AR074003A2 - Planta transgenica o progenie de la misma y celula huesped - Google Patents
Planta transgenica o progenie de la misma y celula huespedInfo
- Publication number
- AR074003A2 AR074003A2 ARP090104180A ARP090104180A AR074003A2 AR 074003 A2 AR074003 A2 AR 074003A2 AR P090104180 A ARP090104180 A AR P090104180A AR P090104180 A ARP090104180 A AR P090104180A AR 074003 A2 AR074003 A2 AR 074003A2
- Authority
- AR
- Argentina
- Prior art keywords
- desaturases
- enzymes
- fungal
- progenie
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Fats And Perfumes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Edible Oils And Fats (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Métodos y composiciones que se relacionan con enzimas fungica desaturasas de hongos, que modulan la cantidad y ubicacion de los enlaces dobles en ácidos grasos poliinsaturados de cadena larga (LC-PUFA). En particular, se proveen métodos y composiciones para mejorar los perfiles de ácidos grasos omega-3 en productos y partes de plantas usando enzimas desaturasas y los ácidos nucleicos que codifican dichas enzimas. En realizaciones particulares, las enzimas desaturasas son 15-desaturasas fungicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38239102P | 2002-05-22 | 2002-05-22 | |
US45312503P | 2003-03-07 | 2003-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074003A2 true AR074003A2 (es) | 2010-12-15 |
Family
ID=29586955
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030101789A AR039851A1 (es) | 2002-05-22 | 2003-05-22 | Acido graso desaturasas de hongos y genes los mismos |
ARP090104180A AR074003A2 (es) | 2002-05-22 | 2009-10-29 | Planta transgenica o progenie de la misma y celula huesped |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030101789A AR039851A1 (es) | 2002-05-22 | 2003-05-22 | Acido graso desaturasas de hongos y genes los mismos |
Country Status (12)
Country | Link |
---|---|
US (2) | US7622632B2 (es) |
EP (1) | EP1549133B1 (es) |
JP (1) | JP4515904B2 (es) |
KR (1) | KR101138631B1 (es) |
AR (2) | AR039851A1 (es) |
AU (1) | AU2003245308B2 (es) |
BR (3) | BR122014000528B1 (es) |
CA (2) | CA2486559C (es) |
ES (1) | ES2542420T3 (es) |
HK (1) | HK1085615A1 (es) |
MX (1) | MXPA04011613A (es) |
WO (1) | WO2003099216A2 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
US7214491B2 (en) | 2003-05-07 | 2007-05-08 | E. I. Du Pont De Nemours And Company | Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts |
CA2881252C (en) * | 2003-08-21 | 2017-02-28 | Monsanto Technology Llc | Soybean oil having 5 to 50% sda and less than 10% gla |
AU2004290052B2 (en) | 2003-11-12 | 2008-12-04 | Corteva Agriscience Llc | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast |
US7504259B2 (en) | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
ATE516295T1 (de) * | 2004-01-20 | 2011-07-15 | Monsanto Technology Llc | Chimäre promotoren zur verwendung in pflanzen |
WO2005102310A1 (en) * | 2004-04-16 | 2005-11-03 | Monsanto Technology Llc | Expression of fatty acid desaturases in corn |
EP2357243B1 (en) | 2004-04-22 | 2018-12-12 | Commonwealth Scientific and Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
DK1756280T3 (en) | 2004-04-22 | 2015-02-02 | Commw Scient Ind Res Org | SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS |
US7256033B2 (en) | 2004-06-25 | 2007-08-14 | E. I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
AU2005304994B2 (en) * | 2004-11-04 | 2011-12-08 | Monsanto Technology Llc | High PUFA oil compositions |
US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
CA2630173C (en) | 2005-11-18 | 2018-01-09 | Commonwealth Scientific And Industrial Research Organisation | Feedstuffs for aquaculture comprising stearidonic acid |
US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
US20070254299A1 (en) * | 2006-05-01 | 2007-11-01 | Yadav Narendra S | Fungal delta 12 desaturase and delta 15 desaturase motifs |
CA2655544A1 (en) | 2006-06-22 | 2007-12-27 | Bioriginal Food & Science Corp. | Fatty acid hydroxylases and uses thereof |
AU2007272252B2 (en) * | 2006-07-11 | 2013-10-03 | Bioriginal Food & Science Corporation | Fatty acid desaturases and uses thereof |
MX2009000757A (es) * | 2006-07-19 | 2009-03-09 | Monsanto Technology Llc | Acido graso desaturasas de tetraselmis suecica. |
EP2059588A4 (en) | 2006-08-29 | 2010-07-28 | Commw Scient Ind Res Org | FATTY ACID SYNTHESIS |
