AR071484A1 - Metodos para la produccion aumentada de proteinas morfogeneticas oseas, tales como bmp-2. - Google Patents

Metodos para la produccion aumentada de proteinas morfogeneticas oseas, tales como bmp-2.

Info

Publication number
AR071484A1
AR071484A1 ARP090101366A AR071484A1 AR 071484 A1 AR071484 A1 AR 071484A1 AR P090101366 A ARP090101366 A AR P090101366A AR 071484 A1 AR071484 A1 AR 071484A1
Authority
AR
Argentina
Prior art keywords
bmp
methods
morphogenetic proteins
oseas
increased production
Prior art date
Application number
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40740265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR071484(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR071484A1 publication Critical patent/AR071484A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporcionan métodos y procesos para la produccion de proteína recombinante. Los métodos son utiles para la produccion de factores de crecimiento, en particular los de la superfamilia de TGF-beta, que incluyen proteínas morfogenéticas oseas (BMP), tales como BMP-2. Las células huésped adecuadas se cultivan en un medio en donde el hierro está presente en una concentracion de al menos 2,25 microM y si el piridoxal está presente, constituye menos de 55% de la concentracion molar de vitamina B6 del medio.
ARP090101366 2008-04-17 2009-04-17 Metodos para la produccion aumentada de proteinas morfogeneticas oseas, tales como bmp-2. AR071484A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4564308P 2008-04-17 2008-04-17

Publications (1)

Publication Number Publication Date
AR071484A1 true AR071484A1 (es) 2010-06-23

Family

ID=40740265

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP090101366 AR071484A1 (es) 2008-04-17 2009-04-17 Metodos para la produccion aumentada de proteinas morfogeneticas oseas, tales como bmp-2.
ARP170102812A AR109907A2 (es) 2008-04-17 2017-10-09 Métodos para la producción de proteínas morfogenéticas óseas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP170102812A AR109907A2 (es) 2008-04-17 2017-10-09 Métodos para la producción de proteínas morfogenéticas óseas

Country Status (19)

Country Link
US (1) US8039231B2 (es)
EP (1) EP2310523B1 (es)
JP (2) JP5739324B2 (es)
KR (1) KR101286895B1 (es)
CN (2) CN107090481A (es)
AR (2) AR071484A1 (es)
AU (1) AU2009236187B2 (es)
CA (1) CA2720980C (es)
CL (1) CL2009000912A1 (es)
DK (1) DK2310523T3 (es)
ES (1) ES2543061T3 (es)
HU (1) HUE027035T2 (es)
IL (1) IL208732A (es)
MX (1) MX2010011356A (es)
PL (1) PL2310523T3 (es)
PT (1) PT2310523E (es)
SI (1) SI2310523T1 (es)
WO (1) WO2009129379A1 (es)
ZA (1) ZA201007099B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009236187B2 (en) * 2008-04-17 2012-08-02 Wyeth Llc Methods for enhanced production of bone morphogenetic proteins
US11078248B2 (en) * 2010-03-19 2021-08-03 Lifenet Health BMP peptides and methods of use
WO2011116391A1 (en) * 2010-03-19 2011-09-22 Lifenet Health Bmp-2 peptides & methods of use
EP2550006B1 (en) * 2010-03-24 2018-08-22 Lifenet Health Bmp-4 peptides&methods of use
CA2794167A1 (en) * 2010-03-24 2011-09-29 Lifenet Health Bmp-7 peptides & methods of use
IL286298B (en) 2010-07-08 2022-08-01 Baxalta Inc A method to generate high molecular weight substituted vwf in cell culture
US20130045471A1 (en) * 2011-02-25 2013-02-21 Bio-Rad Laboratories, Inc. Training system for investigations of bioengineered proteins
TW201247874A (en) * 2011-05-25 2012-12-01 United Biomedical Inc Method for producing the activity of bone activating protein
US20130281355A1 (en) * 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
AU2015210930B2 (en) * 2014-01-30 2020-04-30 Coherus Biosciences, Inc. Perfusion media
EP3612637A4 (en) * 2017-04-21 2021-01-27 Yuhan Corporation DOUBLE-FUNCTION PROTEIN PRODUCTION PROCESS AND ITS DERIVATIVES
KR102056075B1 (ko) * 2018-06-05 2020-01-22 한국과학기술원 목적 단백질의 생산을 향상시키기 위한 동물세포 배양용 배지 조성물 및 이를 이용한 목적 단백질 생산 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5830761A (en) * 1995-06-07 1998-11-03 Genetics Institute, Inc. Medium and methods for culturing mammalian cho cells
US20030036629A1 (en) 1997-12-12 2003-02-20 Barry Foster Novel tgf-beta protein purification methods
WO2002077006A1 (en) * 2001-03-23 2002-10-03 Human Genome Sciences, Inc. Bone morphogenic protein polynucleotides, polypeptides, and antibodies
CA2447791A1 (en) * 2001-06-13 2002-12-19 Neslihan Delacruz Methods of culturing animal cells and polypeptide production in animal cells
ES2344789T5 (es) * 2003-05-15 2017-06-14 Wyeth Llc Alimentación restringida de glucosa para el cultivo de células animales
TWI364458B (en) * 2004-08-27 2012-05-21 Wyeth Res Ireland Ltd Production of tnfr-lg
TWI384069B (zh) * 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
TWI374935B (en) * 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
KR101196103B1 (ko) * 2004-11-02 2012-11-01 아레스 트레이딩 에스.에이. 포유동물 세포용 무?혈청 세포 배양 배지
AU2009236187B2 (en) * 2008-04-17 2012-08-02 Wyeth Llc Methods for enhanced production of bone morphogenetic proteins

Also Published As

Publication number Publication date
CA2720980C (en) 2014-02-25
CA2720980A1 (en) 2009-10-22
PL2310523T3 (pl) 2015-10-30
US8039231B2 (en) 2011-10-18
AU2009236187A1 (en) 2009-10-22
CN107090481A (zh) 2017-08-25
HUE027035T2 (hu) 2016-08-29
JP2011518175A (ja) 2011-06-23
EP2310523A1 (en) 2011-04-20
KR101286895B1 (ko) 2013-07-16
US20090317867A1 (en) 2009-12-24
AU2009236187B2 (en) 2012-08-02
IL208732A (en) 2014-07-31
ZA201007099B (en) 2011-06-29
SI2310523T1 (sl) 2015-10-30
WO2009129379A1 (en) 2009-10-22
JP5739324B2 (ja) 2015-06-24
DK2310523T3 (en) 2015-07-20
KR20110005874A (ko) 2011-01-19
MX2010011356A (es) 2010-11-09
ES2543061T3 (es) 2015-08-14
PT2310523E (pt) 2015-09-07
IL208732A0 (en) 2010-12-30
EP2310523B1 (en) 2015-06-10
JP2015109854A (ja) 2015-06-18
AR109907A2 (es) 2019-02-06
CN102037132A (zh) 2011-04-27
CL2009000912A1 (es) 2009-10-09

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