AR054277A1 - Derivados de piperidin - 4 - il - amida, un proceso para su obtencion, composiciones farmaceuticas que los contienen y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades asociadas con la modulacion de receptores del subtipo 5 de la sst. - Google Patents
Derivados de piperidin - 4 - il - amida, un proceso para su obtencion, composiciones farmaceuticas que los contienen y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades asociadas con la modulacion de receptores del subtipo 5 de la sst.Info
- Publication number
- AR054277A1 AR054277A1 AR20060102259A ARP060102259A AR054277A1 AR 054277 A1 AR054277 A1 AR 054277A1 AR 20060102259 A AR20060102259 A AR 20060102259A AR P060102259 A ARP060102259 A AR P060102259A AR 054277 A1 AR054277 A1 AR 054277A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- formula
- halogen
- compound
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Composiciones farmacéuticas que contienen tales compuestos, a un proceso para su obtencion y a la utilizacion de los mismos para tratar y/o prevenir enfermedades asociadas con la modulacion de los receptores del subtipo 5 de la SST. Reivindicacion 1: Compuestos de la formula (1) en la que R1 se elige entre el grupo formado por etilo, 2-fluoretilo, isopropilo e isobutio; R2 se elige entre el grupo formado por hidrogeno, alquilo C1-7, hidroxi, alcoxi C1-7 , cicloalquilo C3-7, -O-cicloalquilo C3- 7, halogeno, halogeno-alquilo C1-7; -C(O)OR6, en el que R6 es alquilo C1-7; -NH-C(O)-R7, en el que R7 es alquilo C1-7; amino, fenilo, fenilo sustituido de una a tres veces por sustituyentes elegidos entre el grupo formado por halogeno, halogeno- alquilo C1-7 y halogeno-alcoxi C1-7; piridilo, imidazolilo, triazolilo y pirrolilo; R3 se elige entre el grupo formado por hidrogeno, alcoxi C1-7, amino, -NH-C(O)-R8 en el que R8 es alquilo C1-7, -O-bencilo y -O-tetrahidropiranilo; o R2 y R3 junto con los átomos de carbono a los que están unidos forman un anillo y R2 y R3 juntos son -CH=CH-NH-; R4 se elige entre el grupo formado por hidrogeno, halogeno, piridilo y pirimidilo; R5 y R5' con independencia entre si se eligen entre hidrogeno o metilo; A se elige entre el grupo formado por fenilo; fenilo sustituido de una a tres veces por sustituyentes elegidos entre el grupo formado por alquilo C1-7, cicloalquilo C3-7, alquilsulfonilo C1-7, -O-alquilsulfonilo C1-7, alquilsulfonil C1-7- alcoxi C2-7, hidroxi, alcoxi C1-7, -O-cicloalquilo C3-7, cicloalquil C3-7-alcoxi C1-7, hidroxi-alquilo C1-7, hidroxi-alcoxi C2-7, dihidroxi-alcoxi C3-7, alcoxi C1-7-alcoxi C2-7, alcoxi C1-7-hidroxi-alcoxi C3-7, alquilamino C1-7, di(alquil C1- 7)amino, amino-alcoxi C2-7, amino-alquilo C1-7, -C(O)NR10R11, -alquileno C1-7-C(O)NR10R11, -O-alquileno C1-7-C(O)NR10R11, -C(O)OR10, -alquileno C1-7-C(O)OR10, -O-alquileno C1-7-C(O)OR10, halogeno, ciano, halogeno-alquilo C1-7, halogeno-alcoxi C1-7, ciano-alcoxi C1-7; fluorofenilo, piridilo, tetrazolilo y tetrazolil-alcoxi C1-7; 1,3-benzodioxolilo; naftilo; pirimidinilo; piridilo; piridilo sustituido por uno o dos sustituyentes elegidos entre el grupo formado por alquilo C1-7, alcoxi C1-7, amino, alquilamino C1-7, di(alquil C1-7)amino, cicloalquilamino C3-7, halogeno, ciano, morfolinilo, imidazolilo, y -NH-C(O)-R9, en el que R9 es alquilo C1-7 o cicloalquilo C3-7, e indolilo; R10 y R11 con independencia entre si son hidrogeno o alquilo C1-7; y las sales farmacéuticamente aceptables de los mismos. Reivindicacion 23: Un proceso para la obtencion de los compuestos segun una cualquiera de las reivindicaciones de 1 a 22, dicho proceso consiste en: a) hacer reaccionar un compuesto de la formula general (2) en la que A tiene el significado definido en la reivindicacion 1, con un aldehído de la formula (3) en la que R1, R2, R3 y R4 tienen los significados definidos en la reivindicacion 1, empleando un agente reductor para obtener un compuesto de la formula (1) en la que R5 y R5' son hidrogeno, y, si se