AR071217A1 - Derivados bencimidazol - Google Patents
Derivados bencimidazolInfo
- Publication number
- AR071217A1 AR071217A1 ARP090101462A ARP090101462A AR071217A1 AR 071217 A1 AR071217 A1 AR 071217A1 AR P090101462 A ARP090101462 A AR P090101462A AR P090101462 A ARP090101462 A AR P090101462A AR 071217 A1 AR071217 A1 AR 071217A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- integer
- compounds
- represents hydrogen
- bencimidazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
La presente se relaciona con compuesto de formula (1) en la cual R1 representa arilo, que está no sustituido, o mono-, di-, o trisustituido en donde los sustituyentes son seleccionados de manera independiente desde el grupo que consiste en alquilo C1-4, alcoxilo C1-4, halogeno, y trifluorometilo; R2 representa hidrogeno, o -CO-R21, R21 representa alquilo C1-5, fluoroalquilo C1-3, o cicloalquilo C3-6; m representa el entero 2, o 3; p representa el entero 2 o 3; y R3 representa hidrogeno, o alquilo C1-5; y sales farmacéuticamente aceptables de tales compuestos. Estos compuestos son utiles como bloqueadores de panales de calcio. También se reivindica la composicion farmacéutica y uso para preparar medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2008051602 | 2008-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071217A1 true AR071217A1 (es) | 2010-06-02 |
Family
ID=40823387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101462A AR071217A1 (es) | 2008-04-25 | 2009-04-24 | Derivados bencimidazol |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110039905A1 (es) |
| EP (1) | EP2271628A1 (es) |
| JP (1) | JP4806734B2 (es) |
| KR (1) | KR101364909B1 (es) |
| CN (1) | CN102015658B (es) |
| AR (1) | AR071217A1 (es) |
| AU (1) | AU2009239620A1 (es) |
| BR (1) | BRPI0911538B1 (es) |
| CA (1) | CA2722067A1 (es) |
| HK (1) | HK1155739A1 (es) |
| IL (1) | IL208856A0 (es) |
| MX (1) | MX2010011459A (es) |
| NZ (1) | NZ589509A (es) |
| RU (1) | RU2478095C2 (es) |
| TW (1) | TWI401249B (es) |
| WO (1) | WO2009130679A1 (es) |
| ZA (1) | ZA201008448B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4595040B2 (ja) | 2007-04-27 | 2010-12-08 | アクテリオン ファーマシューティカルズ リミテッド | 架橋６員環化合物 |
| WO2010046855A1 (en) | 2008-10-22 | 2010-04-29 | Actelion Pharmaceuticals Ltd | Bridged tetrahydronaphthalene derivatives |
| HUE032044T2 (en) * | 2008-10-22 | 2017-08-28 | Actelion Pharmaceuticals Ltd | The crystalline salt is (lR |
| WO2010046729A2 (en) * | 2008-10-23 | 2010-04-29 | Actelion Pharmaceuticals Ltd | Tetrahydronaphthalene compounds |
| ES2536897T3 (es) | 2010-10-20 | 2015-05-29 | Actelion Pharmaceuticals Ltd. | Preparación de compuestos de biciclo[2,2,2]octan-2-ona |
| DK2630120T3 (en) * | 2010-10-20 | 2018-10-08 | Idorsia Pharmaceuticals Ltd | DIASTEREOSELECTIVE PREPARATION OF BICYCLO [2.2.2] OCTAN-2-ON COMPOUNDS |
| EP3150598B1 (en) * | 2014-05-28 | 2019-02-13 | TOA Eiyo Ltd. | Substituted tropane derivatives |
| CN114340670A (zh) | 2019-07-11 | 2022-04-12 | 普拉克西斯精密药物股份有限公司 | T-型钙通道调节剂的制剂及其使用方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK171349B1 (da) * | 1986-11-14 | 1996-09-16 | Hoffmann La Roche | Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler |
| US6268377B1 (en) * | 1998-09-28 | 2001-07-31 | Merck & Co., Inc. | Method for treating androgen-related conditions |
| WO2003031415A1 (en) | 2001-10-10 | 2003-04-17 | Aryx Therapeutics | Mibefradil-based compounds as calcium channel blockers useful in the treatment of hypertension and angina |
| JP4595040B2 (ja) * | 2007-04-27 | 2010-12-08 | アクテリオン ファーマシューティカルズ リミテッド | 架橋６員環化合物 |
-
2009
- 2009-04-23 EP EP09734909A patent/EP2271628A1/en not_active Withdrawn
- 2009-04-23 WO PCT/IB2009/051668 patent/WO2009130679A1/en active Application Filing
- 2009-04-23 RU RU2010147865/04A patent/RU2478095C2/ru active
- 2009-04-23 NZ NZ589509A patent/NZ589509A/en not_active IP Right Cessation
- 2009-04-23 MX MX2010011459A patent/MX2010011459A/es active IP Right Grant
- 2009-04-23 KR KR1020107026438A patent/KR101364909B1/ko active IP Right Grant
- 2009-04-23 AU AU2009239620A patent/AU2009239620A1/en not_active Abandoned
- 2009-04-23 JP JP2011505634A patent/JP4806734B2/ja not_active Expired - Fee Related
- 2009-04-23 BR BRPI0911538-2A patent/BRPI0911538B1/pt not_active IP Right Cessation
- 2009-04-23 US US12/989,443 patent/US20110039905A1/en not_active Abandoned
- 2009-04-23 CA CA2722067A patent/CA2722067A1/en not_active Abandoned
- 2009-04-23 CN CN2009801155609A patent/CN102015658B/zh not_active Expired - Fee Related
- 2009-04-24 AR ARP090101462A patent/AR071217A1/es unknown
- 2009-04-24 TW TW098113755A patent/TWI401249B/zh not_active IP Right Cessation
-
2010
- 2010-10-21 IL IL208856A patent/IL208856A0/en unknown
- 2010-11-24 ZA ZA2010/08448A patent/ZA201008448B/en unknown
-
2011
- 2011-09-21 HK HK11109943.6A patent/HK1155739A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200944507A (en) | 2009-11-01 |
| BRPI0911538B1 (pt) | 2021-05-18 |
| IL208856A0 (en) | 2011-01-31 |
| KR101364909B1 (ko) | 2014-02-21 |
| RU2478095C2 (ru) | 2013-03-27 |
| CA2722067A1 (en) | 2009-10-29 |
| US20110039905A1 (en) | 2011-02-17 |
| CN102015658A (zh) | 2011-04-13 |
| KR20110011639A (ko) | 2011-02-08 |
| ZA201008448B (en) | 2012-04-25 |
| NZ589509A (en) | 2012-07-27 |
| MX2010011459A (es) | 2010-11-12 |
| JP2011518821A (ja) | 2011-06-30 |
| TWI401249B (zh) | 2013-07-11 |
| JP4806734B2 (ja) | 2011-11-02 |
| RU2010147865A (ru) | 2012-05-27 |
| BRPI0911538A2 (pt) | 2020-01-07 |
| AU2009239620A1 (en) | 2009-10-29 |
| HK1155739A1 (en) | 2012-05-25 |
| EP2271628A1 (en) | 2011-01-12 |
| CN102015658B (zh) | 2013-03-20 |
| WO2009130679A1 (en) | 2009-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |