales modificados geneticamente y metodos para su obtencionInfo
- Publication number
- AR085507A1 AR085507A1 ARP120100647A ARP120100647A AR085507A1 AR 085507 A1 AR085507 A1 AR 085507A1 AR P120100647 A ARP120100647 A AR P120100647A AR P120100647 A ARP120100647 A AR P120100647A AR 085507 A1 AR085507 A1 AR 085507A1
- Authority
- AR
- Argentina
- Prior art keywords
- methods
- obtaining
- genetically modified
- modified animals
- talen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 238000010459 TALEN Methods 0.000 abstract 2
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 101710163270 Nuclease Proteins 0.000 abstract 1
- 108010073062 Transcription Activator-Like Effectors Proteins 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161446651P | 2011-02-25 | 2011-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR085507A1 true AR085507A1 (es) | 2013-10-09 |
Family
ID=46719944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100647A AR085507A1 (es) | 2011-02-25 | 2012-02-28 | Animales modificados geneticamente y metodos para su obtencion |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20120222143A1 (enExample) |
| EP (3) | EP3450563A1 (enExample) |
| JP (4) | JP2014509195A (enExample) |
| KR (1) | KR20140046408A (enExample) |
| CN (4) | CN107090470B (enExample) |
| AR (1) | AR085507A1 (enExample) |
| AU (3) | AU2012222144B2 (enExample) |
| BR (1) | BR112013021785A8 (enExample) |
| CA (1) | CA2828239C (enExample) |
| CL (1) | CL2013002438A1 (enExample) |
| EA (1) | EA201391234A1 (enExample) |
| MX (2) | MX363013B (enExample) |
| WO (1) | WO2012116274A2 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011053982A2 (en) | 2009-11-02 | 2011-05-05 | University Of Washington | Therapeutic nuclease compositions and methods |
| BR112012020257A8 (pt) * | 2010-02-11 | 2018-02-14 | Recombinetics Inc | métodos e aparelhos para produzir artiodátilos transgênicos |
| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| US9528124B2 (en) * | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| JP6063450B2 (ja) | 2011-04-29 | 2017-01-18 | ユニヴァーシティ オブ ワシントン | 治療用ヌクレアーゼ組成物および方法 |
| US8497124B2 (en) * | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| US9179935B2 (en) * | 2012-01-13 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Mechanical biomarkers for oocyte and embryo viability |
| AU2013204327B2 (en) * | 2012-04-20 | 2016-09-01 | Aviagen | Cell transfection method |
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| AR091482A1 (es) * | 2012-06-21 | 2015-02-04 | Recombinetics Inc | Celulas modificadas geneticamente y metodos par su obtencion |
| WO2013191769A1 (en) * | 2012-06-22 | 2013-12-27 | Mayo Foundation For Medical Education And Research | Genome editing |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
| GB201216564D0 (en) * | 2012-09-17 | 2012-10-31 | Univ Edinburgh | Genetically edited animal |
| CA2889502A1 (en) * | 2012-10-30 | 2014-05-08 | Recombinetics, Inc. | Control of sexual maturation in animals |
| BR122019025681B1 (pt) * | 2012-11-01 | 2023-04-18 | Factor Bioscience Inc | Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula |
| CN102964431B (zh) * | 2012-12-03 | 2014-05-07 | 中国农业科学院北京畜牧兽医研究所 | 一对特异识别肌肉生长抑制素基因的多肽及其编码基因和应用 |
| US9708589B2 (en) | 2012-12-18 | 2017-07-18 | Monsanto Technology Llc | Compositions and methods for custom site-specific DNA recombinases |
| WO2014110552A1 (en) * | 2013-01-14 | 2014-07-17 | Recombinetics, Inc. | Hornless livestock |
| US10793867B2 (en) | 2013-03-15 | 2020-10-06 | Monsanto Technology, Llc | Methods for targeted transgene-integration using custom site-specific DNA recombinases |
| US11039586B2 (en) | 2013-03-15 | 2021-06-22 | Monsanto Technology Llc | Creation and transmission of megaloci |
| EP2994531B1 (en) * | 2013-05-10 | 2018-03-28 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| US11077144B2 (en) | 2013-05-13 | 2021-08-03 | Cellectis | CD19 specific chimeric antigen receptor and uses thereof |
| US20140359795A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetic techniques for making animals with sortable sperm |
| US20140359796A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetically sterile animals |
| US9982277B2 (en) | 2013-06-11 | 2018-05-29 | The Regents Of The University Of California | Methods and compositions for target DNA modification |
| PL3033184T3 (pl) | 2013-08-16 | 2021-09-20 | Massachusetts Institute Of Technology | Selektywne dostarczanie materiału do komórek |
| WO2015035034A1 (en) * | 2013-09-04 | 2015-03-12 | Mice With Horns, Llc | Materials and methods for correcting recessive mutations in animals |
| DE102013111099B4 (de) | 2013-10-08 | 2023-11-30 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA |
| EP3060682B1 (en) | 2013-10-25 | 2023-08-30 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| HRP20192080T1 (hr) | 2013-10-31 | 2020-02-07 | Resolve Therapeutics, Llc | Terapeutske fuzije nukleaza-albumine i postupci |
| KR101554166B1 (ko) | 2013-11-13 | 2015-09-22 | 건국대학교 산학협력단 | 재조합 활성 유전자 2 유전자 적중벡터, 그 벡터가 도입된 면역세포 결핍 형질전환 미니 복제돼지 생산과 그 제조방법 및 활용 |
| KR101566498B1 (ko) | 2013-11-13 | 2015-11-06 | 건국대학교 산학협력단 | 인터루킨 2 수용체 감마 유전자 적중벡터, 그 벡터가 도입된 면역세포 결핍 형질전환 미니 복제돼지 생산과 그 제조방법 및 활용 |
| DK3492593T3 (da) * | 2013-11-13 | 2021-11-08 | Childrens Medical Center | Nukleasemedieret regulering af genekspression |
| CN103952424B (zh) * | 2014-04-23 | 2017-01-11 | 尹熙俊 | 生产mstn双侧基因敲除的双肌性状体细胞克隆猪的方法 |
| MX2016014066A (es) * | 2014-04-28 | 2017-05-03 | Recombinetics Inc | Edicion de genes multiples en cerdos. |
| CN103952405B (zh) * | 2014-05-13 | 2016-02-10 | 扬州大学 | 一种山羊mstn基因定点修饰系统及其应用 |
| MX2017003770A (es) | 2014-09-23 | 2017-06-30 | Aggenetics Inc | Materiales y metodos para la produccion de animales con pelo corto. |
| JP7523203B2 (ja) | 2014-10-31 | 2024-07-26 | マサチューセッツ インスティテュート オブ テクノロジー | 生体分子の免疫細胞への送達 |
| HK1242917A1 (zh) * | 2014-11-12 | 2018-07-06 | 重组股份有限公司 | 肿瘤抑制基因的杂合修饰和1型神经纤维瘤病的猪模型 |
| CN104450673B (zh) * | 2014-11-14 | 2017-07-21 | 中国农业大学 | 一种y染色体修饰方法及其应用 |
| CN104388560B (zh) * | 2014-11-14 | 2017-04-12 | 中国农业大学 | 一种y染色体标记方法及其应用 |
| US20180105834A1 (en) * | 2014-11-27 | 2018-04-19 | Institute Of Animal Sciences, Chinese Academy Of Agrigultural Sciences | A method of site-directed insertion to h11 locus in pigs by using site-directed cutting system |
| KR101724805B1 (ko) * | 2014-12-16 | 2017-04-11 | 서울대학교산학협력단 | 유전자 적중 물질을 이용한 조류 유전자 편집방법 및 유전자 편집 조류 |
| EP3245294A4 (en) | 2015-01-12 | 2018-05-30 | Massachusetts Institute of Technology | Gene editing through microfluidic delivery |
| EP3316898A4 (en) * | 2015-06-30 | 2019-02-27 | Regents of the University of Minnesota | HUMANIZED SKELETON MUSCLE |
| JP6925984B2 (ja) | 2015-07-09 | 2021-08-25 | マサチューセッツ インスティテュート オブ テクノロジー | 無核細胞への物質の送達 |
| US11339408B2 (en) | 2015-08-20 | 2022-05-24 | Applied Stemcell, Inc. | Nuclease with enhanced efficiency of genome editing |
| WO2017041051A1 (en) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| EP3673732A3 (en) | 2015-10-27 | 2020-07-29 | Recombinetics, Inc. | Engineering of humanized car t-cells and platelets by genetic complementation |
| ES3040945T3 (en) * | 2015-10-28 | 2025-11-06 | Vertex Pharma | Materials and methods for treatment of duchenne muscular dystrophy |
| CN105543257A (zh) * | 2016-01-18 | 2016-05-04 | 安徽农业大学 | 一种pAPN基因定点修饰猪 |
| KR20230110373A (ko) * | 2016-06-14 | 2023-07-21 | 리전츠 오브 더 유니버스티 오브 미네소타 | 질환을 치료하기 위한 유전적으로 변형된 세포, 조직,및 장기 |
| CA3028074A1 (en) * | 2016-06-16 | 2018-12-20 | Oslo Universitetssykehus Hf | Improved gene editing |
| DK3478830T3 (da) | 2016-07-01 | 2024-05-21 | Resolve Therapeutics Llc | Optimerede binucleasefusioner og metoder |
| US20180084767A1 (en) | 2016-09-21 | 2018-03-29 | Recombinetics, Inc. | Animal models for cardiomyopathy |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| WO2018144087A2 (en) * | 2016-11-03 | 2018-08-09 | Temple University-Of The Commonwealth System Of Higher Education | Dna plasmids for the fast generation of homologous recombination vectors for cell line development |
| CA3057159A1 (en) | 2017-04-12 | 2018-10-18 | Magenta Therapeutics Inc. | Aryl hydrocarbon receptor antagonists and uses thereof |
| CN108728477B (zh) * | 2017-04-24 | 2022-02-22 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| EP3665279B1 (en) * | 2017-08-09 | 2023-07-19 | Benson Hill, Inc. | Compositions and methods for modifying genomes |
| US20190045761A1 (en) | 2017-08-11 | 2019-02-14 | Recombinetics, Inc. | Inducible disease models methods of making them and use in tissue complementation |
| JP7374091B2 (ja) | 2017-08-22 | 2023-11-06 | サナバイオ, エルエルシー | 可溶性インターフェロン受容体およびその使用 |
| CN111542597A (zh) | 2017-10-31 | 2020-08-14 | 美真达治疗公司 | 用于扩增造血干细胞和祖细胞的组合物和方法 |
| WO2019113375A2 (en) | 2017-12-06 | 2019-06-13 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
| CN108949830B (zh) * | 2018-08-03 | 2021-11-26 | 福州大学 | 一种在鱼类中实现基因组编辑、精确定点基因敲入的方法 |
| CN111793654B (zh) * | 2019-04-08 | 2022-05-24 | 中国农业大学 | 一种提高CRISPR/Cas9介导的双等位基因突变效率的方法及其应用 |
| WO2020210237A1 (en) * | 2019-04-08 | 2020-10-15 | Dna Twopointo Inc. | Transposition of nucleic acid constructs into eukaryotic genomes with a transposase from amyelois |
| WO2021087406A1 (en) | 2019-11-01 | 2021-05-06 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progentor cells |
| AU2021263754A1 (en) | 2020-04-27 | 2022-12-01 | Ensoma, Inc. | Methods and compositions for transducing hematopoietic stem and progenitor cells in vivo |
| EP4308694A1 (en) | 2021-03-16 | 2024-01-24 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
| GB202118058D0 (en) | 2021-12-14 | 2022-01-26 | Univ Warwick | Methods to increase yields in crops |
| US20250129385A1 (en) * | 2022-02-01 | 2025-04-24 | Abs Global, Inc. | Gene-editing methods for embryonic stem cells |
| GB2621813A (en) | 2022-06-30 | 2024-02-28 | Univ Newcastle | Preventing disease recurrence in Mitochondrial replacement therapy |
| WO2024036106A1 (en) * | 2022-08-08 | 2024-02-15 | The Board Of Trustees Of The Leland Stanford Junior University | Embryo microglia complementation for in vivo microglia manipulation and production of a non-human animal model for validation of gene function and therapeutic screening |
| GB202314578D0 (en) | 2023-09-22 | 2023-11-08 | Univ Manchester | Methods of producing homoplasmic modified plants or parts thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4888274A (en) | 1985-09-18 | 1989-12-19 | Yale University | RecA nucleoprotein filament and methods |
