AR093291A1 - Celulas con genes neuroendocrinos modificados - Google Patents

Celulas con genes neuroendocrinos modificados

Info

Publication number
AR093291A1
AR093291A1 ARP130103958A ARP130103958A AR093291A1 AR 093291 A1 AR093291 A1 AR 093291A1 AR P130103958 A ARP130103958 A AR P130103958A AR P130103958 A ARP130103958 A AR P130103958A AR 093291 A1 AR093291 A1 AR 093291A1
Authority
AR
Argentina
Prior art keywords
cells
modified
neuroendocrine
neuroendocrine genes
genes
Prior art date
Application number
ARP130103958A
Other languages
English (en)
Inventor
f carlson Daniel
C Fahrenkrug Scott
Lauth Xavier
Original Assignee
Recombinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recombinetics Inc filed Critical Recombinetics Inc
Publication of AR093291A1 publication Critical patent/AR093291A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8778—Swine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Células modificadas genéticamente con un genoma que comprende inactivación de un gen neuroendócrino selectivo para la maduración sexual y métodos de uso de las mismas y procesos para obtenerlas.
ARP130103958A 2012-10-30 2013-10-30 Celulas con genes neuroendocrinos modificados AR093291A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261720187P 2012-10-30 2012-10-30
US201361870510P 2013-08-27 2013-08-27

Publications (1)

Publication Number Publication Date
AR093291A1 true AR093291A1 (es) 2015-05-27

Family

ID=50548813

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130103958A AR093291A1 (es) 2012-10-30 2013-10-30 Celulas con genes neuroendocrinos modificados

Country Status (15)