US8389808B2 (en) | 2007-02-12 | 2013-03-05 | E.I. Du Pont De Nemours And Company | Production of arachidonic acid in oilseed plants |
CA2682177C (en) | 2007-03-28 | 2017-11-21 | Monsanto Technology Llc | Utility of snp markers associated with major soybean plant maturity and growth habit genomic regions |
CA2694661C (en) | 2007-07-31 | 2017-10-03 | Basf Plant Science Gmbh | Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms |
WO2009097403A1 (en) * | 2008-01-29 | 2009-08-06 | Monsanto Technology Llc | Methods of feeding pigs and products comprising beneficial fatty acids |
BRPI0908809A2 (pt) | 2008-02-15 | 2015-08-18 | Monsanto Technology Llc | Planta de soja e semente correspondente ao evento transgênico mon87769 e métodos para sua detecção |
AU2009286755B2 (en) * | 2008-08-26 | 2015-10-22 | Basf Plant Science Gmbh | Nucleic acids encoding desaturases and modified plant oil |
CN103756972B (zh) * | 2008-10-14 | 2019-05-10 | 孟山都技术公司 | 来自半片藻属的脂肪酸脱饱和酶的利用 |
CN113957105B (zh) | 2008-11-18 | 2024-11-01 | 联邦科学技术研究组织 | 产生ω-3脂肪酸的酶和方法 |
EP2370074B1 (en) | 2008-12-11 | 2015-09-30 | Olini Ltd. | Lipid composition for the treatment of skin problems in companion animals |
JP5759990B2 (ja) * | 2009-06-30 | 2015-08-05 | モンサント テクノロジー エルエルシー | オメガ3脂肪酸で補強されたナッツバター及び関連製品 |
US8372465B2 (en) | 2010-02-17 | 2013-02-12 | Bunge Oils, Inc. | Oil compositions of stearidonic acid |
ES2769448T3 (es) | 2012-04-12 | 2020-06-25 | Rothamsted Res Limited | Producción de ácidos grasos poliinsaturados omega-3 de cadena larga |
UA127917C2 (uk) | 2012-06-15 | 2024-02-14 | Коммонвелт Сайнтіфік Енд Індастріел Рісерч Організейшн | Рекомбінантна клітина brassica napus, яка містить довголанцюгові поліненасичені жирні кислоти, трансгенна рослина та насіння brassica napus, спосіб отримання екстрагованого ліпіду рослин, харчового продукту та етилового ефіру поліненасичених жирних кислот |
CN102776213B (zh) * | 2012-08-28 | 2014-07-30 | 江南大学 | 一种用于多不饱和脂肪酸生物合成的脱饱和酶ω3 Des |
GB201217524D0 (en) | 2012-10-01 | 2012-11-14 | Rothamsted Res Ltd | Recombinant organisms |
US9725399B2 (en) | 2013-12-18 | 2017-08-08 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising long chain polyunsaturated fatty acids |
KR102527795B1 (ko) | 2014-06-27 | 2023-05-02 | 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 | 도코사펜타에노산을 포함하는 지질 |
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US4792523A (en) | 1984-08-31 | 1988-12-20 | Cetus Corporation | 3'Expression enhancing fragments and method |
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DE3642829A1 (de) | 1986-08-23 | 1988-05-05 | Hoechst Ag | Resistenzgen gegen phosphinothricin |
ATE87032T1 (de) | 1986-12-05 | 1993-04-15 | Ciba Geigy Ag | Verbessertes verfahren zur transformation von pflanzlichen protoplasten. |
US5011770A (en) | 1987-09-04 | 1991-04-30 | Molecular Devices, Inc. | DNA detection method |
IE63225B1 (en) | 1988-09-13 | 1995-04-05 | Efamol Holdings | Use of fatty acids in the treatment of myalgic encephalomyelitis |
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US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US7705215B1 (en) * | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
DE69033628T2 (de) | 1989-10-31 | 2001-04-19 | Monsanto Co., St. Louis | Promotor für transgene Pflanzen |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
WO1991010725A1 (en) | 1990-01-22 | 1991-07-25 | Dekalb Plant Genetics | Fertile transgenic corn plants |
US7037692B1 (en) * | 1990-03-16 | 2006-05-02 | Calgene, Inc. | Plant desaturases compositions and uses |
EP0476093B1 (en) | 1990-04-04 | 1997-05-07 | Pioneer Hi-Bred International, Inc. | Production of improved rapeseed exhibiting a reduced saturated fatty acid content |
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WO1992017598A1 (en) | 1991-03-29 | 1992-10-15 | The Board Of Trustees Of The University Of Illinois | Production fo transgenic soybean plants |
US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
CA2124673C (en) * | 1991-12-04 | 2008-08-05 | John Browse | Fatty acid desaturase genes from plants |
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BR9306802A (pt) | 1992-07-27 | 1998-12-08 | Pioneer Hi Bred Int | Processo independente de genótipos para produção de planta de soja transgénica e processo de regeneração de plantas de soja a partir de nodos cotiledonais |
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FR2736926B1 (fr) | 1995-07-19 | 1997-08-22 | Rhone Poulenc Agrochimie | 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene |
AR006928A1 (es) | 1996-05-01 | 1999-09-29 | Pioneer Hi Bred Int | Una molecula de adn aislada que codifica una proteina fluorescente verde como marcador rastreable para la transformacion de plantas, un metodo para laproduccion de plantas transgenicas, un vector de expresion, una planta transgenica y celulas de dichas plantas. |
US5850026A (en) | 1996-07-03 | 1998-12-15 | Cargill, Incorporated | Canola oil having increased oleic acid and decreased linolenic acid content |
US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
US6075183A (en) * | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
WO1999061602A1 (en) * | 1998-05-29 | 1999-12-02 | Ohio University | Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products |
WO1999064614A2 (en) | 1998-06-12 | 1999-12-16 | Calgene Llc | Polyunsaturated fatty acids in plants |
DE60037735T2 (de) * | 1999-08-26 | 2009-01-02 | Calgene Llc, Davis | Pflanzen mit veränderten mehrfachungesättigten fettsäuren |
US7087432B2 (en) | 2000-09-28 | 2006-08-08 | Bioriginal Food & Science Corp. | Fad4, Fad5, Fad5-2 and Fad6, novel fatty acid desaturase family members and uses thereof |
US20050108791A1 (en) * | 2001-12-04 | 2005-05-19 | Edgerton Michael D. | Transgenic plants with improved phenotypes |
WO2003075670A1 (en) | 2002-03-08 | 2003-09-18 | Monsanto Technology Llc | Treatment and prevention of inflammatory disorders |
CA2881252C (en) * | 2003-08-21 | 2017-02-28 | Monsanto Technology Llc | Soybean oil having 5 to 50% sda and less than 10% gla |
AU2004290052B2 (en) | 2003-11-12 | 2008-12-04 | Corteva Agriscience Llc | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast |
WO2005102310A1 (en) | 2004-04-16 | 2005-11-03 | Monsanto Technology Llc | Expression of fatty acid desaturases in corn |
JP2006322749A (ja) * | 2005-05-17 | 2006-11-30 | Japan Nuclear Cycle Development Inst States Of Projects | 液体金属用超音波トランスジューサ |
-
2003
- 2003-05-21 CA CA2486559A patent/CA2486559C/en not_active Expired - Lifetime
- 2003-05-21 BR BR122014000528A patent/BR122014000528B1/pt active IP Right Grant
- 2003-05-21 MX MXPA04011613A patent/MXPA04011613A/es active IP Right Grant
- 2003-05-21 BR BR0311324-8A patent/BR0311324A/pt active IP Right Grant
- 2003-05-21 ES ES03738947.5T patent/ES2542420T3/es not_active Expired - Lifetime
- 2003-05-21 US US10/515,283 patent/US7622632B2/en active Active
- 2003-05-21 AU AU2003245308A patent/AU2003245308B2/en not_active Expired
- 2003-05-21 EP EP20030738947 patent/EP1549133B1/en not_active Expired - Lifetime
- 2003-05-21 BR BRPI0311324A patent/BRPI0311324B1/pt unknown
- 2003-05-21 WO PCT/US2003/016144 patent/WO2003099216A2/en active Application Filing
- 2003-05-21 JP JP2004506743A patent/JP4515904B2/ja not_active Expired - Lifetime
- 2003-05-21 CA CA2883729A patent/CA2883729C/en not_active Expired - Lifetime
- 2003-05-21 KR KR1020047018887A patent/KR101138631B1/ko active IP Right Grant
- 2003-05-22 AR ARP030101789A patent/AR039851A1/es active IP Right Grant
-
2006
- 2006-05-17 HK HK06105720.0A patent/HK1085615A1/xx not_active IP Right Cessation
-
2009
- 2009-10-29 AR ARP090104180A patent/AR074003A2/es not_active Application Discontinuation
- 2009-11-23 US US12/624,295 patent/US8362320B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU2003245308A1 (en) | 2003-12-12 |
WO2003099216A3 (en) | 2004-07-01 |
HK1085615A1 (en) | 2006-09-01 |
BR122014000528B1 (pt) | 2016-02-16 |
ES2542420T3 (es) | 2015-08-05 |
CA2486559A1 (en) | 2003-12-04 |
CA2883729A1 (en) | 2003-12-04 |
EP1549133A2 (en) | 2005-07-06 |
US20100212045A1 (en) | 2010-08-19 |
EP1549133B1 (en) | 2015-04-22 |
CA2883729C (en) | 2017-03-07 |
CA2486559C (en) | 2015-07-21 |
MXPA04011613A (es) | 2005-03-07 |
US8362320B2 (en) | 2013-01-29 |
JP2006509494A (ja) | 2006-03-23 |
BRPI0311324B1 (pt) | 2020-01-28 |
KR101138631B1 (ko) | 2012-04-26 |
AU2003245308B2 (en) | 2008-02-07 |
AR039851A1 (es) | 2005-03-02 |
BR0311324A (pt) | 2005-06-28 |
EP1549133A4 (en) | 2007-10-03 |
KR20050042750A (ko) | 2005-05-10 |
US7622632B2 (en) | 2009-11-24 |
JP4515904B2 (ja) | 2010-08-04 |
US20060156435A1 (en) | 2006-07-13 |
WO2003099216A2 (en) | 2003-12-04 |
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