AR069364A1 - Derivados heterociclicos que modulan la miosina del musculo liso y/o la miosina no muscular y composiciones farmaceuticas que los contienen - Google Patents

Derivados heterociclicos que modulan la miosina del musculo liso y/o la miosina no muscular y composiciones farmaceuticas que los contienen

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AR069364A1
AR069364A1 ARP080103556A ARP080103556A AR069364A1 AR 069364 A1 AR069364 A1 AR 069364A1 AR P080103556 A ARP080103556 A AR P080103556A AR P080103556 A ARP080103556 A AR P080103556A AR 069364 A1 AR069364 A1 AR 069364A1
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optionally substituted
heterocycloalkyl
optionally
heteroaryl
cycloalkyl
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Cytokinetics Inc
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Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of AR069364A1 publication Critical patent/AR069364A1/es

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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Se describen entidades químicas que modulan la miosina del musculo liso y/o la miosina no muscular, composiciones farmacéuticas y métodos de tratamiento de enfermedades y afecciones asociadas con la miosina del musculo liso y/o la miosina no muscular. Reivindicacion 1: Al menos una entidad química seleccionada entre el compuesto de formula (1) y sales farmacéuticamente aceptables de los mismos, donde: W1 y W2 se seleccionan independientemente entre CR11R12, NR13 y O; con la condicion de que al menos uno de W1 y W2 sea NR13; W3 se selecciona entre CR1R2, NR14 y O; Z1 se selecciona entre heteroarilo y heterocicloalquilo; Z2 se selecciona entre arilo, heteroarilo y heterocicloalquilo; R8 se selecciona entre hidrogeno, alquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido y heterocicloalquilo opcionalmente sustituido; R1, R2, R11 y R12 se seleccionan independientemente entre hidrogeno, hidroxi, carboxi, sulfonilo, sulfinilo, sulfanilo, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, alcoxi opcionalmente sustituido, ariloxi opcionalmente sustituido, heteroariloxi opcionalmente sustituido, heterocicloalquiloxi opcionalmente sustituido, aminocarboniloxi opcionalmente sustituido, aciloxi opcionalmente sustituido, alcoxicarboniloxi opcionalmente sustituido, alcoxicarbonilo opcionalmente sustituido, amino opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterocicloalquilo opcionalmente sustituido, aminocarbonilo opcionalmente sustituido y aminosulfonilo opcionalmente sustituido; o R1 y R2 pueden unirse opcionalmente junto con cualquiera de los átomos intermedios para formar un grupo seleccionado entre cicloalquilo opcionalmente sustituido y heterocicloalquilo opcionalmente sustituido; R13 y R14 se seleccionan independientemente entre hidrogeno, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido; cicloalquilo opcionalmente sustituido y heterocicloalquilo opcionalmente sustituido; para cada caso, R3, R4, R5 y R6 se seleccionan independientemente entre hidrogeno, hidroxi, carboxi, sulfonilo, sulfinilo, sulfanilo, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, alcoxi opcionalmente sustituido, ariloxi opcionalmente sustituido, heteroariloxi opcionalmente sustituido, heterocicloalquiloxi opcionalmente sustituido, aminocarboniloxi opcionalmente sustituido, aciloxi opcionalmente sustituido, alcoxicarboniloxi opcionalmente sustituido, acilo opcionalmente sustituido, alcoxicarbonilo opcionalmente sustituido, amino opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterocicloalquilo opcionalmente sustituido, aminocarbonilo opcionalmente sustituido y aminosulfonilo opcionalmente sustituido; o R5 y R6 tomados juntos forman un anillo opcionalmente sustituido seleccionado entre cicloalquilo opcionalmente sustituido y heterocicloalquilo opcionalmente sustituido; o R1 y un caso de R5 pueden unirse opcionalmente junto con cualquiera de los átomos intermedios para formar un grupo seleccionado entre cicloalquilo opcionalmente sustituido y heterocicloalquilo opcionalmente sustituido; o R14 y un caso de R5 pueden unirse opcionalmente junto con cualquiera de los átomos intermedios para formar un anillo heterocicloalquilo opcionalmente sustituido; o si W1 es NR13, entonces R13 y R1 pueden unirse opcionalmente junto con cualquiera de los átomos intermedios para formar un anillo heterocicloalquilo opcionalmente sustituido; o si W1 es NR13, entonces R13 y un caso de R5 pueden unirse opcionalmente junto con cualquiera de los átomos intermedios para formar un anillo heterocicloalquilo opcionalmente sustituido; R7 y R10 se seleccionan independientemente entre hidrogeno, ciano, halo, hidroxi, azido, nitro, carboxi, sulfinilo, sulfanilo, alcoxi opcionalmente sustituido, ariloxi opcionalmente sustituido, heteroariloxi opcionalmente sustituido, heterocicloalquiloxi opcionalmente sustituido, alcoxicarbonilo opcionalmente sustituido, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, ariloxi opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heterocicloalquilo opcionalmente sustituido, amino opcionalmente sustituido, acilo opcionalmente sustituido, alcoxicarbonilo opcionalmente sustituido, aminocarbonilo opcionalmente sustituido, aminosulfonilo opcionalmente sustituido, carbaminodoílo opcionalmente sustituido y alquinilo opcionalmente sustituido; m se selecciona entre 0, 1, 2 y 3; n se selecciona entre 0, 1, 2, 3 y 4; p se selecciona entre 0, 1, 2 y 3; y q se selecciona entre 1, 2, 3 y 4.
ARP080103556A 2007-08-15 2008-08-14 Derivados heterociclicos que modulan la miosina del musculo liso y/o la miosina no muscular y composiciones farmaceuticas que los contienen AR069364A1 (es)

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US (3) US8088793B2 (es)
EP (1) EP2195328A4 (es)
JP (1) JP5670731B2 (es)
KR (1) KR20100044251A (es)
CN (1) CN101821279A (es)
AR (1) AR069364A1 (es)
AU (1) AU2008287435B2 (es)
CA (1) CA2696321A1 (es)
CL (1) CL2008002411A1 (es)
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CA2696321A1 (en) 2009-02-19
AU2008287435A1 (en) 2009-02-19
EP2195328A1 (en) 2010-06-16
US8088793B2 (en) 2012-01-03
AU2008287435B2 (en) 2013-05-16
CN101821279A (zh) 2010-09-01
US20090275537A1 (en) 2009-11-05
US20120135964A1 (en) 2012-05-31
EP2195328A4 (en) 2011-06-15
CL2008002411A1 (es) 2009-07-17
MX2010001692A (es) 2010-04-22
JP5670731B2 (ja) 2015-02-18
US20130053348A1 (en) 2013-02-28
WO2009023193A1 (en) 2009-02-19
US8895582B2 (en) 2014-11-25
TWI426908B (zh) 2014-02-21
TW200922583A (en) 2009-06-01
JP2010536752A (ja) 2010-12-02
US8759374B2 (en) 2014-06-24
NZ583351A (en) 2012-05-25
KR20100044251A (ko) 2010-04-29

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