Country Link
US (1) US20140123330A1 (es)
EP (1) EP2914714A4 (es)
JP (2) JP2015533284A (es)
KR (1) KR20150100651A (es)
CN (1) CN105073981A (es)
AP (1) AP2015008495A0 (es)
AR (1) AR093291A1 (es)
AU (1) AU2013337951B2 (es)
BR (1) BR112015009589A2 (es)
CA (1) CA2889502A1 (es)
MX (1) MX2015005255A (es)
NZ (1) NZ629578A (es)
PH (1) PH12015500957A1 (es)
RU (1) RU2015120467A (es)
WO (1) WO2014070887A1 (es)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10920242B2 (en) 2011-02-25 2021-02-16 Recombinetics, Inc. Non-meiotic allele introgression
AU2012333134B2 (en) 2011-07-22 2017-05-25 John Paul Guilinger Evaluation and improvement of nuclease cleavage specificity
GB201122458D0 (en) 2011-12-30 2012-02-08 Univ Wageningen Modified cascade ribonucleoproteins and uses thereof
DK2800811T3 (en) 2012-05-25 2017-07-17 Univ Vienna METHODS AND COMPOSITIONS FOR RNA DIRECTIVE TARGET DNA MODIFICATION AND FOR RNA DIRECTIVE MODULATION OF TRANSCRIPTION
WO2014089290A1 (en) 2012-12-06 2014-06-12 Sigma-Aldrich Co. Llc Crispr-based genome modification and regulation
NZ712727A (en) 2013-03-14 2017-05-26 Caribou Biosciences Inc Compositions and methods of nucleic acid-targeting nucleic acids
US20140359796A1 (en) * 2013-05-31 2014-12-04 Recombinetics, Inc. Genetically sterile animals
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9340800B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College Extended DNA-sensing GRNAS
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
AP2016009207A0 (en) 2013-10-25 2016-05-31 Livestock Improvement Corp Ltd Genetic markers and uses therefor
WO2015070083A1 (en) 2013-11-07 2015-05-14 Editas Medicine,Inc. CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS
US9068179B1 (en) 2013-12-12 2015-06-30 President And Fellows Of Harvard College Methods for correcting presenilin point mutations
CA2946881A1 (en) 2014-04-28 2015-11-05 Recombinetics, Inc. Multiplex gene editing in swine
AU2015298571B2 (en) 2014-07-30 2020-09-03 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
CA2968120A1 (en) 2014-12-18 2016-06-23 Pioneer Hi-Bred International, Inc. Improved molecular breeding methods
US11246299B2 (en) 2015-03-04 2022-02-15 Pormedtec Co., Ltd. Disease model pig exhibiting stable phenotype, and production method thereof
JP6837223B2 (ja) * 2015-03-17 2021-03-03 国立研究開発法人水産研究・教育機構 生物個体群の縮小方法
WO2017070632A2 (en) 2015-10-23 2017-04-27 President And Fellows Of Harvard College Nucleobase editors and uses thereof
JP2020511931A (ja) * 2016-06-16 2020-04-23 オスロ ウニヴェルスィテーツスィーケフース ハーエフＯｓｌｏ Ｕｎｉｖｅｒｓｉｔｅｔｓｓｙｋｅｈｕｓ Ｈｆ 改良された遺伝子編集
CA3032699A1 (en) 2016-08-03 2018-02-08 President And Fellows Of Harvard College Adenosine nucleobase editors and uses thereof
WO2018031683A1 (en) 2016-08-09 2018-02-15 President And Fellows Of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
US20180084767A1 (en) 2016-09-21 2018-03-29 Recombinetics, Inc. Animal models for cardiomyopathy
EP3526320A1 (en) 2016-10-14 2019-08-21 President and Fellows of Harvard College Aav delivery of nucleobase editors
GB201617559D0 (en) 2016-10-17 2016-11-30 University Court Of The University Of Edinburgh The Swine comprising modified cd163 and associated methods
US10745677B2 (en) 2016-12-23 2020-08-18 President And Fellows Of Harvard College Editing of CCR5 receptor gene to protect against HIV infection
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
KR102687373B1 (ko) 2017-03-23 2024-07-23 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
EP3658573A1 (en) 2017-07-28 2020-06-03 President and Fellows of Harvard College Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
WO2019139645A2 (en) 2017-08-30 2019-07-18 President And Fellows Of Harvard College High efficiency base editors comprising gam
CN111757937A (zh) 2017-10-16 2020-10-09 布罗德研究所股份有限公司 腺苷碱基编辑器的用途
CN108034675B (zh) * 2017-12-07 2020-10-30 北京市水产科学研究所 一种鲟鱼talen基因编辑方法
CN107974466B (zh) * 2017-12-07 2020-09-29 中国科学院水生生物研究所 一种鲟鱼CRISPR/Cas9基因编辑方法
CN107760722B (zh) * 2017-12-07 2020-11-06 中国科学院水生生物研究所 一种鲟鱼显微注射的方法及应用
JP2020146307A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146304A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146298A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146318A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146310A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146297A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146316A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146306A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146317A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146315A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146305A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146299A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146308A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146314A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146313A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146311A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146303A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146301A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146309A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146312A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146302A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
WO2020191249A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
CN110452995B (zh) * 2019-08-27 2021-06-15 浙江大学 影响嘉兴黑猪母猪繁殖性能的gpr54基因分子标记及其应用
WO2021102059A1 (en) * 2019-11-19 2021-05-27 Inscripta, Inc. Methods for increasing observed editing in bacteria
MX2022014008A (es) 2020-05-08 2023-02-09 Broad Inst Inc Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo.
CN111616830A (zh) * 2020-07-03 2020-09-04 宁夏大学 一种新型icr小鼠超数排卵方法
CN113025723B (zh) * 2021-01-08 2023-01-20 华中农业大学 一种提高绵羊产羔数的snp标记、检测方法及其应用
CN112790125B (zh) * 2021-01-22 2022-09-06 中国科学院水生生物研究所 一种玉兔百褶裙泰狮金鱼的创制方法
GB202118058D0 (en) 2021-12-14 2022-01-26 Univ Warwick Methods to increase yields in crops
GB2621813A (en) 2022-06-30 2024-02-28 Univ Newcastle Preventing disease recurrence in Mitochondrial replacement therapy
WO2024091883A2 (en) * 2022-10-24 2024-05-02 The Regents Of The University Of California Methods for sex-sorting insects

