AR063310A1 - Procesos para la sintesis de isomeros individuales de cci-779 monopeg - Google Patents

Procesos para la sintesis de isomeros individuales de cci-779 monopeg

Info

Publication number
AR063310A1
AR063310A1 ARP070104572A ARP070104572A AR063310A1 AR 063310 A1 AR063310 A1 AR 063310A1 AR P070104572 A ARP070104572 A AR P070104572A AR P070104572 A ARP070104572 A AR P070104572A AR 063310 A1 AR063310 A1 AR 063310A1
Authority
AR
Argentina
Prior art keywords
cci
processes
monopeg
synthesis
individual isomers
Prior art date
Application number
ARP070104572A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR063310A1 publication Critical patent/AR063310A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proveen procesos para la preparacion de diastereomeros individuales de rapamicina 42 éster con ácido 3-hidroxi-2-(hidroximetil)-2-metiIpropionico (CCI-779) monopeligado.
ARP070104572A 2006-10-18 2007-10-16 Procesos para la sintesis de isomeros individuales de cci-779 monopeg AR063310A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85254306P 2006-10-18 2006-10-18

Publications (1)

Publication Number Publication Date
AR063310A1 true AR063310A1 (es) 2009-01-21

Family

ID=39092934

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104572A AR063310A1 (es) 2006-10-18 2007-10-16 Procesos para la sintesis de isomeros individuales de cci-779 monopeg

Country Status (6)

Country Link
US (1) US7605258B2 (es)
AR (1) AR063310A1 (es)
CL (1) CL2007002988A1 (es)
PE (1) PE20081465A1 (es)
TW (1) TW200824713A (es)
WO (1) WO2008048611A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
US11311512B2 (en) 2014-08-12 2022-04-26 Monash University Lymph directing prodrugs
CN108137482B (zh) 2015-09-08 2024-03-15 莫纳什大学 定向淋巴的前药
US11883497B2 (en) 2017-08-29 2024-01-30 Puretech Lyt, Inc. Lymphatic system-directing lipid prodrugs
US11304954B2 (en) 2017-12-19 2022-04-19 Puretech Lyt, Inc. Lipid prodrugs of mycophenolic acid and uses thereof
WO2019126374A1 (en) * 2017-12-19 2019-06-27 Ariya Therapeutics, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof
US11608345B1 (en) 2017-12-19 2023-03-21 Puretech Lyt, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof
WO2021159021A1 (en) 2020-02-05 2021-08-12 Puretech Lyt, Inc. Lipid prodrugs of neurosteroids

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5780462A (en) 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
US6277983B1 (en) 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
MXPA03002258A (es) 2000-09-19 2003-06-24 Wyeth Corp Esteres de rapamicina solubles en agua.
BRPI0412659A (pt) 2003-07-16 2006-09-26 Wyeth Corp isÈmero c de cci-779, seu processo de preparação, composição farmacêutica compreendendo o mesmo e pacote farmacêutico contendo o referido composto
AU2004265267A1 (en) * 2003-08-07 2005-02-24 Wyeth Regioselective synthesis of CCI-779
GT200500216A (es) 2004-08-10 2006-03-02 Derivados de cci-779 y metodos para su preparacion
KR20070090931A (ko) 2004-12-20 2007-09-06 와이어쓰 라파마이신 유도체 및 신경계장애의 치료에서의 그의 용도
BRPI0519495A2 (pt) 2004-12-20 2009-02-03 Wyeth Corp composto ou um sal farmaceuticamente aceitÁvel do mesmo, uso de um composto, e, mÉtodo para preparar um composto
US7442707B2 (en) 2005-02-09 2008-10-28 Wyeth CCI-779 polymorph and use thereof
BRPI0619578A2 (pt) 2005-12-07 2011-10-04 Wyeth Corp processo para preparar um 42-éster de rapamicina, composto, método para isolar o boronato do 42-éster de rapamicina bruto a partir do licor mãe, método para purificação de um boronato do 42-éster de rapamicina, e, boronato de cci-779
JP2009529050A (ja) * 2006-03-07 2009-08-13 ワイス マクロライド免疫抑制剤の水溶性ポリエチレングリコール複合体を調製するためのプロセス

Also Published As

Publication number Publication date
US20080097093A1 (en) 2008-04-24
US7605258B2 (en) 2009-10-20
PE20081465A1 (es) 2008-11-24
WO2008048611A1 (en) 2008-04-24
CL2007002988A1 (es) 2008-01-18
TW200824713A (en) 2008-06-16

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