desea, convertir el compuesto de la formula (1) en una sal farmacéuticamente aceptable, o, como alternativa, b) hacer reaccionar un compuesto de la formula (2) en la que A tiene el significado definido en la reivindicacion 1, con un haluro de alquilo de la formula (4) en la que de R1 a R5 y R5' tienen los significados definidos en la reivindicacion 1 y Hal es halogeno, mediante la adicion de una base idonea para obtener un compuesto de la formula (1) y, si se desea, convertir el compuesto de la formula (1) en una sal farmacéuticamente aceptable, o, como alternativa, c) acoplar una amina de la formula general (5) en la que de R1 a R5 y R5' tienen los significados definidos en la reivindicacion 1, con un ácido carboxílico de la formula HOOC-A, en la que A tiene el significado definido en la reivindicacion 1, empleando un agente de acoplamiento apropiado para obtener un compuesto de la formula (1) y, si se desea, convertir el compuesto de la formula (1) en una sal farmacéuticamente aceptable, o, como alternativa, d) acoplar una amina de la formula general (6) en la que de R1 a R5 y R5' tienen los significados definidos en la reivindicacion 1, con un cloruro de ácido de la formula A-C(:O)Cl, en la que A tiene el significado definido en la reivindicacion 1, mediante la adicion de una base idonea para obtener un compuesto de la formula (1) y, si se desea, convertir el compuesto de la formula (1) en una sal farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05104774 | 2005-06-02 |
Publications (1)
Publication Number | Publication Date |
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AR054277A1 true AR054277A1 (es) | 2007-06-13 |
Family
ID=36763959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20060102259A AR054277A1 (es) | 2005-06-02 | 2006-05-31 | Derivados de piperidin - 4 - il - amida, un proceso para su obtencion, composiciones farmaceuticas que los contienen y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades asociadas con la modulacion de receptores del subtipo 5 de la sst. |
Country Status (22)
Country | Link |
---|---|
US (1) | US7772253B2 (es) |
EP (1) | EP1893603B1 (es) |
JP (1) | JP4949387B2 (es) |
KR (1) | KR100962732B1 (es) |
CN (1) | CN101189226A (es) |
AR (1) | AR054277A1 (es) |
AT (1) | ATE445612T1 (es) |
AU (1) | AU2006254256B2 (es) |
BR (1) | BRPI0611138A2 (es) |
CA (1) | CA2608819A1 (es) |
DE (1) | DE602006009804D1 (es) |
DK (1) | DK1893603T3 (es) |
ES (1) | ES2330788T3 (es) |
IL (1) | IL187426A (es) |
MX (1) | MX2007014928A (es) |
NO (1) | NO20076060L (es) |
PL (1) | PL1893603T3 (es) |
PT (1) | PT1893603E (es) |
RU (1) | RU2403250C2 (es) |
TW (1) | TWI315305B (es) |
WO (1) | WO2006128803A1 (es) |
ZA (1) | ZA200710169B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7799806B2 (en) | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
US8026365B2 (en) * | 2007-05-25 | 2011-09-27 | Hoffman-La Roche Inc. | 4,4-disubstituted piperidine derivatives |
EP2491026A1 (en) * | 2009-10-20 | 2012-08-29 | Pfizer Inc. | Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators |
US8999889B2 (en) | 2010-02-01 | 2015-04-07 | Basf Se | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests |
EP2605658B1 (en) | 2010-08-18 | 2016-03-23 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
CA2812154A1 (en) | 2010-10-01 | 2012-04-05 | Basf Se | Imine substituted 2, 4 - diaryl - pyrroline derivatives as pesticides |
AR084486A1 (es) | 2010-10-01 | 2013-05-22 | Basf Se | Compuestos de imina |
KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
EP4153589A1 (en) | 2020-05-19 | 2023-03-29 | Kallyope, Inc. | Ampk activators |
CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
CN115215787A (zh) * | 2021-04-19 | 2022-10-21 | 中国科学院上海药物研究所 | 生长抑素受体5拮抗剂及其用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH598231A5 (es) | 1973-07-27 | 1978-04-28 | Hoffmann La Roche | |
AR216043A1 (es) * | 1974-03-21 | 1979-11-30 | Anphar Sa | Procedimiento para la preparacion de 1-derivados de benzoilamino-4-piperidina y sus sales fisiologicamente aceptables |
