AR073727A1 - Derivado de 7-piperidinoalquil-3,4-dihidroquinolona, una composicion farmaceutica que lo contieney su uso en el tratamiento de enfermedades mediadas por el antagonismo del receptor de mch. - Google Patents
Derivado de 7-piperidinoalquil-3,4-dihidroquinolona, una composicion farmaceutica que lo contieney su uso en el tratamiento de enfermedades mediadas por el antagonismo del receptor de mch.Info
- Publication number
- AR073727A1 AR073727A1 ARP090103798A ARP090103798A AR073727A1 AR 073727 A1 AR073727 A1 AR 073727A1 AR P090103798 A ARP090103798 A AR P090103798A AR P090103798 A ARP090103798 A AR P090103798A AR 073727 A1 AR073727 A1 AR 073727A1
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- Prior art keywords
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- disorders
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- alkyl
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Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 208000019901 Anxiety disease Diseases 0.000 abstract 2
- 206010010904 Convulsion Diseases 0.000 abstract 2
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 208000027559 Appetite disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000032841 Bulimia Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010012218 Delirium Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 206010020710 Hyperphagia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 102400001132 Melanin-concentrating hormone Human genes 0.000 abstract 1
- 101800002739 Melanin-concentrating hormone Proteins 0.000 abstract 1
- 102000029828 Melanin-concentrating hormone receptor Human genes 0.000 abstract 1
- 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 206010044565 Tremor Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 208000028683 bipolar I disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
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- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Proveer un compuesto, una sal aceptable para uso farmacéutico o un hidrato del mismo util para prevenir o tratar la depresion, trastornos de la ansiedad (tales como trastorno de ansiedad generalizada, trastorno por estrés postraumático, trastorno de pánico, trastorno obsesivo-compulsivo o trastorno de ansiedad social), trastorno por déficit de atencion, manía, enfermedad maniaco-depresiva, esquizofrenia, trastornos del estado de ánimo, estrés, trastornos del sueno, ataques, trastornos de la memoria, trastornos cognitivos, demencia, amnesia, deliro, obesidad, trastornos alimentarios, trastornos del apetito, hiperfagia, bulimia, cibofobia, diabetes, enfermedades cardiovasculares, hipertension, dislipidemia, infarto de miocardio, trastornos del movimiento (tales como enfermedad de Parkinson, epilepsia, convulsiones o temblores), abuso de drogas, adiccion a las drogas o disfuncion sexual, con base en una accion antagonista del receptor de la hormona concentradora de melanina (receptor MCH). Reivindicacion 1: Un compuesto caracterizado por la formula (1), una sal aceptable para uso farmacéutico o un hidrato del mismo; donde, en la formula (1) R es un átomo de hidrogeno o un grupo alquilo C1-6; A1, A2 y A3, que pueden ser iguales o diferentes, son cada uno un átono de hidrogeno, un átomo de halogeno, un grupo alquilo C1-6 o un grupo alcoxi C1-6; X es un grupo alquileno C1-6; Y es un enlace o un grupo alquileno C1-6; Z es un enlace o un grupo alquileno C1-6, donde el grupo alquileno C1-6 puede sustituirse con un grupo arilo; W es un enlace o un átomo de oxigeno; y Cy es un grupo arilo o un grupo heteroarilo, donde el grupo arilo o el grupo heteroarilo pueden tener uno a tres sustituyentes, que pueden ser iguales o diferentes, seleccionados del grupo que consiste en un átomo de halogeno, un grupo ciano, un grupo alquilo C1-6, un grupo alcoxi C1-6, donde el grupo alquilo C1-6 o el grupo alcoxi C1-6 pueden sustituirse con uno a tres átomos de halogeno, y un grupo alcanoílo C2-6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008257072 | 2008-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073727A1 true AR073727A1 (es) | 2010-11-24 |
Family
ID=42073652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103798A AR073727A1 (es) | 2008-10-02 | 2009-10-01 | Derivado de 7-piperidinoalquil-3,4-dihidroquinolona, una composicion farmaceutica que lo contieney su uso en el tratamiento de enfermedades mediadas por el antagonismo del receptor de mch. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8461182B2 (es) |
| EP (1) | EP2344471B1 (es) |
| JP (1) | JP5541279B2 (es) |
| KR (1) | KR20110067026A (es) |
| CN (1) | CN102239159B (es) |
| AR (1) | AR073727A1 (es) |
| AU (1) | AU2009300607C1 (es) |
| BR (1) | BRPI0925343A2 (es) |
| CA (1) | CA2739513A1 (es) |
| CL (1) | CL2011000734A1 (es) |
| CO (1) | CO6321164A2 (es) |
| CY (1) | CY1114165T1 (es) |
| DK (1) | DK2344471T3 (es) |
| ES (1) | ES2424393T3 (es) |
| HK (1) | HK1159622A1 (es) |
| HR (1) | HRP20130728T1 (es) |
| IL (1) | IL212070A (es) |
| MX (1) | MX2011003500A (es) |
| MY (1) | MY154337A (es) |
| NZ (1) | NZ592008A (es) |
| PE (1) | PE20110410A1 (es) |
| PL (1) | PL2344471T3 (es) |
| PT (1) | PT2344471E (es) |
| RS (1) | RS52964B (es) |
| RU (1) | RU2498981C2 (es) |
| SI (1) | SI2344471T1 (es) |
| UA (1) | UA105187C2 (es) |
| WO (1) | WO2010038901A1 (es) |
| ZA (1) | ZA201102315B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011219467A (ja) * | 2010-03-26 | 2011-11-04 | Taisho Pharmaceutical Co Ltd | ７−ピペリジノアルキル−３，４−ジヒドロキノロン誘導体を含有する医薬 |
| JP6063870B2 (ja) | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
| EP2846804B1 (en) | 2012-05-08 | 2017-11-29 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| AU2013259624B2 (en) | 2012-05-08 | 2017-10-19 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease |
| WO2014142477A1 (en) * | 2013-03-12 | 2014-09-18 | Bio-Pharm Solutions Co., Ltd. | Phenyl carbamate compounds for use in preventing or treating pediatric epilesy and epilesy-related syndromes |
| US9663502B2 (en) | 2013-12-20 | 2017-05-30 | Lycera Corporation | 2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease |
| WO2015095795A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| WO2015095792A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease |
| MX2016010998A (es) | 2014-02-27 | 2017-03-31 | Lycera Corp | Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados. |
| EP3140291A4 (en) | 2014-05-05 | 2018-01-10 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| WO2015171558A2 (en) | 2014-05-05 | 2015-11-12 | Lycera Corporation | BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE |
| EP3256450B1 (en) | 2015-02-11 | 2020-12-02 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as ror-gamma-t inhibitors and uses thereof |
| EP3292119A4 (en) | 2015-05-05 | 2018-10-03 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
| US10611740B2 (en) | 2015-06-11 | 2020-04-07 | Lycera Corporation | Aryl dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| AU2016344111A1 (en) | 2015-10-27 | 2018-05-10 | Merck Sharp & Dohme Corp. | Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof |
| JP2018535958A (ja) | 2015-10-27 | 2018-12-06 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ＲＯＲγＴ阻害薬としての置換インダゾール化合物及びその使用 |
| CA3002853A1 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
| UA124879C2 (uk) * | 2016-02-12 | 2021-12-08 | Сайтокінетікс, Інкорпорейтед | Похідні тетрагідроізохіноліну |
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| NZ318436A (en) * | 1995-09-15 | 1999-02-25 | Synthelabo | Quinolein-2(1h)-one derivatives substituted with a 4-(thieno[3,2-c]pyridin-4-yl)piperazine-1-yl or 4-(4-fluorobenzoyl)piperidin-1-yl group as serotonin antagonists |
| KR20040058191A (ko) * | 2001-10-01 | 2004-07-03 | 다이쇼 세이야꾸 가부시끼가이샤 | Ｍｃｈ 수용체 안타고니스트 |
| HUP0700124A2 (en) * | 2001-10-25 | 2007-06-28 | Takeda Chemical Industries Ltd | Quinoline compound |
| WO2004087680A1 (en) * | 2003-03-31 | 2004-10-14 | Taisho Pharmaceutical Co., Ltd. | Novel quinazoline derivatives and methods of treatment related to the use thereof |
| EP1464335A3 (en) * | 2003-03-31 | 2007-05-09 | Taisho Pharmaceutical Co. Ltd. | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist |
| US20050209274A1 (en) * | 2004-02-26 | 2005-09-22 | Lynch John K | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
| NZ549673A (en) * | 2004-03-30 | 2010-03-26 | Taisho Pharmaceutical Co Ltd | Pyrimidine derivatives and methods of treatment related to the use thereof |
| JP2008514546A (ja) * | 2004-09-30 | 2008-05-08 | 大正製薬株式会社 | ピリジン誘導体及びその使用に関連する治療法 |
| CA2666084A1 (en) | 2006-10-06 | 2008-04-17 | Taisho Pharmaceutical Co., Ltd. | 1-naphthyl alkylpiperidine derivative |
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