AR075422A1 - Composicion farmaceutica que comprende linagliptina, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma - Google Patents

Composicion farmaceutica que comprende linagliptina, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma

Info

Publication number
AR075422A1
AR075422A1 ARP100100419A ARP100100419A AR075422A1 AR 075422 A1 AR075422 A1 AR 075422A1 AR P100100419 A ARP100100419 A AR P100100419A AR P100100419 A ARP100100419 A AR P100100419A AR 075422 A1 AR075422 A1 AR 075422A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical
prevent
reduce
pharmaceutical composition
treat
Prior art date
Application number
ARP100100419A
Other languages
English (en)
Inventor
Wolfram Eisenreich
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42115453&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR075422(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR075422A1 publication Critical patent/AR075422A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004Monosaccharides having only carbon, hydrogen and oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composiciones farmacéuticas de linagliptina, formas farmacéuticas, su preparacion, su uso y métodos para tratar trastornos metabolicos. Reivindicacion 1: Una composicion farmacéutica caracterizada porque comprende linagliptina como un primer ingrediente farmacéutico activo y uno o más excipientes. Reivindicacion 3: La composicion farmacéutica segun la reivindicacion 1, caracterizada porque el primer ingrediente activo tiene una distribucion de tamano de partícula de X90 < 200 mm. Reivindicacion 8: La composicion farmacéutica segun una o más de las reivindicaciones precedentes, caracterizada porque comprende: 0,5 - 25% de los uno o dos ingredientes activos; 40 - 88% de los uno o más diluyentes; 0,5 - 20% de los uno o más aglutinantes; y 0,5 - 20% de los uno o más disgregantes; donde los porcentajes están en peso de la composicion total. Reivindicacion 9: La composicion farmacéutica segun una o más de las reivindicaciones 1 a 8, caracterizada porque está en la forma de un granulado, una cápsula, un comprimido o un comprimido recubierto con película. Reivindicacion 11: La forma farmacéutica segun la reivindicacion 10, caracterizada porque es una forma farmacéutica solida, en particular una cápsula o un comprimido. Reivindicacion 12: La forma farmacéutica segun la reivindicacion 10 u 11, caracterizada porque comprende linagliptina como primer ingrediente farmacéutico activo en una cantidad de 0,1 a 30 mg. Reivindicacion 13: La forma farmacéutica segun la reivindicacion 10, 11 o 12, caracterizada porque comprende adicionalmente un derivado bencénico sustituido con glucopiranosilo de la formula (1) como se define en la reivindicacion 2, como segundo ingrediente farmacéutico activo en una cantidad de 0,5 a 100 mg. Reivindicacion 22: Uso de una composicion farmacéutica segun una de las reivindicaciones 1 a 9 caracterizado porque es para la fabricacion de un medicamento para: prevenir, reducir la progresion, retrasar o tratar un trastorno metabolico seleccionado del grupo que consiste en diabetes mellitus de tipo 1, diabetes mellitus de tipo 2, alteracion de la tolerancia a la glucosa, alteracion de la glucosa sanguínea en ayunas, hiperglucemia, hiperglucemia posprandial, sobrepeso, obesidad y síndrome metabolico; o mejorar el control glucémico y/o reducir la glucosa plasmática en ayunas, la glucosa plasmática posprandial y/o la hemoglobina glicosilada HbA1c; o prevenir, reducir, retrasar o invertir la progresion desde la alteracion de la tolerancia a la glucosa, la resistencia a la insulina y/o el síndrome metabolico hasta la diabetes mellitus de tipo 2; o prevenir, reducir la progresion, retrasar o tratar una afeccion o trastorno seleccionado del grupo de complicaciones de la diabetes mellitus, tales como cataratas y enfermedades micro- y macrovasculares, tales como nefropatía, retinopatía, neuropatía, isquemia tisular, arterioesclerosis, infarto de miocardio, ictus y enfermedad oclusiva de las arterias periféricas; o reducir el peso corporal o prevenir un aumento del peso corporal o facilitar una reduccion del peso corporal; o prevenir, reducir, retrasar o tratar la degeneracion de las células beta pancreáticas y/o el declive de la funcionalidad de las células beta pancreáticas, y/o mejorar y/o restablecer la funcionalidad de las células beta pancreáticas y/o restablecer la funcionalidad de la secrecion de insulina pancreática; o prevenir, reducir, retrasar o tratar enfermedades o trastornos atribuidos a una acumulacion anormal de grasa en el hígado; o mantener y/o mejorar la sensibilidad a la insulina y/o tratar o prevenir la hiperinsulinemia y/o la resistencia a la insulina; en un paciente que lo necesite.
ARP100100419A 2009-02-13 2010-02-12 Composicion farmaceutica que comprende linagliptina, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma AR075422A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15230609P 2009-02-13 2009-02-13

Publications (1)

Publication Number Publication Date
AR075422A1 true AR075422A1 (es) 2011-03-30

Family

ID=42115453

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100419A AR075422A1 (es) 2009-02-13 2010-02-12 Composicion farmaceutica que comprende linagliptina, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma

Country Status (31)

Country Link
US (3) US20100209506A1 (es)
EP (2) EP2395984B1 (es)
JP (1) JP5456795B2 (es)
KR (2) KR20110114658A (es)
CN (3) CN103751193B (es)
AP (1) AP2810A (es)
AR (1) AR075422A1 (es)
AU (1) AU2010212866B2 (es)
BR (1) BRPI1008556A2 (es)
CA (1) CA2752434C (es)
CL (1) CL2011001758A1 (es)
CO (1) CO6410287A2 (es)
DK (1) DK2395984T3 (es)
EA (1) EA023243B1 (es)
EC (1) ECSP11011276A (es)
ES (1) ES2606050T3 (es)
GE (1) GEP20135963B (es)
HU (1) HUE031088T2 (es)
IL (1) IL213721A0 (es)
MA (1) MA33045B1 (es)
MX (1) MX338712B (es)
MY (1) MY159630A (es)
NZ (1) NZ594022A (es)
PE (1) PE20120018A1 (es)
PL (1) PL2395984T3 (es)
SG (1) SG173036A1 (es)
TN (1) TN2011000414A1 (es)
TW (1) TWI483943B (es)
UA (1) UA103915C2 (es)
UY (1) UY32427A (es)
WO (1) WO2010092124A1 (es)

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