GB1574418A (en) * | 1976-11-16 | 1980-09-03 | Anphar Sa | Piperidine derivatives |
CH628885A5 (en) * | 1978-01-01 | 1982-03-31 | Anphar Sa | Piperidine derivative |
JPS5592384A (en) * | 1978-12-30 | 1980-07-12 | Beecham Group Ltd | Compound having pharmacological activity |
US5098915A (en) * | 1989-09-05 | 1992-03-24 | G. D. Searle & Co. | Substituted N-benzylpiperidine amides |
SE9702794D0 (sv) | 1997-07-24 | 1997-07-24 | Astra Pharma Prod | New compounds |
DE60021370C5 (de) | 1999-05-04 | 2007-11-08 | Schering Corp. | Piperazinderivate verwendbar als ccr5 antagonisten |
US6344358B1 (en) * | 1999-05-28 | 2002-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Agent for expression of long-term potentiation of synaptic transmission comprising compound having brain somatostatin activation property |
FR2802206B1 (fr) * | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
CA2530159C (en) | 2003-06-17 | 2010-02-02 | Pfizer Inc. | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors |
WO2005049573A1 (en) | 2003-11-05 | 2005-06-02 | F. Hoffmann-La Roche Ag | Phenyl derivatives as ppar agonists |
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2006
- 2006-05-23 PL PL06755285T patent/PL1893603T3/pl unknown
- 2006-05-23 AT AT06755285T patent/ATE445612T1/de active
- 2006-05-23 ES ES06755285T patent/ES2330788T3/es active Active
- 2006-05-23 DK DK06755285T patent/DK1893603T3/da active
- 2006-05-23 RU RU2007148224/04A patent/RU2403250C2/ru not_active IP Right Cessation
- 2006-05-23 PT PT06755285T patent/PT1893603E/pt unknown
- 2006-05-23 BR BRPI0611138-6A patent/BRPI0611138A2/pt not_active IP Right Cessation
- 2006-05-23 MX MX2007014928A patent/MX2007014928A/es active IP Right Grant
- 2006-05-23 CN CNA2006800194138A patent/CN101189226A/zh active Pending
- 2006-05-23 EP EP06755285A patent/EP1893603B1/en not_active Not-in-force
- 2006-05-23 WO PCT/EP2006/062515 patent/WO2006128803A1/en active Application Filing
- 2006-05-23 KR KR1020077028019A patent/KR100962732B1/ko not_active IP Right Cessation
- 2006-05-23 JP JP2008514062A patent/JP4949387B2/ja not_active Expired - Fee Related
- 2006-05-23 AU AU2006254256A patent/AU2006254256B2/en not_active Ceased
- 2006-05-23 CA CA002608819A patent/CA2608819A1/en not_active Abandoned
- 2006-05-23 DE DE602006009804T patent/DE602006009804D1/de active Active
- 2006-05-26 US US11/442,619 patent/US7772253B2/en not_active Expired - Fee Related
- 2006-05-30 TW TW095119084A patent/TWI315305B/zh not_active IP Right Cessation
- 2006-05-31 AR AR20060102259A patent/AR054277A1/es not_active Application Discontinuation
-
2007
- 2007-11-15 IL IL187426A patent/IL187426A/en not_active IP Right Cessation
- 2007-11-26 NO NO20076060A patent/NO20076060L/no not_active Application Discontinuation
- 2007-11-26 ZA ZA200710169A patent/ZA200710169B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN101189226A (zh) | 2008-05-28 |
KR100962732B1 (ko) | 2010-06-09 |
NO20076060L (no) | 2007-12-28 |
ZA200710169B (en) | 2008-12-31 |
EP1893603A1 (en) | 2008-03-05 |
RU2007148224A (ru) | 2009-07-20 |
PL1893603T3 (pl) | 2010-03-31 |
KR20080008391A (ko) | 2008-01-23 |
US20060276508A1 (en) | 2006-12-07 |
JP2008545730A (ja) | 2008-12-18 |
IL187426A (en) | 2011-10-31 |
AU2006254256B2 (en) | 2012-04-12 |
IL187426A0 (en) | 2008-02-09 |
ES2330788T3 (es) | 2009-12-15 |
TW200716547A (en) | 2007-05-01 |
PT1893603E (pt) | 2009-11-24 |
ATE445612T1 (de) | 2009-10-15 |
JP4949387B2 (ja) | 2012-06-06 |
BRPI0611138A2 (pt) | 2010-08-17 |
RU2403250C2 (ru) | 2010-11-10 |
AU2006254256A1 (en) | 2006-12-07 |
TWI315305B (en) | 2009-10-01 |
DK1893603T3 (da) | 2009-11-30 |
CA2608819A1 (en) | 2006-12-07 |
US7772253B2 (en) | 2010-08-10 |
MX2007014928A (es) | 2008-02-15 |
WO2006128803A1 (en) | 2006-12-07 |
DE602006009804D1 (de) | 2009-11-26 |
EP1893603B1 (en) | 2009-10-14 |
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