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0501882T3 (da) * 1991-03-01 2000-12-11 Merial Sas Fremgangsmåde til anti-LHRH immunoneutralisering af ikke-kastrerede husdyrhanner og peptider dertil
WO2003089590A2 (en) * 2002-04-16 2003-10-30 Vaxin, Inc. TRANSIENT AND/OR PERMANENT MODIFICATION OF SEXUAL BEHAVIOR AND/OR FERTILITY USING RECOMBINANT CHIMERIC GnRH
DE60327344D1 (de) * 2002-10-25 2009-06-04 Takeda Pharmaceutical Gpr54 'knock-out' säugetiere und screening-verfahren, die sie verwenden
WO2011011767A1 (en) * 2009-07-24 2011-01-27 Sigma-Aldrich Co. Method for genome editing
ES2550202T3 (es) * 2009-08-03 2015-11-05 Recombinetics, Inc. Métodos y composiciones para la modificación dirigida de genes
EP2464750A4 (en) * 2009-08-11 2013-10-02 Sangamo Biosciences Inc HOMOZYGOT ORGANIZATIONS INTENDED FOR TARGETED CHANGES
AU2010327998B2 (en) * 2009-12-10 2015-11-12 Iowa State University Research Foundation, Inc. TAL effector-mediated DNA modification
EA201391234A1 (ru) * 2011-02-25 2014-05-30 Рикомбинетикс, Инк. Генетически модифицированные животные и способы их получения
WO2014052693A2 (en) * 2012-09-29 2014-04-03 The Trustees Of The University Of Pennsylvania Veterinary composition and methods for non-surgical neutering and castration

Also Published As

Publication number Publication date
US20140123330A1 (en) 2014-05-01
MX2015005255A (es) 2015-10-29
AU2013337951B2 (en) 2019-10-03
CA2889502A1 (en) 2014-05-08
PH12015500957A1 (en) 2015-08-10
WO2014070887A1 (en) 2014-05-08
JP2019047794A (ja) 2019-03-28
AU2013337951A1 (en) 2015-06-11
KR20150100651A (ko) 2015-09-02
CN105073981A (zh) 2015-11-18
NZ629578A (en) 2017-06-30
JP2015533284A (ja) 2015-11-24
EP2914714A1 (en) 2015-09-09
BR112015009589A2 (pt) 2017-11-14
AP2015008495A0 (en) 2015-05-31
EP2914714A4 (en) 2016-09-21
RU2015120467A (ru) 2016-12-20

Similar Documents

Publication Publication Date Title
AR093291A1 (es) Celulas con genes neuroendocrinos modificados
AR091004A1 (es) Arn en horquilla corta bifuncional (bi-arnhc) especifico de mutaciones de nucleotidos individuales en k-ras
SG11201708681SA (en) Method for in vitro transcription using an immobilized restriction enzyme
CL2016002316A1 (es) Método para provocar un cambio genético en una célula vegetal, basado en someter dicha célula a un corte de adn y una gron modificada.
ES2690212T3 (es) Células estromales mesenquimales y usos relacionados con las mismas
CL2015001054A1 (es) Métodos de cultivo de microorganismos en condiciones mixotrópicas no axénicas.
EP4234703A3 (en) Genome engineering
AR122864A2 (es) Variantes de lipasa y polinucleótidos que las codifican
ECSP14005975A (es) Anticuerpos anti-PHF-tau y sus usos
MX348003B (es) Metodos y medios para modificar un genoma vegetal.
EP2986709A4 (en) Activating an alternative pathway for homology-directed repair to stimulate targeted gene correction and genome engineering
HK1199069A1 (en) Method and kit for dna typing of hla gene hla dna
UY35814A (es) ?lugares óptimos para la soja?.
GT201400221A (es) Compuestos de microarn y métodos de modulación de la actividad de mir-21
MX2018013810A (es) Composiciones y metodos para silenciar la expresion genetica.
UY34401A (es) Métodos para el tratamiento de hcv
AR085507A1 (es) Animales modificados geneticamente y metodos para su obtencion
UY34402A (es) Métodos para el tratamiento de hcv
EA201171018A1 (ru) Биореактор для культивирования клеток млекопитающих
DK3211082T3 (da) Mikrorna-forbindelser og fremgangsmåder til modulering af mir-21-aktivitet
GB2511600A (en) Methods for performing patterned chemistry
SG11201505965TA (en) Culture method for stable undifferentiated proliferation of pluripotent stem cells
UY34371A (es) Moléculas de ácido nucleico que se dirigen a rps6 y confieren resistencia a plagas de coleópteros.
DK2672807T3 (da) Fremgangsmåde og bioreaktor til dyrkning af mikroorganismer
UA115321C2 (uk) Спосіб та комплект для аналізу ahasl генів у рослин

Legal Events

Date Code Title Description
FB Suspension of granting procedure