| US5731178A (en) | 1990-03-21 | 1998-03-24 | Behringwerke Aktiengesellschaft | Attachment-elements for stimulation of eukaryotic expression systems |
| US5510473A (en) | 1990-11-09 | 1996-04-23 | The United States Of American As Represented By The Secretary Of Health And Human Services | Cloning of the recA gene from thermus aquaticus YT-1 |
| US5763240A (en) | 1992-04-24 | 1998-06-09 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
| US5674992A (en) | 1992-08-28 | 1997-10-07 | Cornell Research Foundation, Inc. | CDNA encoding a recA homolog in eukaryotes |
| US5610053A (en) | 1993-04-07 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells |
| US5731411A (en) | 1993-07-12 | 1998-03-24 | The United States Of America As Represented By The Department Of Health And Human Services | Promotion of homologous DNA pairing by RecA-derived peptides |
| EP0821070A1 (en) | 1996-07-22 | 1998-01-28 | Carelli, Claude Marcel Henri | Pit-1 gene polymorphism and trait selection in animals |
| US6037525A (en) | 1996-08-01 | 2000-03-14 | North Carolina State University | Method for reducing expression variability of transgenes in plant cells |
| US5948653A (en) | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
| DE69841139D1 (de) * | 1997-07-14 | 2009-10-22 | Univ Liege | Mutationen im myostatingen steigern muskelmasse in säugetieren |
| US6541684B1 (en) | 1998-02-13 | 2003-04-01 | Trustees Of Columbia University In The City Of New York | Nucleotide sequences encoding maize RAD51 |
| US6388169B1 (en) | 1998-06-08 | 2002-05-14 | Pioneer Hi-Bred International, Inc. | Maize orthologues of bacterial RecA proteins |
| US6774213B1 (en) | 1998-07-24 | 2004-08-10 | Alberto I. Roca | Mutants of MAW motifs of RecA protein homologs, methods of making them, and their uses |
| US6632672B2 (en) | 1998-08-19 | 2003-10-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for genomic modification |
| GB2365445A (en) | 1998-10-12 | 2002-02-20 | Geron Bio Med Ltd | Porcine occcytes with improved developmental competence |
| WO2000023606A1 (en) | 1998-10-22 | 2000-04-27 | Medical College Of Georgia Institute, Inc. | Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors |
| US6720478B1 (en) | 1999-05-05 | 2004-04-13 | Pioneer Hi-Bred International, Inc. | RAD51-like polynucleotide and uses thereof |
| IL146296A0 (en) * | 1999-05-06 | 2002-07-25 | Stem Cell Sciences Pty Ltd | Cell reprogramming |
| AU1100201A (en) | 1999-10-28 | 2001-05-08 | Board Of Trustees Of The Leland Stanford Junior University | Methods of in vivo gene transfer using a sleeping beauty transposon system |
| US6686515B1 (en) | 1999-11-23 | 2004-02-03 | Maxygen, Inc. | Homologous recombination in plants |
| ATE490338T1 (de) | 2000-02-18 | 2010-12-15 | Univ Leland Stanford Junior | Veränderte rekombinasen zur modifizierung des genoms |
| DK1311661T3 (da) | 2000-08-14 | 2012-11-26 | Us Gov Health & Human Serv | Forøget homolog rekombination medieret ved lambda-rekombinationsproteiner |
| AU2002324941A1 (en) | 2001-09-07 | 2003-03-24 | The Regents Of The University Of California | Method of generating a transgenic livestock animal |
| US20030232410A1 (en) * | 2002-03-21 | 2003-12-18 | Monika Liljedahl | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| US7176007B2 (en) | 2002-12-12 | 2007-02-13 | Wisconsin Alumni Research Foundation | RecA mutants |
| CA2512110A1 (en) | 2002-12-31 | 2004-07-22 | Mmi Genomics, Inc. | Compositions, methods, and systems for inferring bovine breed |
| US20040203158A1 (en) | 2003-01-15 | 2004-10-14 | Hackett Perry B. | Transposon-insulator element delivery systems |
| US7985739B2 (en) | 2003-06-04 | 2011-07-26 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced sleeping beauty transposon system and methods for using the same |
| CA2543786A1 (en) | 2003-10-24 | 2005-05-06 | Mmi Genomics, Inc. | Methods and systems for inferring traits to manage non-beef livestock |
| CA2563064A1 (en) * | 2004-04-22 | 2005-11-10 | Kirin Beer Kabushiki Kaisha | Transgenic animals and uses thereof |
| ES2679282T3 (es) * | 2004-10-22 | 2018-08-23 | Revivicor Inc. | Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena |
| CA2667414C (en) * | 2006-11-13 | 2015-12-29 | Sangamo Biosciences, Inc. | Methods and compositions for modification of the human glucocorticoid receptor locus |
| WO2010008562A2 (en) | 2008-07-16 | 2010-01-21 | Recombinetics | Methods and materials for producing transgenic animals |
| US20100105140A1 (en) | 2008-07-16 | 2010-04-29 | Fahrenkrug Scott C | Plaice dna transposon system |
| KR20160015400A (ko) * | 2008-08-22 | 2016-02-12 | 상가모 바이오사이언스 인코포레이티드 | 표적화된 단일가닥 분할 및 표적화된 통합을 위한 방법 및 조성물 |
| US20110023158A1 (en) * | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Bovine genome editing with zinc finger nucleases |
| US20110023140A1 (en) | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Rabbit genome editing with zinc finger nucleases |
| EP2206723A1 (en) * | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| US20120149115A1 (en) * | 2009-06-11 | 2012-06-14 | Snu R&Db Foundation | Targeted genomic rearrangements using site-specific nucleases |
| JP2013500018A (ja) * | 2009-07-24 | 2013-01-07 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | ゲノム編集のための方法 |
| NZ598457A (en) | 2009-08-03 | 2014-06-27 | Recombinetics Inc | Methods and compositions for targeted gene modification |
| KR20170125406A (ko) * | 2009-08-11 | 2017-11-14 | 상가모 테라퓨틱스, 인코포레이티드 | 표적화 변형에 대한 동형접합성 유기체 |
| CA2783351C (en) | 2009-12-10 | 2021-09-07 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| BR112012020257A8 (pt) | 2010-02-11 | 2018-02-14 | Recombinetics Inc | métodos e aparelhos para produzir artiodátilos transgênicos |
| CA2798988C (en) * | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Tal-effector (tale) dna-binding polypeptides and uses thereof |
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2012
- 2012-02-24 EP EP18199895.6A patent/EP3450563A1/en not_active Withdrawn
- 2012-02-24 EP EP12749281.7A patent/EP2678434B1/en active Active
- 2012-02-24 CN CN201611151706.3A patent/CN107090470B/zh active Active
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- 2012-02-24 CA CA2828239A patent/CA2828239C/en active Active
- 2012-02-24 EP EP18204730.8A patent/EP3461898A1/en not_active Withdrawn
- 2012-02-24 CN CN201611152146.3A patent/CN107058383A/zh active Pending
- 2012-02-24 AU AU2012222144A patent/AU2012222144B2/en active Active
- 2012-02-24 BR BR112013021785A patent/BR112013021785A8/pt not_active Application Discontinuation
- 2012-02-24 EA EA201391234A patent/EA201391234A1/ru unknown
- 2012-02-24 WO PCT/US2012/026500 patent/WO2012116274A2/en not_active Ceased
- 2012-02-24 JP JP2013555596A patent/JP2014509195A/ja active Pending
- 2012-02-24 US US13/404,662 patent/US20120222143A1/en not_active Abandoned
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